메뉴 건너뛰기




Volumn 21, Issue 11, 2014, Pages 1271-1278

Late sodium current inhibition: The most promising antiarrhythmic principle in the near future?

Author keywords

Atrial fibrillation; Late sodium current; Post repolarization refractoriness; Proarrhythmia; Ranolazine; Ventricular fibrillation

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; DRONEDARONE; ERYTHROMYCIN; FLECAINIDE; INAKALANT; POTASSIUM CHANNEL BLOCKING AGENT; QUINIDINE; RANOLAZINE; SODIUM CHANNEL; SOTALOL; VERNAKALANT;

EID: 84896304477     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113209990220     Document Type: Article
Times cited : (15)

References (82)
  • 1
    • 77952604921 scopus 로고    scopus 로고
    • A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: The dionysos study
    • Le Heuzey, J. Y.; De Ferrari, G. M.; Radzik, D.; Santini, M.; Zhu, J.; Davy, J. M. A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: The dionysos study. J. Cardiovasc. Electrophysiol., 2010, 21, 597-605.
    • (2010) J. Cardiovasc. Electrophysiol. , vol.21 , pp. 597-605
    • Le Heuzey, J.Y.1    De Ferrari, G.M.2    Radzik, D.3    Santini, M.4    Zhu, J.5    Davy, J.M.6
  • 4
    • 84873821138 scopus 로고    scopus 로고
    • Mechanisms of hepatocellular toxicity associated with dronedarone - A comparison to amiodarone
    • Felser, A.; Blum, K.; Lindinger, P. W.; Bouitbir, J.; Krahenbuhl, S. Mechanisms of hepatocellular toxicity associated with dronedarone - a comparison to amiodarone. Toxicol Sci., 2013, 131, 480-490.
    • (2013) Toxicol Sci. , vol.131 , pp. 480-490
    • Felser, A.1    Blum, K.2    Lindinger, P.W.3    Bouitbir, J.4    Krahenbuhl, S.5
  • 6
    • 84855340766 scopus 로고    scopus 로고
    • Electrophysiologic profile of dronedarone on the ventricular level: Beneficial effect on postrepolarization refractoriness in the presence of rapid phase 3 repolarization
    • Milberg, P.; Frommeyer, G.; Uphaus, T.; Kaiser, D.; Osada, N.; Breithardt, G.; Eckardt, L. Electrophysiologic profile of dronedarone on the ventricular level: Beneficial effect on postrepolarization refractoriness in the presence of rapid phase 3 repolarization. J. Cardiovasc. Pharmacol., 2012, 59, 92-100.
    • (2012) J. Cardiovasc. Pharmacol. , vol.59 , pp. 92-100
    • Milberg, P.1    Frommeyer, G.2    Uphaus, T.3    Kaiser, D.4    Osada, N.5    Breithardt, G.6    Eckardt, L.7
  • 7
    • 84873057304 scopus 로고    scopus 로고
    • Role of late sodium channel current block in the management of atrial fibrillation
    • Burashnikov, A.; Antzelevitch, C. Role of late sodium channel current block in the management of atrial fibrillation. Cardiovasc. Drugs Ther., 2013, 27(1), 79-89.
    • (2013) Cardiovasc. Drugs Ther. , vol.27 , Issue.1 , pp. 79-89
    • Burashnikov, A.1    Antzelevitch, C.2
  • 8
    • 54949132945 scopus 로고    scopus 로고
    • Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart
    • Undrovinas, A.; Maltsev, V. A. Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart. Cardiovasc. Hematol. Agents Med. Chem., 2008, 6, 348-359.
    • (2008) Cardiovasc. Hematol. Agents Med. Chem. , vol.6 , pp. 348-359
    • Undrovinas, A.1    Maltsev, V.A.2
  • 9
    • 79960757657 scopus 로고    scopus 로고
    • Electrophysiologic basis for the antiarrhythmic actions of ranolazine
    • Antzelevitch, C.; Burashnikov, A.; Sicouri, S.; Belardinelli, L. Electrophysiologic basis for the antiarrhythmic actions of ranolazine. Heart Rhythm., 2011, 8, 1281-1290.
    • (2011) Heart Rhythm. , vol.8 , pp. 1281-1290
    • Antzelevitch, C.1    Burashnikov, A.2    Sicouri, S.3    Belardinelli, L.4
  • 11
    • 33847608327 scopus 로고    scopus 로고
    • Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre
    • DOI 10.1016/j.ejphar.2006.11.040, PII S0014299906013306
    • Persson, F.; Andersson, B.; Duker, G.; Jacobson, I.; Carlsson, L. Functional effects of the late sodium current inhibition by azd7009 and lidocaine in rabbit isolated atrial and ventricular tissue and purkinje fibre. Eur. J. Pharmacol., 2007, 558, 133-143. (Pubitemid 46350691)
    • (2007) European Journal of Pharmacology , vol.558 , Issue.1-3 , pp. 133-143
    • Persson, F.1    Andersson, B.2    Duker, G.3    Jacobson, I.4    Carlsson, L.5
  • 12
    • 34748873780 scopus 로고    scopus 로고
    • Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine
    • DOI 10.1161/CIRCULATIONAHA.107.704890
    • Burashnikov, A.; Di Diego, J. M.; Zygmunt, A. C.; Belardinelli, L.; Antzelevitch, C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation, 2007, 116, 1449-1457. (Pubitemid 47480635)
    • (2007) Circulation , vol.116 , Issue.13 , pp. 1449-1457
    • Burashnikov, A.1    Di Diego, J.M.2    Zygmunt, A.C.3    Belardinelli, L.4    Antzelevitch, C.5
  • 14
    • 77951810890 scopus 로고    scopus 로고
    • Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: Its role in the genesis of atrial arrhythmias
    • Guo, D.; Young, L.; Wu, Y.; Belardinelli, L.; Kowey, P. R.; Yan, G. X. Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: Its role in the genesis of atrial arrhythmias. Am. J. Physiol. Heart Circ. Physiol., 2010, 298, H1375-H1381.
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298
    • Guo, D.1    Young, L.2    Wu, Y.3    Belardinelli, L.4    Kowey, P.R.5    Yan, G.X.6
  • 15
    • 84862253884 scopus 로고    scopus 로고
    • Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel: Comparison with ranolazine and dl-sotalol
    • Burashnikov, A.; Pourrier, M.; Gibson, J. K.; Lynch, J. J.; Antzelevitch, C. Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel: Comparison with ranolazine and dl-sotalol. Circ. Arrhythm. Electrophysiol., 2012, 5, 400-408.
    • (2012) Circ. Arrhythm. Electrophysiol. , vol.5 , pp. 400-408
    • Burashnikov, A.1    Pourrier, M.2    Gibson, J.K.3    Lynch, J.J.4    Antzelevitch, C.5
  • 16
    • 0033213925 scopus 로고    scopus 로고
    • Ionic mechanisms of electrical remodeling in human atrial fibrillation
    • DOI 10.1016/S0008-6363(99)00178-9, PII S0008636399001789
    • Bosch, R. F.; Zeng, X.; Grammer, J. B.; Popovic, K.; Mewis, C.; Kuhlkamp, V. Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovasc. Res., 1999, 44, 121-131. (Pubitemid 29431690)
    • (1999) Cardiovascular Research , vol.44 , Issue.1 , pp. 121-131
    • Bosch, R.F.1    Zeng, X.2    Grammer, J.B.3    Popovic, K.4    Mewis, C.5    Kuhlkamp, V.6
  • 18
    • 0029099346 scopus 로고
    • Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats
    • Wijffels, M. C.; Kirchhof, C. J.; Dorland, R.; Allessie, M. A. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation, 1995, 92, 1954-1968.
    • (1995) Circulation , vol.92 , pp. 1954-1968
    • Wijffels, M.C.1    Kirchhof, C.J.2    Dorland, R.3    Allessie, M.A.4
  • 20
    • 33745251122 scopus 로고    scopus 로고
    • Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction
    • Song, Y.; Shryock, J. C.; Wagner, S.; Maier, L. S.; Belardinelli, L. Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J. Pharmacol. Exp. Ther., 2006, 318, 214-222.
    • (2006) J. Pharmacol. Exp. Ther. , vol.318 , pp. 214-222
    • Song, Y.1    Shryock, J.C.2    Wagner, S.3    Maier, L.S.4    Belardinelli, L.5
  • 24
    • 0038643573 scopus 로고    scopus 로고
    • c isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
    • DOI 10.1161/01.RES.0000069686.31472.C5
    • Zhang, T.; Maier, L. S.; Dalton, N. D.; Miyamoto, S.; Ross, J. Jr.; Bers, D. M.; Brown, J. H. The deltac isoform of camkii is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ. Res., 2003, 92, 912-919. (Pubitemid 36542533)
    • (2003) Circulation Research , vol.92 , Issue.8 , pp. 912-919
    • Zhang, T.1    Maier, L.S.2    Dalton, N.D.3    Miyamoto, S.4    Ross Jr., J.5    Bers, D.M.6    Brown, J.H.7
  • 26
    • 33646386662 scopus 로고    scopus 로고
    • Molecular basis of ranolazine block of LQT-3 mutant sodium channels: Evidence for site of action
    • DOI 10.1038/sj.bjp.0706709, PII 0706709
    • Fredj, S.; Sampson, K. J.; Liu, H.; Kass, R. S. Molecular basis of ranolazine block of lqt-3 mutant sodium channels: Evidence for site of action. Br. J. Pharmacol., 2006, 148, 16-24. (Pubitemid 43675596)
    • (2006) British Journal of Pharmacology , vol.148 , Issue.1 , pp. 16-24
    • Fredj, S.1    Sampson, K.J.2    Liu, H.3    Kass, R.S.4
  • 27
    • 0029952835 scopus 로고    scopus 로고
    • Hypoxia increases persistent sodium current in rat ventricular myocytes
    • Ju, Y. K.; Saint, D. A.; Gage, P. W. Hypoxia increases persistent sodium current in rat ventricular myocytes. J. Physiol., 1996, 497(Pt 2), 337-347. (Pubitemid 26418103)
    • (1996) Journal of Physiology , vol.497 , Issue.2 , pp. 337-347
    • Ju, Y.-K.1    Saint, D.A.2    Gage, P.W.3
  • 28
    • 0035115891 scopus 로고    scopus 로고
    • Alterations of sodium channel kinetics and gene expression in the postinfarction remodeled myocardium
    • Huang, B.; El-Sherif, T.; Gidh-Jain, M.; Qin, D.; El-Sherif, N. Alterations of sodium channel kinetics and gene expression in the postinfarction remodeled myocardium. J. Cardiovasc. Electrophysiol., 2001, 12, 218-225. (Pubitemid 32171514)
    • (2001) Journal of Cardiovascular Electrophysiology , vol.12 , Issue.2 , pp. 218-225
    • Huang, B.1    El-Sherif, T.2    Gidh-Jain, M.3    Qin, D.4    El-Sherif, N.5
  • 29
    • 33847261532 scopus 로고    scopus 로고
    • Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability
    • DOI 10.1016/j.ejheart.2006.08.007, PII S1388984206002522
    • Maltsev, V. A.; Silverman, N.; Sabbah, H. N.; Undrovinas, A. I. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability. Eur. J. Heart Fail., 2007, 9, 219-227. (Pubitemid 46330143)
    • (2007) European Journal of Heart Failure , vol.9 , Issue.3 , pp. 219-227
    • Maltsev, V.A.1    Silverman, N.2    Sabbah, H.N.3    Undrovinas, A.I.4
  • 30
    • 80053272921 scopus 로고    scopus 로고
    • A new mechanism preventing proarrhythmia in chronic heart failure: Rapid phase-iii repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacinginduced heart failure
    • Frommeyer, G.; Milberg, P.; Witte, P.; Stypmann, J.; Koopmann, M.; Lucke, M.; Osada, N.; Breithardt, G.; Fehr, M.; Eckardt, L. A new mechanism preventing proarrhythmia in chronic heart failure: Rapid phase-iii repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacinginduced heart failure. Eur. J. Heart Fail., 2011, 13, 1060-1069.
    • (2011) Eur. J. Heart Fail. , vol.13 , pp. 1060-1069
    • Frommeyer, G.1    Milberg, P.2    Witte, P.3    Stypmann, J.4    Koopmann, M.5    Lucke, M.6    Osada, N.7    Breithardt, G.8    Fehr, M.9    Eckardt, L.10
  • 33
    • 84870471264 scopus 로고    scopus 로고
    • Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimental model of chronic heart failure
    • Frommeyer, G.; Schmidt, M.; Clauss, C.; Kaese, S.; Stypmann, J.; Pott, C.; Eckardt, L.; Milberg, P. Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimental model of chronic heart failure. Eur. J. Heart Fail., 2012, 14, 1322-1331.
    • (2012) Eur. J. Heart Fail. , vol.14 , pp. 1322-1331
    • Frommeyer, G.1    Schmidt, M.2    Clauss, C.3    Kaese, S.4    Stypmann, J.5    Pott, C.6    Eckardt, L.7    Milberg, P.8
  • 34
    • 46349111138 scopus 로고    scopus 로고
    • Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations
    • Sicouri, S.; Glass, A.; Belardinelli, L.; Antzelevitch, C. Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations. Heart Rhythm., 2008, 5, 1019-1026.
    • (2008) Heart Rhythm. , vol.5 , pp. 1019-1026
    • Sicouri, S.1    Glass, A.2    Belardinelli, L.3    Antzelevitch, C.4
  • 35
    • 55849135767 scopus 로고    scopus 로고
    • The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation
    • Murdock, D. K.; Overton, N.; Kersten, M.; Kaliebe, J.; Devecchi, F. The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation. Indian Pacing Electrophysiol. J., 2008, 8, 175-181.
    • (2008) Indian Pacing Electrophysiol. J. , vol.8 , pp. 175-181
    • Murdock, D.K.1    Overton, N.2    Kersten, M.3    Kaliebe, J.4    Devecchi, F.5
  • 36
    • 4344577023 scopus 로고    scopus 로고
    • Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
    • DOI 10.1161/01.CIR.0000139333.83620.5D
    • Antzelevitch, C.; Belardinellim L.; Zygmunt, A. C.; Burashnikov, A.; Di Diego, J. M.; Fish, J. M.; Cordeiro, J. M.; Thomas, G. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation, 2004, 110, 904-910. (Pubitemid 39136212)
    • (2004) Circulation , vol.110 , Issue.8 , pp. 904-910
    • Antzelevitch, C.1    Belardinelli, L.2    Zygmunt, A.C.3    Burashnikov, A.4    Di Diego, J.M.5    Fish, J.M.6    Cordeiro, J.M.7    Thomas, G.8
  • 37
    • 79960232282 scopus 로고    scopus 로고
    • The antianginal agent ranolazine is a potent antiarrhythmic agent that reduces ventricular arrhythmias: Through a mechanism favoring inhibition of late sodium channel
    • Kloner, R. A.; Dow, J. S.; Bhandari, A. The antianginal agent ranolazine is a potent antiarrhythmic agent that reduces ventricular arrhythmias: Through a mechanism favoring inhibition of late sodium channel. Cardiovasc. Ther., 2011, 29, e36-e41.
    • (2011) Cardiovasc. Ther. , vol.29
    • Kloner, R.A.1    Dow, J.S.2    Bhandari, A.3
  • 38
    • 80051802104 scopus 로고    scopus 로고
    • Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting
    • Miles, R. H.; Passman, R.; Murdock, D. K. Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting. Am. J. Cardiol., 2011, 108, 673-676.
    • (2011) Am. J. Cardiol. , vol.108 , pp. 673-676
    • Miles, R.H.1    Passman, R.2    Murdock, D.K.3
  • 39
    • 73249135820 scopus 로고    scopus 로고
    • The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: A review of experience with implications for possible "pill in the pocket" approach to atrial fibrillation
    • Murdock, D. K.; Kersten, M.; Kaliebe, J.; Larrain, G. The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: A review of experience with implications for possible "pill in the pocket" approach to atrial fibrillation. Indian Pacing Electrophysiol. J., 2009, 9, 260-267.
    • (2009) Indian Pacing Electrophysiol. J. , vol.9 , pp. 260-267
    • Murdock, D.K.1    Kersten, M.2    Kaliebe, J.3    Larrain, G.4
  • 40
    • 84870397152 scopus 로고    scopus 로고
    • Ranolazine for atrial fibrillation: Buy one get three beneficial mechanisms! Eur
    • Maier, L. S. Ranolazine for atrial fibrillation: Buy one get three beneficial mechanisms! Eur. J. Heart Fail., 2012, 14, 1313-1315.
    • (2012) J. Heart Fail. , vol.14 , pp. 1313-1315
    • Maier, L.S.1
  • 41
    • 67649795769 scopus 로고    scopus 로고
    • Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart
    • Kumar, K.; Nearing, B. D.; Carvas, M.; Nascimento, B. C.; Acar, M.; Belardinelli, L.; Verrier, R. L. Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart. J. Cardiovasc. Electrophysiol., 2009, 20, 796-802.
    • (2009) J. Cardiovasc. Electrophysiol. , vol.20 , pp. 796-802
    • Kumar, K.1    Nearing, B.D.2    Carvas, M.3    Nascimento, B.C.4    Acar, M.5    Belardinelli, L.6    Verrier, R.L.7
  • 42
    • 35148850168 scopus 로고    scopus 로고
    • Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non-ST-segment-elevation acute coronary syndrome: Results from the metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndrome-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36) randomized controlled trial
    • DOI 10.1161/CIRCULATIONAHA.107.724880
    • Scirica, B. M.; Morrow, D. A.; Hod, H.; Murphy, S. A.; Belardinelli, L.; Hedgepeth, C. M.; Molhoek, P.; Verheugt, F. W.; Gersh, B. J.; McCabe, C. H.; Braunwald, E. Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non st-segment elevation acute coronary syndrome: Results from the metabolic efficiency with ranolazine for less ischemia in non st-elevation acute coronary syndrome thrombolysis in myocardial infarction 36 (merlin-timi 36) randomized controlled trial. Circulation, 2007, 116, 1647-1652. (Pubitemid 47537839)
    • (2007) Circulation , vol.116 , Issue.15 , pp. 1647-1652
    • Scirica, B.M.1    Morrow, D.A.2    Hod, H.3    Murphy, S.A.4    Belardinelli, L.5    Hedgepeth, C.M.6    Molhoek, P.7    Verheugt, F.W.A.8    Gersh, B.J.9    McCabe, C.H.10    Braunwald, E.11
  • 43
    • 84877296675 scopus 로고    scopus 로고
    • Sodium channel block by ranolazine in an experimental model of stretchrelated atrial fibrillation: Prolongation of interatrial conduction time and increase in post-repolarization refractoriness
    • Milberg, P.; Frommeyer, G.; Ghezelbash, S.; Rajamani, S.; Osada, N.; Razvan, R.; Belardinelli, L.; Breithardt, G.; Eckardt, L. Sodium channel block by ranolazine in an experimental model of stretchrelated atrial fibrillation: Prolongation of interatrial conduction time and increase in post-repolarization refractoriness. Europace, 2013, 15(5), 761-9.
    • (2013) Europace , vol.15 , Issue.5 , pp. 761-769
    • Milberg, P.1    Frommeyer, G.2    Ghezelbash, S.3    Rajamani, S.4    Osada, N.5    Razvan, R.6    Belardinelli, L.7    Breithardt, G.8    Eckardt, L.9
  • 46
    • 84856442152 scopus 로고    scopus 로고
    • Role of ranolazine in angina, heart failure, arrhythmias, and diabetes
    • Sossalla, S.; Maier, L. S. Role of ranolazine in angina, heart failure, arrhythmias, and diabetes. Pharmacol. Ther., 2012, 133, 311-323.
    • (2012) Pharmacol. Ther. , vol.133 , pp. 311-323
    • Sossalla, S.1    Maier, L.S.2
  • 47
    • 53049104215 scopus 로고    scopus 로고
    • Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-qt syndrome
    • Moss, A. J.; Zareba, W.; Schwarz, K. Q.; Rosero, S.; McNitt, S.; Robinson, J. L. Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-qt syndrome. J. Cardiovasc. Electrophysiol., 2008, 19, 1289-1293.
    • (2008) J. Cardiovasc. Electrophysiol. , vol.19 , pp. 1289-1293
    • Moss, A.J.1    Zareba, W.2    Schwarz, K.Q.3    Rosero, S.4    McNitt, S.5    Robinson, J.L.6
  • 48
    • 78651326450 scopus 로고    scopus 로고
    • Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine
    • Morita, N.; Lee, J. H.; Xie, Y.; Sovari, A.; Qu, Z.; Weiss, J. N.; Karagueuzian, H. S. Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine. J. Am. Coll. Cardiol., 2011, 57, 366-375.
    • (2011) J. Am. Coll. Cardiol. , vol.57 , pp. 366-375
    • Morita, N.1    Lee, J.H.2    Xie, Y.3    Sovari, A.4    Qu, Z.5    Weiss, J.N.6    Karagueuzian, H.S.7
  • 49
    • 84870567980 scopus 로고    scopus 로고
    • New insights into the beneficial electrophysiologic profile of ranolazine in heart failure: Prevention of ventricular fibrillation with increased postrepolarization refractoriness and without drug-induced proarrhythmia
    • Frommeyer, G.; Rajamani, S.; Grundmann, F.; Stypmann, J.; Osada, N.; Breithardt, G.; Belardinelli, L.; Eckardt, L.; Milberg, P. New insights into the beneficial electrophysiologic profile of ranolazine in heart failure: Prevention of ventricular fibrillation with increased postrepolarization refractoriness and without drug-induced proarrhythmia. J. Card. Fail., 2012, 18, 939-949.
    • (2012) J. Card. Fail. , vol.18 , pp. 939-949
    • Frommeyer, G.1    Rajamani, S.2    Grundmann, F.3    Stypmann, J.4    Osada, N.5    Breithardt, G.6    Belardinelli, L.7    Eckardt, L.8    Milberg, P.9
  • 50
    • 34249090724 scopus 로고    scopus 로고
    • Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome
    • DOI 10.1111/j.1540-8167.2007.00813.x
    • Milberg, P.; Tegelkamp, R.; Osada, N.; Schimpf, R.; Wolpert, C.; Breithardt, G.; Borggrefe, M.; Eckardt, L. Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short qt syndrome. J. Cardiovasc. Electrophysiol., 2007, 18, 658-664. (Pubitemid 46800513)
    • (2007) Journal of Cardiovascular Electrophysiology , vol.18 , Issue.6 , pp. 658-664
    • Milberg, P.1    Tegelkamp, R.2    Osada, N.3    Schimpf, R.4    Wolpert, C.5    Breithardt, G.6    Borggrefe, M.7    Eckardt, L.8
  • 52
    • 0344404215 scopus 로고    scopus 로고
    • Postrepolarization refractoriness versus conduction slowing caused by class I antiarrhythmic drugs: Antiarrhythmic and proarrhythmic effects
    • Kirchhof, P. F.; Fabritz, C. L.; Franz, M. R. Postrepolarization refractoriness versus conduction slowing caused by class i antiarrhythmic drugs: Antiarrhythmic and proarrhythmic effects. Circulation, 1998, 97, 2567-2574. (Pubitemid 28294504)
    • (1998) Circulation , vol.97 , Issue.25 , pp. 2567-2574
    • Kirchhof, P.F.1    Larissa Fabritz, C.2    Franz, M.R.3
  • 53
    • 79960166057 scopus 로고    scopus 로고
    • First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model
    • Kloner, R. A.; Dow, J. S.; Bhandari, A. First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model. J. Cardiovasc. Pharmacol. Ther., 2011, 16, 192-196.
    • (2011) J. Cardiovasc. Pharmacol. Ther. , vol.16 , pp. 192-196
    • Kloner, R.A.1    Dow, J.S.2    Bhandari, A.3
  • 55
    • 3242778566 scopus 로고    scopus 로고
    • Na in guinea pig ventricular myocytes
    • DOI 10.1097/00005344-200408000-00008
    • Song, Y.; Shryock, J. C.; Wu, L.; Belardinelli, L. Antagonism by ranolazine of the pro-arrhythmic effects of increasing late ina in guinea pig ventricular myocytes. J. Cardiovasc. Pharmacol., 2004, 44, 192-199. (Pubitemid 38982162)
    • (2004) Journal of Cardiovascular Pharmacology , vol.44 , Issue.2 , pp. 192-199
    • Song, Y.1    Shryock, J.C.2    Wu, L.3    Belardinelli, L.4
  • 57
    • 84855358563 scopus 로고    scopus 로고
    • Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of lqt2 and lqt3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization
    • Milberg, P.; Frommeyer, G.; Kleideiter, A.; Fischer, A.; Osada, N.; Breithardt, G.; Fehr, M.; Eckardt, L. Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of lqt2 and lqt3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. Heart Rhythm., 2011, 8, 1492-1500.
    • (2011) Heart Rhythm. , vol.8 , pp. 1492-1500
    • Milberg, P.1    Frommeyer, G.2    Kleideiter, A.3    Fischer, A.4    Osada, N.5    Breithardt, G.6    Fehr, M.7    Eckardt, L.8
  • 60
    • 44349174320 scopus 로고    scopus 로고
    • Ranolozine-induced suppression of ventricular tachycardia in a patient with nonischemic cardiomyopathy: A case report
    • DOI 10.1111/j.1540-8159.2008.01083.x
    • Murdock, D. K.; Kaliebe, J.; Overton, N. Ranolozine-induced suppression of ventricular tachycardia in a patient with nonischemic cardiomyopathy: A case report. Pacing Clin. Electrophysiol., 2008, 31, 765-768. (Pubitemid 351749321)
    • (2008) PACE - Pacing and Clinical Electrophysiology , vol.31 , Issue.6 , pp. 765-768
    • Murdock, D.K.1    Kaliebe, J.2    Overton, N.3
  • 62
    • 77955422004 scopus 로고    scopus 로고
    • Relationship between nonsustained ventricular tachycardia after non-st-elevation acute coronary syndrome and sudden cardiac death: Observations from the metabolic efficiency with ranolazine for less ischemia in non-st-elevation acute coronary syndrome-thrombolysis in myocardial infarction 36 (merlin-timi 36) randomized controlled trial
    • Scirica, B. M.; Braunwald, E.; Belardinelli, L.; Hedgepeth, C. M.; Spinar, J.; Wang, W.; Qin, J.; Karwatowska-Prokopczuk, E.; Verheugt, F. W.; Morrow, D. A. Relationship between nonsustained ventricular tachycardia after non-st-elevation acute coronary syndrome and sudden cardiac death: Observations from the metabolic efficiency with ranolazine for less ischemia in non-st-elevation acute coronary syndrome-thrombolysis in myocardial infarction 36 (merlin-timi 36) randomized controlled trial. Circulation, 2010, 122, 455-462.
    • (2010) Circulation , vol.122 , pp. 455-462
    • Scirica, B.M.1    Braunwald, E.2    Belardinelli, L.3    Hedgepeth, C.M.4    Spinar, J.5    Wang, W.6    Qin, J.7    Karwatowska-Prokopczuk, E.8    Verheugt, F.W.9    Morrow, D.A.10
  • 63
    • 77649299995 scopus 로고    scopus 로고
    • Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria
    • Sicouri, S.; Burashnikov, A.; Belardinelli, L.; Antzelevitch, C. Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria. Circ. Arrhythm. Electrophysiol., 2010, 3, 88-95.
    • (2010) Circ. Arrhythm. Electrophysiol. , vol.3 , pp. 88-95
    • Sicouri, S.1    Burashnikov, A.2    Belardinelli, L.3    Antzelevitch, C.4
  • 64
    • 77957571615 scopus 로고    scopus 로고
    • Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation
    • Burashnikov, A.; Sicouri, S.; Di Diego, J. M.; Belardinelli, L.; Antzelevitch, C. Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation. J. Am. Coll. Cardiol., 2010, 56, 1216-1224.
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 1216-1224
    • Burashnikov, A.1    Sicouri, S.2    Di Diego, J.M.3    Belardinelli, L.4    Antzelevitch, C.5
  • 66
  • 68
    • 4344633215 scopus 로고    scopus 로고
    • Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block
    • DOI 10.1097/01.fjc.0000129581.81508.78
    • Milberg, P.; Ramtin, S.; Monnig, G.; Osada, N.; Wasmer, K.; Breithardt, G.; Haverkamp, W.; Eckardt, L. Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block. J. Cardiovasc. Pharmacol., 2004, 44, 278-286. (Pubitemid 39129444)
    • (2004) Journal of Cardiovascular Pharmacology , vol.44 , Issue.3 , pp. 278-286
    • Milberg, P.1    Ramtin, S.2    Monnig, G.3    Osada, N.4    Wasmer, K.5    Breithardt, G.6    Haverkamp, W.7    Eckardt, L.8
  • 70
    • 84872006378 scopus 로고    scopus 로고
    • Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia
    • Verrier, R. L.; Pagotto, V. P.; Kanas, A. F.; Sobrado, M. F.; Nearing, B. D.; Zeng, D.; Belardinelli, L. Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia. Heart Rhythm., 2013, 10, 121-127.
    • (2013) Heart Rhythm. , vol.10 , pp. 121-127
    • Verrier, R.L.1    Pagotto, V.P.2    Kanas, A.F.3    Sobrado, M.F.4    Nearing, B.D.5    Zeng, D.6    Belardinelli, L.7
  • 71
    • 50949115126 scopus 로고    scopus 로고
    • Atrial remodeling and atrial fibrillation: Mechanisms and implications
    • Nattel, S.; Burstein, B.; Dobrev, D. Atrial remodeling and atrial fibrillation: Mechanisms and implications. Circ. Arrhythm. Electrophysiol., 2008, 1, 62-73.
    • (2008) Circ. Arrhythm. Electrophysiol. , vol.1 , pp. 62-73
    • Nattel, S.1    Burstein, B.2    Dobrev, D.3
  • 73
    • 10944238690 scopus 로고    scopus 로고
    • AZD7009: A new antiarrhythmic drug with predominant effects on the atria effectively terminates and prevents reinduction of atrial fibrillation and flutter in the sterile pericarditis model
    • DOI 10.1046/j.1540-8167.2004.04354.x
    • Goldstein, R. N.; Khrestian, C.; Carlsson, L.; Waldo, A. L. Azd7009: A new antiarrhythmic drug with predominant effects on the atria effectively terminates and prevents reinduction of atrial fibrillation and flutter in the sterile pericarditis model. J. Cardiovasc. Electrophysiol., 2004, 15, 1444-1450. (Pubitemid 40013678)
    • (2004) Journal of Cardiovascular Electrophysiology , vol.15 , Issue.12 , pp. 1444-1450
    • Goldstein, R.N.1    Khrestian, C.2    Carlsson, L.3    Waldo, A.L.4
  • 74
    • 33646684512 scopus 로고    scopus 로고
    • Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog
    • DOI 10.1097/01.fjc.0000196242.04384.c3, PII 0000534420060100000018
    • Carlsson, L.; Chartier, D.; Nattel, S. Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent azd7009 in atrial and ventricular tissue of the dog. J. Cardiovasc. Pharmacol., 2006, 47, 123-132. (Pubitemid 44378235)
    • (2006) Journal of Cardiovascular Pharmacology , vol.47 , Issue.1 , pp. 123-132
    • Carlsson, L.1    Chartier, D.2    Nattel, S.3
  • 75
    • 33750388727 scopus 로고    scopus 로고
    • Safe and effective conversion of persistent atrial fibrillation to sinus rhythm by intravenous AZD7009
    • DOI 10.1016/j.hrthm.2006.06.035, PII S1547527106017310
    • Crijns, H. J.; Van Gelder, I. C.; Walfridsson, H.; Kulakowski, P.; Ronaszeki, A.; Dedek, V.; Malm, A.; Almgren, O. Safe and effective conversion of persistent atrial fibrillation to sinus rhythm by intravenous azd7009. Heart Rhythm., 2006, 3, 1321-1331. (Pubitemid 44636926)
    • (2006) Heart Rhythm , vol.3 , Issue.11 , pp. 1321-1331
    • Crijns, H.J.1    Van Gelder, I.C.2    Walfridsson, H.3    Kulakowski, P.4    Ronaszeki, A.5    Dedek, V.6    Malm, A.7    Almgren, O.8
  • 79
    • 77953074727 scopus 로고    scopus 로고
    • A multicenter, open-label study of vernakalant for the conversion of atrial fibrillation to sinus rhythm
    • Stiell, I. G.; Roos, J. S.; Kavanagh, K. M.; Dickinson, G. A multicenter, open-label study of vernakalant for the conversion of atrial fibrillation to sinus rhythm. Am. Heart J., 2010, 159, 1095-1101.
    • (2010) Am. Heart J. , vol.159 , pp. 1095-1101
    • Stiell, I.G.1    Roos, J.S.2    Kavanagh, K.M.3    Dickinson, G.4
  • 80
    • 78651329673 scopus 로고    scopus 로고
    • A randomized activecontrolled study comparing the efficacy and safety of vernakalant to amiodarone in recent-onset atrial fibrillation
    • Camm, A. J.; Capucci, A.; Hohnloser, S. H.; Torp-Pedersen, C.; Van Gelder, I. C.; Mangal, B.; Beatch, G. A randomized activecontrolled study comparing the efficacy and safety of vernakalant to amiodarone in recent-onset atrial fibrillation. J. Am. Coll. Cardiol., 2011, 57, 313-321.
    • (2011) J. Am. Coll. Cardiol. , vol.57 , pp. 313-321
    • Camm, A.J.1    Capucci, A.2    Hohnloser, S.H.3    Torp-Pedersen, C.4    Van Gelder, I.C.5    Mangal, B.6    Beatch, G.7
  • 81
    • 84877733730 scopus 로고    scopus 로고
    • Vernakalant: Conversion of atrial fibrillation in patients with ischemic heart disease
    • Torp-Pedersen, C.; Camm, A. J.; Butterfield, N. N.; Dickinson, G.; Beatch, G. N. Vernakalant: Conversion of atrial fibrillation in patients with ischemic heart disease. Int. J. Cardiol., 2013, 166(1), 147-151.
    • (2013) Int. J. Cardiol. , vol.166 , Issue.1 , pp. 147-151
    • Torp-Pedersen, C.1    Camm, A.J.2    Butterfield, N.N.3    Dickinson, G.4    Beatch, G.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.