-
1
-
-
84900876848
-
Use of ranolazine in patients with stable angina pectoris
-
S. Khera, D. Kolte, W.S. Aronow, Use of ranolazine in patients with stable angina pectoris, Cardiology 128 (2014) 251-258.
-
(2014)
Cardiology
, vol.128
, pp. 251-258
-
-
Khera, S.1
Kolte, D.2
Aronow, W.S.3
-
2
-
-
53349097796
-
Ranolazine for chronic stable angina
-
D.T. Nash, S.D. Nash, Ranolazine for chronic stable angina, Lancet 372 (2008) 1335-1341.
-
(2008)
Lancet
, vol.372
, pp. 1335-1341
-
-
Nash, D.T.1
Nash, S.D.2
-
3
-
-
33744455453
-
Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions
-
B.R. Chaitman, Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions, Circulation 113 (2006) 2462-2472.
-
(2006)
Circulation
, vol.113
, pp. 2462-2472
-
-
Chaitman, B.R.1
-
4
-
-
84887491765
-
Effects of ranolazine in symptomatic patients with stable coronary artery disease. A systematic review and meta-analysis
-
G. Savarese, G. Rosano, C. D'Amore, et al., Effects of ranolazine in symptomatic patients with stable coronary artery disease. A systematic review and meta-analysis, Int. J. Cardiol. 169 (2013) 262-270.
-
(2013)
Int. J. Cardiol.
, vol.169
, pp. 262-270
-
-
Savarese, G.1
Rosano, G.2
D'Amore, C.3
-
5
-
-
84947201441
-
Ranolazine: Drug overview and possible role in primary microvascular angina management
-
M. Cattaneo, A.P. Porretta, A. Gallino, Ranolazine: Drug overview and possible role in primary microvascular angina management, Int. J. Cardiol. 181C (2014) 376-381.
-
(2014)
Int. J. Cardiol.
, vol.181 C
, pp. 376-381
-
-
Cattaneo, M.1
Porretta, A.P.2
Gallino, A.3
-
6
-
-
18144403776
-
Treatment of refractory angina pectoris
-
R.M. Gowda, I.A. Khan, G. Punukollu, B.C. Vasavada, C.K. Nair, Treatment of refractory angina pectoris, Int. J. Cardiol. 101 (2005) 1-7.
-
(2005)
Int. J. Cardiol.
, vol.101
, pp. 1-7
-
-
Gowda, R.M.1
Khan, I.A.2
Punukollu, G.3
Vasavada, B.C.4
Nair, C.K.5
-
7
-
-
84873409611
-
Angina pectoris in women: Focus on microvascular disease
-
C. Zuchi, I. Tritto, G. Ambrosio, Angina pectoris in women: Focus on microvascular disease, Int. J. Cardiol. 163 (2013) 132-140.
-
(2013)
Int. J. Cardiol.
, vol.163
, pp. 132-140
-
-
Zuchi, C.1
Tritto, I.2
Ambrosio, G.3
-
8
-
-
43949094514
-
Metabolic agents in the management of diabetic coronary patients: A new era
-
G. Marazzi, M. Volterrani, G.M. Rosano, Metabolic agents in the management of diabetic coronary patients: A new era, Int. J. Cardiol. 127 (2008) 124-125.
-
(2008)
Int. J. Cardiol.
, vol.127
, pp. 124-125
-
-
Marazzi, G.1
Volterrani, M.2
Rosano, G.M.3
-
9
-
-
84868543663
-
A focus on antiarrhythmic properties of ranolazine
-
E. Vizzardi, A. D'Aloia, F. Quinzani, et al., A focus on antiarrhythmic properties of ranolazine, J. Cardiovasc. Pharmacol. Ther. 17 (2012) 353-356.
-
(2012)
J. Cardiovasc. Pharmacol. Ther.
, vol.17
, pp. 353-356
-
-
Vizzardi, E.1
D'Aloia, A.2
Quinzani, F.3
-
10
-
-
84896304477
-
Late sodium current inhibition: The most promising antiarrhythmic principle in the near future?
-
G. Frommeyer, P. Milberg, L.S. Maier, L. Eckardt, Late sodium current inhibition: The most promising antiarrhythmic principle in the near future? Curr. Med. Chem. 21 (2014) 1271-1280.
-
(2014)
Curr. Med. Chem.
, vol.21
, pp. 1271-1280
-
-
Frommeyer, G.1
Milberg, P.2
Maier, L.S.3
Eckardt, L.4
-
11
-
-
84857784060
-
Antiarrhythmic drugs for themaintenance of sinus rhythm: Risks and benefits
-
J. Camm, Antiarrhythmic drugs for themaintenance of sinus rhythm: Risks and benefits, Int. J. Cardiol. 155 (2012) 362-371.
-
(2012)
Int. J. Cardiol.
, vol.155
, pp. 362-371
-
-
Camm, J.1
-
12
-
-
84900609649
-
Combination use of ranolazine with dofetilide for the maintenance of atrial fibrillation
-
S.A. Shah, G. Koyama, D. Da Costa, P. McGregor, M. Kolasa, Combination use of ranolazine with dofetilide for the maintenance of atrial fibrillation, Int. J. Cardiol. 172 (2014) e428-e429.
-
(2014)
Int. J. Cardiol.
, vol.172
, pp. e428-e429
-
-
Shah, S.A.1
Koyama, G.2
Da Costa, D.3
McGregor, P.4
Kolasa, M.5
-
13
-
-
84891735675
-
Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker
-
M.P. van den Berg, F. van den Heuvel, J.P. van Tintelen, P.G. Volders, I.C. van Gelder, Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker, Int. J. Cardiol. 171 (2014) 90-92.
-
(2014)
Int. J. Cardiol.
, vol.171
, pp. 90-92
-
-
Berg Den Van, M.P.1
Heuvel Den F.Van2
Van Tintelen, J.P.3
Volders, P.G.4
Van Gelder, I.C.5
-
14
-
-
4344577023
-
Electrophysiological effects of ranolazine a novel antianginal agent with antiarrhythmic properties
-
C. Antzelevitch, L. Belardinelli, A.C. Zygmunt, et al., Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties, Circulation 110 (2004) 904-910.
-
(2004)
Circulation
, vol.110
, pp. 904-910
-
-
Antzelevitch, C.1
Belardinelli, L.2
Zygmunt, A.C.3
-
15
-
-
3242778566
-
Antagonism by ranolazine of the proarrhythmic effects of increasing late INa in guinea pig ventricular myocytes
-
Y. Song, J.C. Shryock, L. Wu, L. Belardinelli, Antagonism by ranolazine of the proarrhythmic effects of increasing late INa in guinea pig ventricular myocytes, J. Cardiovasc. Pharmacol. 44 (2004) 192-199.
-
(2004)
J. Cardiovasc. Pharmacol.
, vol.44
, pp. 192-199
-
-
Song, Y.1
Shryock, J.C.2
Wu, L.3
Belardinelli, L.4
-
16
-
-
33646007982
-
Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
-
A.I. Undrovinas, L. Belardinelli, N.A. Undrovinas, H.N. Sabbah, Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current, J. Cardiovasc. Electrophysiol. 17 (Suppl. 1) (2006) S169-S177.
-
(2006)
J. Cardiovasc. Electrophysiol.
, vol.17
, pp. 169-177
-
-
Undrovinas, A.I.1
Belardinelli, L.2
Undrovinas, N.A.3
Sabbah, H.N.4
-
17
-
-
34748873780
-
Atriumselective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodiumchannel inactivation between atria and ventricles and the role of ranolazine
-
A. Burashnikov, J.M. Di Diego, A.C. Zygmunt, L. Belardinelli, C. Antzelevitch, Atriumselective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodiumchannel inactivation between atria and ventricles and the role of ranolazine, Circulation 116 (2007) 1449-1457.
-
(2007)
Circulation
, vol.116
, pp. 1449-1457
-
-
Burashnikov, A.1
Di Diego, J.M.2
Zygmunt, A.C.3
Belardinelli, L.4
Antzelevitch, C.5
-
18
-
-
77952165183
-
Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium
-
S. Sossalla, B. Kallmeyer, S. Wagner, et al., Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium, J. Am. Coll. Cardiol. 55 (2010) 2330-2342.
-
(2010)
J. Am. Coll. Cardiol.
, vol.55
, pp. 2330-2342
-
-
Sossalla, S.1
Kallmeyer, B.2
Wagner, S.3
-
19
-
-
79960757657
-
Electrophysiologic basis for the antiarrhythmic actions of ranolazine
-
C. Antzelevitch, A. Burashnikov, S. Sicouri, L. Belardinelli, Electrophysiologic basis for the antiarrhythmic actions of ranolazine, Heart Rhythm. 8 (2011) 1281-1290.
-
(2011)
Heart Rhythm.
, vol.8
, pp. 1281-1290
-
-
Antzelevitch, C.1
Burashnikov, A.2
Sicouri, S.3
Belardinelli, L.4
-
20
-
-
0018460671
-
Effect of tetrodotoxin on action potentials of the conducting system in the dog heart
-
E. Coraboeuf, E. Deroubaix, A. Coulombe, Effect of tetrodotoxin on action potentials of the conducting system in the dog heart, Am. J. Physiol. 236 (1979) H561-H567.
-
(1979)
Am. J. Physiol.
, vol.236
, pp. 561-567
-
-
Coraboeuf, E.1
Deroubaix, E.2
Coulombe, A.3
-
21
-
-
84873057304
-
Role of late sodium channel current block in the management of atrial fibrillation
-
A. Burashnikov, C. Antzelevitch, Role of late sodium channel current block in the management of atrial fibrillation, Cardiovasc. Drugs Ther. 27 (2013) 79-89.
-
(2013)
Cardiovasc. Drugs Ther.
, vol.27
, pp. 79-89
-
-
Burashnikov, A.1
Antzelevitch, C.2
-
22
-
-
54949132945
-
Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart
-
A. Undrovinas, V.A. Maltsev, Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart, Cardiovasc. Hematol. Agents Med. Chem. 6 (2008) 348-359.
-
(2008)
Cardiovasc. Hematol. Agents Med. Chem.
, vol.6
, pp. 348-359
-
-
Undrovinas, A.1
Maltsev, V.A.2
-
23
-
-
0034886161
-
Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle
-
A.C. Zygmunt, G.T. Eddlestone, G.P. Thomas, V.V. Nesterenko, C. Antzelevitch, Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle, Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H689-H697.
-
(2001)
Am. J. Physiol. Heart Circ. Physiol.
, vol.281
, pp. 689-697
-
-
Zygmunt, A.C.1
Eddlestone, G.T.2
Thomas, G.P.3
Nesterenko, V.V.4
Antzelevitch, C.5
-
24
-
-
0026666057
-
Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine
-
A.I. Undrovinas, I.A. Fleidervish, J.C. Makielski, Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine, Circ. Res. 71 (1992) 1231-1241.
-
(1992)
Circ. Res.
, vol.71
, pp. 1231-1241
-
-
Undrovinas, A.I.1
Fleidervish, I.A.2
Makielski, J.C.3
-
25
-
-
0028325970
-
Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes
-
J.Wu, P.B. Corr, Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes, Am. J. Physiol. 266 (1994) H1034-H1046.
-
(1994)
Am. J. Physiol.
, vol.266
, pp. 1034-1046
-
-
Wu, J.1
Corr, P.B.2
-
26
-
-
45549105581
-
Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts-role of late sodium current and intracellular ion accumulation
-
S. Sossalla, S. Wagner, E.C. Rasenack, et al., Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts-role of late sodium current and intracellular ion accumulation, J. Mol. Cell. Cardiol. 45 (2008) 32-43.
-
(2008)
J. Mol. Cell. Cardiol.
, vol.45
, pp. 32-43
-
-
Sossalla, S.1
Wagner, S.2
Rasenack, E.C.3
-
27
-
-
0035115891
-
Alterations of sodium channel kinetics and gene expression in the postinfarction remodeled myocardium
-
B. Huang, T. El-Sherif, M. Gidh-Jain, D. Qin, N. El-Sherif, Alterations of sodium channel kinetics and gene expression in the postinfarction remodeled myocardium, J. Cardiovasc. Electrophysiol. 12 (2001) 218-225.
-
(2001)
J. Cardiovasc. Electrophysiol.
, vol.12
, pp. 218-225
-
-
Huang, B.1
El-Sherif, T.2
Gidh-Jain, M.3
Qin, D.4
El-Sherif, N.5
-
28
-
-
33847261532
-
Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability
-
V.A. Maltsev, N. Silverman, H.N. Sabbah, A.I. Undrovinas, Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability, Eur. J. Heart Fail. 9 (2007) 219-227.
-
(2007)
Eur. J. Heart Fail.
, vol.9
, pp. 219-227
-
-
Maltsev, V.A.1
Silverman, N.2
Sabbah, H.N.3
Undrovinas, A.I.4
-
29
-
-
33845284849
-
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
-
S. Wagner, N. Dybkova, E.C. Rasenack, et al., Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels, J. Clin. Invest. 116 (2006) 3127-3138.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 3127-3138
-
-
Wagner, S.1
Dybkova, N.2
Rasenack, E.C.3
-
30
-
-
79952772425
-
Reactive oxygen species-activated Ca/calmodulin kinase IIdelta is required for late I(Na) augmentation leading to cellular Na and Ca overload
-
S. Wagner, H.M. Ruff, S.L. Weber, et al., Reactive oxygen species-activated Ca/calmodulin kinase IIdelta is required for late I(Na) augmentation leading to cellular Na and Ca overload, Circ. Res. 108 (2011) 555-565.
-
(2011)
Circ. Res.
, vol.108
, pp. 555-565
-
-
Wagner, S.1
Ruff, H.M.2
Weber, S.L.3
-
31
-
-
55949087203
-
Ranolazine inhibits an oxidative stress-induced increase in myocyte sodium and calcium loading during simulated-demand ischemia
-
X.Q. Zhang, S. Yamada, W.H. Barry, Ranolazine inhibits an oxidative stress-induced increase in myocyte sodium and calcium loading during simulated-demand ischemia, J. Cardiovasc. Pharmacol. 51 (2008) 443-449.
-
(2008)
J. Cardiovasc. Pharmacol.
, vol.51
, pp. 443-449
-
-
Zhang, X.Q.1
Yamada, S.2
Barry, W.H.3
-
32
-
-
84883491199
-
Differential cardiac remodeling in preload versus afterload
-
K. Toischer, A.G. Rokita, B. Unsold, et al., Differential cardiac remodeling in preload versus afterload, Circulation 122 (2010) 993-1003.
-
(2010)
Circulation
, vol.122
, pp. 993-1003
-
-
Toischer, K.1
Rokita, A.G.2
Unsold, B.3
-
33
-
-
0030957101
-
Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes
-
C.A. Ward, W.R. Giles, Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes, J. Physiol. 500 (Pt 3) (1997) 631-642.
-
(1997)
J. Physiol.
, vol.500
, pp. 631-642
-
-
Ward, C.A.1
Giles, W.R.2
-
34
-
-
33745251122
-
Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction
-
Y. Song, J.C. Shryock, S.Wagner, L.S. Maier, L. Belardinelli, Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction, J. Pharmacol. Exp. Ther. 318 (2006) 214-222.
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.318
, pp. 214-222
-
-
Song, Y.1
Shryock, J.C.2
Wagner, S.3
Maier, L.S.4
Belardinelli, L.5
-
35
-
-
33751337747
-
Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes
-
S. Fredj, N. Lindegger, K.J. Sampson, P. Carmeliet, R.S. Kass, Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes, Circ. Res. 99 (2006) 1225-1232.
-
(2006)
Circ. Res.
, vol.99
, pp. 1225-1232
-
-
Fredj, S.1
Lindegger, N.2
Sampson, K.J.3
Carmeliet, P.4
Kass, R.S.5
-
36
-
-
80053226953
-
Mechanisms of atrial-selective block of Na(+)channels by ranolazine: I. Experimental analysis of the usedependent block
-
A.C. Zygmunt, V.V. Nesterenko, S. Rajamani, et al., Mechanisms of atrial-selective block of Na(+) channels by ranolazine: I. Experimental analysis of the usedependent block, Am. J. Physiol. Heart Circ. Physiol. 301 (2011) H1606-H1614.
-
(2011)
Am. J. Physiol. Heart Circ. Physiol.
, vol.301
, pp. 1606-1614
-
-
Zygmunt, A.C.1
Nesterenko, V.V.2
Rajamani, S.3
-
37
-
-
84856442152
-
Role of ranolazine in angina, heart failure, arrhythmias, and diabetes
-
S. Sossalla, L.S. Maier, Role of ranolazine in angina, heart failure, arrhythmias, and diabetes, Pharmacol. Ther. 133 (2012) 311-323.
-
(2012)
Pharmacol Ther.
, vol.133
, pp. 311-323
-
-
Sossalla, S.1
Maier, L.S.2
-
38
-
-
11144356285
-
Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina
-
B.R. Chaitman, S.L. Skettino, J.O. Parker, et al., Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina, J. Am. Coll. Cardiol. 43 (2004) 1375-1382.
-
(2004)
J. Am. Coll. Cardiol.
, vol.43
, pp. 1375-1382
-
-
Chaitman, B.R.1
Skettino, S.L.2
Parker, J.O.3
-
39
-
-
0348129532
-
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized controlled trial
-
B.R. Chaitman, C.J. Pepine, J.O. Parker, et al., Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized controlled trial, JAMA 291 (2004) 309-316.
-
(2004)
JAMA
, vol.291
, pp. 309-316
-
-
Chaitman, B.R.1
Pepine, C.J.2
Parker, J.O.3
-
40
-
-
84877776301
-
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: Results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects with Chronic Stable Angina)
-
M. Kosiborod, S.V. Arnold, J.A. Spertus, et al., Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: Results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina), J. Am. Coll. Cardiol. 61 (2013) 2038-2045.
-
(2013)
J. Am. Coll. Cardiol.
, vol.61
, pp. 2038-2045
-
-
Kosiborod, M.1
Arnold, S.V.2
Spertus, J.A.3
-
41
-
-
33847385380
-
Long-term safety of a novel antianginal agent in patientswith severe chronic stable angina: The Ranolazine Open Label Experience (ROLE)
-
M.J. Koren, M.R. Crager, M. Sweeney, Long-term safety of a novel antianginal agent in patientswith severe chronic stable angina: The Ranolazine Open Label Experience (ROLE), J. Am. Coll. Cardiol. 49 (2007) 1027-1034.
-
(2007)
J. Am. Coll. Cardiol.
, vol.49
, pp. 1027-1034
-
-
Koren, M.J.1
Crager, M.R.2
Sweeney, M.3
-
42
-
-
33746192571
-
Antianginal efficacy of ranolazine when added to treatment with amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) trial
-
P.H. Stone, N.A. Gratsiansky, A. Blokhin, I.Z. Huang, L. Meng, E. Investigators, Antianginal efficacy of ranolazine when added to treatment with amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) trial, J. Am. Coll. Cardiol. 48 (2006) 566-575.
-
(2006)
J. Am. Coll. Cardiol.
, vol.48
, pp. 566-575
-
-
Stone, P.H.1
Gratsiansky, N.A.2
Blokhin, A.3
Huang, I.Z.4
Meng, L.5
-
43
-
-
64649089888
-
Efficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-STSegment Elevation Acute Coronary Syndromes) 36 trial
-
S.R. Wilson, B.M. Scirica, E. Braunwald, et al., Efficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-STSegment Elevation Acute Coronary Syndromes) 36 trial, J. Am. Coll. Cardiol. 53 (2009) 1510-1516.
-
(2009)
J. Am. Coll. Cardiol.
, vol.53
, pp. 1510-1516
-
-
Wilson, S.R.1
Scirica, B.M.2
Braunwald, E.3
-
44
-
-
46349111138
-
Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations
-
S. Sicouri, A. Glass, L. Belardinelli, C. Antzelevitch, Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations, Heart Rhythm. 5 (2008) 1019-1026.
-
(2008)
Heart Rhythm.
, vol.5
, pp. 1019-1026
-
-
Sicouri, S.1
Glass, A.2
Belardinelli, L.3
Antzelevitch, C.4
-
45
-
-
67649795769
-
Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart
-
K. Kumar, B.D. Nearing, M. Carvas, et al., Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart, J. Cardiovasc. Electrophysiol. 20 (2009) 796-802.
-
(2009)
J. Cardiovasc. Electrophysiol.
, vol.20
, pp. 796-802
-
-
Kumar, K.1
Nearing, B.D.2
Carvas, M.3
-
46
-
-
77949596392
-
Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart
-
M. Carvas, B.C. Nascimento, M. Acar, B.D. Nearing, L. Belardinelli, R.L. Verrier, Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart, J. Cardiovasc. Pharmacol. 55 (2010) 286-291.
-
(2010)
J. Cardiovasc. Pharmacol.
, vol.55
, pp. 286-291
-
-
Carvas, M.1
Nascimento, B.C.2
Acar, M.3
Nearing, B.D.4
Belardinelli, L.5
Verrier, R.L.6
-
47
-
-
70350219094
-
Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation
-
C. Antzelevitch, A. Burashnikov, Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation, J. Electrocardiol. 42 (2009) 543-548.
-
(2009)
J. Electrocardiol.
, vol.42
, pp. 543-548
-
-
Antzelevitch, C.1
Burashnikov, A.2
-
48
-
-
84899621970
-
Atrial fibrillation therapy now and in the future: Drugs, biologicals, and ablation
-
C.E. Woods, J. Olgin, Atrial fibrillation therapy now and in the future: Drugs, biologicals, and ablation, Circ. Res. 114 (2014) 1532-1546.
-
(2014)
Circ Res.
, vol.114
, pp. 1532-1546
-
-
Woods, C.E.1
Olgin, J.2
-
49
-
-
0026011647
-
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The cardiac arrhythmia suppression trial
-
D.S. Echt, P.R. Liebson, L.B. Mitchell, et al.,Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial, N. Engl. J. Med. 324 (1991) 781-788.
-
(1991)
N. Engl. J. Med.
, vol.324
, pp. 781-788
-
-
Echt, D.S.1
Liebson, P.R.2
Mitchell, L.B.3
-
50
-
-
84886422669
-
Distinctive sodium and calciumregulation associated with sex differences in atrial electrophysiology of rabbits
-
W.C. Tsai, Y.C. Chen, Y.H. Kao, Y.Y. Lu, S.A. Chen, Y.J. Chen, Distinctive sodium and calciumregulation associated with sex differences in atrial electrophysiology of rabbits, Int. J. Cardiol. 168 (2013) 4658-4666.
-
(2013)
Int. J. Cardiol.
, vol.168
, pp. 4658-4666
-
-
Tsai, W.C.1
Chen, Y.C.2
Kao, Y.H.3
Lu, Y.Y.4
Chen, S.A.5
Chen, Y.J.6
-
51
-
-
77957571615
-
Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation
-
A. Burashnikov, S. Sicouri, J.M. Di Diego, L. Belardinelli, C. Antzelevitch, Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation, J. Am. Coll. Cardiol. 56 (2010) 1216-1224.
-
(2010)
J. Am. Coll. Cardiol.
, vol.56
, pp. 1216-1224
-
-
Burashnikov, A.1
Sicouri, S.2
Di Diego, J.M.3
Belardinelli, L.4
Antzelevitch, C.5
-
52
-
-
77649299995
-
Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria
-
S. Sicouri, A. Burashnikov, L. Belardinelli, C. Antzelevitch, Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria, Circ. Arrhythm. Electrophysiol. 3 (2010) 88-95.
-
(2010)
Circ. Arrhythm. Electrophysiol.
, vol.3
, pp. 88-95
-
-
Sicouri, S.1
Burashnikov, A.2
Belardinelli, L.3
Antzelevitch, C.4
-
53
-
-
55849135767
-
The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation
-
D.K. Murdock, N. Overton, M. Kersten, J. Kaliebe, F. Devecchi, The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation, Indian Pacing Electrophysiol. J. 8 (2008) 175-181.
-
(2008)
Indian Pacing Electrophysiol. J.
, vol.8
, pp. 175-181
-
-
Murdock, D.K.1
Overton, N.2
Kersten, M.3
Kaliebe, J.4
Devecchi, F.5
-
54
-
-
73249135820
-
The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: A review of experience with implications for possible "pill in the pocket" approach to atrial fibrillation
-
D.K.Murdock, M. Kersten, J. Kaliebe, G. Larrain, The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: A review of experience with implications for possible "pill in the pocket" approach to atrial fibrillation, Indian Pacing Electrophysiol. J. 9 (2009) 260-267.
-
(2009)
Indian Pacing Electrophysiol. J.
, vol.9
, pp. 260-267
-
-
Murdock, D.K.1
Kersten, M.2
Kaliebe, J.3
Larrain, G.4
-
55
-
-
80051802104
-
Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting
-
R.H. Miles, R. Passman, D.K. Murdock, Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting, Am. J. Cardiol. 108 (2011) 673-676.
-
(2011)
Am. J. Cardiol.
, vol.108
, pp. 673-676
-
-
Miles, R.H.1
Passman, R.2
Murdock, D.K.3
-
56
-
-
34247526904
-
Effects of ranolazine on recurrent cardiovascular events in patientswith non-ST-elevation acute coronary syndromes: The MERLIN-TIMI 36 randomized trial
-
D.A. Morrow, B.M. Scirica, E. Karwatowska-Prokopczuk, et al., Effects of ranolazine on recurrent cardiovascular events in patientswith non-ST-elevation acute coronary syndromes: The MERLIN-TIMI 36 randomized trial, JAMA 297 (2007) 1775-1783.
-
(2007)
JAMA
, vol.297
, pp. 1775-1783
-
-
Morrow, D.A.1
Scirica, B.M.2
Karwatowska-Prokopczuk, E.3
-
57
-
-
35148850168
-
Effect of ranolazine an antianginal agent with novel electrophysiological properties on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: Results from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial
-
B.M. Scirica, D.A. Morrow, H. Hod, et al., Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: Results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial, Circulation 116 (2007) 1647-1652.
-
(2007)
Circulation
, vol.116
, pp. 1647-1652
-
-
Scirica, B.M.1
Morrow, D.A.2
Hod, H.3
-
58
-
-
84922443836
-
Effect of ranolazine on atrial fibrillation in patients with non-ST elevation acute coronary syndromes: Observations from the MERLIN-TIMI 36 trial
-
B.M. Scirica, L. Belardinelli, B.R. Chaitman, et al., Effect of ranolazine on atrial fibrillation in patients with non-ST elevation acute coronary syndromes: Observations from the MERLIN-TIMI 36 trial, Europace 17 (1) (2015) 32-37.
-
(2015)
Europace
, vol.17
, Issue.1
, pp. 32-37
-
-
Scirica, B.M.1
Belardinelli, L.2
Chaitman, B.R.3
-
59
-
-
84929202138
-
-
Available from: 20 September 2014, date last accessed)
-
The HARMONY Study 2014Available from: Http://www.gilead.com/news/press-releases/2014/5/gilead-announces-results-from-phase-2-study-showing-reductionin-atrial-fibrillation-burden-with-the-investigational-combination-of-ranolazineand-lowdose-dronedarone (20 September 2014, date last accessed).
-
The HARMONY Study 2014
-
-
-
62
-
-
44949176560
-
An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes
-
Y. Song, J.C. Shryock, L. Belardinelli, An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes, Am. J. Physiol. Heart Circ. Physiol. 294 (2008) H2031-H2039.
-
(2008)
Am. J. Physiol. Heart Circ. Physiol.
, vol.294
, pp. 2031-2039
-
-
Song, Y.1
Shryock, J.C.2
Belardinelli, L.3
-
63
-
-
77956063496
-
Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure
-
N.A. Undrovinas, V.A. Maltsev, L. Belardinelli, H.N. Sabbah, A. Undrovinas, Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure, J. Physiol. Sci. 60 (2010) 245-257.
-
(2010)
J. Physiol. Sci.
, vol.60
, pp. 245-257
-
-
Undrovinas, N.A.1
Maltsev, V.A.2
Belardinelli, L.3
Sabbah, H.N.4
Undrovinas, A.5
-
64
-
-
70350438424
-
Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart
-
J.A. Wasserstrom, R. Sharma, M.J. O'Toole, et al., Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart, J. Pharmacol. Exp. Ther. 331 (2009) 382-391.
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.331
, pp. 382-391
-
-
Wasserstrom, J.A.1
Sharma, R.2
O'Toole, M.J.3
-
65
-
-
69249151748
-
Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart
-
L. Wu, S. Rajamani, H. Li, C.T. January, J.C. Shryock, L. Belardinelli, Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart, Am. J. Physiol. Heart Circ. Physiol. 297 (2009) H1048-H1057.
-
(2009)
Am. J. Physiol. Heart Circ. Physiol.
, vol.297
, pp. 1048-1057
-
-
Wu, L.1
Rajamani, S.2
Li, H.3
January, C.T.4
Shryock, J.C.5
Belardinelli, L.6
-
66
-
-
54549125837
-
Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3
-
P. Milberg, C. Pott, M. Fink, et al., Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3, Heart Rhythm. 5 (2008) 1444-1452.
-
(2008)
Heart Rhythm.
, vol.5
, pp. 1444-1452
-
-
Milberg, P.1
Pott, C.2
Fink, M.3
-
67
-
-
3342882854
-
Antiarrhythmic effects of ranolazine in a guinea pig in vitromodel of long-QT syndrome
-
L. Wu, J.C. Shryock, Y. Song, Y. Li, C. Antzelevitch, L. Belardinelli, Antiarrhythmic effects of ranolazine in a guinea pig in vitromodel of long-QT syndrome, J. Pharmacol. Exp. Ther. 310 (2004) 599-605.
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.310
, pp. 599-605
-
-
Wu, L.1
Shryock, J.C.2
Song, Y.3
Li, Y.4
Antzelevitch, C.5
Belardinelli, L.6
-
68
-
-
31144473292
-
An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts
-
L. Wu, J.C. Shryock, Y. Song, L. Belardinelli, An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts, J. Pharmacol. Exp. Ther. 316 (2006) 718-726.
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.316
, pp. 718-726
-
-
Wu, L.1
Shryock, J.C.2
Song, Y.3
Belardinelli, L.4
-
69
-
-
76449092876
-
Late Na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model
-
G. Antoons, A. Oros, J.D. Beekman, et al., Late Na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model, J. Am. Coll. Cardiol. 55 (2010) 801-809.
-
(2010)
J. Am. Coll. Cardiol.
, vol.55
, pp. 801-809
-
-
Antoons, G.1
Oros, A.2
Beekman, J.D.3
-
70
-
-
4944257316
-
Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent
-
C. Antzelevitch, L. Belardinelli, L.Wu, et al., Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent, J. Cardiovasc. Pharmacol. Ther. 9 (Suppl. 1) (2004) S65-S83.
-
(2004)
J. Cardiovasc. Pharmacol. Ther.
, vol.9
, pp. 65-83
-
-
Antzelevitch, C.1
Belardinelli, L.2
Wu, L.3
-
71
-
-
52149109259
-
Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart
-
K. Kumar, B.D. Nearing, C.R. Bartoli, K.F. Kwaku, L. Belardinelli, R.L. Verrier, Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart, J. Cardiovasc. Electrophysiol. 19 (2008) 1073-1079.
-
(2008)
J. Cardiovasc. Electrophysiol.
, vol.19
, pp. 1073-1079
-
-
Kumar, K.1
Nearing, B.D.2
Bartoli, C.R.3
Kwaku, K.F.4
Belardinelli, L.5
Verrier, R.L.6
-
72
-
-
70449090162
-
Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion
-
A.K. Dhalla,W.Q.Wang, J. Dow, et al., Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion, Am. J. Physiol. Heart Circ. Physiol. 297 (2009) H1923-H1929.
-
(2009)
Am. J. Physiol. Heart Circ. Physiol.
, vol.297
, pp. 1923-1929
-
-
Dhalla, A.K.1
Wang, W.Q.2
Dow, J.3
-
73
-
-
79960166057
-
First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model
-
R.A. Kloner, J.S. Dow, A. Bhandari, First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model, J. Cardiovasc. Pharmacol. Ther. 16 (2011) 192-196.
-
(2011)
J. Cardiovasc. Pharmacol. Ther.
, vol.16
, pp. 192-196
-
-
Kloner, R.A.1
Dow, J.S.2
Bhandari, A.3
-
74
-
-
79953234505
-
Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model
-
T. Nieminen, D.Y. Nanbu, I.P. Datti, et al., Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model, Heart Rhythm. 8 (2011) 608-614.
-
(2011)
Heart Rhythm.
, vol.8
, pp. 608-614
-
-
Nieminen, T.1
Nanbu, D.Y.2
Datti, I.P.3
-
75
-
-
78651326450
-
Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine
-
N. Morita, J.H. Lee, Y. Xie, et al., Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine, J. Am. Coll. Cardiol. 57 (2011) 366-375.
-
(2011)
J. Am. Coll. Cardiol.
, vol.57
, pp. 366-375
-
-
Morita, N.1
Lee, J.H.2
Xie, Y.3
-
76
-
-
84870567980
-
New insights into the beneficial electrophysiologic profile of ranolazine in heart failure: Prevention of ventricular fibrillation with increased postrepolarization refractoriness and without druginduced proarrhythmia
-
G. Frommeyer, S. Rajamani, F. Grundmann, et al., New insights into the beneficial electrophysiologic profile of ranolazine in heart failure: Prevention of ventricular fibrillation with increased postrepolarization refractoriness and without druginduced proarrhythmia, J. Card. Fail. 18 (2012) 939-949.
-
(2012)
J. Card. Fail.
, vol.18
, pp. 939-949
-
-
Frommeyer, G.1
Rajamani, S.2
Grundmann, F.3
-
77
-
-
84870413566
-
Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits
-
G. Frommeyer, D. Kaiser, T. Uphaus, et al., Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits, Heart Rhythm. 9 (2012) 2051-2058.
-
(2012)
Heart Rhythm.
, vol.9
, pp. 2051-2058
-
-
Frommeyer, G.1
Kaiser, D.2
Uphaus, T.3
-
78
-
-
44249111216
-
Antitorsadogenic effects of ({+/?})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits
-
W.Q. Wang, C. Robertson, A.K. Dhalla, L. Belardinelli, Antitorsadogenic effects of ({+/?})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits, J. Pharmacol. Exp. Ther. 325 (2008) 875-881.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.325
, pp. 875-881
-
-
Wang, W.Q.1
Robertson, C.2
Dhalla, A.K.3
Belardinelli, L.4
-
79
-
-
59749100769
-
Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine
-
L. Wu, D. Guo, H. Li, et al., Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine, Heart Rhythm. 5 (2008) 1726-1734.
-
(2008)
Heart Rhythm.
, vol.5
, pp. 1726-1734
-
-
Wu, L.1
Guo, D.2
Li, H.3
-
80
-
-
79960753496
-
Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade
-
S. Jia, J. Lian, D. Guo, et al., Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade, Br. J. Pharmacol. 164 (2011) 308-316.
-
(2011)
Br. J. Pharmacol.
, vol.164
, pp. 308-316
-
-
Jia, S.1
Lian, J.2
Guo, D.3
-
81
-
-
53049104215
-
Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome
-
A.J. Moss, W. Zareba, K.Q. Schwarz, S. Rosero, S. McNitt, J.L. Robinson, Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome, J. Cardiovasc. Electrophysiol. 19 (2008) 1289-1293.
-
(2008)
J. Cardiovasc. Electrophysiol.
, vol.19
, pp. 1289-1293
-
-
Moss, A.J.1
Zareba, W.2
Schwarz, K.Q.3
Rosero, S.4
McNitt, S.5
Robinson, J.L.6
-
82
-
-
83555164819
-
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks Pacing
-
T.J. Bunch, S.Mahapatra, D. Murdock, et al., Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks, Pacing Clin. Electrophysiol. 34 (2011) 1600-1606.
-
(2011)
Clin. Electrophysiol.
, vol.34
, pp. 1600-1606
-
-
Bunch, T.J.1
Mahapatra, S.2
Murdock, D.3
-
83
-
-
77955422004
-
Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: Observations from the metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndrome-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36) randomized controlled trial
-
B.M. Scirica, E. Braunwald, L. Belardinelli, et al., Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: Observations from the metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndrome-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36) randomized controlled trial, Circulation 122 (2010) 455-462.
-
(2010)
Circulation
, vol.122
, pp. 455-462
-
-
Scirica, B.M.1
Braunwald, E.2
Belardinelli, L.3
-
85
-
-
84870471264
-
Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimentalmodel of chronic heart failure
-
G. Frommeyer, M. Schmidt, C. Clauss, et al., Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimentalmodel of chronic heart failure, Eur. J. Heart Fail. 14 (2012) 1322-1331.
-
(2012)
Eur. J. Heart Fail.
, vol.14
, pp. 1322-1331
-
-
Frommeyer, G.1
Schmidt, M.2
Clauss, C.3
-
86
-
-
84877296675
-
Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: Prolongation of interatrial conduction time and increase in post-repolarization refractoriness
-
P. Milberg, G. Frommeyer, S. Ghezelbash, et al., Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: Prolongation of interatrial conduction time and increase in post-repolarization refractoriness, Europace 15 (2013) 761-769.
-
(2013)
Europace
, vol.15
, pp. 761-769
-
-
Milberg, P.1
Frommeyer, G.2
Ghezelbash, S.3
-
87
-
-
84872006378
-
Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia
-
R.L. Verrier, V.P. Pagotto, A.F. Kanas, et al., Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia, Heart Rhythm. 10 (2013) 121-127.
-
(2013)
Heart Rhythm.
, vol.10
, pp. 121-127
-
-
Verrier, R.L.1
Pagotto, V.P.2
Kanas, A.F.3
|