pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages E5691-E5696

  Tipping, Kevin W ^a   Karamanos, Theodoros K ^a   Jakhria, Toral ^a   Iadanza, Matthew G ^a   Goodchild, Sophia C ^a   Tuma, Roman ^a   Ranson, Neil A ^a   Hewitt, Eric W ^a   Radford, Sheena E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Amyloid; Disassembly; Fibrils; Membrane disruption; Oligomer

Indexed keywords

AMYLOID; BETA 2 MICROGLOBULIN; OLIGOMER; THIOFLAVINE; HEAT SHOCK PROTEIN 70; LYSOZYME; PROTEIN BINDING; RECOMBINANT PROTEIN; THIAZOLE DERIVATIVE;

ARTICLE; CELL DEATH; CIRCULAR DICHROISM; CONTROLLED STUDY; CROSS LINKING; DEPOLYMERIZATION; ENDOSOME; FLUORESCENCE CORRELATION SPECTROSCOPY; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE DAMAGE; MONOCYTE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OSTEOCLASTOGENESIS; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; RELEASE ASSAY; SURFACE AREA; AMYLOIDOSIS; CHEMISTRY; KINETICS; METABOLISM; SPECTROFLUOROMETRY;

AMYLOID; AMYLOIDOSIS; BETA 2-MICROGLOBULIN; ENDOSOMES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LYSOSOMES; MONOCYTES; MURAMIDASE; PROTEIN BINDING; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; THIAZOLES;

EID: 84928963185     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1423174112     Document Type: Article

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