Non-genomic inhibitory signaling of β-carotene in squamous cell carcinoma of the lungs

International Journal of Oncology

Volumn 34, Issue 4, 2009, Pages 1093-1098

  Al Wadei, Hussein A N ^a,b   Schuller, Hildegard M ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b SANA A UNIVERSITY   (Yemen)

Author keywords

Carotene; CAMP signaling; Squamous cell carcinoma

Indexed keywords

ADENYLATE CYCLASE; BETA CAROTENE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENOMICS; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM; LUNG SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BETA CAROTENE; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOASSAY; LUNG NEOPLASMS; MODELS, BIOLOGICAL; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS;

EID: 67649435477     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000236     Document Type: Article

References (24)

1. Burns DM: Tobacco-related diseases. Semin Oncol Nurs 19: 244-249, 2003.
2. Devesa SS, Bray F, Vizcaino AP and Parkin DM: International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising. Int J Cancer 117: 294-299, 2005.
3. Brambilla E, Travis WD, Colby TV, Corrin B and Shimosato Y: The new World Health Organization classification of lung tumours. Eur Respir J 18: 1059-1068, 2001.
4. Miller AB, Altenburg HP, Bueno-de-Mesquita B, Boshuizen HC, Agudo A, Berrino F, Gram IT, Janson L, Linseisen J, Overvad K, Rasmuson T, Vineis P, Lukanova A, Allen N, Amiano P, Barricarte A, Berglund G, Boeing H, Clavel-Chapelon F, Day NE, Hallmans G, Lund E, Martinez C, Navarro C, Palli D, Panico S, Peeters PH, Quiros JR, Tjonneland A, Tumino R, Trichopoulou A, Trichopoulos D, Slimani N and Riboli E: Fruits and vegetables and lung cancer: findings from the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 108: 269-276, 2004.
5. Harris CC, Sporn MB, Kaufman DG, Smith JM, Jackson FE and Saffiotti U: Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo[a]pyrene-Ferric oxide. J Natl Cancer Inst 48: 743-761, 1972.
6. Sporn MB and Suh N: Chemoprevention of cancer. Carcinogenesis 21: 525-530, 2000.
7. Group TA-TB-CCPS: The effects of vitamin E and betacarotene on the incidnec of lung cancer and other organs in male smokers. N Eng J Med 330: 1029-1035, 1994.
8. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S and Hammar S: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334: 1150-1155, 1996.
9. Schuller HM, Tithof PK, Williams M and Plummer H III: The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. Cancer Res 59: 4510-4515, 1999.
10. Schuller HM, Al-Wadei HA and Majidi M: Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma. Carcinogenesis 29: 1979-1985, 2008.
11. Laag E, Majidi M, Cekanova C, Masi T, Takahashi T and Schuller HM: NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells. Int J Cancer 119: 1547-1552, 2006.
12. Schuller HM, Porter B and Riechert A: Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J Cancer Res Clin Oncol 126: 624-630, 2000.
13. Schuller HM, Porter B, Riechert A, Walker K and Schmoyer R: Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. Lung Cancer 45: 11-18, 2004.
14. Al-Wadei HA, Takahashi T and Schuller HM: Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer 118: 1370-1380, 2006.
15. Reddel RR, Ke Y, Gerwin BI, McMenamin MG, Lechner JF, Su RT, Brash DE, Park JB, Rhim JS and Harris CC: Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res 48: 1904-1909, 1988.
16. Feldman RD and Gros R: New insights into the regulation of cAMP synthesis beyond GPCR/G protein activation: implications in cardiovascular regulation. Life Sci 81: 267-271, 2007.
17. Davidovici BB, Tuzun Y and Wolf R: Retinoid receptors. Dermatol Clin 25: 525-530, 2007.
18. Ziouzenkova O and Plutzky J: Retinoid metabolism and nuclear receptor responses: new insights into coordinated regulation of the PPAR-RXR complex. FEBS Lett 582: 32-38, 2008.
19. Copin MC, Devisme L, Buisine MP, Marquette CH, Wurtz A, Aubert JP, Gosselin B and Porchet N: From normal respiratory mucosa to epidermoid carcinoma: expression of human mucin genes. Int J Cancer 86: 162-168, 2000.
20. Aggarwal S, Kim SW, Cheon K, Tabassam FH, Yoon JH and Koo JS: Non-classical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. Mol Biol Cell 17: 566-575, 2006.
21. Al-Wadei HA and Schuller HM: Cyclic adenosine monophosphate-dependent cell type-specific modulation of mitogenic signaling by retinoids in normal and neoplastic lung cells. Cancer Detect Prev 30: 403-411, 2006.
22. Arredondo J, Chernyavsky AI and Grando SA: The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines in BEP2D cells. J Cancer Res Clin Oncol 132: 653-663, 2006.
23. Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE and Grando SA: Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes. FASEB J 20: 2093-2101, 2006.
24. Lowinger TB, Riedl B, Dumas J and Smith RA: Design and discovery of small molecules targeting raf-1 kinase. Curr Pharm Des 8: 2269-2278, 2002.