SCARB2/LIMP-2 regulates IFN production of plasmacytoid dendritic cells by mediating endosomal translocation of TLR9 and nuclear translocation of IRF7

Journal of Immunology

Volumn 194, Issue 10, 2015, Pages 4737-4749

  Guo, Hao ^a,b   Zhang, Jialong ^a   Zhang, Xuyuan ^a,b   Wang, Yanbing ^a   Yu, Haisheng ^a,b   Yin, Xiangyun ^a,b   Li, Jingyun ^a,b   Du, Peishuang ^a   Plumas, Joel ^c   Chaperot, Laurence ^c   Chen, Jianzhu ^a,d   Su, Lishan ^a,e,f   Liu, Yongjun ^a,g   Zhang, Liguo ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c ETABLISSEMENT FRANÇAIS DU SANG   (France)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^g BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; INTERFERON; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 3; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; SCAVENGER RECEPTOR B; SCAVENGER RECEPTOR B2; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; IRF7 PROTEIN, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; SCARB2 PROTEIN, HUMAN; SCAVENGER RECEPTOR; TLR9 PROTEIN, HUMAN;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; ENDOPLASMIC RETICULUM; ENDOSOME; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; INNATE IMMUNITY; LIGAND BINDING; LYSOSOME; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; UPREGULATION; BIOSYNTHESIS; CELL CULTURE; DENDRITIC CELL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELLS, CULTURED; DENDRITIC CELLS; ENDOSOMES; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; PROTEIN TRANSPORT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, SCAVENGER; TOLL-LIKE RECEPTOR 9;

EID: 84929119168     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402312     Document Type: Article

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