Tetramethylpyrazine suppresses transient oxygen- glucose deprivation-induced connexin32 expression and cell apoptosis via the ERK1/2 and p38 mapk pathway in cultured hippocampal neurons

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Gong, Gu ^a   Yuan, Libang ^a   Cai, Lin ^a   Ran, Maorong ^a   Zhang, Yulan ^a   Gong, Huaqu ^a   Dai, Xuemei ^a   Wu, Wei ^a   Dong, Hailong ^b  

^a General Hospital of Chengdu Military Area Command   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 32; GLUCOSE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OXYGEN; PROTEIN BAX; PROTEIN BCL 2; SMALL INTERFERING RNA; TETRAMETHYLPYRAZINE; GAP JUNCTION PROTEIN; PYRAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENZYME ASSAY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HIPPOCAMPUS; LDH RELEASE ASSAY; MTT ASSAY; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; NERVE CELL; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CONNEXINS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HIPPOCAMPUS; MAP KINASE SIGNALING SYSTEM; NEURONS; OXYGEN; PHOSPHORYLATION; PYRAZINES; RATS, WISTAR; RNA INTERFERENCE;

EID: 84907193003     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105944     Document Type: Article

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