Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia

Heart Rhythm

Volumn 10, Issue 1, 2013, Pages 121-127

  Verrier, Richard L ^a   Pagotto, Vitor P F ^a,b   Kanas, Alexandre F ^a,b   Sobrado, Marcel F ^a,b   Nearing, Bruce D ^a   Zeng, Dewan ^c   Belardinelli, Luiz ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c GILEAD SCIENCES   (United States)

Author keywords

Atrial fibrillation; Calcium; Heterogeneity of repolarization; Sodium; Ventricular fibrillation

Indexed keywords

CHLORALOSE; DRONEDARONE; RANOLAZINE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY OBSTRUCTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG POTENTIATION; ELECTRODE; HEART ATRIUM APPENDAGE; HEART ATRIUM FIBRILLATION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE ARRHYTHMIA; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; REPOLARIZATION; T WAVE; TACHYCARDIA;

ACETANILIDES; AMIODARONE; ANIMALS; ATRIAL FIBRILLATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; HEMODYNAMICS; PIPERAZINES; SWINE; TACHYCARDIA, VENTRICULAR;

EID: 84872006378     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2012.09.015     Document Type: Article

References (33)

1. B.M. Psaty, T.A. Manolio, and L.H. Kuller Incidence of and risk factors for atrial fibrillation in older adults Circulation 96 1997 2455 2461
2. H. Sinno, K. Derakhchan, and D. Libersan Atrial ischemia promotes atrial fibrillation in dogs Circulation 107 2003 1930 1936
3. M. Alasady, W.P. Abhayaratna, and D.P. Leong Coronary artery disease affecting the atrial branches is an independent determinant of atrial fibrillation after myocardial infarction Heart Rhythm 8 2011 955 960
4. H.V. Huikuri, A. Castellanos, and R.J. Myerburg Sudden death due to cardiac arrhythmias N Engl J Med 345 2001 1473 1482
5. E. Aliot, A. Capucci, and H.J. Crijns Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation Europace 13 2011 161 173
6. D.M. Roden Drug-induced prolongation of the QT interval N Engl J Med 350 2004 1013 1022
7. C. Patel, G.X. Yan, and P.R. Kowey Dronedarone Circulation 120 2009 636 644
8. S.J. Connolly, A.J. Camm, and J.L. Halperin PALLAS Investigators. Dronedarone in high-risk permanent atrial fibrillation N Engl J Med 365 2011 2268 2276
9. D.A. Morrow, B.M. Scirica, and E. Karwatowska-Prokopczuk Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial JAMA 297 2007 1775 1783
10. D. Hodeige, J.P. Heyndrickz, and P. Chatelain SR 33589, a new amiodarone-like antiarrhythmic agent: antiadrenoceptor activity in anaesthetized and conscious dogs Eur J Pharmacol 279 1995 25 32
11. A. Burashnikov, S. Sicouri, and J.M. Di Diego Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation J Am Coll Cardiol 56 2010 1216 1224
12. R.L. Verrier, A.F. Kanas, and V.P.F. Pagotto Ranolazine protects against ischemia-induced atrial fibrillation in an intact porcine model [abstract] Heart Rhythm 9 2012 S186 S187
13. B.D. Nearing, and R.L. Verrier Tracking heightened cardiac electrical instability by computing interlead heterogeneity of T-wave morphology J Appl Physiol 95 2003 2265 2272
14. B.D. Nearing, G.A. Wellenius, M.A. Mittleman, M.E. Josephson, A.J. Burger, and R.L. Verrier Crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure Circ Arrhythm Electrophysiol 5 2012 84 90
15. R.E. Patterson, and E.S. Kirk Analysis of coronary collateral structure, function, and ischemic border zones in pigs Am J Physiol 244 1983 H23 31
16. K. Kumar, S. Waxman, B.D. Nearing, G. Wellenius, S.X. Zhao, and R.L. Verrier Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart J Am Coll Cardiol 41 2003 1831 1837
17. G.Z. Duray, J.R. Ehrlich, and S.H. Hohnloser Dronedarone: a novel antiarrhythmic agent for the treatment of atrial fibrillation Curr Opin Cardiol 25 2010 53 58
18. S. Sicouri, A. Burashnikov, and L. Belardinelli Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria Circ Arrhythm Electrophysiol 3 2010 88 95
19. M. Rodrigues, A.C. Silva, and A.P. Aguas The coronary circulation of the pig heart: comparison with the human heart Eur J Anat 9 2005 67 87
20. T. Reffelmann, and R.A. Kloner Ranolazine: an anti-anginal drug with further therapeutic potential Expert Rev Cardiovasc Ther 8 2010 319 329
21. C. Antzelevitch, A. Burashnikov, and S. Sicouri Electrophysiologic basis for the antiarrhythmic actions of ranolazine Heart Rhythm 8 2011 1281 1290
22. L. Rivard, H. Sinno, and A. Shiroshita-Takeshita The pharmacological response of ischemia-related atrial fibrillation in dogs: evidence for substrate-specific efficacy Cardiovasc Res 74 2007 104 113
23. P. Chatelain, L. Meysmans, and J.R. Matteazzi Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the beta-adrenoceptor and adenylate cyclase in rat heart Br J Pharmacol 116 1995 1949 1956
24. R. Corbalan, R.L. Verrier, and B. Lown Differing mechanisms for ventricular vulnerability during coronary artery occlusion and release Am Heart J 92 1976 223 230
25. K. Kumar, B.D. Nearing, M. Carvas, B.C.G. Nascimento, L. Belardinelli, and R.L. Verrier Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart J Cardiovasc Electrophysiol 20 2009 796 802
26. A. Manning, V. Thisse, and D. Hodeige SR 33589, a new amiodarone-like antiarrhythmic agent: electrophysiological effects in anesthetized dogs J Cardiovasc Pharmacol 25 1995 252 261
27. A. Burashnikov, J.M. Di Diego, and A.C. Zygmunt Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine Circulation 116 2007 1449 1457
28. A.K. Dhalla, W.Q. Wang, and J. Dow Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion Am J Physiol Heart Circ Physiol 297 2009 H1923 1929
29. N. Morita, J.H. Lee, and Y. Xie Suppression of reentrant and multifocal ventricular fibrillation by the late Na current blocker ranolazine J Am Coll Cardiol 57 2011 366 375
30. T. Nieminen, D.Y. Nanbu, and I.P. Datti Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model Heart Rhythm 8 2011 608 614
31. O. Finance, A. Manning, and P. Chatelain Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs J Cardiovasc Pharmacol 26 1995 570 576
32. S.C. Verduyn, M.A. Vos, and H.D. Leunissen Evaluation of the acute electrophysiologic effects of intravenous dronedarone, an amiodarone-like agent, with special emphasis on ventricular repolarization and acquired Torsade de pointes arrhythmias J Cardiovasc Pharmacol 33 1999 212 222
33. J.M. van Opstal, M. Schoenmakers, and S.C. Verduyn Chronic amiodarone evokes no Torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome Circulation 104 2001 2722 2727