메뉴 건너뛰기




Volumn 8, Issue 3, 2015, Pages 3089-3097

Role of rho kinase signal pathway in inflammatory bowel disease

Author keywords

IBD; Intestinal barrier; Intestinal fibrosis; Rho Rho kinase

Indexed keywords

ALPHA CATENIN; DESMOGLEIN; DESMOPLAKIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MYOSIN; MYOSIN LIGHT CHAIN; RHO KINASE; UVOMORULIN;

EID: 84929192344     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (24)

References (53)
  • 1
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst L and D’Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev 1997; 11: 2295-2322.
    • (1997) Genes Dev , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D’souza-Schorey, C.2
  • 3
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski MS and McCormick F. Proteins regulating Ras and its relatives. Nature 1993; 366: 643-654.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 6
    • 1642422290 scopus 로고    scopus 로고
    • Rho kinase inhibitors block activation of pancreatic stellate cells
    • Masamune A, Kikuta K, Satoh M, Satoh K and Shimosegawa T. Rho kinase inhibitors block activation of pancreatic stellate cells. Br J Pharmacol 2003; 140: 1292-1302.
    • (2003) Br J Pharmacol , vol.140 , pp. 1292-1302
    • Masamune, A.1    Kikuta, K.2    Satoh, M.3    Satoh, K.4    Shimosegawa, T.5
  • 7
    • 84874113901 scopus 로고    scopus 로고
    • Role of Rho-kinase and its inhibitors in pulmonary hypertension
    • Duong-Quy S, Bei Y, Liu Z and Dinh-Xuan AT. Role of Rho-kinase and its inhibitors in pulmonary hypertension. Pharmacol Ther 2013; 137: 352-364.
    • (2013) Pharmacol Ther , vol.137 , pp. 352-364
    • Duong-Quy, S.1    Bei, Y.2    Liu, Z.3    Dinh-Xuan, A.T.4
  • 9
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009; 9: 799-809.
    • (2009) Nat Rev Immunol , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 10
    • 84873716991 scopus 로고    scopus 로고
    • Regulation of intestinal epithelial permeability by tight junctions
    • Suzuki T. Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci 2013; 70: 631-659.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 631-659
    • Suzuki, T.1
  • 12
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • Furuse M, Fujita K, Hiiragi T, Fujimoto K and Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998; 141: 1539-1550.
    • (1998) J Cell Biol , vol.141 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 15
    • 0030669302 scopus 로고    scopus 로고
    • Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
    • Turner JR, Rill BK, Carlson SL, Carnes D, Kerner R, Mrsny RJ and Madara JL. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol 1997; 273: C1378-1385.
    • (1997) Am J Physiol , vol.273 , pp. C1378-C1385
    • Turner, J.R.1    Rill, B.K.2    Carlson, S.L.3    Carnes, D.4    Kerner, R.5    Mrsny, R.J.6    Madara, J.L.7
  • 16
    • 34447281675 scopus 로고    scopus 로고
    • Molecular basis of epithelial barrier regulation: From basic mechanisms to clinical application
    • Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol 2006; 169: 1901-1909.
    • (2006) Am J Pathol , vol.169 , pp. 1901-1909
    • Turner, J.R.1
  • 17
    • 0034823910 scopus 로고    scopus 로고
    • Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia
    • Walsh SV, Hopkins AM, Chen J, Narumiya S, Parkos CA and Nusrat A. Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Gastroenterology 2001; 121: 566-579.
    • (2001) Gastroenterology , vol.121 , pp. 566-579
    • Walsh, S.V.1    Hopkins, A.M.2    Chen, J.3    Narumiya, S.4    Parkos, C.A.5    Nusrat, A.6
  • 18
    • 2142813761 scopus 로고    scopus 로고
    • A porous defense: The leaky epithelial barrier in intestinal disease
    • Clayburgh DR, Shen L and Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 2004; 84: 282-291.
    • (2004) Lab Invest , vol.84 , pp. 282-291
    • Clayburgh, D.R.1    Shen, L.2    Turner, J.R.3
  • 19
    • 34249933089 scopus 로고    scopus 로고
    • Altered permeability in inflammatory bowel disease: Pathophysiology and clinical implications
    • Mankertz J and Schulzke JD. Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr Opin Gastroenterol 2007; 23: 379-383.
    • (2007) Curr Opin Gastroenterol , vol.23 , pp. 379-383
    • Mankertz, J.1    Schulzke, J.D.2
  • 20
    • 40049097843 scopus 로고    scopus 로고
    • Role of the intestinal barrier in inflammatory bowel disease
    • Laukoetter MG, Nava P and Nusrat A. Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol 2008; 14: 401-407.
    • (2008) World J Gastroenterol , vol.14 , pp. 401-407
    • Laukoetter, M.G.1    Nava, P.2    Nusrat, A.3
  • 21
    • 84903443172 scopus 로고    scopus 로고
    • Mucosal barrier, bacteria and inflammatory bowel disease: Possibilities for therapy
    • Merga Y, Campbell BJ and Rhodes JM. Mucosal barrier, bacteria and inflammatory bowel disease: possibilities for therapy. Dig Dis 2014; 32: 475-483.
    • (2014) Dig Dis , vol.32 , pp. 475-483
    • Merga, Y.1    Campbell, B.J.2    Rhodes, J.M.3
  • 23
    • 0026531017 scopus 로고
    • Tumour necrosis factor alpha in stool as a marker of intestinal inflammation
    • Braegger CP, Nicholls S, Murch SH, Stephens S and MacDonald TT. Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 1992; 339: 89-91.
    • (1992) Lancet , vol.339 , pp. 89-91
    • Braegger, C.P.1    Nicholls, S.2    Murch, S.H.3    Stephens, S.4    Macdonald, T.T.5
  • 24
    • 0027486125 scopus 로고
    • Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease
    • Murch SH, Braegger CP, Walker-Smith JA and MacDonald TT. Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993; 34: 1705-1709.
    • (1993) Gut , vol.34 , pp. 1705-1709
    • Murch, S.H.1    Braegger, C.P.2    Walker-Smith, J.A.3    Macdonald, T.T.4
  • 25
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma G and Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003; 3: 521-533.
    • (2003) Nat Rev Immunol , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 27
    • 84895092508 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology, pathogenesis and current therapy
    • Ko JK and Auyeung KK. Inflammatory bowel disease: etiology, pathogenesis and current therapy. Curr Pharm Des 2014; 20: 1082-1096.
    • (2014) Curr Pharm Des , vol.20 , pp. 1082-1096
    • Ko, J.K.1    Auyeung, K.K.2
  • 28
    • 33947631511 scopus 로고    scopus 로고
    • IL-1beta causes an increase in intestinal epithelial tight junction permeability
    • Al-Sadi RM and Ma TY. IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol 2007; 178: 4641-4649.
    • (2007) J Immunol , vol.178 , pp. 4641-4649
    • Al-Sadi, R.M.1    Ma, T.Y.2
  • 29
    • 0036850908 scopus 로고    scopus 로고
    • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    • Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS and Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 2002; 17: 629-638.
    • (2002) Immunity , vol.17 , pp. 629-638
    • Heller, F.1    Fuss, I.J.2    Nieuwenhuis, E.E.3    Blumberg, R.S.4    Strober, W.5
  • 32
    • 26244442836 scopus 로고    scopus 로고
    • Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane
    • Utech M, Ivanov AI, Samarin SN, Bruewer M, Turner JR, Mrsny RJ, Parkos CA and Nusrat A. Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell 2005; 16: 5040-5052.
    • (2005) Mol Biol Cell , vol.16 , pp. 5040-5052
    • Utech, M.1    Ivanov, A.I.2    Samarin, S.N.3    Bruewer, M.4    Turner, J.R.5    Mrsny, R.J.6    Parkos, C.A.7    Nusrat, A.8
  • 35
    • 78650113104 scopus 로고    scopus 로고
    • Rho kinase signalling mediates radiation-induced inflammation and intestinal barrier dysfunction
    • Mihaescu A, Santen S, Jeppsson B and Thorlacius H. Rho kinase signalling mediates radiation-induced inflammation and intestinal barrier dysfunction. Br J Surg 2011; 98: 124-131.
    • (2011) Br J Surg , vol.98 , pp. 124-131
    • Mihaescu, A.1    Santen, S.2    Jeppsson, B.3    Thorlacius, H.4
  • 37
    • 84864475184 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of intestinal fibrosis
    • Speca S, Giusti I, Rieder F and Latella G. Cellular and molecular mechanisms of intestinal fibrosis. World J Gastroenterol 2012; 18: 3635-3661.
    • (2012) World J Gastroenterol , vol.18 , pp. 3635-3661
    • Speca, S.1    Giusti, I.2    Rieder, F.3    Latella, G.4
  • 38
    • 84925610045 scopus 로고    scopus 로고
    • Fibrosis in ulcerative colitis: Mechanisms, features, and consequences of a neglected problem
    • Gordon IO, Agrawal N, Goldblum JR, Fiocchi C and Rieder F. Fibrosis in ulcerative colitis: mechanisms, features, and consequences of a neglected problem. Inflamm Bowel Dis 2014; 20: 2198-2206.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 2198-2206
    • Gordon, I.O.1    Agrawal, N.2    Goldblum, J.R.3    Fiocchi, C.4    Rieder, F.5
  • 39
    • 84905483770 scopus 로고    scopus 로고
    • Mechanisms that mediate the development of fibrosis in patients with Crohn’s disease
    • Li C and Kuemmerle JF. Mechanisms that mediate the development of fibrosis in patients with Crohn’s disease. Inflamm Bowel Dis 2014; 20: 1250-1258.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 1250-1258
    • Li, C.1    Kuemmerle, J.F.2
  • 40
    • 33749599530 scopus 로고    scopus 로고
    • Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn’s disease
    • Beddy D, Mulsow J, Watson RW, Fitzpatrick JM and O’Connell PR. Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn’s disease. Br J Surg 2006; 93: 1290-1296.
    • (2006) Br J Surg , vol.93 , pp. 1290-1296
    • Beddy, D.1    Mulsow, J.2    Watson, R.W.3    Fitzpatrick, J.M.4    O’Connell, P.R.5
  • 41
    • 77956636219 scopus 로고    scopus 로고
    • Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease
    • Gunther U, Bateman AC, Beattie RM, Bauer M, MacDonald TT and Kaskas BA. Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease. Histopathology 2010; 57: 427-435.
    • (2010) Histopathology , vol.57 , pp. 427-435
    • Gunther, U.1    Bateman, A.C.2    Beattie, R.M.3    Bauer, M.4    Macdonald, T.T.5    Kaskas, B.A.6
  • 43
    • 79955459948 scopus 로고    scopus 로고
    • Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration
    • Schram K, Ganguly R, No EK, Fang X, Thong FS and Sweeney G. Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration. Endocrinology 2011; 152: 2037-2047.
    • (2011) Endocrinology , vol.152 , pp. 2037-2047
    • Schram, K.1    Ganguly, R.2    No, E.K.3    Fang, X.4    Thong, F.S.5    Sweeney, G.6
  • 44
    • 0345237913 scopus 로고    scopus 로고
    • Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
    • McKaig BC, McWilliams D, Watson SA and Mahida YR. Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am J Pathol 2003; 162: 1355-1360.
    • (2003) Am J Pathol , vol.162 , pp. 1355-1360
    • McKaig, B.C.1    McWilliams, D.2    Watson, S.A.3    Mahida, Y.R.4
  • 46
    • 0034882269 scopus 로고    scopus 로고
    • Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease
    • Lawrance IC, Maxwell L and Doe W. Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease. Inflamm Bowel Dis 2001; 7: 226-236.
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 226-236
    • Lawrance, I.C.1    Maxwell, L.2    Doe, W.3
  • 47
    • 14544278377 scopus 로고    scopus 로고
    • Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression
    • Bourgier C, Haydont V, Milliat F, Francois A, Holler V, Lasser P, Bourhis J, Mathe D and Vozenin-Brotons MC. Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression. Gut 2005; 54: 336-343.
    • (2005) Gut , vol.54 , pp. 336-343
    • Bourgier, C.1    Haydont, V.2    Milliat, F.3    Francois, A.4    Holler, V.5    Lasser, P.6    Bourhis, J.7    Mathe, D.8    Vozenin-Brotons, M.C.9
  • 50
    • 77949351029 scopus 로고    scopus 로고
    • New insights into epithelial-mesenchymal transition in kidney fibrosis
    • Liu Y. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 2010; 21: 212-222.
    • (2010) J am Soc Nephrol , vol.21 , pp. 212-222
    • Liu, Y.1
  • 51
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S and Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 2009; 19: 156-172.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 52
    • 0036073299 scopus 로고    scopus 로고
    • Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
    • McKaig BC, Hughes K, Tighe PJ and Mahida YR. Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts. Am J Physiol Cell Physiol 2002; 282: C172-182.
    • (2002) Am J Physiol Cell Physiol , vol.282 , pp. C172-C182
    • McKaig, B.C.1    Hughes, K.2    Tighe, P.J.3    Mahida, Y.R.4
  • 53
    • 77953769774 scopus 로고    scopus 로고
    • Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
    • Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M and Kalluri R. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 2010; 285: 20202-20212.
    • (2010) J Biol Chem , vol.285
    • Flier, S.N.1    Tanjore, H.2    Kokkotou, E.G.3    Sugimoto, H.4    Zeisberg, M.5    Kalluri, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.