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Volumn 27, Issue 1, 2013, Pages 79-89

Role of late sodium channel current block in the management of atrial fibrillation

Author keywords

Action potential; Atrial fibrillation; Late sodium channel current; Pharmacology; Ranolazine

Indexed keywords

AMIODARONE; CALCIUM; FLECAINIDE; LIDOCAINE; MEXILETINE; PROPAFENONE; QUINIDINE; RANOLAZINE; SODIUM; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; VERNAKALANT;

EID: 84873057304     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-012-6421-1     Document Type: Review
Times cited : (45)

References (87)
  • 2
    • 54949132945 scopus 로고    scopus 로고
    • Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart
    • 18855648 10.2174/187152508785909447 1:CAS:528:DC%2BD1cXhtlCntbnJ
    • Undrovinas A, Maltsev VA. Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart. Cardiovasc Hematol Agents Med Chem. 2008;6:348-59.
    • (2008) Cardiovasc Hematol Agents Med Chem , vol.6 , pp. 348-359
    • Undrovinas, A.1    Maltsev, V.A.2
  • 3
    • 3342882854 scopus 로고    scopus 로고
    • Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome
    • 15031300 10.1124/jpet.104.066100 1:CAS:528:DC%2BD2cXmtVyksLY%3D
    • Wu L, Shryock JC, Song Y, Li Y, Antzelevitch C, Belardinelli L. Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome. J Pharmacol Exp Ther. 2004;310:599-605.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 599-605
    • Wu, L.1    Shryock, J.C.2    Song, Y.3    Li, Y.4    Antzelevitch, C.5    Belardinelli, L.6
  • 4
    • 76449092876 scopus 로고    scopus 로고
    • Late Na+ current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model
    • 20170820 10.1016/j.jacc.2009.10.033 1:CAS:528:DC%2BC3cXjvF2lur4%3D
    • Antoons G, Oros A, Beekman JDM, Engelen MA, Houtman MJC, Belardinelli L, et al. Late Na+ current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model. J Am Coll Cardiol. 2010;55:801-9.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 801-809
    • Antoons, G.1    Oros, A.2    Beekman, J.D.M.3    Engelen, M.A.4    Houtman, M.J.C.5    Belardinelli, L.6
  • 5
    • 79960757657 scopus 로고    scopus 로고
    • Electrophysiological basis for the antiarrhythmic actions of ranolazine
    • 21421082 10.1016/j.hrthm.2011.03.045
    • Antzelevitch C, Burashnikov A, Sicouri S, Belardinelli L. Electrophysiological basis for the antiarrhythmic actions of ranolazine. Heart Rhythm. 2011;8:1281-90.
    • (2011) Heart Rhythm , vol.8 , pp. 1281-1290
    • Antzelevitch, C.1    Burashnikov, A.2    Sicouri, S.3    Belardinelli, L.4
  • 6
    • 0021256845 scopus 로고
    • Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers
    • 6324914 10.1016/S0006-3495(84)84187-9 1:CAS:528:DyaL2cXhslagsL4%3D
    • Gintant GA, Daytner NB, Cohen IS. Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers. Biophys J. 1984;45:509-12.
    • (1984) Biophys J , vol.45 , pp. 509-512
    • Gintant, G.A.1    Daytner, N.B.2    Cohen, I.S.3
  • 7
    • 0021824529 scopus 로고
    • Slow currents through single sodium channels of the adult rat heart
    • 2411848 10.1085/jgp.86.1.89 1:STN:280:DyaL2M3ptFKgug%3D%3D
    • Patlak JB, Ortiz M. Slow currents through single sodium channels of the adult rat heart. J Gen Physiol. 1985;86:89-104.
    • (1985) J Gen Physiol , vol.86 , pp. 89-104
    • Patlak, J.B.1    Ortiz, M.2
  • 8
    • 0018349527 scopus 로고
    • The steady-state tetrodotoxin-sensitive ("window") sodium current in cardiac Purkinje fibers
    • 571107 10.1007/BF00586939 1:CAS:528:DyaE1MXhvVWhsbs%3D
    • Attwell D, Cohen IS, Eisner DA, Ohba M, Ojeda C. The steady-state tetrodotoxin-sensitive ("window") sodium current in cardiac Purkinje fibers. Pflugers Arch. 1979;379:137-42.
    • (1979) Pflugers Arch , vol.379 , pp. 137-142
    • Attwell, D.1    Cohen, I.S.2    Eisner, D.A.3    Ohba, M.4    Ojeda, C.5
  • 9
    • 0034886161 scopus 로고    scopus 로고
    • Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle
    • 1:CAS:528:DC%2BD3MXmtVClsLw%3D
    • Zygmunt AC, Eddlestone GT, Thomas GP, Nesterenko VV, Antzelevitch C. Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle. Am J Physiol. 2001;281:H689-97.
    • (2001) Am J Physiol , vol.281
    • Zygmunt, A.C.1    Eddlestone, G.T.2    Thomas, G.P.3    Nesterenko, V.V.4    Antzelevitch, C.5
  • 10
    • 31644438932 scopus 로고    scopus 로고
    • The mechanism of ranolazine action to reduce ischemia-induced diastolic dysfunction
    • 10.1093/eurheartj/sui091 1:CAS:528:DC%2BD28Xis1SgsL4%3D
    • Belardinelli L, Shryock JC, Fraser H. The mechanism of ranolazine action to reduce ischemia-induced diastolic dysfunction. Eur Heart J Suppl. 2006;8:A10-3.
    • (2006) Eur Heart J Suppl , vol.8
    • Belardinelli, L.1    Shryock, J.C.2    Fraser, H.3
  • 11
    • 84856442152 scopus 로고    scopus 로고
    • Role of ranolazine in angina, heart failure, arrhythmias, and diabetes
    • 22133843 10.1016/j.pharmthera.2011.11.003 1:CAS:528:DC%2BC38XhvFals7s%3D
    • Sossalla S, Maier LS. Role of ranolazine in angina, heart failure, arrhythmias, and diabetes. Pharmacol Ther. 2012;133:311-23.
    • (2012) Pharmacol Ther , vol.133 , pp. 311-323
    • Sossalla, S.1    Maier, L.S.2
  • 12
    • 33847608327 scopus 로고    scopus 로고
    • Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre
    • 17198698 10.1016/j.ejphar.2006.11.040 1:CAS:528:DC%2BD2sXhvVGgtbc%3D
    • Persson F, Andersson B, Duker G, Jacobson I, Carlsson L. Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre. Eur J Pharmacol. 2007;558:133-43.
    • (2007) Eur J Pharmacol , vol.558 , pp. 133-143
    • Persson, F.1    Andersson, B.2    Duker, G.3    Jacobson, I.4    Carlsson, L.5
  • 13
    • 0036750798 scopus 로고    scopus 로고
    • Heterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts
    • 12392892 10.1006/jmcc.2002.2053 1:CAS:528:DC%2BD38XnslGrur4%3D
    • Li GR, Lau CP, Shrier A. Heterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts. J Mol Cell Cardiol. 2002;34:1185-94.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1185-1194
    • Li, G.R.1    Lau, C.P.2    Shrier, A.3
  • 14
    • 34748873780 scopus 로고    scopus 로고
    • Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine
    • 17785620 10.1161/CIRCULATIONAHA.107.704890 1:CAS:528:DC%2BD2sXhtVKiu7rE
    • Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation. 2007;116:1449-57.
    • (2007) Circulation , vol.116 , pp. 1449-1457
    • Burashnikov, A.1    Di Diego, J.M.2    Zygmunt, A.C.3    Belardinelli, L.4    Antzelevitch, C.5
  • 16
    • 0025829410 scopus 로고
    • A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell
    • 2036721 10.1161/01.RES.68.6.1729 1:STN:280:DyaK3M3ktleisQ%3D%3D
    • Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circ Res. 1991;68:1729-41.
    • (1991) Circ Res , vol.68 , pp. 1729-1741
    • Sicouri, S.1    Antzelevitch, C.2
  • 17
    • 77952165183 scopus 로고    scopus 로고
    • + currents in atrial fibrillation: Effects of ranolazine on arrhythmias and contractility in human atrial myocardium
    • 20488304 10.1016/j.jacc.2009.12.055 1:CAS:528:DC%2BC3cXosVWrsrw%3D
    • + currents in atrial fibrillation: effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol. 2010;55:2330-42.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2330-2342
    • Sossalla, S.1    Kallmeyer, B.2    Wagner, S.3    Mazur, M.4    Maurer, U.5    Toischer, K.6
  • 18
    • 77951810890 scopus 로고    scopus 로고
    • Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: Its role in the genesis of atrial arrhythmias
    • Guo D, Young LH, Wu Y, Belardinelli L, Kowey PR, Yan GX. Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias. Am J Physiol Heart Circ Physiol 2010.
    • (2010) Am J Physiol Heart Circ Physiol
    • Guo, D.1    Young, L.H.2    Wu, Y.3    Belardinelli, L.4    Kowey, P.R.5    Yan, G.X.6
  • 19
    • 0033213925 scopus 로고    scopus 로고
    • Ionic mechanisms of electrical remodeling in human atrial fibrillation
    • 10615396 10.1016/S0008-6363(99)00178-9 1:CAS:528:DyaK1MXmtVyis7o%3D
    • Bosch RF, Zeng X, Grammer JB, Popovic K, Mewis C, Kuhlkamp V. Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovasc Res. 1999;44:121-31.
    • (1999) Cardiovasc Res , vol.44 , pp. 121-131
    • Bosch, R.F.1    Zeng, X.2    Grammer, J.B.3    Popovic, K.4    Mewis, C.5    Kuhlkamp, V.6
  • 20
    • 0030817799 scopus 로고    scopus 로고
    • + current in a chronic dog model of atrial fibrillation
    • 9400386 10.1161/01.RES.81.6.1045 1:CAS:528:DyaK2sXnvFWrurY%3D
    • + current in a chronic dog model of atrial fibrillation. Circ Res. 1997;81:1045-52.
    • (1997) Circ Res , vol.81 , pp. 1045-1052
    • Gaspo, R.1    Bosch, R.F.2    Bou-Abboud, E.3    Nattel, S.4
  • 21
    • 0029099346 scopus 로고
    • Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats
    • 7671380 10.1161/01.CIR.92.7.1954 1:STN:280:DyaK2MvgtFemtg%3D%3D
    • Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation. 1995;92:1954-68.
    • (1995) Circulation , vol.92 , pp. 1954-1968
    • Wijffels, M.C.1    Kirchhof, C.J.2    Dorland, R.3    Allessie, M.A.4
  • 22
    • 0037426439 scopus 로고    scopus 로고
    • Intracellular chloride accumulation and subcellular elemental distribution during atrial fibrillation
    • 12665494 10.1161/01.CIR.0000058462.23347.93
    • Akar JG, Everett TH, Ho R, Craft J, Haines DE, Somlyo AP, et al. Intracellular chloride accumulation and subcellular elemental distribution during atrial fibrillation. Circulation. 2003;107:1810-5.
    • (2003) Circulation , vol.107 , pp. 1810-1815
    • Akar, J.G.1    Everett, T.H.2    Ho, R.3    Craft, J.4    Haines, D.E.5    Somlyo, A.P.6
  • 23
    • 0037066036 scopus 로고    scopus 로고
    • + channel mutation that causes both Brugada and long-QT syndrome phenotypes: A simulation study of mechanism
    • 11889015 10.1161/hc1002.105183
    • + channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 2002;105:1208-13.
    • (2002) Circulation , vol.105 , pp. 1208-1213
    • Clancy, C.E.1    Rudy, Y.2
  • 24
    • 4344577023 scopus 로고    scopus 로고
    • Electrophysiologic effects of ranolazine: A novel anti-anginal agent with antiarrhythmic properties
    • 15302796 10.1161/01.CIR.0000139333.83620.5D 1:CAS:528: DC%2BD2cXms1Ogt7Y%3D
    • Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, et al. Electrophysiologic effects of ranolazine: a novel anti-anginal agent with antiarrhythmic properties. Circulation. 2004;110:904-10.
    • (2004) Circulation , vol.110 , pp. 904-910
    • Antzelevitch, C.1    Belardinelli, L.2    Zygmunt, A.C.3    Burashnikov, A.4    Di Diego, J.M.5    Fish, J.M.6
  • 25
    • 79955373381 scopus 로고    scopus 로고
    • Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents
    • 21184845 10.1016/j.hrthm.2010.12.026
    • Guo D, Lian J, Liu T, Cox R, Margulies KB, Kowey PR, et al. Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents. Heart Rhythm. 2011;8:762-9.
    • (2011) Heart Rhythm , vol.8 , pp. 762-769
    • Guo, D.1    Lian, J.2    Liu, T.3    Cox, R.4    Margulies, K.B.5    Kowey, P.R.6
  • 26
    • 0031697564 scopus 로고    scopus 로고
    • Antiarrhythmic drugs and cardiac ion channels: Mechanisms of action
    • 9785957 10.1016/S0079-6107(98)00002-9 1:CAS:528:DyaK1cXmsVyht78%3D
    • Carmeliet E, Mubagwa K. Antiarrhythmic drugs and cardiac ion channels: mechanisms of action. Prog Biophys Mol Biol. 1998;70:1-72.
    • (1998) Prog Biophys Mol Biol , vol.70 , pp. 1-72
    • Carmeliet, E.1    Mubagwa, K.2
  • 27
    • 33646386662 scopus 로고    scopus 로고
    • Molecular basis of ranolazine block of LQT-3 mutant sodium channels: Evidence for site of action
    • 16520744 10.1038/sj.bjp.0706709 1:CAS:528:DC%2BD28XjvF2lt74%3D
    • Fredj S, Sampson KJ, Liu H, Kass RS. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action. Br J Pharmacol. 2006;148:16-24.
    • (2006) Br J Pharmacol , vol.148 , pp. 16-24
    • Fredj, S.1    Sampson, K.J.2    Liu, H.3    Kass, R.S.4
  • 28
    • 33646007982 scopus 로고    scopus 로고
    • Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
    • 10.1111/j.1540-8167.2006.00401.x
    • Undrovinas AI, Belardinelli L, Undrovinas NA, Sabbah HN. Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol. 2006;17:S161-77.
    • (2006) J Cardiovasc Electrophysiol , vol.17
    • Undrovinas, A.I.1    Belardinelli, L.2    Undrovinas, N.A.3    Sabbah, H.N.4
  • 30
    • 80053226953 scopus 로고    scopus 로고
    • Mechanisms of atrial-selective block of sodium channel by ranolazine I. Experimental analysis of the use-dependent block
    • 21821778 10.1152/ajpheart.00242.2011 1:CAS:528:DC%2BC3MXhtlertr3O
    • Zygmunt AC, Nesterenko VV, Rajamani S, Hu D, Barajas-Martinez H, Belardinelli L, et al. Mechanisms of atrial-selective block of sodium channel by ranolazine I. Experimental analysis of the use-dependent block. Am J Physiol Heart Circ Physiol. 2011;301:H1606-14.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Zygmunt, A.C.1    Nesterenko, V.V.2    Rajamani, S.3    Hu, D.4    Barajas-Martinez, H.5    Belardinelli, L.6
  • 31
    • 0029099681 scopus 로고
    • Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs
    • 7491312 10.1111/j.1540-8159.1995.tb06990.x 1:STN:280: DyaK28%2FotFChtw%3D%3D
    • Whalley DW, Wendt DJ, Grant AO. Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs. PACE. 1995;18:1686-704.
    • (1995) PACE , vol.18 , pp. 1686-1704
    • Whalley, D.W.1    Wendt, D.J.2    Grant, A.O.3
  • 32
    • 84862253884 scopus 로고    scopus 로고
    • Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel. Comparison with ranolazine and dl-sotaol
    • 22322366 10.1161/CIRCEP.111.968305 1:CAS:528:DC%2BC38Xpt1yrtr0%3D
    • Burashnikov A, Pourrier M, Gibson JK, Lynch JJ, Antzelevitch C. Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel. Comparison with ranolazine and dl-sotaol. Circ Arrhythm Electrophysiol. 2012;5:400-8.
    • (2012) Circ Arrhythm Electrophysiol , vol.5 , pp. 400-408
    • Burashnikov, A.1    Pourrier, M.2    Gibson, J.K.3    Lynch, J.J.4    Antzelevitch, C.5
  • 33
    • 0023902688 scopus 로고
    • Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes
    • 2454585 1:CAS:528:DyaL1cXmtVCrs7s%3D
    • Wasserstrom JA, Salata JJ. Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes. Am J Physiol. 1988;254:H1157-66.
    • (1988) Am J Physiol , vol.254
    • Wasserstrom, J.A.1    Salata, J.J.2
  • 34
    • 79957674945 scopus 로고    scopus 로고
    • Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations
    • 21550338 10.1016/j.ejphar.2011.04.042 1:CAS:528:DC%2BC3MXmvVejt70%3D
    • Szel T, Koncz I, Jost N, Baczko I, Husti Z, Virag L, et al. Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations. Eur J Pharmacol. 2011;662:31-9.
    • (2011) Eur J Pharmacol , vol.662 , pp. 31-39
    • Szel, T.1    Koncz, I.2    Jost, N.3    Baczko, I.4    Husti, Z.5    Virag, L.6
  • 35
    • 59749102287 scopus 로고    scopus 로고
    • Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation
    • 19084813 10.1016/j.hrthm.2008.09.015
    • Burashnikov A, Di Diego JM, Sicouri S, Ferreiro M, Carlsson L, Antzelevitch C. Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation. Heart Rhythm. 2008;5:1735-42.
    • (2008) Heart Rhythm , vol.5 , pp. 1735-1742
    • Burashnikov, A.1    Di Diego, J.M.2    Sicouri, S.3    Ferreiro, M.4    Carlsson, L.5    Antzelevitch, C.6
  • 36
    • 77955229586 scopus 로고    scopus 로고
    • AZD1305 exerts atrial-predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its re-induction in the dog
    • 20386458 10.1097/FJC.0b013e3181e0bc6b 1:CAS:528:DC%2BC3cXovFSlt7c%3D
    • Burashnikov A, Zygmunt AC, Di Diego JM, Linhardt G, Carlsson L, Antzelevitch C. AZD1305 exerts atrial-predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its re-induction in the dog. J Cardiovasc Pharmacol. 2010;56:80-90.
    • (2010) J Cardiovasc Pharmacol , vol.56 , pp. 80-90
    • Burashnikov, A.1    Zygmunt, A.C.2    Di Diego, J.M.3    Linhardt, G.4    Carlsson, L.5    Antzelevitch, C.6
  • 37
    • 80053236179 scopus 로고    scopus 로고
    • Mechanisms of atrial-selective block of Na+ channels by ranolazine: II. Insights from a mathematical model
    • 21821780 10.1152/ajpheart.00243.2011 1:CAS:528:DC%2BC3MXhtlertr3P
    • Nesterenko VV, Zygmunt AC, Rajamani S, Belardinelli L, Antzelevitch C. Mechanisms of atrial-selective block of Na+ channels by ranolazine: II. Insights from a mathematical model. Am J Physiol Heart Circ Physiol. 2011;301:H1615-24.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Nesterenko, V.V.1    Zygmunt, A.C.2    Rajamani, S.3    Belardinelli, L.4    Antzelevitch, C.5
  • 38
    • 84555213111 scopus 로고    scopus 로고
    • Atrial-selective inhibition of sodium channel current by Wenxin Keli is effective in suppressing atrial fibrillation
    • 21884675 10.1016/j.hrthm.2011.08.027
    • Burashnikov A, Petroski A, Hu D, Barajas-Martinez H, Antzelevitch C. Atrial-selective inhibition of sodium channel current by Wenxin Keli is effective in suppressing atrial fibrillation. Heart Rhythm. 2012;9:125-31.
    • (2012) Heart Rhythm , vol.9 , pp. 125-131
    • Burashnikov, A.1    Petroski, A.2    Hu, D.3    Barajas-Martinez, H.4    Antzelevitch, C.5
  • 39
    • 67649395977 scopus 로고    scopus 로고
    • Atrial-selective sodium channel block for the treatment of atrial fibrillation
    • 19466903 10.1517/14728210902997939 1:CAS:528:DC%2BD1MXnt1Shsr4%3D
    • Burashnikov A, Antzelevitch C. Atrial-selective sodium channel block for the treatment of atrial fibrillation. Expert Opin Emerg Drugs. 2009;14:233-49.
    • (2009) Expert Opin Emerg Drugs , vol.14 , pp. 233-249
    • Burashnikov, A.1    Antzelevitch, C.2
  • 40
    • 77649091726 scopus 로고    scopus 로고
    • New development in atrial antiarrhythmic drug therapy
    • 20179721 10.1038/nrcardio.2009.245 1:CAS:528:DC%2BC3cXitlSnsro%3D
    • Burashnikov A, Antzelevitch C. New development in atrial antiarrhythmic drug therapy. Nat Rev Cardiol. 2010;7:139-48.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 139-148
    • Burashnikov, A.1    Antzelevitch, C.2
  • 41
    • 80054998466 scopus 로고    scopus 로고
    • Novel pharmacological targets for the rhythm control management of atrial fibrillation
    • 21867730 10.1016/j.pharmthera.2011.08.002 1:CAS:528:DC%2BC3MXhtl2ntrzI
    • Burashnikov A, Antzelevitch C. Novel pharmacological targets for the rhythm control management of atrial fibrillation. Pharmacol Ther. 2011;132:300-13.
    • (2011) Pharmacol Ther , vol.132 , pp. 300-313
    • Burashnikov, A.1    Antzelevitch, C.2
  • 43
    • 77956413990 scopus 로고    scopus 로고
    • Sodium channel (dys)function and cardiac arrhythmias
    • 20645984 10.1111/j.1755-5922.2010.00210.x
    • Remme CA, Bezzina CR. Sodium channel (dys)function and cardiac arrhythmias. Cardiovasc Ther. 2010;28:287-94.
    • (2010) Cardiovasc Ther , vol.28 , pp. 287-294
    • Remme, C.A.1    Bezzina, C.R.2
  • 44
    • 84857640089 scopus 로고    scopus 로고
    • Pathophysiology of the cardiac late Na current and its potential as a drug target
    • 22198344 10.1016/j.yjmcc.2011.12.003 1:CAS:528:DC%2BC38XjtlSntbs%3D
    • Moreno JD, Clancy CE. Pathophysiology of the cardiac late Na current and its potential as a drug target. J Mol Cell Cardiol. 2012;52:608-19.
    • (2012) J Mol Cell Cardiol , vol.52 , pp. 608-619
    • Moreno, J.D.1    Clancy, C.E.2
  • 45
    • 0030899379 scopus 로고    scopus 로고
    • Electrophysiological remodeling of the heart owing to rate
    • 9107155 10.1161/01.CIR.95.7.1745 1:STN:280:DyaK2s3mtFajsw%3D%3D
    • Zipes DP. Electrophysiological remodeling of the heart owing to rate. Circulation. 1997;95:1745-8.
    • (1997) Circulation , vol.95 , pp. 1745-1748
    • Zipes, D.P.1
  • 46
    • 70350681801 scopus 로고    scopus 로고
    • Mechanisms of cardiac arrhythmias and conduction disturbances
    • V. Fuster R.A. O'Rourke R.A. Walsh Poole-Wilson (eds) 12 Mc-Graw-Hill New York
    • Antzelevitch C. Mechanisms of cardiac arrhythmias and conduction disturbances. In: Fuster V, O'Rourke RA, Walsh RA, Poole-Wilson P, editors. Hurst's the heart. 12th ed. New York: Mc-Graw-Hill; 2008. p. 913-45.
    • (2008) Hurst's the Heart , pp. 913-945
    • Antzelevitch, C.1
  • 48
    • 0038663006 scopus 로고    scopus 로고
    • Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity
    • 12695296 10.1161/01.CIR.0000065578.00869.7C
    • Burashnikov A, Antzelevitch C. Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity. Circulation. 2003;107:2355-60.
    • (2003) Circulation , vol.107 , pp. 2355-2360
    • Burashnikov, A.1    Antzelevitch, C.2
  • 49
    • 0034711487 scopus 로고    scopus 로고
    • Electrical heterogeneity, cardiac arrhythmias, and the sodium channel
    • 11090538 10.1161/01.RES.87.11.964 1:CAS:528:DC%2BD3cXoslygsLg%3D
    • Antzelevitch C. Electrical heterogeneity, cardiac arrhythmias, and the sodium channel. Circ Res. 2000;87:964-5.
    • (2000) Circ Res , vol.87 , pp. 964-965
    • Antzelevitch, C.1
  • 50
    • 0030819433 scopus 로고    scopus 로고
    • Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome
    • 9323097 10.1161/01.CIR.96.6.2038 1:CAS:528:DyaK2sXmsVCht7k%3D
    • Shimizu W, Antzelevitch C. Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation. 1997;96:2038-47.
    • (1997) Circulation , vol.96 , pp. 2038-2047
    • Shimizu, W.1    Antzelevitch, C.2
  • 51
    • 52149109259 scopus 로고    scopus 로고
    • Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart
    • 18479333 10.1111/j.1540-8167.2008.01204.x
    • Kumar K, Nearing BD, Bartoli CR, Kwaku KF, Belardinelli L, Verrier RL. Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart. J Cardiovasc Electrophysiol. 2008;19:1073-9.
    • (2008) J Cardiovasc Electrophysiol , vol.19 , pp. 1073-1079
    • Kumar, K.1    Nearing, B.D.2    Bartoli, C.R.3    Kwaku, K.F.4    Belardinelli, L.5    Verrier, R.L.6
  • 52
    • 79953234505 scopus 로고    scopus 로고
    • Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model
    • 21094698 10.1016/j.hrthm.2010.11.029
    • Nieminen T, Nanbu DY, Datti IP, Vaz GR, Tavares CA, Pegler JR, et al. Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model. Heart Rhythm. 2011;8:608-14.
    • (2011) Heart Rhythm , vol.8 , pp. 608-614
    • Nieminen, T.1    Nanbu, D.Y.2    Datti, I.P.3    Vaz, G.R.4    Tavares, C.A.5    Pegler, J.R.6
  • 53
    • 78651326450 scopus 로고    scopus 로고
    • Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine
    • 10.1016/j.jacc.2010.07.045
    • Morita N, Lee JH, Xie Y, Sovari A, Qu Z, Weiss JN, et al. Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine. J Am Coll Cardiol. 2011;52:366-75.
    • (2011) J Am Coll Cardiol , vol.52 , pp. 366-375
    • Morita, N.1    Lee, J.H.2    Xie, Y.3    Sovari, A.4    Qu, Z.5    Weiss, J.N.6
  • 54
    • 79959747581 scopus 로고    scopus 로고
    • Mechanisms of termination and prevention of atrial fibrillation by drug therapy
    • 21334377 10.1016/j.pharmthera.2011.02.002 1:CAS:528:DC%2BC3MXotVemurg%3D
    • Workman AJ, Smith GL, Rankin AC. Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacol Ther. 2011;131:221-41.
    • (2011) Pharmacol Ther , vol.131 , pp. 221-241
    • Workman, A.J.1    Smith, G.L.2    Rankin, A.C.3
  • 55
    • 0031715134 scopus 로고    scopus 로고
    • Cesium-induced atrial tachycardia degenerating into atrial fibrillation in dogs: Atrial torsades de pointes?
    • 9786077 10.1111/j.1540-8167.1998.tb00137.x 1:STN:280: DyaK1M%2FgtVSitA%3D%3D
    • Satoh T, Zipes DP. Cesium-induced atrial tachycardia degenerating into atrial fibrillation in dogs: atrial torsades de pointes? J Cardiovasc Electrophysiol. 1998;9:970-5.
    • (1998) J Cardiovasc Electrophysiol , vol.9 , pp. 970-975
    • Satoh, T.1    Zipes, D.P.2
  • 56
    • 0242712981 scopus 로고    scopus 로고
    • Prolonged atrial action potential durations and polymorphic atrial tachyarrhythmias in patients with long QT syndrome
    • 14521653 10.1046/j.1540-8167.2003.03165.x
    • Kirchhof P, Eckardt L, Franz MR, Monnig G, Loh P, Wedekind H, et al. Prolonged atrial action potential durations and polymorphic atrial tachyarrhythmias in patients with long QT syndrome. J Cardiovasc Electrophysiol. 2003;14:1027-33.
    • (2003) J Cardiovasc Electrophysiol , vol.14 , pp. 1027-1033
    • Kirchhof, P.1    Eckardt, L.2    Franz, M.R.3    Monnig, G.4    Loh, P.5    Wedekind, H.6
  • 57
    • 63049105169 scopus 로고    scopus 로고
    • Atrial arrhythmias in long-QT syndrome under daily life conditions: A nested case control study
    • 19017345 10.1111/j.1540-8167.2008.01339.x
    • Zellerhoff S, Pistulli R, Monnig G, Hinterseer M, Beckmann BM, Kobe J, et al. Atrial arrhythmias in long-QT syndrome under daily life conditions: a nested case control study. J Cardiovasc Electrophysiol. 2009;20:401-7.
    • (2009) J Cardiovasc Electrophysiol , vol.20 , pp. 401-407
    • Zellerhoff, S.1    Pistulli, R.2    Monnig, G.3    Hinterseer, M.4    Beckmann, B.M.5    Kobe, J.6
  • 58
    • 0242719736 scopus 로고    scopus 로고
    • Atrial arrhythmias in the inherited long QT syndrome: Laboratory quirk or clinical arrhythmia?
    • 14521654 10.1046/j.1540-8167.2003.03365.x
    • Vincent GM. Atrial arrhythmias in the inherited long QT syndrome: laboratory quirk or clinical arrhythmia? J Cardiovasc Electrophysiol. 2003;14:1034-5.
    • (2003) J Cardiovasc Electrophysiol , vol.14 , pp. 1034-1035
    • Vincent, G.M.1
  • 59
    • 77957738116 scopus 로고    scopus 로고
    • Guidelines for the management of atrial fibrillation: The task force for the management of atrial fibrillation of the European Society of Cardiology (ESC)
    • Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, et al. Guidelines for the management of atrial fibrillation: the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 2010;12:1360-420.
    • (2010) Eur Heart J , vol.12 , pp. 1360-1420
    • Camm, A.J.1    Kirchhof, P.2    Lip, G.Y.3    Schotten, U.4    Savelieva, I.5    Ernst, S.6
  • 62
    • 84866643004 scopus 로고    scopus 로고
    • High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation
    • 22685113 10.1161/CIRCGENETICS.111.962597
    • Olesen MS, Yuan L, Liang B, Holst AG, Nielsen N, Nielsen JB, et al. High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation. Circ Cardiovasc Genet. 2012;5:450-9.
    • (2012) Circ Cardiovasc Genet , vol.5 , pp. 450-459
    • Olesen, M.S.1    Yuan, L.2    Liang, B.3    Holst, A.G.4    Nielsen, N.5    Nielsen, J.B.6
  • 63
    • 0032871348 scopus 로고    scopus 로고
    • The M cell: Its contribution to the ECG and to normal and abnormal electrical function of the heart
    • 10466495 10.1111/j.1540-8167.1999.tb00287.x 1:STN:280: DyaK1MzpsVeksw%3D%3D
    • Antzelevitch C, Shimizu W, Yan GX, Sicouri S, Weissenburger J, Nesterenko VV, et al. The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol. 1999;10:1124-52.
    • (1999) J Cardiovasc Electrophysiol , vol.10 , pp. 1124-1152
    • Antzelevitch, C.1    Shimizu, W.2    Yan, G.X.3    Sicouri, S.4    Weissenburger, J.5    Nesterenko, V.V.6
  • 64
    • 0036200979 scopus 로고    scopus 로고
    • Prominent IKs in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations
    • 11900293 10.1046/j.1540-8167.2002.00172.x
    • Burashnikov A, Antzelevitch C. Prominent IKs in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations. J Cardiovasc Electrophysiol. 2002;13:172-7.
    • (2002) J Cardiovasc Electrophysiol , vol.13 , pp. 172-177
    • Burashnikov, A.1    Antzelevitch, C.2
  • 65
    • 80054989104 scopus 로고    scopus 로고
    • Absence of early afterdepolarizations in canine atria under long QT syndrome
    • (Abstract)
    • Burashnikov A, Antzelevitch C. Absence of early afterdepolarizations in canine atria under long QT syndrome. Heart Rhythm. 2011;8(5S):S328 (Abstract).
    • (2011) Heart Rhythm , vol.8 , Issue.5 S , pp. 328
    • Burashnikov, A.1    Antzelevitch, C.2
  • 66
    • 0034612363 scopus 로고    scopus 로고
    • Effects of experimental heart failure on atrial cellular and ionic electrophysiology
    • 10840016 10.1161/01.CIR.101.22.2631 1:CAS:528:DC%2BD3cXks1SgsbY%3D
    • Li D, Melnyk P, Feng J, Wang Z, Petrecca K, Shrier A, et al. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation. 2000;101:2631-8.
    • (2000) Circulation , vol.101 , pp. 2631-2638
    • Li, D.1    Melnyk, P.2    Feng, J.3    Wang, Z.4    Petrecca, K.5    Shrier, A.6
  • 67
    • 0038689293 scopus 로고    scopus 로고
    • Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation
    • 12732604
    • Verheule S, Wilson E, Everett T, Shanbhag S, Golden C, Olgin J. Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation. Circulation. 2003;107:2615-22.
    • (2003) Circulation , vol.107 , pp. 2615-2622
    • Verheule, S.1    Wilson, E.2    Everett, T.3    Shanbhag, S.4    Golden, C.5    Olgin, J.6
  • 68
    • 67651008246 scopus 로고    scopus 로고
    • The role of chronic atrial stretch and atrial fibrillation on posterior left atrial wall conduction
    • 19574109 10.1016/j.hrthm.2009.04.008
    • Roberts-Thomson KC, Stevenson I, Kistler PM, Haqqani HM, Spence SJ, Goldblatt JC, et al. The role of chronic atrial stretch and atrial fibrillation on posterior left atrial wall conduction. Heart Rhythm. 2009;6:1109-17.
    • (2009) Heart Rhythm , vol.6 , pp. 1109-1117
    • Roberts-Thomson, K.C.1    Stevenson, I.2    Kistler, P.M.3    Haqqani, H.M.4    Spence, S.J.5    Goldblatt, J.C.6
  • 69
    • 33845659664 scopus 로고    scopus 로고
    • Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: Implications for development of atrial fibrillation
    • 17098760 10.1093/eurheartj/ehl360
    • Kistler PM, Sanders P, Dodic M, Spence SJ, Samuel CS, Zhao C, et al. Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: implications for development of atrial fibrillation. Eur Heart J. 2006;27:3045-56.
    • (2006) Eur Heart J , vol.27 , pp. 3045-3056
    • Kistler, P.M.1    Sanders, P.2    Dodic, M.3    Spence, S.J.4    Samuel, C.S.5    Zhao, C.6
  • 70
    • 84873060548 scopus 로고    scopus 로고
    • Ranolazine causes atrial-selective electrophysiological effects and suppresses the induction of atrial fibrillation in a canine model of heart failue
    • (Abstract, in press)
    • Burashnikov A, Di Diego JM, Moise NS, Kornreich BG, Belardinelli L, Antzelevitch C. Ranolazine causes atrial-selective electrophysiological effects and suppresses the induction of atrial fibrillation in a canine model of heart failue. Heart Rhythm 2012;9 (Abstract, in press).
    • (2012) Heart Rhythm , pp. 9
    • Burashnikov, A.1    Di Diego, J.M.2    Moise, N.S.3    Kornreich, B.G.4    Belardinelli, L.5    Antzelevitch, C.6
  • 71
    • 15944428775 scopus 로고    scopus 로고
    • Age-associated changes in electrophysiologic remodeling: A potential contributor to initiation of atrial fibrillation
    • 15820204 10.1016/j.cardiores.2004.10.033 1:CAS:528:DC%2BD2MXjt1Kitbo%3D
    • Anyukhovsky EP, Sosunov EA, Chandra P, Rosen TS, Boyden PA, Danilo Jr P, et al. Age-associated changes in electrophysiologic remodeling: a potential contributor to initiation of atrial fibrillation. Cardiovasc Res. 2005;66:353-63.
    • (2005) Cardiovasc Res , vol.66 , pp. 353-363
    • Anyukhovsky, E.P.1    Sosunov, E.A.2    Chandra, P.3    Rosen, T.S.4    Boyden, P.A.5    Danilo, Jr.P.6
  • 72
    • 3242811995 scopus 로고    scopus 로고
    • Electrophysiologic and electroanatomic changes in the human atrium associated with age
    • 15234418 10.1016/j.jacc.2004.03.044
    • Kistler PM, Sanders P, Fynn SP, Stevenson IH, Spence SJ, Vohra JK, et al. Electrophysiologic and electroanatomic changes in the human atrium associated with age. J Am Coll Cardiol. 2004;44:109-16.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 109-116
    • Kistler, P.M.1    Sanders, P.2    Fynn, S.P.3    Stevenson, I.H.4    Spence, S.J.5    Vohra, J.K.6
  • 73
    • 44949176560 scopus 로고    scopus 로고
    • An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes
    • 18310511 10.1152/ajpheart.01357.2007 1:CAS:528:DC%2BD1cXmtVegtr0%3D
    • Song Y, Shryock JC, Belardinelli L. An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. Am J Physiol Heart Circ Physiol. 2008;294:H2031-9.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Song, Y.1    Shryock, J.C.2    Belardinelli, L.3
  • 74
    • 46349111138 scopus 로고    scopus 로고
    • Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations
    • 18598958 10.1016/j.hrthm.2008.03.018
    • Sicouri S, Glass A, Belardinelli L, Antzelevitch C. Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations. Heart Rhythm. 2008;5:1019-26.
    • (2008) Heart Rhythm , vol.5 , pp. 1019-1026
    • Sicouri, S.1    Glass, A.2    Belardinelli, L.3    Antzelevitch, C.4
  • 75
    • 77957571615 scopus 로고    scopus 로고
    • Synergistic effect of the combination of dronedarone and ranolazine to suppress atrial fibrillation
    • 20883928 10.1016/j.jacc.2010.08.600 1:CAS:528:DC%2BC3cXhsVagsL7N
    • Burashnikov A, Sicouri S, Di Diego JM, Belardinelli L, Antzelevitch C. Synergistic effect of the combination of dronedarone and ranolazine to suppress atrial fibrillation. J Am Coll Cardiol. 2010;56:1216-24.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1216-1224
    • Burashnikov, A.1    Sicouri, S.2    Di Diego, J.M.3    Belardinelli, L.4    Antzelevitch, C.5
  • 76
    • 67649795769 scopus 로고    scopus 로고
    • Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart
    • 19298570 10.1111/j.1540-8167.2009.01437.x
    • Kumar K, Nearing BD, Carvas M, Nascimento BC, Acar M, Belardinelli L, et al. Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart. J Cardiovasc Electrophysiol. 2009;20:796-802.
    • (2009) J Cardiovasc Electrophysiol , vol.20 , pp. 796-802
    • Kumar, K.1    Nearing, B.D.2    Carvas, M.3    Nascimento, B.C.4    Acar, M.5    Belardinelli, L.6
  • 77
    • 77949596392 scopus 로고    scopus 로고
    • Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart
    • 20075744 10.1097/FJC.0b013e3181d26416 1:CAS:528:DC%2BC3cXktFOmtL8%3D
    • Carvas M, Nascimento BC, Acar M, Nearing BD, Belardinelli L, Verrier RL. Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart. J Cardiovasc Pharmacol. 2010;55:286-91.
    • (2010) J Cardiovasc Pharmacol , vol.55 , pp. 286-291
    • Carvas, M.1    Nascimento, B.C.2    Acar, M.3    Nearing, B.D.4    Belardinelli, L.5    Verrier, R.L.6
  • 78
    • 0035080560 scopus 로고    scopus 로고
    • Evidence that ranolazine behaves as a weak beta1- and beta2-adrenoceptor antagonist in the cat cardiovascular system
    • 11330341 10.1007/s002100000378 1:CAS:528:DC%2BD3MXhslWmu7Y%3D
    • Letienne R, Vie B, Puech A, Vieu S, Le Grand B, John GW. Evidence that ranolazine behaves as a weak beta1- and beta2-adrenoceptor antagonist in the cat cardiovascular system. Naunyn Schmiedebergs Arch Pharmacol. 2001;363:464-71.
    • (2001) Naunyn Schmiedebergs Arch Pharmacol , vol.363 , pp. 464-471
    • Letienne, R.1    Vie, B.2    Puech, A.3    Vieu, S.4    Le Grand, B.5    John, G.W.6
  • 79
    • 77649299995 scopus 로고    scopus 로고
    • Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria
    • 19952329 10.1161/CIRCEP.109.886275 1:CAS:528:DC%2BC3cXjvFCmt7s%3D
    • Sicouri S, Burashnikov A, Belardinelli L, Antzelevitch C. Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria. Circ Arrhythm Electrophysiol. 2010;3:88-95.
    • (2010) Circ Arrhythm Electrophysiol , vol.3 , pp. 88-95
    • Sicouri, S.1    Burashnikov, A.2    Belardinelli, L.3    Antzelevitch, C.4
  • 80
    • 35148850168 scopus 로고    scopus 로고
    • Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: Results from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial
    • 17804441 10.1161/CIRCULATIONAHA.107.724880 1:CAS:528:DC%2BD2sXhtFWru7rP
    • Scirica BM, Morrow DA, Hod H, Murphy SA, Belardinelli L, Hedgepeth CM, et al. Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation. 2007;116:1647-52.
    • (2007) Circulation , vol.116 , pp. 1647-1652
    • Scirica, B.M.1    Morrow, D.A.2    Hod, H.3    Murphy, S.A.4    Belardinelli, L.5    Hedgepeth, C.M.6
  • 81
    • 55849135767 scopus 로고    scopus 로고
    • The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation
    • 18679523
    • Murdock DK, Overton N, Kersten M, Kaliebe J, Devecchi F. The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation. Indian Pacing Electrophysiol J. 2008;8:175-81.
    • (2008) Indian Pacing Electrophysiol J , vol.8 , pp. 175-181
    • Murdock, D.K.1    Overton, N.2    Kersten, M.3    Kaliebe, J.4    Devecchi, F.5
  • 82
    • 73249135820 scopus 로고    scopus 로고
    • The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: A reveiw of experience with implications for possible "pill in the pocket" approach to atrial fibrillation
    • 19763194
    • Murdock DK, Kersten M, Kaliebe J, Larrian G. The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: a reveiw of experience with implications for possible "pill in the pocket" approach to atrial fibrillation. Indian Pacing Electrophysiol J. 2009;9:260-7.
    • (2009) Indian Pacing Electrophysiol J , vol.9 , pp. 260-267
    • Murdock, D.K.1    Kersten, M.2    Kaliebe, J.3    Larrian, G.4
  • 83
    • 80051802104 scopus 로고    scopus 로고
    • Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting
    • 21726841 10.1016/j.amjcard.2011.04.017 1:CAS:528:DC%2BC3MXhtVajtrbI
    • Miles RH, Passman R, Murdock DK. Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting. Am J Cardiol. 2011;108:673-6.
    • (2011) Am J Cardiol , vol.108 , pp. 673-676
    • Miles, R.H.1    Passman, R.2    Murdock, D.K.3
  • 84
    • 84857995406 scopus 로고    scopus 로고
    • The use of ranolazine to facilitate electrical cardioversion in cardioversion-resistant patients: A case series
    • 22229482 10.1111/j.1540-8159.2011.03298.x
    • Murdock DK, Kaliebe J, Larrain G. The use of ranolazine to facilitate electrical cardioversion in cardioversion-resistant patients: a case series. Pacing Clin Electrophysiol. 2012;35:302-7.
    • (2012) Pacing Clin Electrophysiol , vol.35 , pp. 302-307
    • Murdock, D.K.1    Kaliebe, J.2    Larrain, G.3
  • 85
    • 84864953997 scopus 로고    scopus 로고
    • Comparison of effectiveness of ranolazine plus amiodarone versus amiodarone alone for conversion of recent-onset atrial fibrillation
    • 22621799 10.1016/j.amjcard.2012.04.044 1:CAS:528:DC%2BC38Xntlyqs7s%3D
    • Fragakis N, Koskinas KC, Katritsis DG, Pagourelias ED, Zografos T, Geleris P. Comparison of effectiveness of ranolazine plus amiodarone versus amiodarone alone for conversion of recent-onset atrial fibrillation. Am J Cardiol. 2012;110:673-7.
    • (2012) Am J Cardiol , vol.110 , pp. 673-677
    • Fragakis, N.1    Koskinas, K.C.2    Katritsis, D.G.3    Pagourelias, E.D.4    Zografos, T.5    Geleris, P.6
  • 87
    • 84055178015 scopus 로고    scopus 로고
    • Atrial-selective sodium channel block strategy to suppress atrial fibrillation. Ranolazine versus propafenone
    • 22005044 10.1124/jpet.111.186395 1:CAS:528:DC%2BC38XjtVSlsb4%3D
    • Burashnikov A, Belardinelli L, Antzelevitch C. Atrial-selective sodium channel block strategy to suppress atrial fibrillation. Ranolazine versus propafenone. J Pharmacol Exp Ther. 2012;340:161-8.
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 161-168
    • Burashnikov, A.1    Belardinelli, L.2    Antzelevitch, C.3


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