Novel supercritical carbon dioxide impregnation technique for the production of amorphous solid drug dispersions: A comparison to hot melt extrusion

Molecular Pharmaceutics

Volumn 12, Issue 5, 2015, Pages 1377-1390

  Potter, Catherine ^a   Tian, Yiwei ^a   Walker, Gavin ^b   McCoy, Colin ^a   Hornsby, Peter ^a   Donnelly, Conor ^a   Jones, David S ^a   Andrews, Gavin P ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

hot melt extrusion; PVP; solid dispersions; Soluplus; supercritical fluid impregnation

Indexed keywords

CARBON DIOXIDE; INDOMETACIN; POLYMER; POVIDONE; MACROGOL DERIVATIVE; POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMER; POLYVINYL DERIVATIVE;

AMORPHOUS SOLID DISPERSION; ARTICLE; CHEMICAL PROCEDURES; CONTROLLED STUDY; DISPERSION; DISSOLUTION; DRUG CONCENTRATION; DRUG RELEASE; DRUG SOLUTION; DRUG STABILITY; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; GLASS TRANSITION TEMPERATURE; HOT MELT EXTRUSION; HYDROGEN BOND; MELTING POINT; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SPRAY DRYING; SUPERCRITICAL FLUID IMPREGNATION; CHEMISTRY; DRUG FORMULATION; INFRARED SPECTROSCOPY; MEDICINAL CHEMISTRY; PROCEDURES; SOLUBILITY;

CARBON DIOXIDE; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; INDOMETHACIN; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYLS; POVIDONE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84929170053     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500644h     Document Type: Article

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