Endoplasmic reticulum stress impairs insulin receptor signaling in the brains of obese rats

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Liang, Lina ^a   Chen, Jing ^a   Zhan, Libin ^a   Lu, Xiaoguang ^b   Sun, Xiaoxin ^a   Sui, Hua ^a   Zheng, Luping ^a   Xiang, Hong ^a   Zhang, Fuliang ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; INITIATION FACTOR 2ALPHA; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN IRE1; PROTEIN IRE1 ALPHA; PROTEIN KINASE B; SERINE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; COGNITIVE DEFECT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FRONTAL CORTEX; HIPPOCAMPUS; INSULIN RESISTANCE; LIPID DIET; MALE; MORRIS WATER MAZE TEST; NONHUMAN; OBESITY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TASK PERFORMANCE; WESTERN BLOTTING; ANIMAL; FRONTAL LOBE; MAZE TEST; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BLOTTING, WESTERN; BRAIN; ENDOPLASMIC RETICULUM STRESS; FRONTAL LOBE; HIPPOCAMPUS; MALE; MAP KINASE SIGNALING SYSTEM; MAZE LEARNING; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 84929303491     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126384     Document Type: Article

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