Berberine reduces Fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Huang, Kaipeng ^a   Liu, Weihua ^b   Lan, Tian ^c   Xie, Xi ^a   Peng, Jing ^a   Huang, Juan ^a   Wang, Shaogui ^a   Shen, Xiaoyan ^a   Liu, Peiqing ^a   Huang, Heqing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BERBERINE; FIBRONECTIN; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SPHINGOSINE 1 PHOSPHATE 2 RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE MODEL; DOWN REGULATION; ENZYME REPRESSION; KIDNEY; MALE; MESANGIUM CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BERBERINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DOWN-REGULATION; FIBRONECTINS; GENE EXPRESSION REGULATION; KIDNEY; MEMBRANE PROTEINS; MESANGIAL CELLS; NF-KAPPA B; PHOSPHORIC MONOESTER HYDROLASES; RATS; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION;

EID: 84865293512     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043874     Document Type: Article

References (31)

1. Schena FP, Gesualdo L, (2005) Pathogenetic mechanisms of diabetic nephropathy. J Am Soc Nephrol 16: S30-S33.
2. Kanwar YS, Sun L, Xie P, Liu FY, Chen S, (2011) A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol Mech Dis 6: 395-423.
3. Jia HJ, Qi XD, Fang SH, Jin YH, Han XY, et al. (2009) Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression. Regul Pept 154: 69-76.
4. Wahab N, Cox D, Witherden A, Mason RM, (2007) Connective tissue growth factor (CTGF) promotes activated mesangial cell survival via up-regulation of mitogen-activated protein kinase phosphatese-1 (MKP-1). Biochem J 406: 131-138.
5. Liu WH, Tang FT, Deng YH, Li XJ, Lan T, et al. (2009) Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition. Mol Cell Biochem 325: 99-105.
6. Giunti S, Barit D, Cooper ME, (2006) Diabetic nephropathy: from mechanisms to rational therapies. Minerva Med 97: 241-262.
7. Fyrst H, Saba JD, (2010) An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol 6: 489-497.
8. Alvarez SE, Milstien S, Spiegel S, (2007) Autocrine and paracrine roles of sphingosine-1-phosphate. Trends endocrinol and Metab 18: 300-307.
9. Kihara A, Mitsutake S, Mizutani Y, Igarashi Y, (2007) Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog Lipid Res 46: 126-144.
10. Spiegel S, Milstien S, (2003) Sphingosine-1-phosphate: an enigmatic signaling lipid. Nat Rev Mol Cell Biol 4: 397-407.
11. Ogretmen B, Hannun YA, (2004) Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 4: 604-616.
12. Yatomi Y, (2006) Sphingosine1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. Curr Pharm Des 11: 575-587.
13. Wang F, Okamoto Y, Inoki I, Yoshioka K, Du W, et al. (2010) Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. J Clin Invest 120: 3979-3995.
14. Whetzel AM, Bolick DT, Srinivasan S, Macdonald TL, Morris MA, et al. (2006) Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. Circ Res 99: 731-739.
15. Randriamboavonjy V, Badenhoop K, Schmidt H, Geisslinger G, Fisslthaler B, et al. (2009) The S1P2 receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is downregulated in type 2 diabetes. Basic Res Cardiol 104: 333-340.
16. Lan T, Shen XY, Liu PQ, Liu WH, Xu SW, et al. (2010) Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. Arch Biochem Biophys 502: 112-120.
17. Lan T, Liu WH, Xie X, Xu SW, Huang KP, et al. (2011) Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. Mol Endocrinol 25: 2094-2105.
18. Liu WH, Lan T, Xie X, Huang KP, Peng J, et al. (2012) S1P2 receptor mediates sphingosine-1- phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition. Exp Cell Res 318: 936-943.
19. Xia X, Yan JH, Shen YF, Tang KX, Yin J, et al. (2011) Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic Gluconeogenesis. PLoS One 6: 1-10.
20. Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, et al. (2010) TNF alpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase. Akt and NF kappaB signaling J Cell Sci 123: 4145-4155.
21. Kong W, Wei J, Abidi P, Lin M, Inaba S, et al. (2004) Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 10: 1344-1351.
22. Liu WH, Zhang XY, Liu PQ, Shen XY, Lan T, et al. (2010) Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury. Eur J Pharmacol 638: 150-155.
23. Jiang Q, Liu PQ, Wu XQ, Liu WH, Shen XY, et al. (2011) Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathway. Mol Cell Endocrinol 331: 34-40.
24. Liu WH, Liu PQ, Tao S, Deng YH, Li XJ, et al. (2008) Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose. Arch Biochem Biophys 475: 128-134.
25. Olivera A, Rosenfeldt HM, Bektas M, Wang F, Ishii I, et al. (2003) Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem 278: 46452-46460.
26. English D, Garcia JG, Brindley DN, (2001) Platelet-released phospholipids link haemostasis and angiogenesis. Cardiovasc Res 49: 588-599.
27. Aarthi JJ, Darendeliler MA, Pushparaj PN, (2011) Dissecting the role of the S1P/S1PR axis in health and disease. J Dent Res 90: 841-854.
28. Hanafusa N, Yatomi Y, Yamada K, Hori Y, Nangaku M, et al. (2002) Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. Nephrol Dial Transplant 17: 580-586.
29. Katsuma S, Ruike Y, Yano T, Kimura M, Hirasawa A, et al. (2005) Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. FEBS Lett 579: 2576-2582.
30. Imasawa T, Kitamura H, Ohkawa R, Satoh Y, Miyashita A, et al. (2010) Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy. Exp Toxicol Pathol 62: 53-60.
31. Navarro González JF, Mora Fernández C, Muros de Fuentes M, García Pérez J, (2011) Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol 7: 327-340.