Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages 5661-5666

  Chow, Jeng Yeong ^a   Tian, Bo Xue ^b,c   Ramamoorthy, Gurusankar ^a   Hillerich, Brandan S ^d   Seidel, Ronald D ^d   Almo, Steven C ^d   Jacobson, Matthew P ^b,c   Poulter, C Dale ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Annotation; Cyclase; Sesquiterpene; Structure function

Indexed keywords

BACTERIAL ENZYME; CATION; CUCUMENE; FARNESYL CATION; PENTALENENE SYNTHASE; SESQUITERPENE; SESQUITERPENE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG; CARBON; TERPENE SYNTHASE; TRANSFERASE;

ALGORITHM; ARTICLE; BIOCHEMICAL ANALYSIS; CARBOCATION; CHEMICAL REACTION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; STATIC ELECTRICITY; STREPTOMYCES CLAVULIGERUS; WORKFLOW; BIOLOGY; CHEMISTRY; CLUSTER ANALYSIS; COMPUTER PROGRAM; COMPUTER SIMULATION; ENZYMOLOGY; PROTEIN TERTIARY STRUCTURE; STREPTOMYCES; STRUCTURE ACTIVITY RELATION;

STREPTOMYCES CLAVULIGERUS;

ALGORITHMS; ALKYL AND ARYL TRANSFERASES; CARBON; CATALYTIC DOMAIN; CATIONS; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; PROTEIN STRUCTURE, TERTIARY; SOFTWARE; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84928969455     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505127112     Document Type: Article

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