Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms

European Journal of Pharmacology

Volumn 760, Issue , 2015, Pages 103-112

  Ni, Wei Jian ^a   Ding, Hai Hua ^a   Tang, Li Qin ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Berberine; Diabetic nephropathy; Mechanisms; Renoprotection; Signaling pathway

Indexed keywords

ALDEHYDE REDUCTASE; BERBERINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; TRANSCRIPTION FACTOR AP 1; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; DIABETIC NEPHROPATHY; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; DYSLIPIDEMIA; HUMAN; HYPERGLYCEMIA; INNATE IMMUNITY; INSULIN RESISTANCE; KIDNEY BLOOD FLOW; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RENAL PROTECTION; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; METABOLISM; PHYSIOLOGY; TREATMENT OUTCOME;

ANIMALS; BERBERINE; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; HUMANS; HYPOGLYCEMIC AGENTS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 84928914138     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.04.017     Document Type: Review

References (52)

1. A.S. Awad, M.D. Rouse, K. Khutsishvili, L. Huang, W.K. Bolton, K.R. Lynch, and M.D. Okusa Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes Kidney Int. 79 2011 1090 1098
2. J.M. Catania, G. Chen, and A.R. Parrish Role of matrix metalloproteinases in renal pathophysiologies Am. J. Physiol. Ren. Physiol. 292 2007 F905 F911
3. B.H. Choi, I.S. Ahn, Y.H. Kim, J.W. Park, S.Y. Lee, C.K. Hyun, and M.S. Do Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte Exp. Mol. Med. 38 2006 599 605
4. T. Cvetkovic, B. Mitic, G. Lazarevic, P. Vlahovic, S. Antic, and V. Stefanovic Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy J. Diabetes Complicat. 23 2009 337 342
5. X.W. Deng, and N. Xie [Progress of berberine for treatment of type 2 diabetes] Zhongguo Zhong Yao Za Zhi 39 2014 1374 1378
6. M. Dunlop Aldose reductase and the role of the polyol pathway in diabetic nephropathy Kidney Int. Suppl. 77 2000 S3 S12
7. J.L. Evans, I.D. Goldfine, B.A. Maddux, and G.M. Grodsky Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52 2003 1 8
8. A. Fukuhara, M. Matsuda, M. Nishizawa, K. Segawa, M. Tanaka, K. Kishimoto, Y. Matsuki, M. Murakami, T. Ichisaka, H. Murakami, E. Watanabe, T. Takagi, M. Akiyoshi, T. Ohtsubo, S. Kihara, S. Yamashita, M. Makishima, T. Funahashi, S. Yamanaka, R. Hiramatsu, Y. Matsuzawa, and I. Shimomura Visfatin: a protein secreted by visceral fat that mimics the effects of insulin Science 307 2005 426 430
9. Y.Y. Hsu, C.S. Chen, S.N. Wu, Y.J. Jong, and Y.C. Lo Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells Eur. J. Pharm. Sci. 46 2012 415 425
10. Y.Y. Hsu, Y.T. Tseng, and Y.C. Lo Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth Toxicol. Appl. Pharmacol. 272 2013 787 796
11. J. Huang, K. Huang, T. Lan, X. Xie, X. Shen, P. Liu, and H. Huang Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway Mol. Cell. Endocrinol. 365 2013 231 240
12. K. Huang, W. Liu, T. Lan, X. Xie, J. Peng, J. Huang, S. Wang, X. Shen, P. Liu, and H. Huang Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models PLoS One 7 2012 e43874
13. H.W. Jeong, K.C. Hsu, J.W. Lee, M. Ham, J.Y. Huh, H.J. Shin, W.S. Kim, and J.B. Kim Berberine suppresses proinflammatory responses through AMPK activation in macrophages Am. J. Physiol. Endocrinol. Metab. 296 2009 E955 E964
14. Q. Jiang, P. Liu, X. Wu, W. Liu, X. Shen, T. Lan, S. Xu, J. Peng, X. Xie, and H. Huang Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-kappaB signaling pathway Mol. Cell. Endocrinol. 331 2011 34 40
15. B.B. Kahn, T. Alquier, D. Carling, and D.G. Hardie AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism Cell Metab. 1 2005 15 25
16. M. Kamiyama, M. Urushihara, T. Morikawa, Y. Konishi, M. Imanishi, A. Nishiyama, and H. Kobori Oxidative stress/angiotensinogen/renin-angiotensin system axis in patients with diabetic nephropathy Int. J. Mol. Sci. 14 2013 23045 23062
17. R. Kikkawa, D. Koya, and M. Haneda Progression of diabetic nephropathy Am. J. Kidney Dis. 41 2003 S19 S21
18. P.J. Klover, A.H. Clementi, and R.A. Mooney Interleukin-6 depletion selectively improves hepatic insulin action in obesity Endocrinology 146 2005 3417 3427
19. V. Kolavennu, L. Zeng, H. Peng, Y. Wang, and F.R. Danesh Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control Diabetes 57 2008 714 723
20. R. Komers, T.T. Oyama, D.R. Beard, and S. Anderson Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats Br. J. Pharmacol. 162 2011 163 174
21. W. Kong, J. Wei, P. Abidi, M. Lin, S. Inaba, C. Li, Y. Wang, Z. Wang, S. Si, H. Pan, S. Wang, J. Wu, Y. Wang, Z. Li, J. Liu, and J.D. Jiang Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins Nat. Med. 10 2004 1344 1351
22. D. Konrad, R. Somwar, G. Sweeney, K. Yaworsky, M. Hayashi, T. Ramlal, and A. Klip The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation Diabetes 50 2001 1464 1471
23. R. Krysiak, A. Gdula-Dymek, R. Bachowski, and B. Okopien Pleiotropic effects of atorvastatin and fenofibrate in metabolic syndrome and different types of pre-diabetes Diabetes Care 33 2010 2266 2270
24. T. Lan, T. Wu, C. Chen, X. Chen, J. Hao, J. Huang, L. Wang, and H. Huang Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: involvement of suppression of cell cycle progression and NF-kappaB/AP-1 pathways Mol. Cell. Endocrinol. 384 2014 109 116
25. H. Li, W. Chen, Y. Zhou, P. Abidi, O. Sharpe, W.H. Robinson, F.B. Kraemer, and J. Liu Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements J. Lipid Res. 50 2009 820 831
26. X. Li, W. Liu, Q. Wang, P. Liu, Y. Deng, T. Lan, X. Zhang, B. Qiu, H. Ning, and H. Huang Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose Mol. Cell. Endocrinol. 307 2009 157 162
27. K.W. Liang, C.T. Ting, S.C. Yin, Y.T. Chen, S.J. Lin, J.K. Liao, and S.L. Hsu Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury Biochem. Pharmacol. 71 2006 806 817
28. W. Liu, X. Zhang, P. Liu, X. Shen, T. Lan, W. Li, Q. Jiang, X. Xie, and H. Huang Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury Eur. J. Pharmacol. 638 2010 150 155
29. S. Mezzano, C. Aros, A. Droguett, M.E. Burgos, L. Ardiles, C. Flores, H. Schneider, M. Ruiz-Ortega, and J. Egido NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy Nephrol. Dial. Transplant. 19 2004 2505 2512
30. H.K. Moghaddam, T. Baluchnejadmojarad, M. Roghani, M. Khaksari, P. Norouzi, M. Ahooie, and F. Mahboobi Berberine ameliorate oxidative stress and astrogliosis in the hippocampus of STZ-induced diabetic rats Mol. Neurobiol. 49 2014 820 826
31. J.F. Navarro-Gonzalez, C. Mora-Fernandez, D.F.M. Muros, and J. Garcia-Perez Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy Nat. Rev. Nephrol. 7 2011 327 340
32. W.J. Ni, L.Q. Tang, and W. Wei Research progress on signaling pathway in diabetic nephropathy Diabetes Metab. Res. Rev. 31 2015 221 233
33. S.A. Price, S. Agthong, A.B. Middlemas, and D.R. Tomlinson Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase Diabetes 53 2004 1851 1856
34. M. Ravid Dual blockade of the renin-angiotensin system in diabetic nephropathy Diabetes Care 32 Suppl 2 2009 S410 S413
35. H.B. Schonthaler, J. Guinea-Viniegra, and E.F. Wagner Targeting inflammation by modulating the Jun/AP-1 pathway Ann. Rheum. Dis. 70 Suppl 1 2011 i109 i112
36. S.K. Srivastava, K.V. Ramana, and A. Bhatnagar Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options Endocr. Rev. 26 2005 380 392
37. L.Q. Tang, S. Liu, S.T. Zhang, L.N. Zhu, and F.L. Wang Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy Mol. Biol. Rep. 41 2014 3339 3347
38. L.Q. Tang, F.L. Wang, L.N. Zhu, F. Lv, S. Liu, and S.T. Zhang Berberine ameliorates renal injury by regulating G proteins-AC- cAMP signaling in diabetic rats with nephropathy Mol. Biol. Rep. 40 2013 3913 3923
39. E. Tarabra, S. Giunti, F. Barutta, G. Salvidio, D. Burt, G. Deferrari, R. Gambino, D. Vergola, S. Pinach, P.C. Perin, G. Camussi, and G. Gruden Effect of the monocyte chemoattractant protein-1/CC chemokine receptor 2 system on nephrin expression in streptozotocin-treated mice and human cultured podocytes Diabetes 58 2009 2109 2118
40. N.A. Turner, S.G. Ball, and A.J. Balmforth The mechanism of angiotensin II-induced extracellular signal-regulated kinase-1/2 activation is independent of angiotensin AT(1A) receptor internalisation Cell Signal. 13 2001 269 277
41. X. Wan, X. Chen, L. Liu, Y. Zhao, W.J. Huang, Q. Zhang, G.G. Miao, W. Chen, H.G. Xie, and C.C. Cao Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of NFkappaB signaling pathway in rats PLoS One 8 2013 e59794
42. L. Wang, X.P. Xing, A. Holmes, C. Wadham, J.R. Gamble, M.A. Vadas, and P. Xia Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells Circ. Res. 97 2005 891 899
43. G. Wolf New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology Eur. J. Clin. Investig. 34 2004 785 796
44. D. Wu, W. Wen, C.L. Qi, R.X. Zhao, J.H. Lu, C.Y. Zhong, and Y.Y. Chen Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin Phytomedicine 19 2012 712 718
45. J. Wu, C. Mei, H. Vlassara, G.E. Striker, and F. Zheng Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells Am. J. Physiol. Ren. Physiol. 297 2009 F1622 F1631
46. X. Xia, J. Yan, Y. Shen, K. Tang, J. Yin, Y. Zhang, D. Yang, H. Liang, J. Ye, and J. Weng Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis PLoS One 6 2011 e16556
47. X. Xie, X. Chang, L. Chen, K. Huang, J. Huang, S. Wang, X. Shen, P. Liu, and H. Huang Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling Mol. Cell. Endocrinol. 381 2013 56 65
48. S.M. Yang, S.M. Ka, H.L. Wu, Y.C. Yeh, C.H. Kuo, K.F. Hua, G.Y. Shi, Y.J. Hung, F.C. Hsiao, S.S. Yang, Y.S. Shieh, S.H. Lin, C.W. Wei, J.S. Lee, C.Y. Yang, and A. Chen Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-kappaB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis Diabetologia 57 2014 424 434
49. Y. Yang, W. Ni, M. Cai, L. Tang, and W. Wei The renoprotective effects of berberine via the EP4-Galphas-cAMP signaling pathway in different stages of diabetes in rats J. Recept. Signal Transduct. Res. 34 2014 445 455
50. J. Yin, H. Xing, and J. Ye Efficacy of berberine in patients with type 2 diabetes mellitus Metabolism 57 2008 712 717
51. Y. Zhang, X. Li, D. Zou, W. Liu, J. Yang, N. Zhu, L. Huo, M. Wang, J. Hong, P. Wu, G. Ren, and G. Ning Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine J. Clin. Endocrinol. Metab. 93 2008 2559 2565
52. J. Zhou, S. Zhou, J. Tang, K. Zhang, L. Guang, Y. Huang, Y. Xu, Y. Ying, L. Zhang, and D. Li Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats Eur. J. Pharmacol. 606 2009 262 268