Catalytic mechanism and product specificity of oxidosqualene-lanosterol cyclase: A QM/MM study

Journal of Physical Chemistry B

Volumn 116, Issue 47, 2012, Pages 13857-13862

  Tian, Bo Xue ^a   Eriksson, Leif A ^b  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC MECHANISMS; CATIONIC INTERMEDIATES; CYCLASES; KEY ENZYMES; LANOSTEROL; PRODUCT SPECIFICITY; QM/MM CALCULATIONS; RATE LIMITING; WILD TYPES;

THERMODYNAMICS;

BIOCHEMISTRY;

LANOSTEROL SYNTHASE; MUTASE; TRITERPENE;

ARTICLE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; METABOLISM; MUTAGENESIS; MUTATION; PROTEIN CONFORMATION; QUANTUM THEORY;

BIOCATALYSIS; INTRAMOLECULAR TRANSFERASES; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; PROTEIN CONFORMATION; QUANTUM THEORY; SUBSTRATE SPECIFICITY; TRITERPENES;

EID: 84870307882     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp3091396     Document Type: Article

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