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Volumn 8, Issue , 2014, Pages 28-35

Recent progress in the use of glucagon and glucagon receptor antagonists in the treatment of diabetes mellitus

Author keywords

Diabetes mellitus; Glucagon; Glucagon receptor antagonists; Pancreas

Indexed keywords

5 HYDROXYALKYL 4 PHENYLPYRIDINE; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE; BI 32169; BICYCLIC 19 RESIDUE PEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCAGON RECEPTOR; GLUCAGON RECEPTOR ANTAGONIST; ISOSERINE; MONOCLONAL ANTIBODY; N [3 CANO 6 (1,1 DIMETHYLPROPYL) 4,5,6,7 TETRAHYDRO 1 BENZOTHIEN 2 YL] 2 ETHYLBUTAMIDE; NEUTRALIZING ANTIBODY; NNC 250926; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

EID: 84928989530     PISSN: None     EISSN: 18741045     Source Type: Journal    
DOI: 10.2174/1874104501408010028     Document Type: Article
Times cited : (21)

References (69)
  • 1
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio, L.L.; Drucker, D.J. Biology of incretins: GLP-1 and GIP. Gastroenterol., 2007, 132, 2131-57.
    • (2007) Gastroenterol. , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 4
    • 0033783115 scopus 로고    scopus 로고
    • Distribution of NPY and SP and their effects on glucagon secretion from the in vitro normal and diabetic pancreatic tissues
    • Ponery, A.S.; Adeghate, E. Distribution of NPY and SP and their effects on glucagon secretion from the in vitro normal and diabetic pancreatic tissues. Peptides, 2000, 21(10), 1503-09.
    • (2000) Peptides , vol.21 , Issue.10 , pp. 1503-1509
    • Ponery, A.S.1    Adeghate, E.2
  • 5
    • 55049124487 scopus 로고    scopus 로고
    • Physiology of the pancreatic alpha-cell and glucagon secretion: Role in glucose ho-meostasis and diabetes
    • Quesada, I.; Tuduri, E.; Ripoll, C.; Nadal, A. Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose ho-meostasis and diabetes. J. Endocrinol., 2008, 199, 5-19.
    • (2008) J. Endocrinol. , vol.199 , pp. 5-19
    • Quesada, I.1    Tuduri, E.2    Ripoll, C.3    Nadal, A.4
  • 9
    • 0034524938 scopus 로고    scopus 로고
    • Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
    • Shah, P.; Vella, A.; Basu, A.; Basu, R.; Schwenk, W.F.; Rizza, R.A. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab., 2000, 85, 4053-59.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 4053-4059
    • Shah, P.1    Vella, A.2    Basu, A.3    Basu, R.4    Schwenk, W.F.5    Rizza, R.A.6
  • 10
    • 0018864840 scopus 로고
    • Regulation of hepatic fatty acid oxidation and ketone body production
    • McGarry, J.D.; Foster, D.W. Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem., 1980, 49, 395-20.
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 395-420
    • McGarry, J.D.1    Foster, D.W.2
  • 11
    • 0029120207 scopus 로고
    • Glucagon receptor mRNA distribution in rat tissues
    • Hansen, L.H.; Abrahamsen, N.; Nishimura, E. Glucagon receptor mRNA distribution in rat tissues. Peptides, 1995, 16, 1163-66.
    • (1995) Peptides , vol.16 , pp. 1163-1166
    • Hansen, L.H.1    Abrahamsen, N.2    Nishimura, E.3
  • 12
    • 0029840285 scopus 로고    scopus 로고
    • Molecular and cellular aspects of the glucagon receptor: Role in diabetes and metabolism
    • Burcelin, R.; Katz, E.B.; Charron, M.J. Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism. Diabetes Metab., 1996, 22, 373-96.
    • (1996) Diabetes Metab. , vol.22 , pp. 373-396
    • Burcelin, R.1    Katz, E.B.2    Charron, M.J.3
  • 13
    • 0015500765 scopus 로고
    • The glucagon-sensitive adenylate cyclase system in plasma membranes of rat liver. VII. Hormonal stimulation: Reversibility and dependence on concentration of free hormone
    • Birnbaumer, L.; Pohl, S.L.; Rodbell, M. The glucagon-sensitive adenylate cyclase system in plasma membranes of rat liver. VII. Hormonal stimulation: reversibility and dependence on concentration of free hormone. J. Biol. Chem., 1972, 247, 2038-43.
    • (1972) J. Biol. Chem. , vol.247 , pp. 2038-2043
    • Birnbaumer, L.1    Pohl, S.L.2    Rodbell, M.3
  • 14
    • 0032877316 scopus 로고    scopus 로고
    • Impact of lack of suppression of glucagon on glucose tolerance in humans
    • Shah, P.; Basu, A.; Basu, R.; Rizza, R. Impact of lack of suppression of glucagon on glucose tolerance in humans. Am. J. Physiol. Endocrinol. Metab., 1999, 277, E283-90.
    • (1999) Am. J. Physiol. Endocrinol. Metab. , vol.277 , pp. E283-E290
    • Shah, P.1    Basu, A.2    Basu, R.3    Rizza, R.4
  • 15
  • 17
    • 0033866831 scopus 로고    scopus 로고
    • New approaches in the treatment of type 2 diabetes
    • Zhang, B.B.; Moller, D.E. New approaches in the treatment of type 2 diabetes. Curr. Opin. Chem. Biol., 2000, 4, 461-67.
    • (2000) Curr. Opin. Chem. Biol. , vol.4 , pp. 461-467
    • Zhang, B.B.1    Moller, D.E.2
  • 19
    • 79551600048 scopus 로고    scopus 로고
    • Glu-cagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
    • Lee, Y.; Wang, M-Y.; Du, X.Q.; Charron, M.J.; Unger, R.H. Glu-cagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice. Diabetes, 2011, 60, 391-97.
    • (2011) Diabetes , vol.60 , pp. 391-397
    • Lee, Y.1    Wang, M.-Y.2    Du, X.Q.3    Charron, M.J.4    Unger, R.H.5
  • 22
    • 33750877987 scopus 로고    scopus 로고
    • Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice
    • Sorensen, H.; Brand, C.L.; Neschen, S.; Holst, J.J.; Fosgerau, K.; Nishimura, E.; Shulman, G.I. Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice. Diabetes, 2006, 55, 2843-48.
    • (2006) Diabetes , vol.55 , pp. 2843-2848
    • Sorensen, H.1    Brand, C.L.2    Neschen, S.3    Holst, J.J.4    Fosgerau, K.5    Nishimura, E.6    Shulman, G.I.7
  • 23
    • 84864479943 scopus 로고    scopus 로고
    • Targeting the glucagon receptor family for diabetes and obesity therapy
    • Cho, Y.M.; Merchant, C.E.; Kieffer, T.J. Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacol. Ther., 2012, 135(3), 247-78.
    • (2012) Pharmacol. Ther. , vol.135 , Issue.3 , pp. 247-278
    • Cho, Y.M.1    Merchant, C.E.2    Kieffer, T.J.3
  • 24
    • 0842288445 scopus 로고    scopus 로고
    • Reduction in gluca-gon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice
    • Liang, Y.; Osborne, M.C.; Monia, B.P.; Bhanot, S.; Gaarde, W.A.; Reed, C.; She, P.; Jetton, T.L.; Demarest, K.T. Reduction in gluca-gon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes, 2004, 53, 410-17.
    • (2004) Diabetes , vol.53 , pp. 410-417
    • Liang, Y.1    Osborne, M.C.2    Monia, B.P.3    Bhanot, S.4    Gaarde, W.A.5    Reed, C.6    She, P.7    Jetton, T.L.8    Demarest, K.T.9
  • 26
    • 64749101898 scopus 로고    scopus 로고
    • Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes
    • Ali, S.; Drucker, D.J. Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes. Am. J. Physiol. Endo-crinol. Metab., 2009, 296, E415-21.
    • (2009) Am. J. Physiol. Endo-Crinol. Metab. , vol.296 , pp. E415-E421
    • Ali, S.1    Drucker, D.J.2
  • 27
    • 0028112003 scopus 로고
    • Immunoneutralisation of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats
    • Brand, C.L.; Rolin, B.; Jørgensen, P.N.; Svendsen, I.; Kristensen, J.S.; Holst, J.J. Immunoneutralisation of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats. Diabetologia, 1994, 37, 985-93.
    • (1994) Diabetologia , vol.37 , pp. 985-993
    • Brand, C.L.1    Rolin, B.2    Jørgensen, P.N.3    Svendsen, I.4    Kristensen, J.S.5    Holst, J.J.6
  • 29
    • 0029760864 scopus 로고    scopus 로고
    • Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits
    • Brand, C.L.; Joergensen, P.N.; Svendsen, I.; Holst, J.J. Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits. Diabetes, 1996, 45, 1076-83.
    • (1996) Diabetes , vol.45 , pp. 1076-1083
    • Brand, C.L.1    Joergensen, P.N.2    Svendsen, I.3    Holst, J.J.4
  • 30
    • 0000864505 scopus 로고    scopus 로고
    • Subchronic glucagon neutralisation improves diabetes in ob/ob mice
    • Brand, C.L.; Hansen, B.; Gronemann, S.; Moysen, M.; Holst, J.J. Subchronic glucagon neutralisation improves diabetes in ob/ob mice. Diabetes, 2000, 49(S1), A81.
    • (2000) Diabetes , vol.49 , Issue.1 S , pp. A81
    • Brand, C.L.1    Hansen, B.2    Gronemann, S.3    Moysen, M.4    Holst, J.J.5
  • 34
    • 0033177983 scopus 로고    scopus 로고
    • Generation of mice expressing the human glucagon receptor with a direct replacement vector
    • Shiao, L.L.; Cascieri, M.A.; Trumbauer, M.; Chen, H.; Sullivan, K.A. Generation of mice expressing the human glucagon receptor with a direct replacement vector. Transgenic Res., 1999, 8, 295-02.
    • (1999) Transgenic Res. , vol.8 , pp. 295-302
    • Shiao, L.L.1    Cascieri, M.A.2    Trumbauer, M.3    Chen, H.4    Sullivan, K.A.5
  • 36
    • 0019958804 scopus 로고
    • Structure-conformation-activity studies of glucagon and semi-synthetic glucagon analogs
    • Hruby, V.J. Structure-conformation-activity studies of glucagon and semi-synthetic glucagon analogs. Mol. Cell Biochem., 1982, 44, 49-64.
    • (1982) Mol. Cell Biochem. , vol.44 , pp. 49-64
    • Hruby, V.J.1
  • 37
    • 0027417418 scopus 로고
    • New glucagon analogues with conformational restrictions and altered amphiphilic-ity: Effects on binding, adenylate cyclase and glycogenolytic activities
    • Hruby, V.J.; Gysin, B.; Trivedi, D.; Johnson, D.G. New glucagon analogues with conformational restrictions and altered amphiphilic-ity: effects on binding, adenylate cyclase and glycogenolytic activities. Life Sci., 1993, 52, 845-55.
    • (1993) Life Sci. , vol.52 , pp. 845-855
    • Hruby, V.J.1    Gysin, B.2    Trivedi, D.3    Johnson, D.G.4
  • 39
    • 0020471569 scopus 로고
    • Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist
    • Johnson, D.G.; Goebel, C.U.; Hruby, V.J.; Bregman, M.D.; Trivedi, D. Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist. Science, 1982, 215, 1115-6.
    • (1982) Science , vol.215 , pp. 1115-1116
    • Johnson, D.G.1    Goebel, C.U.2    Hruby, V.J.3    Bregman, M.D.4    Trivedi, D.5
  • 40
    • 0024842752 scopus 로고
    • Biological activities of des His1[Glu9]glucagon amide, a glucagon antagonist
    • Unson, C.G.; Gurzenda, E.M.; Merrifield, R.B. Biological activities of des His1[Glu9]glucagon amide, a glucagon antagonist. Peptides, 1989, 10, 1171-7.
    • (1989) Peptides , vol.10 , pp. 1171-1177
    • Unson, C.G.1    Gurzenda, E.M.2    Merrifield, R.B.3
  • 41
    • 0034909040 scopus 로고    scopus 로고
    • Development of potent glucagon antagonists: Structure-activity relationship study of glycine at position 4
    • Ahn, J.M.; Medeiros, M.; Trivedi, D.; Hruby, V.J. Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4. J. Pept. Res., 2001, 58(2), 151-8.
    • (2001) J. Pept. Res. , vol.58 , Issue.2 , pp. 151-158
    • Ahn, J.M.1    Medeiros, M.2    Trivedi, D.3    Hruby, V.J.4
  • 42
    • 4644250057 scopus 로고    scopus 로고
    • BI-32169, a Bicyclic 19-Peptide with Strong Glucagon Receptor Antagonist Activity from Streptomyces sp
    • Potterat, O.; Wagner, K.; Gemmecker, G.; Mack, J.; Puder, C.; Vettermann, R.; Streicher, R. BI-32169, a Bicyclic 19-Peptide with Strong Glucagon Receptor Antagonist Activity from Streptomyces sp. J. Nat. Prod., 2004, 67(9), 1528-31.
    • (2004) J. Nat. Prod. , vol.67 , Issue.9 , pp. 1528-1531
    • Potterat, O.1    Wagner, K.2    Gemmecker, G.3    Mack, J.4    Puder, C.5    Vettermann, R.6    Streicher, R.7
  • 43
    • 77649270287 scopus 로고    scopus 로고
    • The glucagon receptor antagonist BI-32169 constitutes a new class of lasso pep-tides
    • Knappe, T.A.; Linne, U.; Xie, X.; Marahiel, M.A. The glucagon receptor antagonist BI-32169 constitutes a new class of lasso pep-tides. FEBS Lett., 2010, 584, 785-9.
    • (2010) FEBS Lett. , vol.584 , pp. 785-789
    • Knappe, T.A.1    Linne, U.2    Xie, X.3    Marahiel, M.A.4
  • 44
    • 33749479524 scopus 로고    scopus 로고
    • Glucagon-mediated internalization of serine-phosphorylated gluca-gon receptor and Gsa in rat liver
    • Merlen, C.; Fabrega, S.; Desbuquois, B.; Unson, C.G.; Authier, F. Glucagon-mediated internalization of serine-phosphorylated gluca-gon receptor and Gsa in rat liver. FEBS Lett., 2006, 580, 5697-04.
    • (2006) FEBS Lett. , vol.580 , pp. 5697-5704
    • Merlen, C.1    Fabrega, S.2    Desbuquois, B.3    Unson, C.G.4    Authier, F.5
  • 45
    • 0029891226 scopus 로고    scopus 로고
    • Low level cyclic adenosine 3', 5'-monophosphate accumulation analysis of [des-His1, des-Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists
    • Van Tine, B.A.; Azizeh, B.Y.; Trivedi, D.; Phelps, J.R.; Houslay, M.D.; Johnson, D.G.; Hruby, V.J. Low level cyclic adenosine 3', 5'-monophosphate accumulation analysis of [des-His1, des-Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists. Endocrinol., 1996, 137, 3316-22.
    • (1996) Endocrinol. , vol.137 , pp. 3316-3322
    • Van Tine, B.A.1    Azizeh, B.Y.2    Trivedi, D.3    Phelps, J.R.4    Houslay, M.D.5    Johnson, D.G.6    Hruby, V.J.7
  • 48
    • 0035195977 scopus 로고    scopus 로고
    • Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
    • Petersen, K.F.; Sullivan, J.T. Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia, 2001, 44, 2018-24.
    • (2001) Diabetologia , vol.44 , pp. 2018-2024
    • Petersen, K.F.1    Sullivan, J.T.2
  • 58
    • 79959739474 scopus 로고    scopus 로고
    • The impact of epigenomics on future drug design and new therapies
    • Hamm, C.A.; Costa, F.F. The impact of epigenomics on future drug design and new therapies. Drug Discov Today, 2011, 16(13), 626-35.
    • (2011) Drug Discov Today , vol.16 , Issue.13 , pp. 626-635
    • Hamm, C.A.1    Costa, F.F.2
  • 60
    • 79952111963 scopus 로고    scopus 로고
    • Nucleosome dynamics and histone variants
    • Ray-Gallet, D.; Almouzni, G. Nucleosome dynamics and histone variants. Essays Biochem., 2010, 48, 75-87.
    • (2010) Essays Biochem. , vol.48 , pp. 75-87
    • Ray-Gallet, D.1    Almouzni, G.2
  • 61
    • 40649111338 scopus 로고    scopus 로고
    • Non-coding RNAs, epigenetics and complexity
    • Costa, F.F. Non-coding RNAs, epigenetics and complexity. Gene, 2008, 410, 9-17.
    • (2008) Gene , vol.410 , pp. 9-17
    • Costa, F.F.1
  • 62
    • 67650462249 scopus 로고    scopus 로고
    • DNA hypomethylation in the origin and pathogenesis of human diseases
    • Pogribny, I.P.; Beland, F.A. DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol. Life Sci., 2009, 66, 2249-61.
    • (2009) Cell Mol. Life Sci. , vol.66 , pp. 2249-2261
    • Pogribny, I.P.1    Beland, F.A.2
  • 63
    • 1842855402 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
    • Wang, Q.; Li, L.; Xu, E.; Wong, V.; Rhodes, C; Brubaker, P.L. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Dia-betologia, 2004, 47(3), 478-87.
    • (2004) Dia-Betologia , vol.47 , Issue.3 , pp. 478-487
    • Wang, Q.1    Li, L.2    Xu, E.3    Wong, V.4    Rhodes, C.5    Brubaker, P.L.6
  • 64
    • 77950624912 scopus 로고    scopus 로고
    • Epigenetic mechanisms in the development of type 2 diabetes
    • Pinney, S.E.; Simmons, R.A. Epigenetic mechanisms in the development of type 2 diabetes. Trends Endocrinol. Metab., 2010, 21, 223-9.
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 223-229
    • Pinney, S.E.1    Simmons, R.A.2
  • 65
    • 64649092274 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor y activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of eu-chromatin structure
    • Evans-Molina, C; Robbins, R.D.; Kono, T.; Tersey, S.A.; Vester-mark, G.L.; Nunemaker, C.S.; Garmey J.C.; Deering T.G.; Keller S.R.; Maier B.; Mirmira, R.G. Peroxisome proliferator-activated receptor y activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of eu-chromatin structure. Mol. Cell Biol, 2009, 29(8), 2053-67.
    • (2009) Mol. Cell Biol , vol.29 , Issue.8 , pp. 2053-2067
    • Evans-Molina, C.1    Robbins, R.D.2    Kono, T.3    Tersey, S.A.4    Vester-Mark, G.L.5    Nunemaker, C.S.6    Garmey, J.C.7    Deering, T.G.8    Keller, S.R.9    Maier, B.10    Mirmira, R.G.11
  • 67
    • 84860786148 scopus 로고    scopus 로고
    • (2012). Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH
    • Soupart, A.; Coffernils, M.; Couturier, B.; Gankam-Kengne, F.; Decaux, G. (2012). Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH. Clin. J. Am. Soc. Nephrol, 2012, 7(5), 742-7.
    • (2012) Clin. J. Am. Soc. Nephrol , vol.7 , Issue.5 , pp. 742-747
    • Soupart, A.1    Coffernils, M.2    Couturier, B.3    Gankam-Kengne, F.4    Decaux, G.5
  • 69
    • 0021340276 scopus 로고
    • Comparative study on cytotoxicities and biochemical properties of an-thraquinone mycotoxins emodin and skyrin from Penicillium is-landicum Sopp
    • Kawai, K.; Kato, T.; Mori, H.; Kitamura, J.; Nozawa, Y. A comparative study on cytotoxicities and biochemical properties of an-thraquinone mycotoxins emodin and skyrin from Penicillium is-landicum Sopp. Toxicol. Lett, 1984, 20(2),155-60.
    • (1984) Toxicol. Lett , vol.20 , Issue.2 , pp. 155-160
    • Kawai, K.1    Kato, T.2    Mori, H.3    Kitamura, J.4    Nozawa, Y.A.5


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