Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 2, 2006, Pages

  Xia, L ^a,c   Wang, H ^a,c   Goldberg, H J ^b,c   Munk, S ^a,c   Fantus, I G ^b,c   Whiteside, C I ^a,b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Diabetic nephropathy; p22phox; p47phox; Reactive oxygen species; Tempol; Tiron

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; COLLAGEN TYPE 4; COMPLEMENTARY RNA; DICHLOROFLUORESCEIN; DIPHENYLIODONIUM SALT; GLUCOSE; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN P22; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TEMPOL; TIRON; CARRIER PROTEIN; CYBA PROTEIN, HUMAN; NEUTROPHIL CYTOSOLIC FACTOR 1; NOX4 PROTEIN, RAT; PHOSPHOPROTEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME REGULATION; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; MESANGIUM CELL; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; ENZYMOLOGY; METABOLISM; OXIDATION REDUCTION REACTION; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; CELLS, CULTURED; COLLAGEN TYPE IV; GLUCOSE; MEMBRANE TRANSPORT PROTEINS; MESANGIAL CELLS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MODELS, BIOLOGICAL; NADPH OXIDASE; OXIDATION-REDUCTION; PHOSPHOPROTEINS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TRANSFECTION; UP-REGULATION;

EID: 33644866156     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00119.2005     Document Type: Article

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