Lutein Protects against Methotrexate-Induced and Reactive Oxygen Species-Mediated Apoptotic Cell Injury of IEC-6 Cells

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Chang, Chi Jen ^a,b   Lin, Ji Fan ^a   Chang, Hsun Hsien ^c   Lee, Gon Ann ^d   Hung, Chi Feng ^b,c  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c HARVARD MEDICAL SCHOOL   (United States)

^d FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CATALASE; METHOTREXATE; PEROXIREDOXIN 1; PROTEIN BAD; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; XANTHOPHYLL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL STRAIN IEC 6; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME REGULATION; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; JEJUNUM; MITOCHONDRIAL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CASPASE 3; CATALASE; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; ENZYME ACTIVATION; EPITHELIAL CELLS; INTESTINAL MUCOSA; LUTEIN; MEMBRANE POTENTIAL, MITOCHONDRIAL; METHOTREXATE; OXIDATIVE STRESS; PEROXIREDOXINS; RATS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 84883616638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072553     Document Type: Article

References (43)

1. Fox AD, Kripke SA, De Paula J, Berman JM, Settle RG, et al. (1988) Effect of a glutamine-supplemented enteral diet on methotrexate-induced enterocolitis. JPEN J Parenter Enteral Nutr 12: 325-331.
2. Margolis S, Philips FS, Sternberg SS, (1971) The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis. Cancer Res 31: 2037-2046.
3. Frei E 3rd, Jaffe N, Tattersall MH, Pitman S, Parker L, (1975) New approaches to cancer chemotherapy with methotrexate. N Engl J Med 292: 846-851.
4. Jolly LE Jr, Fletcher HP, (1977) The effect of repeated oral dosing of methotrexate on its intestinal absorption in the rat. Toxicol Appl Pharmacol 39: 23-32.
5. Takeuchi H, Kosakai Y, Tsurui K, Hasegawa K, Horie T, et al. (1989) Change in small intestinal brush border membranes of rats following methotrexate administration. Pharmacol Toxicol 65: 269-273.
6. Tsurui K, Kosakai Y, Horie T, Awazu S, (1990) Vitamin A protects the small intestine from methotrexate-induced damage in rats. J Pharmacol Exp Ther 253: 1278-1284.
7. Mueller-Koch Y, Vogelsang H, Kopp R, Lohse P, Keller G, et al. (2005) Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer. Gut 54: 1733-1740.
8. Yuncu M, Eralp A, Celik A, (2006) Effect of aged garlic extract against methotrexate-induced damage to the small intestine in rats. Phytother Res 20: 504-510.
9. Yamamoto J, Horie T, Awazu S, (1997) Amelioration of methotrexate-induced malabsorption by vitamin A. Cancer Chemother Pharmacol. 39: 239-244.
10. Gibson RJ, Keefe DM, Clarke JM, Regester GO, Thompson FM, et al. (2002) The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer. Cancer Chemother Pharmacol 50: 53-58.
11. Howarth GS, Cool JC, Bourne AJ, Ballard FJ, Read LC, (1998) Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate. Growth Factors 15: 279-292.
12. Yuncu M, Eralp A, Koruk M, Sari I, Bagci C, et al. (2004) Effect of vitamin A against methotrexate-induced damage to the small intestine in rats. Med Princ Pract 13: 346-352.
13. Vardi N, Parlakpinar H, Ozturk F, Ates B, Gul M, et al. (2008) Potent protective effect of apricot and beta-carotene on methotrexate-induced intestinal oxidative damage in rats. Food Chem Toxicol 46: 3015-3022.
14. Kolli VK, Abraham P, Isaac B, Kasthuri N (2012) Preclinical Efficacy of Melatonin to Reduce Methotrexate-Induced Oxidative Stress and Small Intestinal Damage in Rats. Dig Dis Sci.
15. Gao F, Horie T, (2000) Protective effect of prostaglandins on the methotrexate induced damage of small intestine in rats. In Vivo 14: 453-456.
16. Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E, (1993) Carotenoid content of fruits and vegetables: an evaluation of analytic data. J Am Diet Assoc 93: 284-296.
17. Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, et al. (2012) Neuroprotective effects of lutein in the retina. Curr Pharm Des 18: 51-56.
18. Huang C, Hsu P, Hung Y, Liao Y, Liu C, et al. (2005) Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production. Apoptosis 10: 895-907.
19. Muller K, Carpenter KL, Challis IR, Skepper JN, Arends MJ, (2002) Carotenoids induce apoptosis in the T-lymphoblast cell line Jurkat E6.1. Free Radic Res 36: 791-802.
20. Cha KH, Koo SY, Lee DU, (2008) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells. J Agric Food Chem 56: 10521-10526.
21. Li T, Ito K, Horie T, (2003) Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells. Am J Physiol Gastrointest Liver Physiol 285: G602-610.
22. Carrasco RA, Stamm NB, Patel BK, (2003) One-step cellular caspase-3/7 assay. Biotechniques 34: 1064-1067.
23. Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C, (1993) A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun 197: 40-45.
24. Xiao D, Vogel V, Singh SV, (2006) Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak. Mol Cancer Ther 5: 2931-2945.
25. Gomaa I, Ali SE, El-Tayeb TA, Abdel-Kader MH, (2012) Chlorophyll derivative mediated PDT versus methotrexate: An in vitro study using MCF-7 cells. Photodiagnosis Photodyn Ther 9: 362-368.
26. Horie T, Li T, Ito K, Sumi S, Fuwa T, (2006) Aged garlic extract protects against methotrexate-induced apoptotic cell injury of IEC-6 cells. J Nutr 136: 861S-863S.
27. Yin J, Meng Q, Zhang G, Sun Y, (2009) Differential methotrexate hepatotoxicity on rat hepatocytes in 2-D monolayer culture and 3-D gel entrapment culture. Chem Biol Interact 180: 368-375.
28. Gao F, Horie T, (2002) A synthetic analog of prostaglandin E(1) prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats. Life Sci 71: 1091-1099.
29. Kim Y, Seo JH, Kim H, (2011) beta-Carotene and lutein inhibit hydrogen peroxide-induced activation of NF-kappaB and IL-8 expression in gastric epithelial AGS cells. J Nutr Sci Vitaminol (Tokyo) 57: 216-223.
30. Krishnaswamy R, Devaraj SN, Padma VV, (2010) Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expression. Free Radic Biol Med 49: 50-60.
31. Kalariya NM, Ramana KV, Srivastava SK, van Kuijk FJ, (2008) Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells. Exp Eye Res 86: 70-80.
32. Nunez G, Benedict MA, Hu Y, Inohara N, (1998) Caspases: the proteases of the apoptotic pathway. Oncogene 17: 3237-3245.
33. Green DR, Reed JC, (1998) Mitochondria and apoptosis. Science 281: 1309-1312.
34. Herman S, Zurgil N, Deutsch M, (2005) Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines. Inflamm Res 54: 273-280.
35. Phillips DC, Woollard KJ, Griffiths HR, (2003) The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. Br J Pharmacol 138: 501-511.
36. Sung JY, Hong JH, Kang HS, Choi I, Lim SD, et al. (2000) Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis. Immunopharmacology 47: 35-44.
37. Kremer JM, (2004) Toward a better understanding of methotrexate. Arthritis Rheum 50: 1370-1382.
38. Miyazono Y, Gao F, Horie T, (2004) Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scand J Gastroenterol 39: 1119-1127.
39. Ciralik H, Bulbuloglu E, Cetinkaya A, Kurutas EB, Celik M, et al. (2006) Effects of N-acetylcysteine on methotrexate-induced small intestinal damage in rats. Mt Sinai J Med 73: 1086-1092.
40. Simone CB 2nd, Simone NL, Simone V, Simone CB, (2007) Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Altern Ther Health Med 13: 22-28.
41. Ustundag B, Kazez A, Demirbag M, Canatan H, Halifeoglu I, et al. (2000) Protective effect of melatonin on antioxidative system in experimental ischemia-reperfusion of rat small intestine. Cell Physiol Biochem 10: 229-236.
42. Reboul E, Abou L, Mikail C, Ghiringhelli O, Andre M, et al. (2005) Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). Biochem J 387: 455-461.
43. Goni I, Serrano J, Saura-Calixto F, (2006) Bioaccessibility of beta-carotene, lutein, and lycopene from fruits and vegetables. J Agric Food Chem 54: 5382-5387.