Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host

Journal of Antibiotics

Volumn 68, Issue 6, 2015, Pages 385-394

  Yamada, Yuuki ^a   Arima, Shiho ^a   Nagamitsu, Tohru ^a   Johmoto, Kohei ^b   Uekusa, Hidehiro ^b   Eguchi, Tadashi ^b   Shin Ya, Kazuo ^c   Cane, David E ^d   Ikeda, Haruo ^a  

^a KITASATO UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; CLAVULATRIENE; CYCLOOCTAT 7(8),10(14) DIENE; DITERPENE; HYDROPYRENE; HYDROPYRENOL; ISOELISABETHATRIENE B; ISOHIRSUT 1 ENE; ISOHIRSUT 4 ENE; ODYVERDIENE A; ODYVERDIENE B; PRENYL BETA ELEMENE; PRENYLGERMACRENE B; SESQUITERPENE; TERPENE; TSUKUBADIENE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; RECOMBINANT PROTEIN; TERPENE SYNTHASE; TRANSFERASE;

ARTICLE; BACTERIAL GENE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; GENETIC ENGINEERING; HETEROLOGOUS EXPRESSION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HOST; MASS SPECTROMETRY; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES; TERPENE SYNTHASE GENE; ACTINOMYCETALES; CHEMICAL DATABASE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG DEVELOPMENT; ENZYMOLOGY; GENETICS; ISOLATION AND PURIFICATION; MASS FRAGMENTOGRAPHY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; TRANSGENIC ORGANISM; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); STREPTOMYCES;

ACTINOMYCETALES; ALKYL AND ARYL TRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DATABASES, CHEMICAL; DITERPENES; DRUG DISCOVERY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANISMS, GENETICALLY MODIFIED; PHYSICOCHEMICAL PHENOMENA; RECOMBINANT PROTEINS; SESQUITERPENES; STREPTOMYCES; TERPENES;

EID: 84933504076     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2014.171     Document Type: Article

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