-
1
-
-
34248223285
-
Biology of incretins: GLP-1 and GIP
-
Baggio, L.L.; Drucker, D.J. Biology of incretins: GLP-1 and GIP. Gastroenterol., 2007, 132, 2131-57.
-
(2007)
Gastroenterol.
, vol.132
, pp. 2131-2157
-
-
Baggio, L.L.1
Drucker, D.J.2
-
2
-
-
13944284105
-
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor
-
Duffy, J.L.; Kirk, B.A.; Konteatis, Z.; Campbell, E.L.; Liang, R.; Brady, E.J.; Candelore, M.R.; Ding, V.D.; Jiang, G.; Liu, F.; Qure-shi, S.A.; Saperstein, R.; Szalkowski, D; Tong, S.; Tota, L.M.; Xie, D; Yang, X.; Zafian, P.; Zheng, S.; Chapman, K.T.; Zhang, B.B.; Tata, J.R. Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor. Bioorg. Med. Chem. Lett., 2005, 15, 1401-05.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 1401-1405
-
-
Duffy, J.L.1
Kirk, B.A.2
Konteatis, Z.3
Campbell, E.L.4
Liang, R.5
Brady, E.J.6
Candelore, M.R.7
Ding, V.D.8
Jiang, G.9
Liu, F.10
Qure-Shi, S.A.11
Saperstein, R.12
Szalkowski, D.13
Tong, S.14
Tota, L.M.15
Xie, D.16
Yang, X.17
Zafian, P.18
Zheng, S.19
Chapman, K.T.20
Zhang, B.B.21
Tata, J.R.22
more..
-
3
-
-
34447619696
-
Decreases the hyperglucagonemia of diabetic rats
-
Al-Shamsi, M.; Amin, A.; Adeghate, E. Vitamin E decreases the hyperglucagonemia of diabetic rats. Ann. NY Acad. Sci., 2006, 1084, 432-41.
-
(2006)
Ann. NY Acad. Sci.
, vol.1084
, pp. 432-441
-
-
Al-Shamsi, M.1
Amin, A.2
Adeghate, E.3
Vitamin, E.4
-
4
-
-
0033783115
-
Distribution of NPY and SP and their effects on glucagon secretion from the in vitro normal and diabetic pancreatic tissues
-
Ponery, A.S.; Adeghate, E. Distribution of NPY and SP and their effects on glucagon secretion from the in vitro normal and diabetic pancreatic tissues. Peptides, 2000, 21(10), 1503-09.
-
(2000)
Peptides
, vol.21
, Issue.10
, pp. 1503-1509
-
-
Ponery, A.S.1
Adeghate, E.2
-
5
-
-
55049124487
-
Physiology of the pancreatic alpha-cell and glucagon secretion: Role in glucose ho-meostasis and diabetes
-
Quesada, I.; Tuduri, E.; Ripoll, C.; Nadal, A. Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose ho-meostasis and diabetes. J. Endocrinol., 2008, 199, 5-19.
-
(2008)
J. Endocrinol.
, vol.199
, pp. 5-19
-
-
Quesada, I.1
Tuduri, E.2
Ripoll, C.3
Nadal, A.4
-
6
-
-
33645051453
-
Intra-islet insulin suppresses glucagon release via GABA-GABA(A) receptor system
-
Xu, E.; Kumar, M.; Zhang, Y.; Ju, W.; Obata, T.; Zhang, N.; Liu, S.; Wendt, A.; Deng, S.; Ebina, Y.; Wheeler, M.B.; Braun, M.; Wang, Q. Intra-islet insulin suppresses glucagon release via GABA-GABA(A) receptor system. Cell Metab. 2006, 3, 47-8.
-
(2006)
Cell Metab
, vol.3
, pp. 47-48
-
-
Xu, E.1
Kumar, M.2
Zhang, Y.3
Ju, W.4
Obata, T.5
Zhang, N.6
Liu, S.7
Wendt, A.8
Deng, S.9
Ebina, Y.10
Wheeler, M.B.11
Braun, M.12
Wang, Q.13
-
7
-
-
0036729484
-
Seven transmembrane receptors. Nat
-
Pierce, K.L.; Premont, R.T.; Lefkowitz, R.J. Seven transmembrane receptors. Nat. Rev. Mol. Cell Biol., 2002, 3, 639-50.
-
(2002)
Rev. Mol. Cell Biol.
, vol.3
, pp. 639-650
-
-
Pierce, K.L.1
Premont, R.T.2
Lefkowitz, R.J.3
-
8
-
-
0028219003
-
The human glucagon receptor-encoding gene: Structure, cDNA sequence and chromosomal localization
-
Lok, S.; Kuijper, J.L.; Jelinek, L.J.; Kramer, J.M.; Whitmore, T.E.; Sprecher, C.A.; Mathewes, S.; Grant, F.J.; Biggs, S.H.; Rosenberg, G.B. The human glucagon receptor-encoding gene: structure, cDNA sequence and chromosomal localization. Gene, 1994, 140(2), 203-09.
-
(1994)
Gene
, vol.140
, Issue.2
, pp. 203-209
-
-
Lok, S.1
Kuijper, J.L.2
Jelinek, L.J.3
Kramer, J.M.4
Whitmore, T.E.5
Sprecher, C.A.6
Mathewes, S.7
Grant, F.J.8
Biggs, S.H.9
Rosenberg, G.B.10
-
9
-
-
0034524938
-
Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
-
Shah, P.; Vella, A.; Basu, A.; Basu, R.; Schwenk, W.F.; Rizza, R.A. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab., 2000, 85, 4053-59.
-
(2000)
J. Clin. Endocrinol. Metab.
, vol.85
, pp. 4053-4059
-
-
Shah, P.1
Vella, A.2
Basu, A.3
Basu, R.4
Schwenk, W.F.5
Rizza, R.A.6
-
10
-
-
0018864840
-
Regulation of hepatic fatty acid oxidation and ketone body production
-
McGarry, J.D.; Foster, D.W. Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem., 1980, 49, 395-20.
-
(1980)
Annu. Rev. Biochem.
, vol.49
, pp. 395-420
-
-
McGarry, J.D.1
Foster, D.W.2
-
11
-
-
0029120207
-
Glucagon receptor mRNA distribution in rat tissues
-
Hansen, L.H.; Abrahamsen, N.; Nishimura, E. Glucagon receptor mRNA distribution in rat tissues. Peptides, 1995, 16, 1163-66.
-
(1995)
Peptides
, vol.16
, pp. 1163-1166
-
-
Hansen, L.H.1
Abrahamsen, N.2
Nishimura, E.3
-
12
-
-
0029840285
-
Molecular and cellular aspects of the glucagon receptor: Role in diabetes and metabolism
-
Burcelin, R.; Katz, E.B.; Charron, M.J. Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism. Diabetes Metab., 1996, 22, 373-96.
-
(1996)
Diabetes Metab.
, vol.22
, pp. 373-396
-
-
Burcelin, R.1
Katz, E.B.2
Charron, M.J.3
-
13
-
-
0015500765
-
The glucagon-sensitive adenylate cyclase system in plasma membranes of rat liver. VII. Hormonal stimulation: Reversibility and dependence on concentration of free hormone
-
Birnbaumer, L.; Pohl, S.L.; Rodbell, M. The glucagon-sensitive adenylate cyclase system in plasma membranes of rat liver. VII. Hormonal stimulation: reversibility and dependence on concentration of free hormone. J. Biol. Chem., 1972, 247, 2038-43.
-
(1972)
J. Biol. Chem.
, vol.247
, pp. 2038-2043
-
-
Birnbaumer, L.1
Pohl, S.L.2
Rodbell, M.3
-
14
-
-
0032877316
-
Impact of lack of suppression of glucagon on glucose tolerance in humans
-
Shah, P.; Basu, A.; Basu, R.; Rizza, R. Impact of lack of suppression of glucagon on glucose tolerance in humans. Am. J. Physiol. Endocrinol. Metab., 1999, 277, E283-90.
-
(1999)
Am. J. Physiol. Endocrinol. Metab.
, vol.277
, pp. E283-E290
-
-
Shah, P.1
Basu, A.2
Basu, R.3
Rizza, R.4
-
16
-
-
0037417984
-
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice
-
Gelling, R.W.; Du, X.Q.; Dichmann, D.S.; Romer, J.; Huang, H.; Cui, L.; Obici, S.; Tang, B.; Holst, J.J.; Fledelius, C.; Johansen, P.B.; Rossetti, L.; Jelicks, L.A.; Serup, P.; Nishimura, E.; Charron, M.J. Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc. Natl. Acad. Sci. USA, 2003, 100, 1438-43.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1438-1443
-
-
Gelling, R.W.1
Du, X.Q.2
Dichmann, D.S.3
Romer, J.4
Huang, H.5
Cui, L.6
Obici, S.7
Tang, B.8
Holst, J.J.9
Fledelius, C.10
Johansen, P.B.11
Rossetti, L.12
Jelicks, L.A.13
Serup, P.14
Nishimura, E.15
Charron, M.J.16
-
17
-
-
0033866831
-
New approaches in the treatment of type 2 diabetes
-
Zhang, B.B.; Moller, D.E. New approaches in the treatment of type 2 diabetes. Curr. Opin. Chem. Biol., 2000, 4, 461-67.
-
(2000)
Curr. Opin. Chem. Biol.
, vol.4
, pp. 461-467
-
-
Zhang, B.B.1
Moller, D.E.2
-
18
-
-
33845919110
-
Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia
-
Conarello, S.L.; Jiang, G.; Mu, J.; Li, Z.; Woods, J.; Zycband, E.; Ronan, J.; Liu, F.; Roy, R.S.; Zhu, L.; Charron, M.J.; Zhang, B.B. Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Diabetologia, 2007, 50, 142-50.
-
(2007)
Diabetologia
, vol.50
, pp. 142-150
-
-
Conarello, S.L.1
Jiang, G.2
Mu, J.3
Li, Z.4
Woods, J.5
Zycband, E.6
Ronan, J.7
Liu, F.8
Roy, R.S.9
Zhu, L.10
Charron, M.J.11
Zhang, B.B.12
-
19
-
-
79551600048
-
Glu-cagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
-
Lee, Y.; Wang, M-Y.; Du, X.Q.; Charron, M.J.; Unger, R.H. Glu-cagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice. Diabetes, 2011, 60, 391-97.
-
(2011)
Diabetes
, vol.60
, pp. 391-397
-
-
Lee, Y.1
Wang, M.-Y.2
Du, X.Q.3
Charron, M.J.4
Unger, R.H.5
-
20
-
-
0036296165
-
Glycemic control in mice with targeted disruption of the glu-cagon receptor gene
-
Parker, J.C.; Andrews, K.M.; Allen, M.R.; Stock, J.L.; Mc-Neish, J.D. Glycemic control in mice with targeted disruption of the glu-cagon receptor gene. Biochem. Biophys. Res. Commun., 2002, 290, 839-43.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.290
, pp. 839-843
-
-
Parker, J.C.1
Andrews, K.M.2
Allen, M.R.3
Stock, J.L.4
Mc-Neish, J.D.5
-
21
-
-
54849431792
-
The Glucagon receptor is required for the adaptive metabolic response to fasting
-
Longuet, C.; Sinclair, E.M.; Maida, A.; Baggio, L.L.; Maziarz, M.; Charron, M.J.; Drucker, D.J. The Glucagon receptor is required for the adaptive metabolic response to fasting. Cell Metab., 2008, 8, 359-71.
-
(2008)
Cell Metab.
, vol.8
, pp. 359-371
-
-
Longuet, C.1
Sinclair, E.M.2
Maida, A.3
Baggio, L.L.4
Maziarz, M.5
Charron, M.J.6
Drucker, D.J.7
-
22
-
-
33750877987
-
Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice
-
Sorensen, H.; Brand, C.L.; Neschen, S.; Holst, J.J.; Fosgerau, K.; Nishimura, E.; Shulman, G.I. Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice. Diabetes, 2006, 55, 2843-48.
-
(2006)
Diabetes
, vol.55
, pp. 2843-2848
-
-
Sorensen, H.1
Brand, C.L.2
Neschen, S.3
Holst, J.J.4
Fosgerau, K.5
Nishimura, E.6
Shulman, G.I.7
-
23
-
-
84864479943
-
Targeting the glucagon receptor family for diabetes and obesity therapy
-
Cho, Y.M.; Merchant, C.E.; Kieffer, T.J. Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacol. Ther., 2012, 135(3), 247-78.
-
(2012)
Pharmacol. Ther.
, vol.135
, Issue.3
, pp. 247-278
-
-
Cho, Y.M.1
Merchant, C.E.2
Kieffer, T.J.3
-
24
-
-
0842288445
-
Reduction in gluca-gon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice
-
Liang, Y.; Osborne, M.C.; Monia, B.P.; Bhanot, S.; Gaarde, W.A.; Reed, C.; She, P.; Jetton, T.L.; Demarest, K.T. Reduction in gluca-gon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes, 2004, 53, 410-17.
-
(2004)
Diabetes
, vol.53
, pp. 410-417
-
-
Liang, Y.1
Osborne, M.C.2
Monia, B.P.3
Bhanot, S.4
Gaarde, W.A.5
Reed, C.6
She, P.7
Jetton, T.L.8
Demarest, K.T.9
-
25
-
-
85047693695
-
Hepatic and glucagonlike peptide-1-mediated reversal of diabetes by glucagon receptor antisense oli-gonucleotide inhibitors
-
Sloop, K.W.; Cao, J.X.; Siesky, A.M.; Zhang, H.Y.; Bodenmiller, D.M.; Cox, A.L.; Jacobs, S.J.; Moyers, J.S.; Owens, R.A.; Showal-ter, A.D.; Brenner, M.B.; Raap, A.; Gromada, J.; Berridge, B.R.; Monteith, D.K.; Porksen, N.; McKay, R.A.; Monia, B.P.; Bhanot, S.; Watts, L.M.; Michael, M.D. Hepatic and glucagonlike peptide-1-mediated reversal of diabetes by glucagon receptor antisense oli-gonucleotide inhibitors. J. Clin. Invest., 2004, 113, 1571-81.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1571-1581
-
-
Sloop, K.W.1
Cao, J.X.2
Siesky, A.M.3
Zhang, H.Y.4
Bodenmiller, D.M.5
Cox, A.L.6
Jacobs, S.J.7
Moyers, J.S.8
Owens, R.A.9
Showal-Ter, A.D.10
Brenner, M.B.11
Raap, A.12
Gromada, J.13
Berridge, B.R.14
Monteith, D.K.15
Porksen, N.16
McKay, R.A.17
Monia, B.P.18
Bhanot, S.19
Watts, L.M.20
Michael, M.D.21
more..
-
26
-
-
64749101898
-
Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes
-
Ali, S.; Drucker, D.J. Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes. Am. J. Physiol. Endo-crinol. Metab., 2009, 296, E415-21.
-
(2009)
Am. J. Physiol. Endo-Crinol. Metab.
, vol.296
, pp. E415-E421
-
-
Ali, S.1
Drucker, D.J.2
-
27
-
-
0028112003
-
Immunoneutralisation of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats
-
Brand, C.L.; Rolin, B.; Jørgensen, P.N.; Svendsen, I.; Kristensen, J.S.; Holst, J.J. Immunoneutralisation of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats. Diabetologia, 1994, 37, 985-93.
-
(1994)
Diabetologia
, vol.37
, pp. 985-993
-
-
Brand, C.L.1
Rolin, B.2
Jørgensen, P.N.3
Svendsen, I.4
Kristensen, J.S.5
Holst, J.J.6
-
28
-
-
0028869619
-
Role of glucagon in maintanence of euglycemia in fed and fasted rats
-
Brand, C.L.; Jørgensen, P.N.; Knigge, U.; Warberg, J.; Svendsen, I.; Kristensen, J.S.; Holst, J.J. Role of glucagon in maintanence of euglycemia in fed and fasted rats. Am. J. Physiol., 1995, 32, E469-77.
-
(1995)
Am. J. Physiol.
, vol.32
, pp. E469-E477
-
-
Brand, C.L.1
Jørgensen, P.N.2
Knigge, U.3
Warberg, J.4
Svendsen, I.5
Kristensen, J.S.6
Holst, J.J.7
-
29
-
-
0029760864
-
Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits
-
Brand, C.L.; Joergensen, P.N.; Svendsen, I.; Holst, J.J. Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits. Diabetes, 1996, 45, 1076-83.
-
(1996)
Diabetes
, vol.45
, pp. 1076-1083
-
-
Brand, C.L.1
Joergensen, P.N.2
Svendsen, I.3
Holst, J.J.4
-
30
-
-
0000864505
-
Subchronic glucagon neutralisation improves diabetes in ob/ob mice
-
Brand, C.L.; Hansen, B.; Gronemann, S.; Moysen, M.; Holst, J.J. Subchronic glucagon neutralisation improves diabetes in ob/ob mice. Diabetes, 2000, 49(S1), A81.
-
(2000)
Diabetes
, vol.49
, Issue.1 S
, pp. A81
-
-
Brand, C.L.1
Hansen, B.2
Gronemann, S.3
Moysen, M.4
Holst, J.J.5
-
31
-
-
0035855876
-
Identification of alky-lidene hydrazides as glucagon receptor antagonists
-
Ling, A.; Hong, Y.; Gonzalez, J.; Gregor, V.; Polinsky, A.; Kuki, A.; Shi, S.; Teston, K.; Murphy, D.; Porter, J.; Kiel, D.; Lakis, J.; Anderes, K.; May, J.; Knudsen, L.B.; Lau, J. Identification of alky-lidene hydrazides as glucagon receptor antagonists. J. Med. Chem., 2001, 44, 3141-49.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 3141-3149
-
-
Ling, A.1
Hong, Y.2
Gonzalez, J.3
Gregor, V.4
Polinsky, A.5
Kuki, A.6
Shi, S.7
Teston, K.8
Murphy, D.9
Porter, J.10
Kiel, D.11
Lakis, J.12
Anderes, K.13
May, J.14
Knudsen, L.B.15
Lau, J.16
-
32
-
-
18244375583
-
Human glucagon receptor antagonists based on alkylidene hydrazides
-
Ling, A.; Plewe, M.; Gonzalez, J.; Madsen, P.; Sams, C.K.; Lau, J.; Gregor, V.; Murphy, D.; Teston, K.; Kuki, A.; Shi, S.; Truesdale, L.; Kiel, D.; May, J.; Lakis, J.; Anderes, K.; Iatsimirskaia, E.; Sidelmann, U.G.; Knudsen, L.B.; Brand, C.L.; Polinsky, A. Human glucagon receptor antagonists based on alkylidene hydrazides. Bioorg. Med. Chem., 2002, 12, 663-66.
-
(2002)
Bioorg. Med. Chem.
, vol.12
, pp. 663-666
-
-
Ling, A.1
Plewe, M.2
Gonzalez, J.3
Madsen, P.4
Sams, C.K.5
Lau, J.6
Gregor, V.7
Murphy, D.8
Teston, K.9
Kuki, A.10
Shi, S.11
Truesdale, L.12
Kiel, D.13
May, J.14
Lakis, J.15
Anderes, K.16
Iatsimirskaia, E.17
Sidelmann, U.G.18
Knudsen, L.B.19
Brand, C.L.20
Polinsky, A.21
more..
-
33
-
-
0033605578
-
Characterization of a novel, nonpeptidyl antagonist of the human glucagon receptor
-
Cascieri, M.A.; Koch, G.E.; Ber, E.; Sadowski, S.J.; Louizides, D.; de Laszlo, S.E.; Hacker, C.; Hagmann, W.K.; MacCoss, M.; Chic-chi, G.G.; Vicario, P.P. Characterization of a novel, nonpeptidyl antagonist of the human glucagon receptor. J. Biol. Chem., 1999, 274, 8694-97.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8694-8697
-
-
Cascieri, M.A.1
Koch, G.E.2
Ber, E.3
Sadowski, S.J.4
Louizides, D.5
De Laszlo, S.E.6
Hacker, C.7
Hagmann, W.K.8
Maccoss, M.9
Chic-Chi, G.G.10
Vicario, P.P.11
-
34
-
-
0033177983
-
Generation of mice expressing the human glucagon receptor with a direct replacement vector
-
Shiao, L.L.; Cascieri, M.A.; Trumbauer, M.; Chen, H.; Sullivan, K.A. Generation of mice expressing the human glucagon receptor with a direct replacement vector. Transgenic Res., 1999, 8, 295-02.
-
(1999)
Transgenic Res.
, vol.8
, pp. 295-302
-
-
Shiao, L.L.1
Cascieri, M.A.2
Trumbauer, M.3
Chen, H.4
Sullivan, K.A.5
-
35
-
-
0027241458
-
Synthetic linear and cyclic glucagon antagonists
-
Dharanipragada, R.; Trivedi, D.; Bannister, A.; Siegel, M.; Tourwe, D.; Mollova, N.; Schram, K.; Hruby, V.J. Synthetic linear and cyclic glucagon antagonists. Int. J. Pept. Protein Res., 1993, 42, 68-7.
-
(1993)
Int. J. Pept. Protein Res.
, vol.42
, pp. 68-77
-
-
Dharanipragada, R.1
Trivedi, D.2
Bannister, A.3
Siegel, M.4
Tourwe, D.5
Mollova, N.6
Schram, K.7
Hruby, V.J.8
-
36
-
-
0019958804
-
Structure-conformation-activity studies of glucagon and semi-synthetic glucagon analogs
-
Hruby, V.J. Structure-conformation-activity studies of glucagon and semi-synthetic glucagon analogs. Mol. Cell Biochem., 1982, 44, 49-64.
-
(1982)
Mol. Cell Biochem.
, vol.44
, pp. 49-64
-
-
Hruby, V.J.1
-
37
-
-
0027417418
-
New glucagon analogues with conformational restrictions and altered amphiphilic-ity: Effects on binding, adenylate cyclase and glycogenolytic activities
-
Hruby, V.J.; Gysin, B.; Trivedi, D.; Johnson, D.G. New glucagon analogues with conformational restrictions and altered amphiphilic-ity: effects on binding, adenylate cyclase and glycogenolytic activities. Life Sci., 1993, 52, 845-55.
-
(1993)
Life Sci.
, vol.52
, pp. 845-855
-
-
Hruby, V.J.1
Gysin, B.2
Trivedi, D.3
Johnson, D.G.4
-
38
-
-
4644301168
-
Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists
-
Dallas-Yang, Q.; Shen, X.; Strowski, M.; Brady, E.; Saperstein, R.; Gibson, R.E.; Szalkowski, D.; Qureshi, S.A.; Candelore, M.R.; Fenyk-Melody, J.E.; Parmee, E.R.; Zhang, B.B.; Jiang, G. Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists. Eur. J. Pharmacol., 2004, 501, 225-34.
-
(2004)
Eur. J. Pharmacol.
, vol.501
, pp. 225-234
-
-
Dallas-Yang, Q.1
Shen, X.2
Strowski, M.3
Brady, E.4
Saperstein, R.5
Gibson, R.E.6
Szalkowski, D.7
Qureshi, S.A.8
Candelore, M.R.9
Fenyk-Melody, J.E.10
Parmee, E.R.11
Zhang, B.B.12
Jiang, G.13
-
39
-
-
0020471569
-
Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist
-
Johnson, D.G.; Goebel, C.U.; Hruby, V.J.; Bregman, M.D.; Trivedi, D. Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist. Science, 1982, 215, 1115-6.
-
(1982)
Science
, vol.215
, pp. 1115-1116
-
-
Johnson, D.G.1
Goebel, C.U.2
Hruby, V.J.3
Bregman, M.D.4
Trivedi, D.5
-
40
-
-
0024842752
-
Biological activities of des His1[Glu9]glucagon amide, a glucagon antagonist
-
Unson, C.G.; Gurzenda, E.M.; Merrifield, R.B. Biological activities of des His1[Glu9]glucagon amide, a glucagon antagonist. Peptides, 1989, 10, 1171-7.
-
(1989)
Peptides
, vol.10
, pp. 1171-1177
-
-
Unson, C.G.1
Gurzenda, E.M.2
Merrifield, R.B.3
-
41
-
-
0034909040
-
Development of potent glucagon antagonists: Structure-activity relationship study of glycine at position 4
-
Ahn, J.M.; Medeiros, M.; Trivedi, D.; Hruby, V.J. Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4. J. Pept. Res., 2001, 58(2), 151-8.
-
(2001)
J. Pept. Res.
, vol.58
, Issue.2
, pp. 151-158
-
-
Ahn, J.M.1
Medeiros, M.2
Trivedi, D.3
Hruby, V.J.4
-
42
-
-
4644250057
-
BI-32169, a Bicyclic 19-Peptide with Strong Glucagon Receptor Antagonist Activity from Streptomyces sp
-
Potterat, O.; Wagner, K.; Gemmecker, G.; Mack, J.; Puder, C.; Vettermann, R.; Streicher, R. BI-32169, a Bicyclic 19-Peptide with Strong Glucagon Receptor Antagonist Activity from Streptomyces sp. J. Nat. Prod., 2004, 67(9), 1528-31.
-
(2004)
J. Nat. Prod.
, vol.67
, Issue.9
, pp. 1528-1531
-
-
Potterat, O.1
Wagner, K.2
Gemmecker, G.3
Mack, J.4
Puder, C.5
Vettermann, R.6
Streicher, R.7
-
43
-
-
77649270287
-
The glucagon receptor antagonist BI-32169 constitutes a new class of lasso pep-tides
-
Knappe, T.A.; Linne, U.; Xie, X.; Marahiel, M.A. The glucagon receptor antagonist BI-32169 constitutes a new class of lasso pep-tides. FEBS Lett., 2010, 584, 785-9.
-
(2010)
FEBS Lett.
, vol.584
, pp. 785-789
-
-
Knappe, T.A.1
Linne, U.2
Xie, X.3
Marahiel, M.A.4
-
44
-
-
33749479524
-
Glucagon-mediated internalization of serine-phosphorylated gluca-gon receptor and Gsa in rat liver
-
Merlen, C.; Fabrega, S.; Desbuquois, B.; Unson, C.G.; Authier, F. Glucagon-mediated internalization of serine-phosphorylated gluca-gon receptor and Gsa in rat liver. FEBS Lett., 2006, 580, 5697-04.
-
(2006)
FEBS Lett.
, vol.580
, pp. 5697-5704
-
-
Merlen, C.1
Fabrega, S.2
Desbuquois, B.3
Unson, C.G.4
Authier, F.5
-
45
-
-
0029891226
-
Low level cyclic adenosine 3', 5'-monophosphate accumulation analysis of [des-His1, des-Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists
-
Van Tine, B.A.; Azizeh, B.Y.; Trivedi, D.; Phelps, J.R.; Houslay, M.D.; Johnson, D.G.; Hruby, V.J. Low level cyclic adenosine 3', 5'-monophosphate accumulation analysis of [des-His1, des-Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists. Endocrinol., 1996, 137, 3316-22.
-
(1996)
Endocrinol.
, vol.137
, pp. 3316-3322
-
-
Van Tine, B.A.1
Azizeh, B.Y.2
Trivedi, D.3
Phelps, J.R.4
Houslay, M.D.5
Johnson, D.G.6
Hruby, V.J.7
-
46
-
-
51849157833
-
Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent in-sulinotropic polypeptide receptor
-
Kodra, J.T.; Jørgensen, A.S.; Andersen, B.; Behrens, C.; Brand, C.L.; Christensen, I.T.; Guldbrandt, M.; Jeppesen, C.B.; Knudsen, L.B.; Madsen, P.; Nishimura, E.; Sams, C.; Sidelmann, U.G.; Pedersen, R.A.; Lynn, F.C.; Lau, J. Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent in-sulinotropic polypeptide receptor. J. Med. Chem., 2008, 51(17), 5387-96.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.17
, pp. 5387-5396
-
-
Kodra, J.T.1
Jørgensen, A.S.2
Andersen, B.3
Behrens, C.4
Brand, C.L.5
Christensen, I.T.6
Guldbrandt, M.7
Jeppesen, C.B.8
Knudsen, L.B.9
Madsen, P.10
Nishimura, E.11
Sams, C.12
Sidelmann, U.G.13
Pedersen, R.A.14
Lynn, F.C.15
Lau, J.16
-
47
-
-
34247237309
-
Novel Glucagon Receptor Antagonist, NNC 25-0926, Blunts Hepatic Glucose Production in the Conscious Dog
-
Rivera, N.; Everett-Grueter, C.A.; Edgerton, D.S.; Rodewald, T.; Neal, D.W.; Nishimura, E.; Larsen, M.O.; Jacobsen, L.O.; Kris-tensen, K.; Brand, C.L.; Cherrington, A.D. A Novel Glucagon Receptor Antagonist, NNC 25-0926, Blunts Hepatic Glucose Production in the Conscious Dog. J. Pharmacol. Exp. Ther., 2007, 321(2), 743-52.
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.321
, Issue.2
, pp. 743-752
-
-
Rivera, N.1
Everett-Grueter, C.A.2
Edgerton, D.S.3
Rodewald, T.4
Neal, D.W.5
Nishimura, E.6
Larsen, M.O.7
Jacobsen, L.O.8
Kris-Tensen, K.9
Brand, C.L.10
Cherrington, A.11
-
48
-
-
0035195977
-
Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
-
Petersen, K.F.; Sullivan, J.T. Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia, 2001, 44, 2018-24.
-
(2001)
Diabetologia
, vol.44
, pp. 2018-2024
-
-
Petersen, K.F.1
Sullivan, J.T.2
-
49
-
-
0037059908
-
Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a New Class of Glucagon Receptor Antagonists
-
Ladouceur, G.H.; Cook, J.H.; Doherty, E.M.; Schoen, W.R.; Mac-Dougall, M.L.; Livingston, J.N. Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a New Class of Glucagon Receptor Antagonists. Bioorg. Med. Chem. Lett., 2002, 12, 461-4.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 461-464
-
-
Ladouceur, G.H.1
Cook, J.H.2
Doherty, E.M.3
Schoen, W.R.4
Mac-Dougall, M.L.5
Livingston, J.N.6
-
50
-
-
9444280124
-
A Novel Glucagon Receptor Antagonist Inhibits Glucagon Mediated Biological Effects
-
Qureshi, S.A.; Candelore, M.R.; Xie, D.; Yang, X.; Tota, L.M.; Ding, VD-H.; Li, Z.; Bansal, A.; Miller, C.; Cohen, S.M.; Jiang, G.; Brady, E.; Saperstein, R.; Duffy, J.L.; Tata, J.R.; Chapman, K.T.; Moller, D.E.; Zhang, B.B. A Novel Glucagon Receptor Antagonist Inhibits Glucagon Mediated Biological Effects. Diabetes, 2004, 53, 3267-73.
-
(2004)
Diabetes
, vol.53
, pp. 3267-3273
-
-
Qureshi, S.A.1
Candelore, M.R.2
Xie, D.3
Yang, X.4
Tota, L.M.5
Ding, V.-H.6
Li, Z.7
Bansal, A.8
Miller, C.9
Cohen, S.M.10
Jiang, G.11
Brady, E.12
Saperstein, R.13
Duffy, J.L.14
Tata, J.R.15
Chapman, K.T.16
Moller, D.E.17
Zhang, B.B.18
-
51
-
-
0033663923
-
Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes
-
Parker, J.C.; McPherson, R.K.; Andrews, K.M.; Levy, C.B.; Dubins, J.S.; Chin, J.E.; Perry, P.V.; Hulin, B.; Perry, D.A.; Ina-gaki, T.; Dekker, K.A.; Tachikawa, K.; Sugie, Y.; Treadway, J.L. Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes. Diabetes, 2000, 49, 2079-86.
-
(2000)
Diabetes
, vol.49
, pp. 2079-2086
-
-
Parker, J.C.1
McPherson, R.K.2
Andrews, K.M.3
Levy, C.B.4
Dubins, J.S.5
Chin, J.E.6
Perry, P.V.7
Hulin, B.8
Perry, D.A.9
Ina-Gaki, T.10
Dekker, K.A.11
Tachikawa, K.12
Sugie, Y.13
Treadway, J.L.14
-
52
-
-
11144358087
-
Biaryl amide glucagon receptor antagonists
-
Kurukulasuriya, R.; Sorensen, B.K.; Link, J.T., Patel, J.R.; Jae, H.S.; Winn, M.X.; Rohde, J.R.; Grihalde, N.D.; Lin, C.W.; Ogiela, C.A.; Adler, A.L.; Collins, C.A. Biaryl amide glucagon receptor antagonists. Bioorg. Med. Chem. Lett., 2004, 14(9), 2047-50.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, Issue.9
, pp. 2047-2050
-
-
Kurukulasuriya, R.1
Sorensen, B.K.2
Link, J.T.3
Patel, J.R.4
Jae, H.S.5
Winn, M.X.6
Rohde, J.R.7
Grihalde, N.D.8
Lin, C.W.9
Ogiela, C.A.10
Adler, A.L.11
Collins, C.A.12
-
53
-
-
24344439816
-
Discovery of novel, potent, and orally active spiro-urea human glu-cagon receptor antagonists
-
Shen, D.M.; Zhang, F.; Brady, E.J.; Candelore, M.R.; Dallas-Yang, Q.; Ding, V.D.; Dragovic, J.; Feeney, W.P.; Jiang, G.; McCann, P.E.; Mock, S.; Qureshi, S.A.; Saperstein, R.; Shen, X.; Tam-vakopoulos, C.; Tong, X.; Tota, L.M.; Wright, M.J.; Yang, X.; Zheng, S.; Chapman, K.T.; Zhang, B.B.; Tata, J.R.; Parmee, E.R. Discovery of novel, potent, and orally active spiro-urea human glu-cagon receptor antagonists. Bioorg. Med. Chem. Lett., 2005, 15(20), 4564-69.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, Issue.20
, pp. 4564-4569
-
-
Shen, D.M.1
Zhang, F.2
Brady, E.J.3
Candelore, M.R.4
Dallas-Yang, Q.5
Ding, V.D.6
Dragovic, J.7
Feeney, W.P.8
Jiang, G.9
McCann, P.E.10
Mock, S.11
Qureshi, S.A.12
Saperstein, R.13
Shen, X.14
Tam-Vakopoulos, C.15
Tong, X.16
Tota, L.M.17
Wright, M.J.18
Yang, X.19
Zheng, S.20
Chapman, K.T.21
Zhang, B.B.22
Tata, J.R.23
Parmee, E.R.24
more..
-
54
-
-
33846225690
-
Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor
-
Liang, R.; Abrardo, L.; Brady, E.J.; Candelore, M.R.; Ding, V.; Saperstein, R.; Tota, L.M.; Wright, M.; Mock, S.; Tamvakopolous, C.; Tong, S.; Zheng, S.; Zhang, B.B.; Tata, J.R.; Parmee, E.R. Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg. Med. Chem. Lett., 2007, 17(3), 587-92.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, Issue.3
, pp. 587-592
-
-
Liang, R.1
Abrardo, L.2
Brady, E.J.3
Candelore, M.R.4
Ding, V.5
Saperstein, R.6
Tota, L.M.7
Wright, M.8
Mock, S.9
Tamvakopolous, C.10
Tong, S.11
Zheng, S.12
Zhang, B.B.13
Tata, J.R.14
Parmee, E.R.15
-
55
-
-
78650512228
-
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core
-
Shen, D.M.; Brady, E.J.; Candelore, M.R.; Dallas-Yang, Q.; Ding, V.D.; Feeney, W.P.; Jiang, G.; McCann, M.E.; Mock, S.; Qureshi, S.A.; Saperstein, R.; Shen, X.; Tong, X.; Tota, L.M.; Wright, M.J.; Yang, X.; Zheng, S.; Chapman, K.T.; Zhang, B.B.; Tata, J.R.; Par-Mee, E.R. Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core. Bioorg. Med. Chem. Lett., 2011, 21(1), 76-81.
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, Issue.1
, pp. 76-81
-
-
Shen, D.M.1
Brady, E.J.2
Candelore, M.R.3
Dallas-Yang, Q.4
Ding, V.D.5
Feeney, W.P.6
Jiang, G.7
McCann, M.E.8
Mock, S.9
Qureshi, S.A.10
Saperstein, R.11
Shen, X.12
Tong, X.13
Tota, L.M.14
Wright, M.J.15
Yang, X.16
Zheng, S.17
Chapman, K.T.18
Zhang, B.B.19
Tata, J.R.20
Par-Mee, E.R.21
more..
-
56
-
-
44749089590
-
Discovery of potent, orally active ben-zimidazole glucagon receptor antagonists
-
Kim, R.M.; Chang, J.; Lins, A.R.; Brady, E.; Candelore, M.R.; Dallas-Yang, Q.; Ding, V.; Dragovic, J.; Iliff, S.; Jiang, G.; Mock, S.; Qureshi, S.; Saperstein, R.; Szalkowski, D.; Tamvakopoulos, C.; Tota, L.; Wright, M.; Yang, X.; Tata, J.R.; Chapman, K.; Zhang, B.B.; Parmee, E.R. Discovery of potent, orally active ben-zimidazole glucagon receptor antagonists. Bioorg. Med. Chem. Lett., 2008, 18(13), 3701-05.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, Issue.13
, pp. 3701-3705
-
-
Kim, R.M.1
Chang, J.2
Lins, A.R.3
Brady, E.4
Candelore, M.R.5
Dallas-Yang, Q.6
Ding, V.7
Dragovic, J.8
Iliff, S.9
Jiang, G.10
Mock, S.11
Qureshi, S.12
Saperstein, R.13
Szalkowski, D.14
Tamvakopoulos, C.15
Tota, L.16
Wright, M.17
Yang, X.18
Tata, J.R.19
Chapman, K.20
Zhang, B.B.21
Parmee, E.R.22
more..
-
57
-
-
33846226456
-
New beta-alanine derivatives are orally available glucagon receptor antagonists
-
Lau, J.; Behrens, C.; Sidelmann, U.G.; Knudsen, L.B.; Lundt, B.; Sams, C.; Ynddal, L.; Brand, C.L.; Pridal, L.; Ling, A.; Kiel, D.; Plewe, M.; Shi, S.; Madsen, P. New beta-alanine derivatives are orally available glucagon receptor antagonists. J. Med. Chem., 2007, 50(1), 113-28.
-
(2007)
J. Med. Chem.
, vol.50
, Issue.1
, pp. 113-128
-
-
Lau, J.1
Behrens, C.2
Sidelmann, U.G.3
Knudsen, L.B.4
Lundt, B.5
Sams, C.6
Ynddal, L.7
Brand, C.L.8
Pridal, L.9
Ling, A.10
Kiel, D.11
Plewe, M.12
Shi, S.13
Madsen, P.14
-
58
-
-
79959739474
-
The impact of epigenomics on future drug design and new therapies
-
Hamm, C.A.; Costa, F.F. The impact of epigenomics on future drug design and new therapies. Drug Discov Today, 2011, 16(13), 626-35.
-
(2011)
Drug Discov Today
, vol.16
, Issue.13
, pp. 626-635
-
-
Hamm, C.A.1
Costa, F.F.2
-
59
-
-
70450217879
-
Methylomes at base resolution show widespread epigenomic differences
-
Lister, R.; Pelizzola, M.; Dowen, R.H.; Hawkins, R.D.; Hon, G.; Tonti-Filippini, J.; Nery, J.R.; Lee, L.; Ye, Z.; Ngo, Q-M.; Edsall, L.; Antosiewicz-Bourget, J.; Stewart, R.; Ruotti, V.; Millar, A.H.; Thomson, J.A.; Ren, B.; Ecker, J.R. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature, 2009, 462(7271), 315-22.
-
(2009)
Nature
, vol.462
, Issue.7271
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
Dowen, R.H.3
Hawkins, R.D.4
Hon, G.5
Tonti-Filippini, J.6
Nery, J.R.7
Lee, L.8
Ye, Z.9
Ngo, Q.-M.10
Edsall, L.11
Antosiewicz-Bourget, J.12
Stewart, R.13
Ruotti, V.14
Millar, A.H.15
Thomson, J.A.16
Ren, B.17
Ecker, J.R.18
Human, D.19
-
60
-
-
79952111963
-
Nucleosome dynamics and histone variants
-
Ray-Gallet, D.; Almouzni, G. Nucleosome dynamics and histone variants. Essays Biochem., 2010, 48, 75-87.
-
(2010)
Essays Biochem.
, vol.48
, pp. 75-87
-
-
Ray-Gallet, D.1
Almouzni, G.2
-
61
-
-
40649111338
-
Non-coding RNAs, epigenetics and complexity
-
Costa, F.F. Non-coding RNAs, epigenetics and complexity. Gene, 2008, 410, 9-17.
-
(2008)
Gene
, vol.410
, pp. 9-17
-
-
Costa, F.F.1
-
62
-
-
67650462249
-
DNA hypomethylation in the origin and pathogenesis of human diseases
-
Pogribny, I.P.; Beland, F.A. DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol. Life Sci., 2009, 66, 2249-61.
-
(2009)
Cell Mol. Life Sci.
, vol.66
, pp. 2249-2261
-
-
Pogribny, I.P.1
Beland, F.A.2
-
63
-
-
1842855402
-
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
-
Wang, Q.; Li, L.; Xu, E.; Wong, V.; Rhodes, C; Brubaker, P.L. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Dia-betologia, 2004, 47(3), 478-87.
-
(2004)
Dia-Betologia
, vol.47
, Issue.3
, pp. 478-487
-
-
Wang, Q.1
Li, L.2
Xu, E.3
Wong, V.4
Rhodes, C.5
Brubaker, P.L.6
-
64
-
-
77950624912
-
Epigenetic mechanisms in the development of type 2 diabetes
-
Pinney, S.E.; Simmons, R.A. Epigenetic mechanisms in the development of type 2 diabetes. Trends Endocrinol. Metab., 2010, 21, 223-9.
-
(2010)
Trends Endocrinol. Metab.
, vol.21
, pp. 223-229
-
-
Pinney, S.E.1
Simmons, R.A.2
-
65
-
-
64649092274
-
Peroxisome proliferator-activated receptor y activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of eu-chromatin structure
-
Evans-Molina, C; Robbins, R.D.; Kono, T.; Tersey, S.A.; Vester-mark, G.L.; Nunemaker, C.S.; Garmey J.C.; Deering T.G.; Keller S.R.; Maier B.; Mirmira, R.G. Peroxisome proliferator-activated receptor y activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of eu-chromatin structure. Mol. Cell Biol, 2009, 29(8), 2053-67.
-
(2009)
Mol. Cell Biol
, vol.29
, Issue.8
, pp. 2053-2067
-
-
Evans-Molina, C.1
Robbins, R.D.2
Kono, T.3
Tersey, S.A.4
Vester-Mark, G.L.5
Nunemaker, C.S.6
Garmey, J.C.7
Deering, T.G.8
Keller, S.R.9
Maier, B.10
Mirmira, R.G.11
-
66
-
-
79957944601
-
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus
-
Christensen, D.P.; Dahllöf, M.; Lundh, M.; Rasmussen, D.N.; Nielsen, M.D.; Billestrup, N.; Grunnet, L.G.; Mandrup-Poulsen, T. Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol. Med., 2011, 17(5-6), 378.
-
(2011)
Mol. Med.
, vol.17
, Issue.5-6
, pp. 378
-
-
Christensen, D.P.1
Dahllöf, M.2
Lundh, M.3
Rasmussen, D.N.4
Nielsen, M.D.5
Billestrup, N.6
Grunnet, L.G.7
Mandrup-Poulsen, T.8
-
67
-
-
84860786148
-
(2012). Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH
-
Soupart, A.; Coffernils, M.; Couturier, B.; Gankam-Kengne, F.; Decaux, G. (2012). Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH. Clin. J. Am. Soc. Nephrol, 2012, 7(5), 742-7.
-
(2012)
Clin. J. Am. Soc. Nephrol
, vol.7
, Issue.5
, pp. 742-747
-
-
Soupart, A.1
Coffernils, M.2
Couturier, B.3
Gankam-Kengne, F.4
Decaux, G.5
-
68
-
-
80255127461
-
(2011). Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists
-
Sinz, C; Chang, J.; Lins, A. R.; Brady, E.; Candelore, M.; Dallas-Yang, Q.; Ding, V.; Jiang, G.; Lin, Z.; Mock, S.; Qureshi, S.; Salituro, G.; Saperstein, R.; Shang, J.; Szalkowski, D.; Tota, L.; Vincent, S.; Wright, M.; Xu, S.; Yang, X.; Zhang, B.; Tata, J.; Kim, R.; Parmee, E. (2011). Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists. Bioorg Med. Chem. Lett, 2011, 21(23), 7131-6.
-
(2011)
Bioorg Med. Chem. Lett
, vol.21
, Issue.23
, pp. 7131-7136
-
-
Sinz, C.1
Chang, J.2
Lins, A.R.3
Brady, E.4
Candelore, M.5
Dallas-Yang, Q.6
Ding, V.7
Jiang, G.8
Lin, Z.9
Mock, S.10
Qureshi, S.11
Salituro, G.12
Saperstein, R.13
Shang, J.14
Szalkowski, D.15
Tota, L.16
Vincent, S.17
Wright, M.18
Xu, S.19
Yang, X.20
Zhang, B.21
Tata, J.22
Kim, R.23
Parmee, E.24
more..
-
69
-
-
0021340276
-
Comparative study on cytotoxicities and biochemical properties of an-thraquinone mycotoxins emodin and skyrin from Penicillium is-landicum Sopp
-
Kawai, K.; Kato, T.; Mori, H.; Kitamura, J.; Nozawa, Y. A comparative study on cytotoxicities and biochemical properties of an-thraquinone mycotoxins emodin and skyrin from Penicillium is-landicum Sopp. Toxicol. Lett, 1984, 20(2),155-60.
-
(1984)
Toxicol. Lett
, vol.20
, Issue.2
, pp. 155-160
-
-
Kawai, K.1
Kato, T.2
Mori, H.3
Kitamura, J.4
Nozawa, Y.A.5
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