Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

Nature

Volumn 505, Issue 7484, 2014, Pages 550-554

  Cruchaga, Carlos ^a   Karch, Celeste M ^a   Jin, Sheng Chih ^a   Benitez, Bruno A ^a   Cai, Yefei ^a   Guerreiro, Rita ^b,c   Harari, Oscar ^a   Norton, Joanne ^a   Budde, John ^a   Bertelsen, Sarah ^a   Jeng, Amanda T ^a   Cooper, Breanna ^a   Skorupa, Tara ^a   Carrell, David ^a   Levitch, Denise ^a   Hsu, Simon ^a   Choi, Jiyoon ^a   Ryten, Mina ^b   Hardy, John ^b   Trabzuni, Daniah ^b   Weale, Michael E ^d   Ramasamy, Adaikalavan ^d   Smith, Colin ^t   Sassi, Celeste ^b,c   Bras, Jose ^b   Gibbs, J Raphael ^b,c   Hernandez, Dena G ^b,c   Lupton, Michelle K ^d,e   Powell, John ^d   Forabosco, Paola ^f   Ridge, Perry G ^g   Corcoran, Christopher D ^h   Tschanz, Joann T ^h   Norton, Maria C ^h   Munger, Ronald G ^h   Schmutz, Cameron ^g   Leary, Maegan ^g   Demirci, F Yesim ⁱ   Bamne, Mikhil N ⁱ   Wang, Xingbin ⁱ   Lopez, Oscar L ^j   Ganguli, Mary ^j   Medway, Christopher ^k   Turton, James ^k   Lord, Jenny ^k   Braae, Anne ^k   Barber, Imelda ^k   Brown, Kristelle ^k   Passmore, Peter ^u   Craig, David ^u   Johnston, Janet ^u   McGuinness, Bernadette ^u   Todd, Stephen ^u   Heun, Reinhard ^v   Kölsch, Heike ^w   Kehoe, Patrick G ^x   Hooper, Nigel M ^y   Vardy, Emma R L C ^z   Mann, David M ^aa   Pickering Brown, Stuart ^aa   Kalsheker, Noor ^k   Lowe, James ^k   Morgan, Kevin ^k   David Smith, A ^ab   Wilcock, Gordon ^ab   Warden, Donald ^ab   Holmes, Clive ^ac   Pastor, Pau ^l,m,n   Lorenzo Betancor, Oswaldo ^l   Brkanac, Zoran ^o   Scott, Erick ^p   Topol, Eric ^p   Rogaeva, Ekaterina ^q   Singleton, Andrew B ^c   Kamboh, M Ilyas ^i,j   St George Hyslop, Peter ^q,r   Cairns, Nigel ^a,s   Morris, John C ^a,s   Kauwe, John S K ^g   Goate, Alison M ^a,s   more..

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^f CNR   (Italy)

^g BRIGHAM YOUNG UNIVERSITY   (United States)

^h UTAH STATE UNIVERSITY   (United States)

ⁱ UNIVERSITY OF PITTSBURGH   (United States)

^j UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^l UNIVERSITY OF NAVARRA   (Spain)

^m UNIVERSITY CLINIC OF NAVARRA   (Spain)

ⁿ CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^o UNIVERSITY OF WASHINGTON   (United States)

^p SCRIPPS RESEARCH INSTITUTE   (United States)

^q UNIVERSITY OF TORONTO   (Canada)

^r UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^s WASHINGTON UNIVERSITY   (United States)

^t UNIVERSITY OF EDINBURGH   (United Kingdom)

^u QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^v ROYAL DERBY HOSPITAL   (United Kingdom)

^w UNIVERSITY OF BONN   (Germany)

^x UNIVERSITY OF BRISTOL   (United Kingdom)

^y UNIVERSITY OF LEEDS   (United Kingdom)

^z NEWCASTLE UNIVERSITY   (United Kingdom)

^aa UNIVERSITY OF MANCHESTER   (United Kingdom)

^ab UNIVERSITY OF OXFORD   (United Kingdom)

^ac UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN;

AFRICAN AMERICAN; BRAIN; DATA SET; DISEASE INCIDENCE; GENE EXPRESSION; GENOME; HEALTH RISK; MENTAL HEALTH; PATHOLOGY; PROTEIN; RISK FACTOR;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN REGION; CASE CONTROL STUDY; CONTROLLED STUDY; EXOME; FEMALE; GENE; GENE FREQUENCY; GENE OVEREXPRESSION; GENE SEQUENCE; GENE SILENCING; GENETIC ASSOCIATION; GENETIC CODE; GENETIC RISK; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; PHOSPHOLIPASE D3 GENE; PRIORITY JOURNAL; SEGREGATION ANALYSIS; VERY ELDERLY;

AFRICAN AMERICANS; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; BRAIN; CASE-CONTROL STUDIES; EUROPE; EXOME; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; MALE; PEPTIDE FRAGMENTS; PHOSPHOLIPASE D; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS;

EUROPE; UNITED STATES;

EID: 84892819277     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12825     Document Type: Article

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