Real time Raman imaging to understand dissolution performance of amorphous solid dispersions

Journal of Controlled Release

Volumn 188, Issue , 2014, Pages 53-60

  Tres, Francesco ^a   Treacher, Kevin ^b   Booth, Jonathan ^b   Hughes, Les P ^b   Wren, Stephen A C ^b   Aylott, Jonathan W ^a   Burley, Jonathan C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Amorphous solid dispersions; Intrinsic dissolution rate; Multi variate curve resolution (MCR); Poorly soluble drugs; Raman imaging; Solid state transformations

Indexed keywords

AMORPHOUS MATERIALS; DISPERSIONS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ROTATING DISKS;

AMORPHOUS SOLID DISPERSIONS; CURVE RESOLUTION; DISSOLUTION RATES; POORLY SOLUBLE DRUGS; RAMAN IMAGING; SOLID STATE TRANSFORMATIONS;

DISSOLUTION;

COPOVIDONE; FELODIPINE; POLYMER; UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; DRUG VEHICLE; POLY(VINYLPYRROLIDONE-CO-VINYL-ACETATE); PYRROLIDINE DERIVATIVE; VINYL DERIVATIVE;

ARTICLE; DISPERSION; DISSOLUTION; DRUG SOLUBILITY; HYDROPHOBICITY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TIME; X RAY POWDER DIFFRACTION; CHEMISTRY; CRYSTALLIZATION; DRUG FORMULATION; POWDER DIFFRACTION; PROCEDURES; SOLUBILITY; X RAY DIFFRACTION;

ANTIHYPERTENSIVE AGENTS; CRYSTALLIZATION; DRUG COMPOUNDING; FELODIPINE; PHARMACEUTICAL VEHICLES; POWDER DIFFRACTION; PYRROLIDINES; SOLUBILITY; SPECTRUM ANALYSIS, RAMAN; VINYL COMPOUNDS; X-RAY DIFFRACTION;

EID: 84903540202     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.05.061     Document Type: Article

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