Leukemic plasmacytoid dendritic cells share phenotypic and functional features with their normal counterparts

European Journal of Immunology

Volumn 34, Issue 2, 2004, Pages 418-426

  Chaperot, Laurence ^a   Perrot, Ivan ^b   Jacob, Marie Christine ^a   Blanchard, Dominique ^b   Salaun, Véronique ^c   Deneys, Véronique ^d   Lebecque, Serge ^b   Brière, Francine ^b   Bensa, Jean Claude ^a   Plumas, Joël ^a  

^a ETABLISSEMENT FRANÇAIS DU SANG   (France)

^b MERCK RESEARCH LABORATORIES   (United States)

^c CAEN UNIVERSITY HOSPITAL   (France)

^d Hôpital Saint Luc   (Belgium)

Author keywords

Antigen presentation; Influenza virus; Plasmacytoid dendritic cells; Th polarization

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD83 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 3; INTERLEUKIN 4; BLOOD DENDRITIC CELL ANTIGEN 4, HUMAN; CYTOKINE; MEMBRANE ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL FUNCTION; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; LEUKEMIA CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CLONE; MALE; PHENOTYPE; PRIORITY JOURNAL; SCHOOL CHILD; T LYMPHOCYTE; TH2 CELL; VIRUS; ADOLESCENT; CELL DIFFERENTIATION; CHILD; CYTOLOGY; FLOW CYTOMETRY; IMMUNOLOGY; IMMUNOPHENOTYPING; LEUKEMIA; METABOLISM; MIDDLE AGED; ORTHOMYXOVIRUS; PATHOLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGEN PRESENTATION; ANTIGENS, SURFACE; CD40 LIGAND; CELL DIFFERENTIATION; CHILD; CYTOKINES; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-3; LEUKEMIA; MALE; MIDDLE AGED; ORTHOMYXOVIRIDAE;

EID: 1642363341     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324531     Document Type: Article

References (36)

1. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
2. Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B. and Palucka, K., Immunobiology of dendritic cells. Annu. Rev. Immunol. 2000. 18: 767-811.
3. Guermonprez, P., Valladeau, J., Zitvogel, L., Thery, C. and Amigorena, S., Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 2002. 20: 621-667.
4. Langenkamp, A., Messi, M., Lanzavecchia, A. and Sallusto, F., Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat. Immunol. 2000. 1: 311-316.
5. Grouard, G., Rissoan, M. C., Filgueira, L., Durand, I., Banchereau, J. and Liu, Y. J., The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40 ligand. J. Exp. Med. 1997. 185: 1101-1111.
6. Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A. and Colonna, M., Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 1999. 5: 919-923.
7. Rissoan, M. C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., de Waal Malefyt, R. and Liu, Y. J., Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999. 283: 1183-1186.
8. Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D. W. and Schmitz, J., BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 2000. 165: 6037-6046.
9. Dzionek, A., Sohma, Y., Nagafune, J., Cella, M., Colonna, M., Facchetti, F., Gunther, G., Johnston, I., Lanzavecchia, A., Nagasaka, T., Okada, T., Vermi, W., Winkels, G., Yamamoto, T., Zysk, M., Yamaguchi, Y. and Schmitz, J., BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J. Exp. Med. 2001. 194: 1823-1834.
10. Dzionek, A., Inagaki, Y., Okawa, K., Nagafune, J., Rock, J. J., Sohma, Y., Winkels, G., Zysk, M., Yamaguchi, Y. and Schmitz, J. J., Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions. Hum. Immunol. 2002. 63: 1133-1148.
11. Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S. and Liu, Y. J., The nature of the principal type 1 interferon-producing cells in human blood. Science 1999. 284: 1835-1837.
12. + dendritic cells to produce type I IFN. J. Immunol. 2001. 166: 2291-2295.
13. Krug, A., Towarowski, A., Britsch, S., Rothenfusser, S., Hornung, V., Bals, R., Giese, T., Engelmann, H., Endres, S., Krieg, A. M. and Hartmann, G., Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 2001. 31: 3026-3037.
14. + dendritic cells. J. Immunol. 2001. 166: 5000-5007.
15. Kadowaki, N., Antonenko, S., Lau, J. Y. and Liu, Y. J., Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J. Exp. Med. 2000. 192: 219-226.
16. Cella, M., Facchetti, F., Lanzavecchia, A. and Colonna, , M.,1 Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat. Immunol. 2000. 1: 305-310.
17. Ito, T., Amakawa, R., Kaisho, T., Hemmi, H., Tajima, K., Uehira, K., Ozaki, Y., Tomizawa, H., Akira, S. and Fukuhara, S., Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 2002. 195: 1507-1512.
18. Jurk, M., Heil, F., Vollmer, J., Schetter, C., Krieg, A. M., Wagner, H., Lipford, G. and Bauer, S., Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 2002. 3: 499.
19. Liu, Y. J., Kanzler, H., Soumelis, V. and Gillet, M., Dendritic cell lineage, plasticity and cross-regulation. Nat. Immunol. 2001. 2: 585-589.
20. Colonna, M., Krug, A. and Cella, M., Interferon-producing cells: on the front line in immune responses against pathogens. Curr. Opin. Immunol. 2002. 14: 373-379.
21. Gilliet, M. and Liu, Y. J., Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J. Exp. Med. 2002. 195: 695-704.
22. + T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood 2003. 2: 2.
23. Chaperot, L., Bendriss, N., Manches, O., Gressin, R., Maynadie, M., Trimoreau, F., Orfeuvre, H., Corront, B., Feuillard, J., Sotto, J. J., Bensa, J. C., Briere, F., Plumas, J. and Jacob, M. C., Identification of a leukemic counterpart of the plasmacytoid dendritic cells. Blood 2001. 97: 3210-3217.
24. + lineage negative (lin-) leukemia/lymphoma: a new entity developed from malignant early plasmacytoid dendritic cells (pDC). Hematologica 2003. 88: 941-955.
25. + malignancies. Blood 2002. 99: 1556-1563.
26. Rissoan, M. C., Duhen, T., Bridon, J. M., Bendriss-Vermare, N., Peronne, C., de Saint Vis, B., Briere, F. and Bates, E. E., Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood 2002. 100: 3295-3303.
27. Briere, F., Bendriss-Vermare, N., Delale, T., Burg, S., Corbet, C., Rissoan, M. C., Chaperot, L., Plumas, J., Jacob, M. C., Trinchieri, G. and Bates, E. E., Origin and filiation of human plasmacytoid dendritic cells. Hum. Immunol. 2002. 63: 1081-1093.
28. Kuwana, M., Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets. Hum. Immunol. 2002. 63: 1156-1163.
29. Gilliet, M. and Liu, Y. J., Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum. Immunol. 2002. 63: 1149-1155.
30. Pitti, R. M., Marsters, S. A., Lawrence, D. A., Roy, M., Kischkel, F. C., Dowd, P., Huang, A., Donahue, C. J., Sherwood, S. W., Baldwin, D. T., Godowski, P. J., Wood, W. I., Gurney, A. L., Hillan, K. J., Cohen, R. L., Goddard, A. D., Botstein, D. and Ashkenazi, A., Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 1998. 396: 699-703.
31. Rivoltini, L., Carrabba, M., Huber, V., Castelli, C., Novellino, L., Dalerba, P., Mortarini, R., Arancia, G., Anichini, A., Fais, S. and Parmiani, G., Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction. Immunol. Rev. 2002. 188: 97-113.
32. Medema, J. P., de Jong, J., van Hall, T., Melief, C. J. and Offringa, R., Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J. Exp. Med. 1999. 190: 1033-1038.
33. Maeurer, M. J., Gollin, S. M., Martin, D., Swaney, W., Bryant, J., Castelli, C., Robbins, P., Parmiani, G., Storkus, W. J. and Lotze, M. T., Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen. J. Clin. Invest. 1996. 98: 1633-1641.
34. +T cell anergy by peripheral blood DC2 precursors. Eur. J. Immunol. 2001. 31: 2547-2557.
35. Kohrgruber, N., Halanek, N., Groger, M., Winter, D., Rappers-berger, K., Schmitt-Egenolf, M., Stingl, G. and Maurer, D., Survival, maturation, and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines. J. Immunol. 1999. 163: 3250-3259.
36. Leroux, D., Mugneret, F., Callanan, M., Radford-Weiss, I., Dastugue, N., Feuillard, J., Le Mee, F., Plessis, G., Talmant, P., Gachard, N., Uettwiller, F., Pages, M. P., Mozziconacci, M. J., Eclache, V., Sibille, C., Avet-Loiseau, H. and Lafage-Pochitaloff, M., CD4(+), CD56(+) DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: a study of 21 cases by the Groupe Francais de Cytogenetique Hematologique. Blood 2002. 99: 4154-4159.