Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility

International Journal of Pharmaceutics

Volumn 413, Issue 1-2, 2011, Pages 237-244

  Mou, Dongsheng ^a   Chen, Huabing ^a   Wan, Jiangling ^a   Xu, Huibi ^a   Yang, Xiangliang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Acid base neutralization; Dried drug nanosuspensions; Nanosuspensions; Oral bioavailability enhancement; Ph dependent solubility; Poorly soluble drugs

Indexed keywords

ITRACONAZOLE; MANNITOL; POLOXAMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; FOOD INTAKE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION; SPRAY DRYING; SUSPENSION;

ADMINISTRATION, ORAL; ANIMALS; ANTIFUNGAL AGENTS; BIOLOGICAL AVAILABILITY; DESICCATION; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; ITRACONAZOLE; MANNICH BASES; METHYLCELLULOSE; NANOPARTICLES; PARTICLE SIZE; POLOXAMER; RATS; RATS, WISTAR; SOLUBILITY; SUSPENSIONS;

EID: 79958005215     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.04.034     Document Type: Article

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