-
1
-
-
0021832252
-
Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum
-
Foster A.C., Whetsell W.O., Bird E.D., Schwarcz R. Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum. Brain Res 1985, 336:207-214.
-
(1985)
Brain Res
, vol.336
, pp. 207-214
-
-
Foster, A.C.1
Whetsell, W.O.2
Bird, E.D.3
Schwarcz, R.4
-
2
-
-
33846463399
-
Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism
-
Pucci L., Perozzi S., Cimadamore F., Orsomando G., Raffaelli N. Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism. FEBS J 2007, 274:827-840.
-
(2007)
FEBS J
, vol.274
, pp. 827-840
-
-
Pucci, L.1
Perozzi, S.2
Cimadamore, F.3
Orsomando, G.4
Raffaelli, N.5
-
3
-
-
0019440926
-
Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS
-
Stone T.W., Perkins M.N. Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 1981, 72:411-412.
-
(1981)
Eur J Pharmacol
, vol.72
, pp. 411-412
-
-
Stone, T.W.1
Perkins, M.N.2
-
4
-
-
0017887867
-
Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice
-
Lapin I.P. Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J Neural Transm 1978, 42:37-43.
-
(1978)
J Neural Transm
, vol.42
, pp. 37-43
-
-
Lapin, I.P.1
-
5
-
-
0020702374
-
Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain
-
Schwarcz R., Whetsell W.O., Mangano R.M. Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 1983, 219:316-318.
-
(1983)
Science
, vol.219
, pp. 316-318
-
-
Schwarcz, R.1
Whetsell, W.O.2
Mangano, R.M.3
-
6
-
-
0021042967
-
On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds
-
Foster A.C., Collins J.F., Schwarcz R. On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds. Neuropharmacology 1983, 22:1331-1342.
-
(1983)
Neuropharmacology
, vol.22
, pp. 1331-1342
-
-
Foster, A.C.1
Collins, J.F.2
Schwarcz, R.3
-
7
-
-
0024499063
-
Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system
-
Whetsell W.O., Schwarcz R. Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system. Neurosci Lett 1989, 97:271-275.
-
(1989)
Neurosci Lett
, vol.97
, pp. 271-275
-
-
Whetsell, W.O.1
Schwarcz, R.2
-
8
-
-
0036128148
-
Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes
-
Tavares R.G., Tasca C.I., Santos C.E., Alves L.B., Porciuncula L.O., Emanuelli T., et al. Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes. Neurochem Int 2002, 40:621-627.
-
(2002)
Neurochem Int
, vol.40
, pp. 621-627
-
-
Tavares, R.G.1
Tasca, C.I.2
Santos, C.E.3
Alves, L.B.4
Porciuncula, L.O.5
Emanuelli, T.6
-
9
-
-
73249145672
-
Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease
-
2094-6-36
-
Ting K.K., Brew B.J., Guillemin G.J. Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease. J Neuroinflamm 2009, 6(36). 2094-6-36.
-
(2009)
J Neuroinflamm
, vol.6
, Issue.36
-
-
Ting, K.K.1
Brew, B.J.2
Guillemin, G.J.3
-
10
-
-
84877881003
-
Quinolinic acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms
-
Perez-De La Cruz V., Carrillo-Mora P., Santamaria A. Quinolinic acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms. Int J Tryptophan Res 2012, 5:1-8.
-
(2012)
Int J Tryptophan Res
, vol.5
, pp. 1-8
-
-
Perez-De La Cruz, V.1
Carrillo-Mora, P.2
Santamaria, A.3
-
11
-
-
0025936872
-
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates
-
Rios C., Santamaria A. Quinolinic acid is a potent lipid peroxidant in rat brain homogenates. Neurochem Res 1991, 16:1139-1143.
-
(1991)
Neurochem Res
, vol.16
, pp. 1139-1143
-
-
Rios, C.1
Santamaria, A.2
-
12
-
-
0027180115
-
MK-801 an N-methyl-d-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum
-
Santamaria A., Rios C. MK-801 an N-methyl-d-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. Neurosci Lett 1993, 159:51-54.
-
(1993)
Neurosci Lett
, vol.159
, pp. 51-54
-
-
Santamaria, A.1
Rios, C.2
-
13
-
-
0031024185
-
The effect of quinolinate on rat brain lipid peroxidation is dependent on iron
-
Stipek S., Stastny F., Platenik J., Crkovska J., Zima T. The effect of quinolinate on rat brain lipid peroxidation is dependent on iron. Neurochem Int 1997, 30:233-237.
-
(1997)
Neurochem Int
, vol.30
, pp. 233-237
-
-
Stipek, S.1
Stastny, F.2
Platenik, J.3
Crkovska, J.4
Zima, T.5
-
14
-
-
0035000815
-
Quinolinic acid-iron(ii) complexes: slow autoxidation, but enhanced hydroxyl radical production in the Fenton reaction
-
Platenik J., Stopka P., Vejrazka M., Stipek S. Quinolinic acid-iron(ii) complexes: slow autoxidation, but enhanced hydroxyl radical production in the Fenton reaction. Free Radic Res 2001, 34:445-459.
-
(2001)
Free Radic Res
, vol.34
, pp. 445-459
-
-
Platenik, J.1
Stopka, P.2
Vejrazka, M.3
Stipek, S.4
-
15
-
-
70349754448
-
Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons
-
Braidy N., Grant R., Adams S., Brew B.J., Guillemin G.J. Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotox Res 2009, 16:77-86.
-
(2009)
Neurotox Res
, vol.16
, pp. 77-86
-
-
Braidy, N.1
Grant, R.2
Adams, S.3
Brew, B.J.4
Guillemin, G.J.5
-
16
-
-
0031763724
-
Nitric oxide synthase inhibition prevents acute quinolinate-induced striatal neurotoxicity
-
Perez-Severiano F., Escalante B., Rios C. Nitric oxide synthase inhibition prevents acute quinolinate-induced striatal neurotoxicity. Neurochem Res 1998, 23:1297-1302.
-
(1998)
Neurochem Res
, vol.23
, pp. 1297-1302
-
-
Perez-Severiano, F.1
Escalante, B.2
Rios, C.3
-
17
-
-
0033406026
-
Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl
-
Behan W.M., McDonald M., Darlington L.G., Stone T.W. Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl. Br J Pharmacol 1999, 128:1754-1760.
-
(1999)
Br J Pharmacol
, vol.128
, pp. 1754-1760
-
-
Behan, W.M.1
McDonald, M.2
Darlington, L.G.3
Stone, T.W.4
-
18
-
-
0029995487
-
Antioxidant treatment protects striatal neurons against excitotoxic insults
-
Nakao N., Grasbon-Frodl E.M., Widner H., Brundin P. Antioxidant treatment protects striatal neurons against excitotoxic insults. Neuroscience 1996, 73:185-200.
-
(1996)
Neuroscience
, vol.73
, pp. 185-200
-
-
Nakao, N.1
Grasbon-Frodl, E.M.2
Widner, H.3
Brundin, P.4
-
19
-
-
0033988627
-
Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions
-
Vazquez S., Garner B., Sheil M.M., Truscott R.J. Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions. Free Radic Res 2000, 32:11-23.
-
(2000)
Free Radic Res
, vol.32
, pp. 11-23
-
-
Vazquez, S.1
Garner, B.2
Sheil, M.M.3
Truscott, R.J.4
-
20
-
-
0037449906
-
Electrochemical and in vitro evaluation of the redox-properties of kynurenine species
-
Giles G.I., Collins C.A., Stone T.W., Jacob C. Electrochemical and in vitro evaluation of the redox-properties of kynurenine species. Biochem Biophys Res Commun 2003, 300:719-724.
-
(2003)
Biochem Biophys Res Commun
, vol.300
, pp. 719-724
-
-
Giles, G.I.1
Collins, C.A.2
Stone, T.W.3
Jacob, C.4
-
21
-
-
0029973593
-
Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine
-
Okuda S., Nishiyama N., Saito H., Katsuki H. Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine. Proc Natl Acad Sci U S A 1996, 93:12553-12558.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 12553-12558
-
-
Okuda, S.1
Nishiyama, N.2
Saito, H.3
Katsuki, H.4
-
22
-
-
0031972945
-
3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity
-
Okuda S., Nishiyama N., Saito H., Katsuki H. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem 1998, 70:299-307.
-
(1998)
J Neurochem
, vol.70
, pp. 299-307
-
-
Okuda, S.1
Nishiyama, N.2
Saito, H.3
Katsuki, H.4
-
23
-
-
70049088665
-
5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones
-
Smith A.J., Smith R.A., Stone T.W. 5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones. Neurotox Res 2009, 15:303-310.
-
(2009)
Neurotox Res
, vol.15
, pp. 303-310
-
-
Smith, A.J.1
Smith, R.A.2
Stone, T.W.3
-
24
-
-
0032698232
-
3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum
-
Guidetti P., Schwarcz R. 3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum. Eur J Neurosci 1999, 11:3857-3863.
-
(1999)
Eur J Neurosci
, vol.11
, pp. 3857-3863
-
-
Guidetti, P.1
Schwarcz, R.2
-
25
-
-
0034691246
-
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction
-
Goldstein L.E., Leopold M.C., Huang X., Atwood C.S., Saunders A.J., Hartshorn M., et al. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry 2000, 39:7266-7275.
-
(2000)
Biochemistry
, vol.39
, pp. 7266-7275
-
-
Goldstein, L.E.1
Leopold, M.C.2
Huang, X.3
Atwood, C.S.4
Saunders, A.J.5
Hartshorn, M.6
-
26
-
-
0023940733
-
Superoxide dismutase enhances the formation of hydroxyl radicals in the reaction of 3-hydroxyanthranilic acid with molecular oxygen
-
Iwahashi H., Ishii T., Sugata R., Kido R. Superoxide dismutase enhances the formation of hydroxyl radicals in the reaction of 3-hydroxyanthranilic acid with molecular oxygen. Biochem J 1988, 251:893-899.
-
(1988)
Biochem J
, vol.251
, pp. 893-899
-
-
Iwahashi, H.1
Ishii, T.2
Sugata, R.3
Kido, R.4
-
27
-
-
0025317656
-
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases
-
Christen S., Peterhans E., Stocker R. Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases. Proc Natl Acad Sci U S A 1990, 87:2506-2510.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 2506-2510
-
-
Christen, S.1
Peterhans, E.2
Stocker, R.3
-
28
-
-
33845492329
-
In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain
-
Leipnitz G., Schumacher C., Dalcin K.B., Scussiato K., Solano A., Funchal C., et al. In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain. Neurochem Int 2007, 50:83-94.
-
(2007)
Neurochem Int
, vol.50
, pp. 83-94
-
-
Leipnitz, G.1
Schumacher, C.2
Dalcin, K.B.3
Scussiato, K.4
Solano, A.5
Funchal, C.6
-
29
-
-
84910118539
-
The Janus faces of 3-hydroxykynurenine: dual redox modulatory activity and lack of neurotoxicity in the rat striatum
-
Colin-Gonzalez A.L., Maya-Lopez M., Pedraza-Chaverri J., Ali S.F., Chavarria A., Santamaria A. The Janus faces of 3-hydroxykynurenine: dual redox modulatory activity and lack of neurotoxicity in the rat striatum. Brain Res 2014, 1589:1-14.
-
(2014)
Brain Res
, vol.1589
, pp. 1-14
-
-
Colin-Gonzalez, A.L.1
Maya-Lopez, M.2
Pedraza-Chaverri, J.3
Ali, S.F.4
Chavarria, A.5
Santamaria, A.6
-
30
-
-
80053196130
-
On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress
-
Lugo-Huitron R., Blanco-Ayala T., Ugalde-Muniz P., Carrillo-Mora P., Pedraza-Chaverri J., Silva-Adaya D., et al. On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress. Neurotoxicol Teratol 2011, 33:538-547.
-
(2011)
Neurotoxicol Teratol
, vol.33
, pp. 538-547
-
-
Lugo-Huitron, R.1
Blanco-Ayala, T.2
Ugalde-Muniz, P.3
Carrillo-Mora, P.4
Pedraza-Chaverri, J.5
Silva-Adaya, D.6
-
31
-
-
0035478066
-
The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications
-
Hilmas C., Pereira E.F., Alkondon M., Rassoulpour A., Schwarcz R., Albuquerque E.X. The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. J Neurosci 2001, 21:7463-7473.
-
(2001)
J Neurosci
, vol.21
, pp. 7463-7473
-
-
Hilmas, C.1
Pereira, E.F.2
Alkondon, M.3
Rassoulpour, A.4
Schwarcz, R.5
Albuquerque, E.X.6
-
32
-
-
0019967973
-
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
-
Perkins M.N., Stone T.W. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 1982, 247:184-187.
-
(1982)
Brain Res
, vol.247
, pp. 184-187
-
-
Perkins, M.N.1
Stone, T.W.2
-
33
-
-
65549091842
-
Oxidation of l-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase
-
Rafice S.A., Chauhan N., Efimov I., Basran J., Raven E.L. Oxidation of l-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase. Biochem Soc Trans 2009, 37:408-412.
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 408-412
-
-
Rafice, S.A.1
Chauhan, N.2
Efimov, I.3
Basran, J.4
Raven, E.L.5
-
34
-
-
84929266674
-
Structural and functional analyses of human tryptophan 2,3-dioxygenase
-
Meng B., Wu D., Gu J., Ouyang S., Ding W., Liu Z.J. Structural and functional analyses of human tryptophan 2,3-dioxygenase. Proteins 2014, 82:3210-3216.
-
(2014)
Proteins
, vol.82
, pp. 3210-3216
-
-
Meng, B.1
Wu, D.2
Gu, J.3
Ouyang, S.4
Ding, W.5
Liu, Z.J.6
-
35
-
-
0034192239
-
Heme: a regulator of rat hepatic tryptophan 2,3-dioxygenase?
-
Ren S., Correia M.A. Heme: a regulator of rat hepatic tryptophan 2,3-dioxygenase?. Arch Biochem Biophys 2000, 377:195-203.
-
(2000)
Arch Biochem Biophys
, vol.377
, pp. 195-203
-
-
Ren, S.1
Correia, M.A.2
-
36
-
-
33847417014
-
Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation
-
Li J.S., Han Q., Fang J., Rizzi M., James A.A., Li J. Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation. Arch Insect Biochem Physiol 2007, 64:74-87.
-
(2007)
Arch Insect Biochem Physiol
, vol.64
, pp. 74-87
-
-
Li, J.S.1
Han, Q.2
Fang, J.3
Rizzi, M.4
James, A.A.5
Li, J.6
-
37
-
-
84880331865
-
NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice
-
Walker A.K., Budac D.P., Bisulco S., Lee A.W., Smith R.A., Beenders B., et al. NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice. Neuropsychopharmacology 2013, 38:1609-1616.
-
(2013)
Neuropsychopharmacology
, vol.38
, pp. 1609-1616
-
-
Walker, A.K.1
Budac, D.P.2
Bisulco, S.3
Lee, A.W.4
Smith, R.A.5
Beenders, B.6
-
38
-
-
0029762061
-
Importance of the two interferon-stimulated response element (ISRE) sequences in the regulation of the human indoleamine 2,3-dioxygenase gene
-
Konan K.V., Taylor M.W. Importance of the two interferon-stimulated response element (ISRE) sequences in the regulation of the human indoleamine 2,3-dioxygenase gene. J Biol Chem 1996, 271:19140-19145.
-
(1996)
J Biol Chem
, vol.271
, pp. 19140-19145
-
-
Konan, K.V.1
Taylor, M.W.2
-
39
-
-
84898038703
-
Kynurenines in CNS disease: regulation by inflammatory cytokines
-
Campbell B.M., Charych E., Lee A.W., Moller T. Kynurenines in CNS disease: regulation by inflammatory cytokines. Front Neurosci 2014, 8:12.
-
(2014)
Front Neurosci
, vol.8
, pp. 12
-
-
Campbell, B.M.1
Charych, E.2
Lee, A.W.3
Moller, T.4
-
40
-
-
0023926018
-
Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity
-
Takikawa O., Kuroiwa T., Yamazaki F., Kido R. Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity. J Biol Chem 1988, 263:2041-2048.
-
(1988)
J Biol Chem
, vol.263
, pp. 2041-2048
-
-
Takikawa, O.1
Kuroiwa, T.2
Yamazaki, F.3
Kido, R.4
-
41
-
-
84857046187
-
Interleukin-1beta: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis
-
Zunszain P.A., Anacker C., Cattaneo A., Choudhury S., Musaelyan K., Myint A.M., et al. Interleukin-1beta: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology 2012, 37:939-949.
-
(2012)
Neuropsychopharmacology
, vol.37
, pp. 939-949
-
-
Zunszain, P.A.1
Anacker, C.2
Cattaneo, A.3
Choudhury, S.4
Musaelyan, K.5
Myint, A.M.6
-
42
-
-
46349106773
-
Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?
-
Connor T.J., Starr N., O'Sullivan J.B., Harkin A. Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?. Neurosci Lett 2008, 441:29-34.
-
(2008)
Neurosci Lett
, vol.441
, pp. 29-34
-
-
Connor, T.J.1
Starr, N.2
O'Sullivan, J.B.3
Harkin, A.4
-
43
-
-
84886800861
-
Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine
-
Molteni R., Macchi F., Zecchillo C., Dell'agli M., Colombo E., Calabrese F., et al. Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine. Eur Neuropsychopharmacol 2013, 23:1645-1655.
-
(2013)
Eur Neuropsychopharmacol
, vol.23
, pp. 1645-1655
-
-
Molteni, R.1
Macchi, F.2
Zecchillo, C.3
Dell'agli, M.4
Colombo, E.5
Calabrese, F.6
-
44
-
-
43149110841
-
Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment
-
Giorgini F., Moller T., Kwan W., Zwilling D., Wacker J.L., Hong S., et al. Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. J Biol Chem 2008, 283:7390-7400.
-
(2008)
J Biol Chem
, vol.283
, pp. 7390-7400
-
-
Giorgini, F.1
Moller, T.2
Kwan, W.3
Zwilling, D.4
Wacker, J.L.5
Hong, S.6
-
45
-
-
1042302739
-
Expression of the kynurenine pathway enzymes in human microglia and macrophages
-
Guillemin G.J., Smith D.G., Smythe G.A., Armati P.J., Brew B.J. Expression of the kynurenine pathway enzymes in human microglia and macrophages. Adv Exp Med Biol 2003, 527:105-112.
-
(2003)
Adv Exp Med Biol
, vol.527
, pp. 105-112
-
-
Guillemin, G.J.1
Smith, D.G.2
Smythe, G.A.3
Armati, P.J.4
Brew, B.J.5
-
46
-
-
0034652442
-
Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway
-
Dang Y., Dale W.E., Brown O.R. Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway. Free Radic Biol Med 2000, 28:615-624.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 615-624
-
-
Dang, Y.1
Dale, W.E.2
Brown, O.R.3
-
47
-
-
0018901290
-
L-Kynurenine: its synthesis and possible regulatory function in brain
-
Gal E.M., Sherman A.D. l-Kynurenine: its synthesis and possible regulatory function in brain. Neurochem Res 1980, 5:223-239.
-
(1980)
Neurochem Res
, vol.5
, pp. 223-239
-
-
Gal, E.M.1
Sherman, A.D.2
-
48
-
-
0025057695
-
Uptake of kynurenine into rat brain slices
-
Speciale C., Schwarcz R. Uptake of kynurenine into rat brain slices. J Neurochem 1990, 54:156-163.
-
(1990)
J Neurochem
, vol.54
, pp. 156-163
-
-
Speciale, C.1
Schwarcz, R.2
-
49
-
-
0034894035
-
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection
-
Guillemin G.J., Kerr S.J., Smythe G.A., Smith D.G., Kapoor V., Armati P.J., et al. Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection. J Neurochem 2001, 78:842-853.
-
(2001)
J Neurochem
, vol.78
, pp. 842-853
-
-
Guillemin, G.J.1
Kerr, S.J.2
Smythe, G.A.3
Smith, D.G.4
Kapoor, V.5
Armati, P.J.6
-
50
-
-
0030957197
-
Brain-specific modulation of kynurenic acid synthesis in the rat
-
Gramsbergen J.B., Hodgkins P.S., Rassoulpour A., Turski W.A., Guidetti P., Schwarcz R. Brain-specific modulation of kynurenic acid synthesis in the rat. J Neurochem 1997, 69:290-298.
-
(1997)
J Neurochem
, vol.69
, pp. 290-298
-
-
Gramsbergen, J.B.1
Hodgkins, P.S.2
Rassoulpour, A.3
Turski, W.A.4
Guidetti, P.5
Schwarcz, R.6
-
51
-
-
0344110533
-
Systemic d-amphetamine administration causes a reduction of kynurenic acid levels in rat brain
-
Rassoulpour A., Wu H.Q., Poeggeler B., Schwarcz R. Systemic d-amphetamine administration causes a reduction of kynurenic acid levels in rat brain. Brain Res 1998, 802:111-118.
-
(1998)
Brain Res
, vol.802
, pp. 111-118
-
-
Rassoulpour, A.1
Wu, H.Q.2
Poeggeler, B.3
Schwarcz, R.4
-
52
-
-
0027389647
-
On the production and disposition of quinolinic acid in rat brain and liver slices
-
Speciale C., Schwarcz R. On the production and disposition of quinolinic acid in rat brain and liver slices. J Neurochem 1993, 60:212-218.
-
(1993)
J Neurochem
, vol.60
, pp. 212-218
-
-
Speciale, C.1
Schwarcz, R.2
-
53
-
-
0027716965
-
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from l-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate
-
Heyes M.P., Saito K., Major E.O., Milstien S., Markey S.P., Vickers J.H. A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from l-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Brain 1993, 116(Pt 6):1425-1450.
-
(1993)
Brain
, vol.116
, pp. 1425-1450
-
-
Heyes, M.P.1
Saito, K.2
Major, E.O.3
Milstien, S.4
Markey, S.P.5
Vickers, J.H.6
-
54
-
-
0022471686
-
Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro
-
Foster A.C., White R.J., Schwarcz R. Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. J Neurochem 1986, 47:23-30.
-
(1986)
J Neurochem
, vol.47
, pp. 23-30
-
-
Foster, A.C.1
White, R.J.2
Schwarcz, R.3
-
55
-
-
0026076136
-
Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism
-
Fukui S., Schwarcz R., Rapoport S.I., Takada Y., Smith Q.R. Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 1991, 56:2007-2017.
-
(1991)
J Neurochem
, vol.56
, pp. 2007-2017
-
-
Fukui, S.1
Schwarcz, R.2
Rapoport, S.I.3
Takada, Y.4
Smith, Q.R.5
-
56
-
-
78650031174
-
Huntington's disease: from molecular pathogenesis to clinical treatment
-
Ross C.A., Tabrizi S.J. Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol 2011, 10:83-98.
-
(2011)
Lancet Neurol
, vol.10
, pp. 83-98
-
-
Ross, C.A.1
Tabrizi, S.J.2
-
57
-
-
12144288251
-
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
-
Wexler N.S., Lorimer J., Porter J., Gomez F., Moskowitz C., Shackell E., et al. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A 2004, 101:3498-3503.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3498-3503
-
-
Wexler, N.S.1
Lorimer, J.2
Porter, J.3
Gomez, F.4
Moskowitz, C.5
Shackell, E.6
-
58
-
-
9644270316
-
Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease
-
Guidetti P., Luthi-Carter R.E., Augood S.J., Schwarcz R. Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease. Neurobiol Dis 2004, 17:455-461.
-
(2004)
Neurobiol Dis
, vol.17
, pp. 455-461
-
-
Guidetti, P.1
Luthi-Carter, R.E.2
Augood, S.J.3
Schwarcz, R.4
-
59
-
-
0028903541
-
Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases
-
Jauch D., Urbanska E.M., Guidetti P., Bird E.D., Vonsattel J.P., Whetsell W.O., et al. Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases. J Neurol Sci 1995, 130:39-47.
-
(1995)
J Neurol Sci
, vol.130
, pp. 39-47
-
-
Jauch, D.1
Urbanska, E.M.2
Guidetti, P.3
Bird, E.D.4
Vonsattel, J.P.5
Whetsell, W.O.6
-
60
-
-
0026539659
-
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease
-
Heyes M.P., Saito K., Crowley J.S., Davis L.E., Demitrack M.A., Der M., et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain 1992, 115(Pt 5):1249-1273.
-
(1992)
Brain
, vol.115
, pp. 1249-1273
-
-
Heyes, M.P.1
Saito, K.2
Crowley, J.S.3
Davis, L.E.4
Demitrack, M.A.5
Der, M.6
-
61
-
-
33745279104
-
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
-
Guidetti P., Bates G.P., Graham R.K., Hayden M.R., Leavitt B.R., MacDonald M.E., et al. Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. Neurobiol Dis 2006, 23:190-197.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 190-197
-
-
Guidetti, P.1
Bates, G.P.2
Graham, R.K.3
Hayden, M.R.4
Leavitt, B.R.5
MacDonald, M.E.6
-
62
-
-
77950361001
-
Expression analysis of novel striatal-enriched genes in Huntington disease
-
Mazarei G., Neal S.J., Becanovic K., Luthi-Carter R., Simpson E.M., Leavitt B.R. Expression analysis of novel striatal-enriched genes in Huntington disease. Hum Mol Genet 2010, 19:609-622.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 609-622
-
-
Mazarei, G.1
Neal, S.J.2
Becanovic, K.3
Luthi-Carter, R.4
Simpson, E.M.5
Leavitt, B.R.6
-
63
-
-
18144386929
-
Tryptophan metabolism and oxidative stress in patients with Huntington's disease
-
Stoy N., Mackay G.M., Forrest C.M., Christofides J., Egerton M., Stone T.W., et al. Tryptophan metabolism and oxidative stress in patients with Huntington's disease. J Neurochem 2005, 93:611-623.
-
(2005)
J Neurochem
, vol.93
, pp. 611-623
-
-
Stoy, N.1
Mackay, G.M.2
Forrest, C.M.3
Christofides, J.4
Egerton, M.5
Stone, T.W.6
-
64
-
-
71649101571
-
Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington's disease
-
Forrest C.M., Mackay G.M., Stoy N., Spiden S.L., Taylor R., Stone T.W., et al. Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington's disease. J Neurochem 2010, 112:112-122.
-
(2010)
J Neurochem
, vol.112
, pp. 112-122
-
-
Forrest, C.M.1
Mackay, G.M.2
Stoy, N.3
Spiden, S.L.4
Taylor, R.5
Stone, T.W.6
-
65
-
-
77953107292
-
Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease
-
Sathyasaikumar K.V., Stachowski E.K., Amori L., Guidetti P., Muchowski P.J., Schwarcz R. Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease. J Neurochem 2010, 113:1416-1425.
-
(2010)
J Neurochem
, vol.113
, pp. 1416-1425
-
-
Sathyasaikumar, K.V.1
Stachowski, E.K.2
Amori, L.3
Guidetti, P.4
Muchowski, P.J.5
Schwarcz, R.6
-
66
-
-
49249089029
-
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
-
Bjorkqvist M., Wild E.J., Thiele J., Silvestroni A., Andre R., Lahiri N., et al. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med 2008, 205:1869-1877.
-
(2008)
J Exp Med
, vol.205
, pp. 1869-1877
-
-
Bjorkqvist, M.1
Wild, E.J.2
Thiele, J.3
Silvestroni, A.4
Andre, R.5
Lahiri, N.6
-
67
-
-
68249112361
-
Distinct neuroinflammatory profile in post-mortem human Huntington's disease
-
Silvestroni A., Faull R.L., Strand A.D., Moller T. Distinct neuroinflammatory profile in post-mortem human Huntington's disease. Neuroreport 2009, 20:1098-1103.
-
(2009)
Neuroreport
, vol.20
, pp. 1098-1103
-
-
Silvestroni, A.1
Faull, R.L.2
Strand, A.D.3
Moller, T.4
-
68
-
-
34447636065
-
Microglial activation in presymptomatic Huntington's disease gene carriers
-
Tai Y.F., Pavese N., Gerhard A., Tabrizi S.J., Barker R.A., Brooks D.J., et al. Microglial activation in presymptomatic Huntington's disease gene carriers. Brain 2007, 130:1759-1766.
-
(2007)
Brain
, vol.130
, pp. 1759-1766
-
-
Tai, Y.F.1
Pavese, N.2
Gerhard, A.3
Tabrizi, S.J.4
Barker, R.A.5
Brooks, D.J.6
-
69
-
-
78650477632
-
Kynurenine and its metabolites in Alzheimer's disease patients
-
Gulaj E., Pawlak K., Bien B., Pawlak D. Kynurenine and its metabolites in Alzheimer's disease patients. Adv Med Sci 2010, 55:204-211.
-
(2010)
Adv Med Sci
, vol.55
, pp. 204-211
-
-
Gulaj, E.1
Pawlak, K.2
Bien, B.3
Pawlak, D.4
-
70
-
-
77955069370
-
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease
-
Bonda D.J., Mailankot M., Stone J.G., Garrett M.R., Staniszewska M., Castellani R.J., et al. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Rep 2010, 15:161-168.
-
(2010)
Redox Rep
, vol.15
, pp. 161-168
-
-
Bonda, D.J.1
Mailankot, M.2
Stone, J.G.3
Garrett, M.R.4
Staniszewska, M.5
Castellani, R.J.6
-
71
-
-
84879097853
-
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls
-
Schwarz M.J., Guillemin G.J., Teipel S.J., Buerger K., Hampel H. Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls. Eur Arch Psychiatry Clin Neurosci 2013, 263:345-352.
-
(2013)
Eur Arch Psychiatry Clin Neurosci
, vol.263
, pp. 345-352
-
-
Schwarz, M.J.1
Guillemin, G.J.2
Teipel, S.J.3
Buerger, K.4
Hampel, H.5
-
72
-
-
23044462498
-
Indoleamine 2,3-dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus
-
Guillemin G.J., Brew B.J., Noonan C.E., Takikawa O., Cullen K.M. Indoleamine 2,3-dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus. Neuropathol Appl Neurobiol 2005, 31:395-404.
-
(2005)
Neuropathol Appl Neurobiol
, vol.31
, pp. 395-404
-
-
Guillemin, G.J.1
Brew, B.J.2
Noonan, C.E.3
Takikawa, O.4
Cullen, K.M.5
-
73
-
-
2342507918
-
A beta 1-42 induces production of quinolinic acid by human macrophages and microglia
-
Guillemin G.J., Smythe G.A., Veas L.A., Takikawa O., Brew B.J. A beta 1-42 induces production of quinolinic acid by human macrophages and microglia. Neuroreport 2003, 14:2311-2315.
-
(2003)
Neuroreport
, vol.14
, pp. 2311-2315
-
-
Guillemin, G.J.1
Smythe, G.A.2
Veas, L.A.3
Takikawa, O.4
Brew, B.J.5
-
74
-
-
67650472723
-
Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42: implications for the pathogenesis of Alzheimer's disease
-
Yamada A., Akimoto H., Kagawa S., Guillemin G.J., Takikawa O. Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42: implications for the pathogenesis of Alzheimer's disease. J Neurochem 2009, 110:791-800.
-
(2009)
J Neurochem
, vol.110
, pp. 791-800
-
-
Yamada, A.1
Akimoto, H.2
Kagawa, S.3
Guillemin, G.J.4
Takikawa, O.5
-
75
-
-
0034948192
-
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
-
Lue L.F., Rydel R., Brigham E.F., Yang L.B., Hampel H., Murphy G.M., et al. Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 2001, 35:72-79.
-
(2001)
Glia
, vol.35
, pp. 72-79
-
-
Lue, L.F.1
Rydel, R.2
Brigham, E.F.3
Yang, L.B.4
Hampel, H.5
Murphy, G.M.6
-
76
-
-
35948985848
-
Up-regulation of the brain indoleamine 2,3-dioxygenase activity in a mouse model of Alzheimer's disease by systemic endotoxin challenge
-
Akimoto H., Yamada A., Takikawa O. Up-regulation of the brain indoleamine 2,3-dioxygenase activity in a mouse model of Alzheimer's disease by systemic endotoxin challenge. Int Cong Ser 2007, 1304:357-361.
-
(2007)
Int Cong Ser
, vol.1304
, pp. 357-361
-
-
Akimoto, H.1
Yamada, A.2
Takikawa, O.3
-
77
-
-
67651243648
-
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons
-
Rahman A., Ting K., Cullen K.M., Braidy N., Brew B.J., Guillemin G.J. The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS ONE 2009, 4:e6344.
-
(2009)
PLoS ONE
, vol.4
, pp. e6344
-
-
Rahman, A.1
Ting, K.2
Cullen, K.M.3
Braidy, N.4
Brew, B.J.5
Guillemin, G.J.6
-
78
-
-
0036186338
-
Increased neopterin production and tryptophan degradation in advanced Parkinson's disease
-
Widner B., Leblhuber F., Fuchs D. Increased neopterin production and tryptophan degradation in advanced Parkinson's disease. J Neural Transm 2002, 109:181-189.
-
(2002)
J Neural Transm
, vol.109
, pp. 181-189
-
-
Widner, B.1
Leblhuber, F.2
Fuchs, D.3
-
79
-
-
0026671306
-
Kynurenine pathway abnormalities in Parkinson's disease
-
Ogawa T., Matson W.R., Beal M.F., Myers R.H., Bird E.D., Milbury P., et al. Kynurenine pathway abnormalities in Parkinson's disease. Neurology 1992, 42:1702-1706.
-
(1992)
Neurology
, vol.42
, pp. 1702-1706
-
-
Ogawa, T.1
Matson, W.R.2
Beal, M.F.3
Myers, R.H.4
Bird, E.D.5
Milbury, P.6
-
80
-
-
18144406846
-
A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease
-
Giorgini F., Guidetti P., Nguyen Q., Bennett S.C., Muchowski P.J. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet 2005, 37:526-531.
-
(2005)
Nat Genet
, vol.37
, pp. 526-531
-
-
Giorgini, F.1
Guidetti, P.2
Nguyen, Q.3
Bennett, S.C.4
Muchowski, P.J.5
-
81
-
-
79958044624
-
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease
-
Campesan S., Green E.W., Breda C., Sathyasaikumar K.V., Muchowski P.J., Schwarcz R., et al. The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Curr Biol 2011, 21:961-966.
-
(2011)
Curr Biol
, vol.21
, pp. 961-966
-
-
Campesan, S.1
Green, E.W.2
Breda, C.3
Sathyasaikumar, K.V.4
Muchowski, P.J.5
Schwarcz, R.6
-
82
-
-
79958021894
-
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration
-
Zwilling D., Huang S.Y., Sathyasaikumar K.V., Notarangelo F.M., Guidetti P., Wu H.Q., et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell 2011, 145:863-874.
-
(2011)
Cell
, vol.145
, pp. 863-874
-
-
Zwilling, D.1
Huang, S.Y.2
Sathyasaikumar, K.V.3
Notarangelo, F.M.4
Guidetti, P.5
Wu, H.Q.6
-
83
-
-
84878618542
-
The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease
-
Amaral M., Outeiro T.F., Scrutton N.S., Giorgini F. The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. J Mol Med (Berl.) 2013, 91:705-713.
-
(2013)
J Mol Med (Berl.)
, vol.91
, pp. 705-713
-
-
Amaral, M.1
Outeiro, T.F.2
Scrutton, N.S.3
Giorgini, F.4
-
84
-
-
0031434549
-
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase
-
Rover S., Cesura A.M., Huguenin P., Kettler R., Szente A. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem 1997, 40:4378-4385.
-
(1997)
J Med Chem
, vol.40
, pp. 4378-4385
-
-
Rover, S.1
Cesura, A.M.2
Huguenin, P.3
Kettler, R.4
Szente, A.5
-
85
-
-
24144486516
-
Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys
-
Samadi P., Gregoire L., Rassoulpour A., Guidetti P., Izzo E., Schwarcz R., et al. Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys. Mov Disord 2005, 20:792-802.
-
(2005)
Mov Disord
, vol.20
, pp. 792-802
-
-
Samadi, P.1
Gregoire, L.2
Rassoulpour, A.3
Guidetti, P.4
Izzo, E.5
Schwarcz, R.6
-
86
-
-
84869105177
-
Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048
-
Beconi M.G., Yates D., Lyons K., Matthews K., Clifton S., Mead T., et al. Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug Metab Dispos 2012, 40:2297-2306.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 2297-2306
-
-
Beconi, M.G.1
Yates, D.2
Lyons, K.3
Matthews, K.4
Clifton, S.5
Mead, T.6
-
87
-
-
84907924586
-
Targets for future clinical trials in Huntington's disease: what's in the pipeline?
-
Wild E.J., Tabrizi S.J. Targets for future clinical trials in Huntington's disease: what's in the pipeline?. Mov Disord 2014, 29:1434-1445.
-
(2014)
Mov Disord
, vol.29
, pp. 1434-1445
-
-
Wild, E.J.1
Tabrizi, S.J.2
-
88
-
-
84922765434
-
Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease
-
Toledo-Sherman L.M., Prime M.E., Mrzljak L., Beconi M.G., Beresford A., Brookfield F.A., et al. Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem 2015, 58:1159-1183.
-
(2015)
J Med Chem
, vol.58
, pp. 1159-1183
-
-
Toledo-Sherman, L.M.1
Prime, M.E.2
Mrzljak, L.3
Beconi, M.G.4
Beresford, A.5
Brookfield, F.A.6
-
89
-
-
84890948960
-
Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain
-
Giorgini F., Huang S.Y., Sathyasaikumar K.V., Notarangelo F.M., Thomas M.A., Tararina M., et al. Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain. J Biol Chem 2013, 288:36554-36566.
-
(2013)
J Biol Chem
, vol.288
, pp. 36554-36566
-
-
Giorgini, F.1
Huang, S.Y.2
Sathyasaikumar, K.V.3
Notarangelo, F.M.4
Thomas, M.A.5
Tararina, M.6
-
90
-
-
84876286750
-
Structural basis of kynurenine 3-monooxygenase inhibition
-
Amaral M., Levy C., Heyes D.J., Lafite P., Outeiro T.F., Giorgini F., et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature 2013, 496:382-385.
-
(2013)
Nature
, vol.496
, pp. 382-385
-
-
Amaral, M.1
Levy, C.2
Heyes, D.J.3
Lafite, P.4
Outeiro, T.F.5
Giorgini, F.6
-
91
-
-
84866297918
-
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
-
van der Goot A.T., Zhu W., Vazquez-Manrique R.P., Seinstra R.I., Dettmer K., Michels H., et al. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proc Natl Acad Sci U S A 2012, 109:14912-14917.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 14912-14917
-
-
van der Goot, A.T.1
Zhu, W.2
Vazquez-Manrique, R.P.3
Seinstra, R.I.4
Dettmer, K.5
Michels, H.6
-
92
-
-
78650645106
-
Oren-gedoku-to and its constituents with therapeutic potential in Alzheimer's disease inhibit indoleamine 2,3-dioxygenase activity in vitro
-
Yu C.J., Zheng M.F., Kuang C.X., Huang W.D., Yang Q. Oren-gedoku-to and its constituents with therapeutic potential in Alzheimer's disease inhibit indoleamine 2,3-dioxygenase activity in vitro. J Alzheimers Dis 2010, 22:257-266.
-
(2010)
J Alzheimers Dis
, vol.22
, pp. 257-266
-
-
Yu, C.J.1
Zheng, M.F.2
Kuang, C.X.3
Huang, W.D.4
Yang, Q.5
-
93
-
-
84908670456
-
The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease
-
Yu D., Tao B.B., Yang Y.Y., Du L.S., Yang S.S., He X.J., et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis 2015, 43:291-302.
-
(2015)
J Alzheimers Dis
, vol.43
, pp. 291-302
-
-
Yu, D.1
Tao, B.B.2
Yang, Y.Y.3
Du, L.S.4
Yang, S.S.5
He, X.J.6
-
94
-
-
84884542405
-
The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain
-
Mazarei G., Budac D.P., Lu G., Lee H., Moller T., Leavitt B.R. The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain. Exp Neurol 2013, 249:144-148.
-
(2013)
Exp Neurol
, vol.249
, pp. 144-148
-
-
Mazarei, G.1
Budac, D.P.2
Lu, G.3
Lee, H.4
Moller, T.5
Leavitt, B.R.6
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