-
1
-
-
53649103112
-
Gerontology: Healthy old age
-
Kirkwood TB. Gerontology: Healthy old age. Nature. 2008; 455:739-740.
-
(2008)
Nature
, vol.455
, pp. 739-740
-
-
Kirkwood, T.B.1
-
2
-
-
50849124484
-
Cancer and aging: more puzzles, more promises
-
Blagosklonny MV, Campisi J. Cancer and aging: more puzzles, more promises? Cell Cycle. 2008; 7:2615-2618.
-
(2008)
Cell Cycle
, vol.7
, pp. 2615-2618
-
-
Blagosklonny, M.V.1
Campisi, J.2
-
3
-
-
51549117737
-
SEER Cancer Statistics Review 1975-2007 Bethesday, MD
-
based on November 2009 SEER data submission, posted to the SEER web site 2010
-
Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, et al. SEER Cancer Statistics Review 1975-2007 Bethesday, MD: National Cance Institute; 2010. Available from: http://seer.cancer.gov/csr/1975 2007//, based on November 2009 SEER data submission, posted to the SEER web site, 2010.
-
(2010)
National Cance Institute
-
-
Altekruse, S.F.1
Kosary, C.L.2
Krapcho, M.3
Neyman, N.4
Aminou, R.5
Waldron, W.6
-
4
-
-
79957532005
-
Aging and cancer: can mTOR inhibitors kill two birds with one drug?
-
Sharp Z, Richardson A. Aging and cancer: can mTOR inhibitors kill two birds with one drug? Targeted Oncology. 2011; 6:41-51.
-
(2011)
Targeted Oncology
, vol.6
, pp. 41-51
-
-
Sharp, Z.1
Richardson, A.2
-
5
-
-
74049092809
-
Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research
-
Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN. Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis. 2010; 31:83-89.
-
(2010)
Carcinogenesis
, vol.31
, pp. 83-89
-
-
Hursting, S.D.1
Smith, S.M.2
Lashinger, L.M.3
Harvey, A.E.4
Perkins, S.N.5
-
6
-
-
77951176737
-
Extending Healthy Life Span--From Yeast to Humans
-
Fontana L, Partridge L, Longo VD. Extending Healthy Life Span- -From Yeast to Humans. Science. 2010; 328:321-326.
-
(2010)
Science
, vol.328
, pp. 321-326
-
-
Fontana, L.1
Partridge, L.2
Longo, V.D.3
-
7
-
-
72849115497
-
How Does Calorie Restriction Increase the Longevity of Mammals?
-
In: Guarente LP, Partridge L, Wallace DC, editors. Cold Spring Harbor, NY 11724: Cold Spring Harbor Laboratory Press
-
Weindruch R, Colman RJ, Pérez V, Richardson AG. How Does Calorie Restriction Increase the Longevity of Mammals? In: Guarente LP, Partridge L, Wallace DC, editors. Molecular Biology of Aging. Cold Spring Harbor, NY 11724: Cold Spring Harbor Laboratory Press; 2008; 409-426.
-
(2008)
Molecular Biology of Aging.
, pp. 409-426
-
-
Weindruch, R.1
Colman, R.J.2
Pérez, V.3
Richardson, A.G.4
-
8
-
-
78751704345
-
Growth hormone, insulin and aging: The benefits of endocrine defects
-
Bartke A. Growth hormone, insulin and aging: The benefits of endocrine defects. Exp Gerontol. 2011; 46:108-111.
-
(2011)
Exp Gerontol
, vol.46
, pp. 108-111
-
-
Bartke, A.1
-
9
-
-
0345237923
-
Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity
-
Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A. Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity. J Gerontol A Biol Sci Med Sci. 2003; 58:B291-B296.
-
(2003)
J Gerontol A Biol Sci Med Sci
, vol.58
-
-
Ikeno, Y.1
Bronson, R.T.2
Hubbard, G.B.3
Lee, S.4
Bartke, A.5
-
10
-
-
65549149453
-
Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice
-
Ikeno Y, Hubbard GB, Lee S, Cortez LA, Lew CM, Webb CR, et al. Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2009; 64A:522-529.
-
(2009)
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
, vol.64 A
, pp. 522-529
-
-
Ikeno, Y.1
Hubbard, G.B.2
Lee, S.3
Cortez, L.A.4
Lew, C.M.5
Webb, C.R.6
-
11
-
-
30944458446
-
Extension of chronological life span in yeast by decreased TOR pathway signaling
-
Powers RW, 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006; 20:174-184.
-
(2006)
Genes Dev
, vol.20
, pp. 174-184
-
-
Powers, R.W.1
Kaeberlein, M.2
Caldwell, S.D.3
Kennedy, B.K.4
Fields, S.5
-
12
-
-
84860461929
-
TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
-
Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, et al. TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metabolism. 2012;15:713-724.
-
(2012)
Cell Metabolism
, vol.15
, pp. 713-724
-
-
Robida-Stubbs, S.1
Glover-Cutter, K.2
Lamming, D.W.3
Mizunuma, M.4
Narasimhan, S.D.5
Neumann-Haefelin, E.6
-
13
-
-
72649091698
-
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
-
Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, et al. Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. Cell Metabolism. 2010; 11:35-46.
-
(2010)
Cell Metabolism
, vol.11
, pp. 35-46
-
-
Bjedov, I.1
Toivonen, J.M.2
Kerr, F.3
Slack, C.4
Jacobson, J.5
Foley, A.6
-
14
-
-
56749182467
-
-
Nadon NL, Strong R, Miller RA, Nelson J, Javors M, Sharp ZD, et al. Design of aging intervention studies: the NIA interventions testing program. AGE. 2008; 30:187-199.
-
(2008)
Design of aging intervention studies: the NIA interventions testing program. AGE
, vol.30
, pp. 187-199
-
-
Nadon, N.L.1
Strong, R.2
Miller, R.A.3
Nelson, J.4
Javors, M.5
Sharp, Z.D.6
-
15
-
-
56749182467
-
-
Nadon NL, Strong R, Miller RA, Nelson J, Javors M, Sharp ZD, et al. Design of aging intervention studies: the NIA interventions testing program. Age (Dordr). 2008; 30:187-199.
-
(2008)
Design of aging intervention studies: the NIA interventions testing program. Age (Dordr)
, vol.30
, pp. 187-199
-
-
Nadon, N.L.1
Strong, R.2
Miller, R.A.3
Nelson, J.4
Javors, M.5
Sharp, Z.D.6
-
16
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009; 460:392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
17
-
-
79951794971
-
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
-
Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, et al. Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice. J Gerontol A Biol Sci Med Sci. 2011; 66:191-201.
-
(2011)
J Gerontol A Biol Sci Med Sci
, vol.66
, pp. 191-201
-
-
Miller, R.A.1
Harrison, D.E.2
Astle, C.M.3
Baur, J.A.4
Boyd, A.R.5
de Cabo, R.6
-
18
-
-
0035835815
-
The retinoblastoma gene: a prototypic and multifunctional tumor suppressor
-
Zheng L, Lee WH. The retinoblastoma gene: a prototypic and multifunctional tumor suppressor. Exp Cell Res. 2001; 264:2-18.
-
(2001)
Exp Cell Res
, vol.264
, pp. 2-18
-
-
Zheng, L.1
Lee, W.H.2
-
19
-
-
0033616597
-
RBmediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice
-
Mar 30
-
Nikitin AY, Juarez-Perez MI, Li S, Huang L, Lee WH. RBmediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice. Proc Natl Acad Sci U S A. 1999 Mar 30; 96:3916-3921.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3916-3921
-
-
Nikitin, A.Y.1
Juarez-Perez, M.I.2
Li, S.3
Huang, L.4
Lee, W.H.5
-
20
-
-
0037328392
-
-
Sharp ZD, Lee WH, Nikitin AY, Flesken-Nikitin A, Ikeno Y, Reddick R, et al. Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice. Carcinogenesis. 2003; 24:179-183.
-
(2003)
Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice. Carcinogenesis
, vol.24
, pp. 179-183
-
-
Sharp, Z.D.1
Lee, W.H.2
Nikitin, A.Y.3
Flesken-Nikitin, A.4
Ikeno, Y.5
Reddick, R.6
-
21
-
-
0029811983
-
Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice
-
Nikitin A, Lee WH. Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice. Genes Dev. 1996; 10:1870-1879.
-
(1996)
Genes Dev
, vol.10
, pp. 1870-1879
-
-
Nikitin, A.1
Lee, W.H.2
-
23
-
-
22744445281
-
Overview of caloric restriction and ageing
-
Masoro EJ. Overview of caloric restriction and ageing. Mech Ageing Dev. 2005;126:913-922.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 913-922
-
-
Masoro, E.J.1
-
24
-
-
1842732174
-
Temporal linkage between the phenotypic and genomic responses to caloric restriction
-
Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR. Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc Natl Acad Sci U S A. 2004; 101:5524-5529.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 5524-5529
-
-
Dhahbi, J.M.1
Kim, H.J.2
Mote, P.L.3
Beaver, R.J.4
Spindler, S.R.5
-
25
-
-
84871962435
-
mTOR inhibitor RAD001 promotes metastasis in a rat model of pancreaticneuroendocrine cancer
-
Pool SE, Bison S, Koelewijn SJ, van der Graaf LM, Melis M, Krenning EP, et al. mTOR inhibitor RAD001 promotes metastasis in a rat model of pancreaticneuroendocrine cancer. Cancer Res. 2013; 73:12-18.
-
(2013)
Cancer Res
, vol.73
, pp. 12-18
-
-
Pool, S.E.1
Bison, S.2
Koelewijn, S.J.3
van der Graaf, L.M.4
Melis, M.5
Krenning, E.P.6
-
26
-
-
77952101348
-
Specific killing of Rb mutant cancer cells by inactivating TSC2
-
Li B, Gordon GM, Du CH, Xu J, Du W. Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell. 2010; 17:469-480.
-
(2010)
Cancer Cell
, vol.17
, pp. 469-480
-
-
Li, B.1
Gordon, G.M.2
Du, C.H.3
Xu, J.4
Du, W.5
-
27
-
-
70350539313
-
Mutation of the Rb1 Pathway Leads to Overexpression of mTor, Constitutive Phosphorylation of Akt on Serine 473, Resistance to Anoikis and a Block in c-Raf Activation
-
El-Naggar S, Liu Y, Dean DC. Mutation of the Rb1 Pathway Leads to Overexpression of mTor, Constitutive Phosphorylation of Akt on Serine 473, Resistance to Anoikis and a Block in c-Raf Activation. Mol Cell Biol. 2009; 29:5710-5717.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5710-5717
-
-
El-Naggar, S.1
Liu, Y.2
Dean, D.C.3
-
28
-
-
84869155458
-
A Novel Tumor suppressor network in squamous malignancies
-
Costa C, Santos M, Segrelles C, Duenas M, Lara MF, Agirre X, et al. A Novel Tumor suppressor network in squamous malignancies. Sci Rep. 2012; 2:828.
-
(2012)
Sci Rep
, vol.2
, pp. 828
-
-
Costa, C.1
Santos, M.2
Segrelles, C.3
Duenas, M.4
Lara, M.F.5
Agirre, X.6
-
29
-
-
77952083662
-
Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
-
Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, et al. Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice. Am J Pathol. 2010; 176:2092-2097.
-
(2010)
Am J Pathol
, vol.176
, pp. 2092-2097
-
-
Anisimov, V.N.1
Zabezhinski, M.A.2
Popovich, I.G.3
Piskunova, T.S.4
Semenchenko, A.V.5
Tyndyk, M.L.6
-
30
-
-
84872573944
-
New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis
-
Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, et al. New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis. Aging (Albany NY). 2012; 4: 715-722.
-
(2012)
Aging (Albany NY)
, vol.4
, pp. 715-722
-
-
Comas, M.1
Toshkov, I.2
Kuropatwinski, K.K.3
Chernova, O.B.4
Polinsky, A.5
Blagosklonny, M.V.6
-
31
-
-
84872564714
-
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice
-
Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, et al. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice. Aging (Albany NY). 2012; 4:709-714.
-
(2012)
Aging (Albany NY)
, vol.4
, pp. 709-714
-
-
Komarova, E.A.1
Antoch, M.P.2
Novototskaya, L.R.3
Chernova, O.B.4
Paszkiewicz, G.5
Leontieva, O.V.6
-
32
-
-
84862646284
-
Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug
-
Mercier I, Camacho J, Titchen K, Gonzales DM, Quann K, Bryant KG, et al. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am J Pathol. 2012; 181:278-293.
-
(2012)
Am J Pathol
, vol.181
, pp. 278-293
-
-
Mercier, I.1
Camacho, J.2
Titchen, K.3
Gonzales, D.M.4
Quann, K.5
Bryant, K.G.6
-
33
-
-
50849110457
-
Prevention of cancer by inhibiting aging
-
Blagosklonny MV. Prevention of cancer by inhibiting aging. Cancer Biol Ther. 2008; 7:1520-1524.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1520-1524
-
-
Blagosklonny, M.V.1
-
34
-
-
84862777192
-
The translational landscape of mTOR signalling steers cancer initiation and metastasis
-
Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012; 485:55-61
-
(2012)
Nature
, vol.485
, pp. 55-61
-
-
Hsieh, A.C.1
Liu, Y.2
Edlind, M.P.3
Ingolia, N.T.4
Janes, M.R.5
Sher, A.6
-
35
-
-
0035171928
-
comparison with standard subcutaneous octreotide therapy
-
The clinical management of neuroendocrine tumors with longacting repeatable (LAR) octreotide
-
Dogliotti L, Tampellini M, Stivanello M, Gorzegno G, Fabiani L. The clinical management of neuroendocrine tumors with longacting repeatable (LAR) octreotide: comparison with standard subcutaneous octreotide therapy. Ann Oncol. 2001; 12:Suppl 2:S105-109.
-
(2001)
Ann Oncol.
, vol.12
, Issue.SUPPL 2
-
-
Dogliotti, L.1
Tampellini, M.2
Stivanello, M.3
Gorzegno, G.4
Fabiani, L.5
-
36
-
-
83255167036
-
-
Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2)
-
Pavel ME, Hainsworth JD, Baudin E, Peeters M, Horsch D, Winkler RE, et al. Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet. 2011; 378:2005-2012.
-
(2011)
a randomised, placebo-controlled, phase 3 study. Lancet
, vol.378
, pp. 2005-2012
-
-
Pavel, M.E.1
Hainsworth, J.D.2
Baudin, E.3
Peeters, M.4
Horsch, D.5
Winkler, R.E.6
-
37
-
-
0035300441
-
The retinoblastoma gene regulates somatic growth during mouse development
-
Nikitin A, Shan B, Flesken-Nikitin A, Chang KH, Lee WH. The retinoblastoma gene regulates somatic growth during mouse development. Cancer Res. 2001; 61:3110-3118.
-
(2001)
Cancer Res
, vol.61
, pp. 3110-3118
-
-
Nikitin, A.1
Shan, B.2
Flesken-Nikitin, A.3
Chang, K.H.4
Lee, W.H.5
-
38
-
-
0026744563
-
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
-
Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature. 1992; 359:288-294.
-
(1992)
Nature
, vol.359
, pp. 288-294
-
-
Lee, E.Y.1
Chang, C.Y.2
Hu, N.3
Wang, Y.C.4
Lai, C.C.5
Herrup, K.6
-
42
-
-
0025841730
-
Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice
-
Bronson RT, Lipman RD. Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. Growth Dev Aging. 1991; 55:169-184.
-
(1991)
Growth Dev Aging
, vol.55
, pp. 169-184
-
-
Bronson, R.T.1
Lipman, R.D.2
-
43
-
-
31344478502
-
Housing Density Does Not Influence the Longevity Effect of Calorie Restriction
-
Ikeno Y, Hubbard GB, Lee S, Richardson A, Strong R, Diaz V, et al. Housing Density Does Not Influence the Longevity Effect of Calorie Restriction. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2005; 60:1510-1517.
-
(2005)
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
, vol.60
, pp. 1510-1517
-
-
Ikeno, Y.1
Hubbard, G.B.2
Lee, S.3
Richardson, A.4
Strong, R.5
Diaz, V.6
|