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Volumn 10, Issue 4, 2015, Pages

β-Carotene-induced apoptosis is mediated with loss of Ku proteins in gastric cancer AGS cells

Author keywords

Apoptosis; Caspase 3; Ku proteins; Reactive oxygen species; Carotene

Indexed keywords

ACETYLCYSTEINE; BETA CAROTENE; CASPASE 3; CYTOCHROME C; KU ANTIGEN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

EID: 84929377628     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-015-0467-1     Document Type: Article
Times cited : (39)

References (58)
  • 1
    • 67649435477 scopus 로고    scopus 로고
    • Non-genomic inhibitory signaling of beta-carotene in squamous cell carcinoma of the lungs
    • COI: 1:CAS:528:DC%2BD1MXkt1eisro%3D, PID: 19287967
    • Al-Wadei HA, Schuller HM (2009) Non-genomic inhibitory signaling of beta-carotene in squamous cell carcinoma of the lungs. Int J Oncol 34:1093–1098
    • (2009) Int J Oncol , vol.34 , pp. 1093-1098
    • Al-Wadei, H.A.1    Schuller, H.M.2
  • 2
    • 0346095555 scopus 로고    scopus 로고
    • From 1989 to 2001: what have we learned about the biological actions of β-carotene?
    • COI: 1:CAS:528:DC%2BD2cXitlCrtQ%3D%3D, PID: 14704324
    • Bendich A (2004) From 1989 to 2001: what have we learned about the biological actions of β-carotene? J Nutr 134:225S–230S
    • (2004) J Nutr , vol.134 , pp. 225-230
    • Bendich, A.1
  • 3
    • 0031054975 scopus 로고    scopus 로고
    • Ku selectively transfers between DNA molecules with homologous end
    • COI: 1:CAS:528:DyaK2sXhslalu7s%3D, PID: 9038190
    • Bliss TM, Lane DP (1997) Ku selectively transfers between DNA molecules with homologous end. J Biol Chem 272:5765–5773
    • (1997) J Biol Chem , vol.272 , pp. 5765-5773
    • Bliss, T.M.1    Lane, D.P.2
  • 4
    • 0035702774 scopus 로고    scopus 로고
    • Beta-carotene inhibits growth of human colon carcinoma cells in vitro by induction of apoptosis
    • COI: 1:CAS:528:DC%2BD38XisVKhsLo%3D, PID: 11843179
    • Briviba K, Schnäbele K, Schwertle E, Blockhaus M, Rechkemmer G (2001) Beta-carotene inhibits growth of human colon carcinoma cells in vitro by induction of apoptosis. Biol Chem 382:1663–1668
    • (2001) Biol Chem , vol.382 , pp. 1663-1668
    • Briviba, K.1    Schnäbele, K.2    Schwertle, E.3    Blockhaus, M.4    Rechkemmer, G.5
  • 5
    • 84883616638 scopus 로고    scopus 로고
    • Lutein protects against methotrexate-induced and reactive oxygen species-mediated apoptotic cell injury of IEC-6 cells
    • COI: 1:CAS:528:DC%2BC3sXhsVKrtLrP, PID: 24039779
    • Chang CJ, Lin JF, Chang HH, Lee GA, Hung CF (2013) Lutein protects against methotrexate-induced and reactive oxygen species-mediated apoptotic cell injury of IEC-6 cells”. PLoS One 8(9):e72553
    • (2013) PLoS One , vol.8 , Issue.9 , pp. e72553
    • Chang, C.J.1    Lin, J.F.2    Chang, H.H.3    Lee, G.A.4    Hung, C.F.5
  • 6
    • 84929318050 scopus 로고    scopus 로고
    • Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals
    • PID: 25197620
    • Chaube SK, Shrivastav TG, Tiwari M, Prasad S, Tripathi A, Pandey AK (2014) Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals. Springerplus 3:464
    • (2014) Springerplus , vol.3 , pp. 464
    • Chaube, S.K.1    Shrivastav, T.G.2    Tiwari, M.3    Prasad, S.4    Tripathi, A.5    Pandey, A.K.6
  • 7
    • 84863108461 scopus 로고    scopus 로고
    • Reactive oxygen species mediate Jak2/Stat3 activation and IL-8 expression in pulmonary epithelial cells stimulated with lipid-associated membrane proteins from Mycoplasma pneumoniae
    • COI: 1:CAS:528:DC%2BC38Xlslais7o%3D, PID: 22270622
    • Choi SY, Lim JW, Shimizu T, Kuwano K, Kim JM, Kim H (2012) Reactive oxygen species mediate Jak2/Stat3 activation and IL-8 expression in pulmonary epithelial cells stimulated with lipid-associated membrane proteins from Mycoplasma pneumoniae. Inflamm Res 61:493–501
    • (2012) Inflamm Res , vol.61 , pp. 493-501
    • Choi, S.Y.1    Lim, J.W.2    Shimizu, T.3    Kuwano, K.4    Kim, J.M.5    Kim, H.6
  • 8
    • 36049032810 scopus 로고    scopus 로고
    • beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells
    • COI: 1:CAS:528:DC%2BD2sXhtlWrsbrI, PID: 17911009
    • Cui Y, Lu Z, Bai L, Shi Z, Zhao WE, Zhao B (2007) beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. Eur J Cancer 43:2590–2601
    • (2007) Eur J Cancer , vol.43 , pp. 2590-2601
    • Cui, Y.1    Lu, Z.2    Bai, L.3    Shi, Z.4    Zhao, W.E.5    Zhao, B.6
  • 10
    • 0141433204 scopus 로고    scopus 로고
    • Beta-carotene supplementation protects from photoaging-associated mitochondrial DNA mutation
    • COI: 1:CAS:528:DC%2BD3sXksVWqt7g%3D, PID: 12859149
    • Eicker J, Kürten V, Wild S, Riss G, Goralczyk R, Krutmann J, Berneburg M (2003) Beta-carotene supplementation protects from photoaging-associated mitochondrial DNA mutation. Photochem Photobiol Sci 2:655–659
    • (2003) Photochem Photobiol Sci , vol.2 , pp. 655-659
    • Eicker, J.1    Kürten, V.2    Wild, S.3    Riss, G.4    Goralczyk, R.5    Krutmann, J.6    Berneburg, M.7
  • 12
    • 0036781171 scopus 로고    scopus 로고
    • Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of bcl-XS and activation of caspase-3
    • COI: 1:CAS:528:DC%2BD38XotFKitb0%3D, PID: 12239627
    • Emanuele S, Calvaruso G, Lauricella M, Giuliano M, Bellavia G, D’Anneo A, Vento R, Tesoriere G (2002) Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of bcl-XS and activation of caspase-3. Int J Oncol 21:857–865
    • (2002) Int J Oncol , vol.21 , pp. 857-865
    • Emanuele, S.1    Calvaruso, G.2    Lauricella, M.3    Giuliano, M.4    Bellavia, G.5    D’Anneo, A.6    Vento, R.7    Tesoriere, G.8
  • 13
    • 0033569747 scopus 로고    scopus 로고
    • Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes
    • COI: 1:STN:280:DyaK1MvksFGgtA%3D%3D, PID: 10514462
    • Esposti MD, Hatzinisiriou I, McLennan H, Ralph S (1999) Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes. J Biol Chem 274:29831–29837
    • (1999) J Biol Chem , vol.274 , pp. 29831-29837
    • Esposti, M.D.1    Hatzinisiriou, I.2    McLennan, H.3    Ralph, S.4
  • 14
    • 0033006852 scopus 로고    scopus 로고
    • Ku, a DNA repair protein with multiple cellular functions
    • COI: 1:CAS:528:DyaK1MXjtFWltrY%3D, PID: 10377944
    • Featherstone C, Jackson SP (1999) Ku, a DNA repair protein with multiple cellular functions. Mutat Res 434:3–15
    • (1999) Mutat Res , vol.434 , pp. 3-15
    • Featherstone, C.1    Jackson, S.P.2
  • 15
    • 33749590001 scopus 로고    scopus 로고
    • The nuclear DNA repair protein Ku70/80 is a tumor-associated antigen displaying rapid receptor mediated endocytosis
    • COI: 1:CAS:528:DC%2BD28XhtVylsLjI, PID: 16929494
    • Fransson J, Borrebaeck CA (2006) The nuclear DNA repair protein Ku70/80 is a tumor-associated antigen displaying rapid receptor mediated endocytosis. Int J Cancer 119:2492–2496
    • (2006) Int J Cancer , vol.119 , pp. 2492-2496
    • Fransson, J.1    Borrebaeck, C.A.2
  • 16
    • 84899696166 scopus 로고    scopus 로고
    • Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines
    • COI: 1:CAS:528:DC%2BC2cXotVSnu7k%3D, PID: 24596385
    • Gloria NF, Soares N, Brand C, Oliveira FL, Borojevic R, Teodoro AJ (2014) Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines. Anticancer Res 34:1377–1386
    • (2014) Anticancer Res , vol.34 , pp. 1377-1386
    • Gloria, N.F.1    Soares, N.2    Brand, C.3    Oliveira, F.L.4    Borojevic, R.5    Teodoro, A.J.6
  • 17
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • COI: 1:CAS:528:DyaK1MXltlGktrg%3D, PID: 10444588
    • Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899–1911
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 18
    • 0030858967 scopus 로고    scopus 로고
    • Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
    • COI: 1:CAS:528:DyaK2sXksl2mt74%3D, PID: 9223317
    • Gu Y, Jin S, Gao Y, Weaver DT, Alt FW (1997) Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci USA 94:8076–8081
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8076-8081
    • Gu, Y.1    Jin, S.2    Gao, Y.3    Weaver, D.T.4    Alt, F.W.5
  • 19
    • 34548142633 scopus 로고    scopus 로고
    • Beta-carotene inhibits tumor-specific angiogenesis by altering the cytokine profile and inhibits the nuclear translocation of transcription factors in B16F-10 melanoma cells
    • COI: 1:CAS:528:DC%2BD2sXhtFSksLjF, PID: 17761639
    • Guruvayoorappan C, Kuttan G (2007) Beta-carotene inhibits tumor-specific angiogenesis by altering the cytokine profile and inhibits the nuclear translocation of transcription factors in B16F-10 melanoma cells. Integr Cancer Ther 6:258–270
    • (2007) Integr Cancer Ther , vol.6 , pp. 258-270
    • Guruvayoorappan, C.1    Kuttan, G.2
  • 20
    • 0033972730 scopus 로고    scopus 로고
    • Future perspectives and potential implications of cardiac myocyte apoptosis
    • COI: 1:CAS:528:DC%2BD3cXltVGruw%3D%3D, PID: 10728403
    • Haunstetter A, Izumo S (2000) Future perspectives and potential implications of cardiac myocyte apoptosis. Cardiovasc Res 45:795–801
    • (2000) Cardiovasc Res , vol.45 , pp. 795-801
    • Haunstetter, A.1    Izumo, S.2
  • 21
    • 0032719378 scopus 로고    scopus 로고
    • Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells
    • COI: 1:CAS:528:DyaK1MXnslylt7g%3D, PID: 10590315
    • Ito A, Uehara T, Tokumitsu A, Okuma Y, Nomura Y (1999) Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells. Biochim Biophys Acta 1452:263–274
    • (1999) Biochim Biophys Acta , vol.1452 , pp. 263-274
    • Ito, A.1    Uehara, T.2    Tokumitsu, A.3    Okuma, Y.4    Nomura, Y.5
  • 22
    • 77955885287 scopus 로고    scopus 로고
    • Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells
    • PID: 20388956
    • Jang SH, Lim JW, Kim H (2009a) Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells. J Physiol Pharmacol 60:131–137
    • (2009) J Physiol Pharmacol , vol.60 , pp. 131-137
    • Jang, S.H.1    Lim, J.W.2    Kim, H.3
  • 23
    • 69149103822 scopus 로고    scopus 로고
    • Mechanism of beta-carotene-induced apoptosis of gastric cancer cells: involvement of ataxia-telangiectasia-mutated
    • COI: 1:CAS:528:DC%2BD1MXht1SntbrL
    • Jang SH, Lim JW, Kim H (2009b) Mechanism of beta-carotene-induced apoptosis of gastric cancer cells: involvement of ataxia-telangiectasia-mutated. Ann NewYork Acad Sci 1171:156–162
    • (2009) Ann NewYork Acad Sci , vol.1171 , pp. 156-162
    • Jang, S.H.1    Lim, J.W.2    Kim, H.3
  • 24
    • 0345329610 scopus 로고    scopus 로고
    • Ku autoantigen affects the susceptibility to anticancer drugs
    • COI: 1:CAS:528:DyaK1MXlsVOltb8%3D, PID: 10463600
    • Kim SH, Kim D, Han JS, Jeong CS, Chung BS, Kang CD, Li GC (1999) Ku autoantigen affects the susceptibility to anticancer drugs. Cancer Res 59:4012–4017
    • (1999) Cancer Res , vol.59 , pp. 4012-4017
    • Kim, S.H.1    Kim, D.2    Han, J.S.3    Jeong, C.S.4    Chung, B.S.5    Kang, C.D.6    Li, G.C.7
  • 25
    • 0141738708 scopus 로고    scopus 로고
    • Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocyte
    • COI: 1:CAS:528:DC%2BD3sXnslyru78%3D, PID: 14527084
    • Kim JS, He L, Qian T, Lemasters JJ (2003) Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocyte. Curr Mol Med 3:527–535
    • (2003) Curr Mol Med , vol.3 , pp. 527-535
    • Kim, J.S.1    He, L.2    Qian, T.3    Lemasters, J.J.4
  • 26
    • 84899647478 scopus 로고    scopus 로고
    • Glutamine deprivation induces interleukin-8 expression in ataxia telangiectasia fibroblasts
    • COI: 1:CAS:528:DC%2BC2cXns1amsg%3D%3D, PID: 24413629
    • Kim MH, Kim A, Lim JW, Kim H (2014a) Glutamine deprivation induces interleukin-8 expression in ataxia telangiectasia fibroblasts. Inflamm Res 63:347–356
    • (2014) Inflamm Res , vol.63 , pp. 347-356
    • Kim, M.H.1    Kim, A.2    Lim, J.W.3    Kim, H.4
  • 27
    • 84899929201 scopus 로고    scopus 로고
    • β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α
    • COI: 1:CAS:528:DC%2BC2cXmtlCltLw%3D, PID: 24746828
    • Kim YS, Lee HA, Lim JY, Kim Y, Jung CH, Yoo SH, Kim Y (2014b) β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α. J Nutr Biochem 25:655–664
    • (2014) J Nutr Biochem , vol.25 , pp. 655-664
    • Kim, Y.S.1    Lee, H.A.2    Lim, J.Y.3    Kim, Y.4    Jung, C.H.5    Yoo, S.H.6    Kim, Y.7
  • 29
    • 27144458415 scopus 로고    scopus 로고
    • Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells
    • COI: 1:CAS:528:DC%2BD2MXhtVWnt7bJ, PID: 15905197
    • Lee JC, Lee CH, Su CL, Huangss CW, Liu Hs, Lin CN, Won SJ (2005) Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. Carcinogenesis 26:1716–1730
    • (2005) Carcinogenesis , vol.26 , pp. 1716-1730
    • Lee, J.C.1    Lee, C.H.2    Su, C.L.3    Huangss, C.W.4    Liu, H.5    Lin, C.N.6    Won, S.J.7
  • 30
    • 84882658697 scopus 로고    scopus 로고
    • Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells
    • COI: 1:CAS:528:DC%2BC3sXhs1agsb7I, PID: 23900747
    • Lee HA, Park S, Kim Y (2013) Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells. Oncol Rep 30(4):1869–1877
    • (2013) Oncol Rep , vol.30 , Issue.4 , pp. 1869-1877
    • Lee, H.A.1    Park, S.2    Kim, Y.3
  • 31
    • 0028937877 scopus 로고
    • Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
    • COI: 1:CAS:528:DyaK2MXktVKjsbk%3D, PID: 7855602
    • Lees-Miller SP, Godbout R, Chan DW, Weinfeld M, Day RS 3rd, Barron GM, Allalunis-Turner J (1995) Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 267:1183–1185
    • (1995) Science , vol.267 , pp. 1183-1185
    • Lees-Miller, S.P.1    Godbout, R.2    Chan, D.W.3    Weinfeld, M.4    Day, R.S.5    Barron, G.M.6    Allalunis-Turner, J.7
  • 32
    • 0037195933 scopus 로고    scopus 로고
    • Expression of Ku70 and Ku80 mediated by NF-κB and cyclooxygenase-2 is related to proliferation in human gastric cancer cells
    • Lim JW, Kim H, Kim KH (2012) Expression of Ku70 and Ku80 mediated by NF-κB and cyclooxygenase-2 is related to proliferation in human gastric cancer cells. J Biol Chem 277:46093–46100
    • (2012) J Biol Chem , vol.277 , pp. 46093-46100
    • Lim, J.W.1    Kim, H.2    Kim, K.H.3
  • 33
    • 84906097596 scopus 로고    scopus 로고
    • β-Carotene inhibits neuroblastoma tumorigenesis by regulating cell differentiation and cancer cell stemness
    • COI: 1:CAS:528:DC%2BC2cXhtF2ku7rL, PID: 25019987
    • Lim JY, Kim YS, Kim KM, Min SJ, Kim Y (2014) β-Carotene inhibits neuroblastoma tumorigenesis by regulating cell differentiation and cancer cell stemness. Biochem Biophys Res Commun 450:1475–1480
    • (2014) Biochem Biophys Res Commun , vol.450 , pp. 1475-1480
    • Lim, J.Y.1    Kim, Y.S.2    Kim, K.M.3    Min, S.J.4    Kim, Y.5
  • 34
    • 0031860923 scopus 로고    scopus 로고
    • DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties
    • COI: 1:CAS:528:DyaK1cXkt1Wjtrs%3D, PID: 9632806
    • Liu L, Kwak YT, Bex F, García-Martínez LF, Li XH, Meek K, Lane WS, Gaynor RB (1998) DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties. Mol Cell Biol 18:4221–4234
    • (1998) Mol Cell Biol , vol.18 , pp. 4221-4234
    • Liu, L.1    Kwak, Y.T.2    Bex, F.3    García-Martínez, L.F.4    Li, X.H.5    Meek, K.6    Lane, W.S.7    Gaynor, R.B.8
  • 35
    • 0343776197 scopus 로고    scopus 로고
    • Role of reactive oxygen species in apoptosis: implications for cancer therapy
    • COI: 1:CAS:528:DyaK1MXnvFeis7o%3D, PID: 10687951
    • Mates JM, Sanchez-Jimenez FM (2000) Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 32:157–170
    • (2000) Int J Biochem Cell Biol , vol.32 , pp. 157-170
    • Mates, J.M.1    Sanchez-Jimenez, F.M.2
  • 36
    • 0033032444 scopus 로고    scopus 로고
    • Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation
    • COI: 1:CAS:528:DyaK1MXivVOls7c%3D, PID: 10193575
    • Matsura T, Kai M, Fujii Y, Ito H, Yamada K (1999) Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation. Free Radic Res 30:73–83
    • (1999) Free Radic Res , vol.30 , pp. 73-83
    • Matsura, T.1    Kai, M.2    Fujii, Y.3    Ito, H.4    Yamada, K.5
  • 37
    • 84884844440 scopus 로고    scopus 로고
    • Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities
    • PID: 24093108
    • Mishra A, Sharma AK, Kumar S, Saxena AK, Pandey AK (2013) Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities. Biomed Res Int 2013:915436
    • (2013) Biomed Res Int , vol.2013 , pp. 915436
    • Mishra, A.1    Sharma, A.K.2    Kumar, S.3    Saxena, A.K.4    Pandey, A.K.5
  • 38
    • 0037163038 scopus 로고    scopus 로고
    • Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide
    • COI: 1:CAS:528:DC%2BD38XmsFyqtLw%3D, PID: 12068015
    • Mizutani H, Tada-Oikawa S, Hiraku Y, Oikawa S, Kojima M, Kawanishi S (2002) Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide. J Biol Chem 277:30684–30689
    • (2002) J Biol Chem , vol.277 , pp. 30684-30689
    • Mizutani, H.1    Tada-Oikawa, S.2    Hiraku, Y.3    Oikawa, S.4    Kojima, M.5    Kawanishi, S.6
  • 39
    • 18944377963 scopus 로고    scopus 로고
    • The double life of the Ku protein: facing the DNA breaks and the extracellular environment
    • COI: 1:CAS:528:DC%2BD28XktlCruw%3D%3D, PID: 15738653
    • Muller C, Paupert J, Monferran S, Salles B (2005) The double life of the Ku protein: facing the DNA breaks and the extracellular environment. Cell Cycle 4:438–441
    • (2005) Cell Cycle , vol.4 , pp. 438-441
    • Muller, C.1    Paupert, J.2    Monferran, S.3    Salles, B.4
  • 40
    • 0029068871 scopus 로고
    • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    • COI: 1:CAS:528:DyaK2MXmvVGqu7k%3D, PID: 7596430
    • Nicholson DW et al (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37–43
    • (1995) Nature , vol.376 , pp. 37-43
    • Nicholson, D.W.1
  • 41
    • 20444427216 scopus 로고    scopus 로고
    • Can beta-carotene regulate cell growth by a redox mechanism? An answer from cultured cells
    • COI: 1:CAS:528:DC%2BD2MXltFCrtLo%3D, PID: 15949689
    • Palozza P (2005) Can beta-carotene regulate cell growth by a redox mechanism? An answer from cultured cells. Biochim Biophys Acta 1740:215–221
    • (2005) Biochim Biophys Acta , vol.1740 , pp. 215-221
    • Palozza, P.1
  • 42
    • 0035341998 scopus 로고    scopus 로고
    • Beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells
    • COI: 1:CAS:528:DC%2BD3MXislGqtL8%3D, PID: 11316580
    • Palozza P, Calviello G, Serini S, Maggiano N, Lanza P, Ranelletti FO, Bartoli GM (2001) Beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells. Free Radic Biol Med 30:1000–1007
    • (2001) Free Radic Biol Med , vol.30 , pp. 1000-1007
    • Palozza, P.1    Calviello, G.2    Serini, S.3    Maggiano, N.4    Lanza, P.5    Ranelletti, F.O.6    Bartoli, G.M.7
  • 43
    • 0037050725 scopus 로고    scopus 로고
    • Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism
    • COI: 1:CAS:528:DC%2BD38XpsFWjsw%3D%3D, PID: 11807783
    • Palozza P, Serini S, Torsello A, Boninsegna A, Covacci V, Maggiano N, Ranelletti FO, Wolf FI, Calviello G (2002) Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism. Int J Cancer 97:593–600
    • (2002) Int J Cancer , vol.97 , pp. 593-600
    • Palozza, P.1    Serini, S.2    Torsello, A.3    Boninsegna, A.4    Covacci, V.5    Maggiano, N.6    Ranelletti, F.O.7    Wolf, F.I.8    Calviello, G.9
  • 45
    • 0037312590 scopus 로고    scopus 로고
    • Beta-carotene regulates NF-kappaB DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cells
    • COI: 1:CAS:528:DC%2BD3sXhtV2ntLs%3D, PID: 12566471
    • Palozza P, Serini S, Torsello A, Di Nicuolo F, Piccioni E, Ubaldi V, Pioli C, Wolf FI, Calviello G (2003b) Beta-carotene regulates NF-kappaB DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cells. J Nutr 133:381–388
    • (2003) J Nutr , vol.133 , pp. 381-388
    • Palozza, P.1    Serini, S.2    Torsello, A.3    Di Nicuolo, F.4    Piccioni, E.5    Ubaldi, V.6    Pioli, C.7    Wolf, F.I.8    Calviello, G.9
  • 46
    • 0034015563 scopus 로고    scopus 로고
    • Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition
    • COI: 1:CAS:528:DC%2BD3cXjtlyluro%3D, PID: 10796891
    • Pastorino JG, Hoek JB (2000) Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. Hepatology 31:1141–1152
    • (2000) Hepatology , vol.31 , pp. 1141-1152
    • Pastorino, J.G.1    Hoek, J.B.2
  • 47
    • 84881255289 scopus 로고    scopus 로고
    • β, β-carotene 15,15′-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells
    • PID: 23803888
    • Pham DN, Leclerc D, Lévesque N, Deng L, Rozen R (2013) β, β-carotene 15,15′-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells. Am J Clin Nutr 98(2):413–422
    • (2013) Am J Clin Nutr , vol.98 , Issue.2 , pp. 413-422
    • Pham, D.N.1    Leclerc, D.2    Lévesque, N.3    Deng, L.4    Rozen, R.5
  • 48
    • 0033178242 scopus 로고    scopus 로고
    • Detection of apoptosis and changes in mitochondrial membrane potential with chloromethyl-X-rosamine
    • COI: 1:STN:280:DyaK1MzjtlCnuw%3D%3D, PID: 10404153
    • Poot M, Pierce RC (1999) Detection of apoptosis and changes in mitochondrial membrane potential with chloromethyl-X-rosamine. Cytometry 36:359–360
    • (1999) Cytometry , vol.36 , pp. 359-360
    • Poot, M.1    Pierce, R.C.2
  • 49
    • 33745818640 scopus 로고    scopus 로고
    • ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis
    • COI: 1:CAS:528:DC%2BD28XntFWru7s%3D, PID: 16843824
    • Prasad V, Chandele A, Jagtap JC, Sudheer Kumar P, Shastry P (2006) ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis. Free Radic Biol Med 41:431–442
    • (2006) Free Radic Biol Med , vol.41 , pp. 431-442
    • Prasad, V.1    Chandele, A.2    Jagtap, J.C.3    Sudheer Kumar, P.4    Shastry, P.5
  • 50
    • 20444413050 scopus 로고    scopus 로고
    • Beta-carotene uptake and metabolism in human lung bronchial epithelial cultured cells depending on delivery vehicle
    • PID: 15949679
    • Rodríguez AM, Sastre S, Ribot J, Palou A (2005) Beta-carotene uptake and metabolism in human lung bronchial epithelial cultured cells depending on delivery vehicle. Biochim Biophys Acta 1740:132–138
    • (2005) Biochim Biophys Acta , vol.1740 , pp. 132-138
    • Rodríguez, A.M.1    Sastre, S.2    Ribot, J.3    Palou, A.4
  • 51
    • 0033957359 scopus 로고    scopus 로고
    • Morphologic and biochemical hallmarks of apoptosis
    • COI: 1:CAS:528:DC%2BD3cXltVGlsg%3D%3D, PID: 10728374
    • Saraste A, Pulkki K (2000) Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res 45:528–537
    • (2000) Cardiovasc Res , vol.45 , pp. 528-537
    • Saraste, A.1    Pulkki, K.2
  • 52
    • 21344441240 scopus 로고    scopus 로고
    • Beta-carotene breakdown products may impair mitochondrial functions-potential side effects of high-dose beta-carotene supplementation
    • COI: 1:CAS:528:DC%2BD2MXlvVWlsLY%3D, PID: 15992676
    • Siems W, Wiswedel I, Salerno C, Crifò C, Augustin W, Schild L, Langhans CD, Sommerburg O (2005) Beta-carotene breakdown products may impair mitochondrial functions-potential side effects of high-dose beta-carotene supplementation. J Nutr Biochem 16:385–397
    • (2005) J Nutr Biochem , vol.16 , pp. 385-397
    • Siems, W.1    Wiswedel, I.2    Salerno, C.3    Crifò, C.4    Augustin, W.5    Schild, L.6    Langhans, C.D.7    Sommerburg, O.8
  • 53
    • 0141814999 scopus 로고    scopus 로고
    • Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42 J cells
    • COI: 1:CAS:528:DC%2BD3sXnt1ejt7g%3D, PID: 12867423
    • Song JY, Lim JW, Kim H, Morio T, Kim KH (2003) Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42 J cells. J Biol Chem 278:36676–36687
    • (2003) J Biol Chem , vol.278 , pp. 36676-36687
    • Song, J.Y.1    Lim, J.W.2    Kim, H.3    Morio, T.4    Kim, K.H.5
  • 55
    • 0036189567 scopus 로고    scopus 로고
    • Translocation of Ku86/Ku70 to the multiple myeloma cell membrane: functional implications
    • COI: 1:CAS:528:DC%2BD38XhslWgtLc%3D, PID: 11882358
    • Tai YT, Podar K, Kraeft SK, Wang F, Young G, Lin B, Gupta D, Chen LB, Anderson KC (2002) Translocation of Ku86/Ku70 to the multiple myeloma cell membrane: functional implications. Exp Hematol 30:212–213
    • (2002) Exp Hematol , vol.30 , pp. 212-213
    • Tai, Y.T.1    Podar, K.2    Kraeft, S.K.3    Wang, F.4    Young, G.5    Lin, B.6    Gupta, D.7    Chen, L.B.8    Anderson, K.C.9
  • 56
    • 0037118941 scopus 로고    scopus 로고
    • Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes
    • COI: 1:CAS:528:DC%2BD38Xls1ans7k%3D, PID: 12137926
    • Takuma K, Mori K, Lee E, Enomoto R, Baba A, Matsuda T (2002) Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes. Brain Res 946:232–238
    • (2002) Brain Res , vol.946 , pp. 232-238
    • Takuma, K.1    Mori, K.2    Lee, E.3    Enomoto, R.4    Baba, A.5    Matsuda, T.6
  • 57
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • COI: 1:CAS:528:DyaK2MXktlClt70%3D, PID: 7878464
    • Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267:1456–1462
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 58
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • COI: 1:CAS:528:DyaK1cXlsFKls7g%3D, PID: 9716137
    • Woo RA, McLure KG, Lees-Miller SP, Rancourt DE, Lee PW (1998) DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394:700–704
    • (1998) Nature , vol.394 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.