Human glucagon receptor antagonists based on alkylidene hydrazides

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 663-666

  Ling, Anthony ^a   Plewe, Michael ^a   Gonzalez, Javier ^a   Madsen, Peter ^b   Sams, Christian K ^b   Lau, Jesper ^b   Gregor, Vlad ^c   Murphy, Doug ^a   Teston, Kimberly ^a   Kuki, Atsuo ^a   Shi, Shenghua ^a   Truesdale, Larry ^a   Kiel, Dan ^a   May, John ^a   Lakis, James ^a   Anderes, Kenna ^a   Iatsimirskaia, Eugenia ^a   Sidelmann, Ulla G ^b   Knudsen, Lotte B ^b   Brand, Christian L ^b   Polinsky, Alex ^a   more..

^a PFIZER INC   (United States)

^b NOVO NORDISK A S   (Denmark)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 CYANOBENZOIC ACID (4 ISOPROPYLBENZYLOXY 3,5 DIMETHOXYMETHYLENE)HYDRAZIDE; GLUCAGON RECEPTOR; HYDRAZIDE DERIVATIVE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; HYDRAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DIET RESTRICTION; DRUG CLEARANCE; DRUG HALF LIFE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; NONHUMAN; RAT; ANIMAL; BINDING COMPETITION; DRUG ANTAGONISM; DRUG EFFECT; INJECTION; METABOLIC CLEARANCE RATE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; BLOOD GLUCOSE; HUMANS; HYDRAZINES; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; INJECTIONS; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; RATS; RECEPTORS, GLUCAGON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244375583     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00819-8     Document Type: Article

References (13)