Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart

Journal of Cardiovascular Electrophysiology

Volumn 20, Issue 7, 2009, Pages 796-802

  Kumar, Kapil ^a   Nearing, Bruce D ^a   Carvas, Marcelo ^b   Nascimento, Bruno C G ^b   Acar, Mariana ^b   Belardinelli, Luiz ^c   Verrier, Richard L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c CV THERAPEUTICS INC   (United States)

Author keywords

Atrial effective refractory period; Atrial electrical properties; Atrial fibrillation; Ranolazine

Indexed keywords

ACETYLCHOLINE; RANOLAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG BLOOD LEVEL; ELECTROCARDIOGRAPHY MONITORING; HEART ATRIUM FIBRILLATION; HEART CATHETERIZATION; HEART CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART LEFT ATRIUM; HEART MUSCLE REFRACTORY PERIOD; HEART PACING; HEART RIGHT ATRIUM; NONHUMAN; PRIORITY JOURNAL; SWINE;

ACETANILIDES; ACETYLCHOLINE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; HEART ATRIA; HEART CONDUCTION SYSTEM; INFUSIONS, INTRAVENOUS; MALE; PIPERAZINES; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; SWINE; TIME FACTORS;

EID: 67649795769     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2009.01437.x     Document Type: Article

References (26)

1. Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, Halperin JL, Le Heuzey JY, Kay GN, Lowe JE, Olsson SB, Prystowsky EN, Tamargo JL, Wann S, Smith SC, Jacobs AK, Adams CD, Anderson JL, Antman EM, Halperin JL, Hunt SA, Nishimura R, Ornato JP, Page RL, Riegel B, Priori SG, Blanc JJ, Budaj A, Camm AJ, Dean V, Deckers JW, Despres C, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo JL, Zamorano JL : ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation): Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 2006 114 : e257 e354.
2. The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators : A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 2002 347 : 1825 1833.
3. Roy D, Talajic M, Nattel S, Wyse DG, Dorian P, Lee KL, Bourassa MG, Arnold JM, Buxton AE, Camm AJ, Connolly SJ, Dubuc M, Ducharme A, Guerra PG, Hohnloser SH, Lambert J, Le Heuzey JY, O'Hara G, Pedersen OD, Rouleau JL, Singh BN, Stevenson LW, Stevenson WG, Thibault B, Waldo AL Atrial Fibrillation and Congestive Heart Failure Investigators : Rhythm control versus rate control for atrial fibrillation and heart failure. N Engl J Med 2008 358 : 2667 2677. (Pubitemid 351860859)
4. The AFFIRM Investigators : Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study. Circulation 2004 109 : 1509 1513.
5. Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, Murphy SA, Budaj A, Varshavsky S, Wolff AA, Skene A, McCabe CH, Braunwald E MERLIN-TIMI 36 Trial Investigators : Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: The MERLIN-TIMI 36 randomized trial. JAMA 2007 297 : 1775 1783. (Pubitemid 46658646)
6. Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C : Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation. Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine-selective sodium channel block as a novel strategy for the management of AF. Circulation 2007 116 : 1449 1457.
7. Sarmast F, Kolli A, Zaitsev A, Parisian K, Dhamoon AS, Guha PK, Warren M, Anumonwo JM, Taffet SM, Berenfeld O, Jalife J : Cholinergic atrial fibrillation: I(K,ACh) gradients determine unequal left/right atrial frequencies and rotor dynamics. Cardiovasc Res 2003 59 : 863 873. (Pubitemid 38366242)
8. Olshansky B : Interrelationships between the autonomic nervous system and atrial fibrillation. Prog Cardiovasc Dis 2005 48 : 57 78. (Pubitemid 41372118)
9. Nattel S, Shiroshita-Takeshita A, Brundel BJJM, Rivard L : Mechanism of atrial fibrillation: Lessons from animal models. Prog Cardiovasc Dis 2005 48 : 9 28. (Pubitemid 41368555)
10. Burashnikov A, Antzelevitch C : Role of repolarization restitution in the development of coarse and fine atrial fibrillation in the isolated canine right atria. J Cardiovasc Electrophysiol 2005 16 : 639 645. (Pubitemid 40807656)
11. Scherlag BJ, Hou YL, Lin J, Lu Z, Zacharias S, Dasari T, Niu G, Ghias M, Patterson E, Jackman WM, Lazzara R, Po SS : An acute model for atrial fibrillation arising from a peripheral atrial site: Evidence for primary and secondary triggers. J Cardiovasc Electrophysiol 2008 19 : 519 527. (Pubitemid 351623914)
12. Kumar K, Nearing BD, Bartoli CR, Kwaku KF, Belardinelli L, Verrier RL : Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart. J Cardiovasc Electrophysiol 2008 19 : 1073 1079.
13. Kumar K, Nguyen K, Waxman S, Nearing BD, Wellenius G, Zhao SX, Verrier RL : Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart. J Am Coll Cardiol 2003 41 : 1831 1837. (Pubitemid 36584260)
14. Everett TH, Kok LC, Vaughn RH, Moorman JR, Haines DE : Frequency domain algorithm for quantifying atrial fibrillation organization to increase defibrillation efficacy. IEEE Trans Biomed Eng 2001 48 : 969 978. (Pubitemid 32776938)
15. Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G : Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 2004 110 : 904 910. (Pubitemid 39136212)
16. Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S : Ranolazine: Ion-channel-blocking actions and in vivo electrophysiological effects. Br J Pharmacol 2004 142 : 1300 1308. (Pubitemid 39185852)
17. Scirica BM, Morrow DA, Hod H, Murphy SA, Belardinelli L, Hedgepeth CM, Molhoek P, Verheugt FWA, Gersh BJ, McCabe CH, Braunwald E : Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non-ST-segment elevation and acute coronary syndrome. Results from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation 2007 116 : 1647 1652. (Pubitemid 47537839)
18. Sicouri S, Glass A, Belardinelli L, Antzelevitch C : Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations. Heart Rhythm 2008 5 : 1019 1026.
19. Murdock DK, Overton N, Kersten M, Kaliebe J, Devecchi F : The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation. Indian Pacing Electrophysiol J 2008 8 : 175 181.
20. Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C : Atrial-selective sodium channel block as a strategy for suppression of atrial fibrillation. Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Online Data Supplement : Available at : http://circ.ahajournals.org/cgi/content/full/CIRCULATIONAHA.107. 704890/DC1.
21. Po SS, Li Y, Tang D, Liu H, Geng N, Jackman WM, Scherlag B, Lazzara R, Patterson E : Rapid and stable re-entry within the pulmonary vein as a mechanism initiating paroxysmal atrial fibrillation. J Am Coll Cardiol 2005 45 : 1871 1877. (Pubitemid 40779870)
22. Po SS, Scherlag BJ, Yamanashi WS, Edwards J, Zhou J, Wu R, Geng N, Lazzara R, Jackman WM : Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions. Heart Rhythm 2006 3 : 201 208. (Pubitemid 43149995)
23. Lin J, Scherlag BJ, Zhou J, Lu Z, Patterson E, Jackman WM, Lazzara R, Po SS : Autonomic mechanism to explain complex fractionated atrial electrograms (CFAE). J Cardiovasc Electrophysiol 2007 18 : 1197 1205. (Pubitemid 47609881)
24. Tan AY, Chen P-S, Chen LS, Fishbein MC : Autonomic nerves in pulmonary veins. Heart Rhythm 2007 4 : 557 560.
25. Chou CC, Nguyen BL, Tan AY, Chang PC, Lee HL, Lin FC, Yeh SJ, Fishbein MC, Lin SF, Wu D, Wen MS, Chen PS : Intracellular calcium dynamics and acetylcholine-induced triggered activity in the pulmonary veins of dogs with pacing-induced heart failure. Heart Rhythm 2008 5 : 1170 1177.
26. Berenfeld O : Quantifying activation frequency in atrial fibrillation to establish underlying mechanisms and ablation guidance. Heart Rhythm 2007 4 : 1225 1234. (Pubitemid 47324116)