5-Hydroxyanthranilic Acid, a Tryptophan Metabolite, Generates Oxidative Stress and Neuronal Death via p38 Activation in Cultured Cerebellar Granule Neurones

Neurotoxicity Research

Volumn 15, Issue 4, 2009, Pages 303-310

  Smith, Andrew J ^a   Smith, Robert A ^a   Stone, Trevor W ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

5 Hydroxyanthranilic acid; Cerebellar granule neurones; Kynurenines; Neurotoxicity; Oxidative stress; Quinolinic acid; Tryptophan

Indexed keywords

3 HYDROXYANTHRANILIC ACID; 3 HYDROXYKYNURENINE; 5 HYDROXYANTHRANILIC ACID; ANTHRANILIC ACID DERIVATIVE; CASPASE 3; CATALASE; KYNURENINE; SUPEROXIDE DISMUTASE; SYNAPTOPHYSIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL GRANULE; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVATION; METABOLITE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TOXICOKINETICS;

3-HYDROXYANTHRANILIC ACID; ALDOSTERONE; ANIMALS; ANIMALS, NEWBORN; ANTHRANILIC ACIDS; CASPASE 3; CATALASE; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CYCLOHEXIMIDE; FLUORESCEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KYNURENINE; NEURITES; NEURONS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN SYNTHESIS INHIBITORS; RATS; TIME FACTORS;

EID: 70049088665     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12640-009-9034-0     Document Type: Article

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