Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na+ current in the heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 3, 2009, Pages

  Wu, Lin ^a   Rajamani, Sridharan ^a   Li, Hong ^a   January, Craig T ^b   Shryock, John C ^a   Belardinelli, Luiz ^a  

^a Gilead Sciences   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Ion currents; Late sodium current; Monophasic action potential; Repolarization reserve; Ventricular tachycardia

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 4 AMINOPYRIDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; RANOLAZINE; TETRODOTOXIN;

ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART ARRHYTHMIA; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE TACHYCARDIA; HUMAN; HUMAN CELL; ISOLATED HEART; NONHUMAN; POLYMORPHIC VENTRICULAR TACHYCARDIA; PRIORITY JOURNAL; RABBIT; SODIUM CURRENT; T WAVE; TORSADE DES POINTES;

4-AMINOPYRIDINE; ACETANILIDES; ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BARIUM COMPOUNDS; CELL LINE; CHLORIDES; ENZYME INHIBITORS; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; KIDNEY; PATCH-CLAMP TECHNIQUES; PIPERAZINES; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; PYRIDINES; RABBITS; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TACHYCARDIA, VENTRICULAR; TETRODOTOXIN; TORSADES DE POINTES;

EID: 69249151748     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00467.2009     Document Type: Article

References (38)

1. Abrahamsson C, Carlsson L, Duker G. Lidocaine and nisoldipine attenuate almokalant-induced dispersion of repolarization and early afterdepolarizations in vitro. J Cardiovasc Electrophysiol 7: 1074-1081, 1996.
2. An RH, Bangalore R, Rosero SZ, Kass RS. Lidocaine block of LQT-3 mutant human Na+ channels. Circ Res 79: 103-108, 1996.
3. Antzelevitch C. Role of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes. Heart Rhythm 2: S9-15, 2005.
4. Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110: 904-910, 2004.
5. Attwell D, Cohen I, Eisner D, Ohba M, Ojeda C. The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. Pflugers Arch 379: 137-142, 1979.
6. Belardinelli L, Antzelevitch C, Vos MA. Assessing predictors of drug-induced torsade de pointes. Trends Pharmacol Sci 24: 619-625, 2003.
7. Berecki G, Zegers JG, Bhuiyan ZA, Verkerk AO, Wilders R, van Ginneken AC. Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique. J Physiol 570: 237-250, 2006.
8. Biliczki P, Virag L, Iost N, Papp JG, Varro A. Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve. Br J Pharmacol 137: 361-368, 2002.
9. Castle NA, Slawsky MT. Characterization of 4-aminopyridine block of the transient outward K+ current in adult rat ventricular myocytes. J Pharmacol Exp Ther 265: 1450-1459, 1993.
10. Coraboeuf E, Deroubaix E, Coulombe A. Effect of tetrodotoxin on action potentials of the conducting system in the dog heart. Am J Physiol Heart Circ Physiol 236: H561-H567, 1979.
11. Dukes ID, Morad M. The transient K+ current in rat ventricular myocytes: evaluation of its Ca2+ and Na+ dependence. J Physiol 435: 395-420, 1991.
12. Hondeghem LM. TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability). Novartis Found Symp 266: 235-250, 2005.
13. Kunze DL, Lacerda AE, Wilson DL, Brown AM. Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels. J Gen Physiol 86: 691-719, 1985.
14. Lehtonen A, Fodstad H, Laitinen-Forsblom P, Toivonen L, Kontula K, Swan H. Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes. Heart Rhythm 4: 603-607, 2007.
15. Makita N, Horie M, Nakamura T, Ai T, Sasaki K, Yokoi H, Sakurai M, Sakuma I, Otani H, Sawa H, Kitabatake A. Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation. Circulation 106: 1269-1274, 2002.
16. Maltsev VA, Silverman N, Sabbah HN, Undrovinas AI. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail 9: 219-227, 2007.
17. Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC. A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci USA 97: 12329-12333, 2000.
18. Napolitano C, Bloise R, Priori SG. Gene-specific therapy for inherited arrhythmogenic diseases. Pharmacol Ther 110: 1-13, 2006.
19. Nattel S, Quantz MA. Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms. Cardiovasc Res 22: 808-817, 1988.
20. Rajamani S, Shryock JC, Belardinelli L. Rapid kinetic interactions of ranolazine with HERG K+ current. J Cardiovasc Pharmacol 51: 581-589, 2008.
21. Remme CA, Bezzina CR. Genetic modulation of cardiac repolarization reserve. Heart Rhythm 4: 608-610, 2007.
22. Roden DM. Long QT syndrome: reduced repolarization reserve and the genetic link. J Intern Med 259: 59-69, 2006.
23. Roden DM. Taking the "idio" out of " idiosyncratic": predicting torsades de pointes. Pacing Clin Electrophysiol 21: 1029-1034, 1998.
24. Saint DA. The cardiac persistent sodium current: an appealing therapeutic target? Br J Pharmacol 153: 1133-1142, 2008.
25. Shimizu W, Aiba T, Antzelevitch C. Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. Long QT syndrome and Brugada syndrome. Curr Pharm Des 11: 1561-1572, 2005.
26. Shimizu W, Antzelevitch C. Cellular basis for long QT, transmural dispersion of repolarization, and torsade de pointes in the long QT syndrome. J Electrocardiol Suppl 32: 177-184, 1999.
27. Song Y, Shryock JC, Wu L, Belardinelli L. Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes. J Cardiovasc Pharmacol 44: 192-199, 2004.
28. Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 297: 1333-1336, 2002.
29. Undrovinas AI, Maltsev VA, Kyle JW, Silverman N, Sabbah HN. Gating of the late Na+ channel in normal and failing human myocardium. J Mol Cell Cardiol 34: 1477-1489, 2002.
30. Veldkamp MW, van Ginneken AC, Bouman LN. Single delayed rectifier channels in the membrane of rabbit ventricular myocytes. Circ Res 72: 865-878, 1993.
31. Viskin S. Long QT syndromes and torsade de pointes. Lancet 354: 1625-1633, 1999.
32. Wang WQ, Robertson C, Dhalla AK, Belardinelli L. Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)propyl] -1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther 325: 875-881, 2008.
33. Warren M, Guha PK, Berenfeld O, Zaitsev A, Anumonwo JM, Dhamoon AS, Bagwe S, Taffet SM, Jalife J. Blockade of the inward rectifying potassium current terminates ventricular fibrillation in the guinea pig heart. J Cardiovasc Electrophysiol 14: 621-631, 2003.
34. Wu L, Guo D, Li H, Hackett J, Yan GX, Jiao Z, Antzelevitch C, Shryock JC, Belardinelli L. Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine. Heart Rhythm 5: 1726-1734, 2008.
35. Wu L, Rajamani S, Shryock JC, Li H, Ruskin J, Antzelevitch C, Belardinelli L. Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone. Cardiovasc Res 77: 481-488, 2008.
36. Wu L, Shryock JC, Song Y, Belardinelli L. An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts. J Pharmacol Exp Ther 316: 718-726, 2006.
37. Wu L, Shryock JC, Song Y, Li Y, Antzelevitch C, Belardinelli L. Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome. J Pharmacol Exp Ther 310: 599-605, 2004.
38. Zaza A, Belardinelli L, Shryock JC. Pathophysiology and pharmacology of the cardiac "late sodium current." Pharmacol Ther 119: 326-339, 2008.