메뉴 건너뛰기




Volumn 15, Issue 5, 2015, Pages 523-531

Systemic inflammation as a therapeutic target in acute ischemic stroke

Author keywords

acute stroke; copeptin; prognosis; systematic review

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIDIABETIC AGENT; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; ANTITHROMBOCYTIC AGENT; C REACTIVE PROTEIN; CHEMOKINE; COMPLEMENT; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN; FIBRIC ACID DERIVATIVE; GELATINASE B; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINIC ACID; PRAVASTATIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; RANTES; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; BIOLOGICAL MARKER;

EID: 84928883129     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.2015.1035712     Document Type: Review
Times cited : (153)

References (95)
  • 1
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R. Origin and physiological roles of inflammation. Nature 2008;454:428-35
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 2
    • 38449088697 scopus 로고    scopus 로고
    • Clinical significance of acute phase reaction in stroke patients
    • Dziedzic T. Clinical significance of acute phase reaction in stroke patients. Front Biosci 2008;13:2922-7
    • (2008) Front Biosci , vol.13 , pp. 2922-2927
    • Dziedzic, T.1
  • 3
    • 17044455688 scopus 로고    scopus 로고
    • Interleukin-6 and stroke: Cerebral ischemia versus nonspecific factors influencing interleukin-6
    • Dziedzic T, Slowik A, Szczudlik A. Interleukin-6 and stroke: cerebral ischemia versus nonspecific factors influencing interleukin-6. Stroke 2003;34:e229-30
    • (2003) Stroke , vol.34 , pp. e229-e230
    • Dziedzic, T.1    Slowik, A.2    Szczudlik, A.3
  • 4
    • 0031780850 scopus 로고    scopus 로고
    • Persistent inflammatory response in stroke survivors
    • Beamer NB, Coull BM, Clark WM, et al. Persistent inflammatory response in stroke survivors. Neurology 1998;50:1722-8
    • (1998) Neurology , vol.50 , pp. 1722-1728
    • Beamer, N.B.1    Coull, B.M.2    Clark, W.M.3
  • 5
    • 0038785544 scopus 로고    scopus 로고
    • C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: The Cardiovascular Health Study
    • Cao JJ, Thach C, Manolio TA, et al. C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health Study. Circulation 2003;108:166-70
    • (2003) Circulation , vol.108 , pp. 166-170
    • Cao, J.J.1    Thach, C.2    Manolio, T.A.3
  • 6
    • 0035170373 scopus 로고    scopus 로고
    • Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: The Framingham study
    • Rost NS, Wolf PA, Kase CS, et al. Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. Stroke 2001;32:2575-9
    • (2001) Stroke , vol.32 , pp. 2575-2579
    • Rost, N.S.1    Wolf, P.A.2    Kase, C.S.3
  • 7
    • 0029076766 scopus 로고
    • Interleukin-6 and interleukin-1 receptor antagonist in acute stroke
    • Beamer NB, Coull BM, Clark WM, et al. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol 1995;37:800-5
    • (1995) Ann Neurol , vol.37 , pp. 800-805
    • Beamer, N.B.1    Coull, B.M.2    Clark, W.M.3
  • 8
    • 0029132696 scopus 로고
    • Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke
    • Tarkowski E, Rosengren L, Blomstrand C, et al. Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke 1995;26:1393-8
    • (1995) Stroke , vol.26 , pp. 1393-1398
    • Tarkowski, E.1    Rosengren, L.2    Blomstrand, C.3
  • 9
    • 0028220499 scopus 로고
    • Proinflammatory cytokines in serum of patients with acute cerebral ischemia: Kinetics of secretion and relation to the extent of brain damage and outcome of disease
    • Fassbender K, Rossol S, Kammer T, et al. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. J Neurol Sci 1994;122:135-9
    • (1994) J Neurol Sci , vol.122 , pp. 135-139
    • Fassbender, K.1    Rossol, S.2    Kammer, T.3
  • 10
    • 1542376082 scopus 로고    scopus 로고
    • Serum interleukin-6 predicts cortisol release in acute stroke patients
    • Szczudlik A, Dziedzic T, Bartus S, et al. Serum interleukin-6 predicts cortisol release in acute stroke patients. J Endocrinol Invest 2004;27:37-41
    • (2004) J Endocrinol Invest , vol.27 , pp. 37-41
    • Szczudlik, A.1    Dziedzic, T.2    Bartus, S.3
  • 11
    • 0041903685 scopus 로고    scopus 로고
    • Multiple levels of regulation of the interleukin-6 system in stroke
    • Acalovschi D, Wiest T, Hartmann M, et al. Multiple levels of regulation of the interleukin-6 system in stroke. Stroke 2003;34:1864-9
    • (2003) Stroke , vol.34 , pp. 1864-1869
    • Acalovschi, D.1    Wiest, T.2    Hartmann, M.3
  • 12
    • 0037532616 scopus 로고    scopus 로고
    • An early and sustained peripheral inflammatory response in acute ischaemic stroke: Relationships with infection and atherosclerosis
    • Emsley HC, Smith CJ, Gavin CM, et al. An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J Neuroimmunol 2003;139: 93-101
    • (2003) J Neuroimmunol , vol.139 , pp. 93-101
    • Emsley, H.C.1    Smith, C.J.2    Gavin, C.M.3
  • 13
    • 0036792815 scopus 로고    scopus 로고
    • Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke
    • Winbeck K, Poppert H, Etgen T, et al. Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke. Stroke 2002;33:2459-64
    • (2002) Stroke , vol.33 , pp. 2459-2464
    • Winbeck, K.1    Poppert, H.2    Etgen, T.3
  • 14
    • 24044467143 scopus 로고    scopus 로고
    • Inflammatory response after acute ischemic stroke
    • Marquardt L, Ruf A, Mansmann U, et al. Inflammatory response after acute ischemic stroke. J Neurol Sci 2005;236:65-71
    • (2005) J Neurol Sci , vol.236 , pp. 65-71
    • Marquardt, L.1    Ruf, A.2    Mansmann, U.3
  • 15
    • 4644330988 scopus 로고    scopus 로고
    • C-reactive protein and white blood cell count increases in the first 24 hours after acute stroke
    • Christensen H, Boysen G. C-reactive protein and white blood cell count increases in the first 24 hours after acute stroke. Cerebrovasc Dis 2004;18:214-19
    • (2004) Cerebrovasc Dis , vol.18 , pp. 214-219
    • Christensen, H.1    Boysen, G.2
  • 16
    • 0029816909 scopus 로고    scopus 로고
    • Serial measurement of interleukin-6, transforming growth factor-beta, and S-100 protein in patients with acute stroke
    • Kim JS, Yoon SS, Kim YH, Ryu JS. Serial measurement of interleukin-6, transforming growth factor-beta, and S-100 protein in patients with acute stroke. Stroke 1996;27: 1553-7
    • (1996) Stroke , vol.27 , pp. 1553-1557
    • Kim, J.S.1    Yoon, S.S.2    Kim, Y.H.3    Ryu, J.S.4
  • 17
    • 18944391802 scopus 로고    scopus 로고
    • IL-6: An early marker for outcome in acute ischemic stroke
    • Waje-Andreassen U, Kra°kenes J, Ulvestad E, et al. IL-6: an early marker for outcome in acute ischemic stroke. Acta Neurol Scand 2005;111:360-5
    • (2005) Acta Neurol Scand , vol.111 , pp. 360-365
    • Waje-Andreassen, U.1    Krakenes, J.2    Ulvestad, E.3
  • 18
    • 21244451120 scopus 로고    scopus 로고
    • Assessment of acute phase proteins in acute ischemic stroke
    • Tamam Y, Iltumur K, Apak I. Assessment of acute phase proteins in acute ischemic stroke. Tohoku J Exp Med 2005;206:91-8
    • (2005) Tohoku J Exp Med , vol.206 , pp. 91-98
    • Tamam, Y.1    Iltumur, K.2    Apak, I.3
  • 19
    • 55049111080 scopus 로고    scopus 로고
    • Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome
    • Basic Kes V, Simundic AM, Nikolac N, et al. Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome. Clin Biochem 2008;41:1330-4
    • (2008) Clin Biochem , vol.41 , pp. 1330-1334
    • Basic Kes, V.1    Simundic, A.M.2    Nikolac, N.3
  • 20
    • 77952309802 scopus 로고    scopus 로고
    • The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome
    • Worthmann H, Tryc AB, Goldbecker A, et al. The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome. Cerebrovasc Dis 2010;30:85-92
    • (2010) Cerebrovasc Dis , vol.30 , pp. 85-92
    • Worthmann, H.1    Tryc, A.B.2    Goldbecker, A.3
  • 21
    • 79953806045 scopus 로고    scopus 로고
    • Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume
    • Ormstad H, Aass HC, Lund-Sørensen N, et al. Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume. J Neurol 2011;258:677-85
    • (2011) J Neurol , vol.258 , pp. 677-685
    • Ormstad, H.1    Aass, H.C.2    Lund-Sørensen, N.3
  • 22
    • 33751225029 scopus 로고    scopus 로고
    • Variability of the systemic acute phase response after ischemic stroke
    • Smith CJ, Emsley HC, Vail A, et al. Variability of the systemic acute phase response after ischemic stroke. J Neurol Sci 2006;251:77-81
    • (2006) J Neurol Sci , vol.251 , pp. 77-81
    • Smith, C.J.1    Emsley, H.C.2    Vail, A.3
  • 23
    • 0035067998 scopus 로고    scopus 로고
    • C-reactive protein in ischemic stroke: An independent prognostic factor
    • Di Napoli M, Papa F, Bocola V. C-reactive protein in ischemic stroke: an independent prognostic factor. Stroke 2001;32:917-24
    • (2001) Stroke , vol.32 , pp. 917-924
    • Di Napoli, M.1    Papa, F.2    Bocola, V.3
  • 24
    • 4344590867 scopus 로고    scopus 로고
    • Systemic inflammatory response depends on initial stroke severity but is attenuated by successful thrombolysis
    • Audebert HJ, Rott MM, Eck T, Haberl RL. Systemic inflammatory response depends on initial stroke severity but is attenuated by successful thrombolysis. Stroke 2004;35: 2128-33
    • (2004) Stroke , vol.35 , pp. 2128-2133
    • Audebert, H.J.1    Rott, M.M.2    Eck, T.3    Haberl, R.L.4
  • 25
    • 0035690171 scopus 로고    scopus 로고
    • Temporal profile of serum anti-inflammatory and pro-inflammatory interleukins in acute ischemic stroke patients
    • Perini F, Morra M, Alecci M, et al. Temporal profile of serum anti-inflammatory and pro-inflammatory interleukins in acute ischemic stroke patients. Neurol Sci 2001;22:289-96
    • (2001) Neurol Sci , vol.22 , pp. 289-296
    • Perini, F.1    Morra, M.2    Alecci, M.3
  • 26
    • 25444508186 scopus 로고    scopus 로고
    • Serum interleukin-6 soluble receptor in relation to interleukin-6 in stroke patients
    • Dziedzic T, Gryz EA, Turaj W, et al. Serum interleukin-6 soluble receptor in relation to interleukin-6 in stroke patients. J Mol Neurosci 2004;24:293-8
    • (2004) J Mol Neurosci , vol.24 , pp. 293-298
    • Dziedzic, T.1    Gryz, E.A.2    Turaj, W.3
  • 27
    • 33750343590 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2, and outcome after ischemic stroke
    • Elkind MS, Tai W, Coates K, et al. High-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2, and outcome after ischemic stroke. Arch Intern Med 2006;166:2073-80
    • (2006) Arch Intern Med , vol.166 , pp. 2073-2080
    • Elkind, M.S.1    Tai, W.2    Coates, K.3
  • 28
    • 0033795665 scopus 로고    scopus 로고
    • Proinflammatory cytokines and early neurological worsening in ischemic stroke
    • Vila N, Castillo J, Davalos A, Chamorro A. Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke 2000;31:2325-9
    • (2000) Stroke , vol.31 , pp. 2325-2329
    • Vila, N.1    Castillo, J.2    Davalos, A.3    Chamorro, A.4
  • 29
    • 0348141857 scopus 로고    scopus 로고
    • Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke
    • Montaner J, Rovira A, Molina CA, et al. Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke. J Cereb Blood Flow Metab 2003;23:1403-7
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 1403-1407
    • Montaner, J.1    Rovira, A.2    Molina, C.A.3
  • 30
    • 33744779094 scopus 로고    scopus 로고
    • Inflammatory biomarkers in blood of patients with acute brain ischemia
    • Sotgiu S, Zanda B, Marchetti B, et al. Inflammatory biomarkers in blood of patients with acute brain ischemia. Eur J Neurol 2006;13:505-13
    • (2006) Eur J Neurol , vol.13 , pp. 505-513
    • Sotgiu, S.1    Zanda, B.2    Marchetti, B.3
  • 31
    • 1342291175 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients
    • Intiso D, Zarrelli MM, Lagioia G, et al. Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients. Neurol Sci 2004;24:390-6
    • (2004) Neurol Sci , vol.24 , pp. 390-396
    • Intiso, D.1    Zarrelli, M.M.2    Lagioia, G.3
  • 32
    • 0034771083 scopus 로고    scopus 로고
    • Early TNF-alpha levels correlate with ischaemic stroke severity
    • Zaremba J, Losy J. Early TNF-alpha levels correlate with ischaemic stroke severity. Acta Neurol Scand 2001;104:288-95
    • (2001) Acta Neurol Scand , vol.104 , pp. 288-295
    • Zaremba, J.1    Losy, J.2
  • 33
    • 71949088734 scopus 로고    scopus 로고
    • A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke
    • Chapman KZ, Dale VQ, Denes A, et al. A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke. J Cereb Blood Flow Metab 2009;29:1764-8
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1764-1768
    • Chapman, K.Z.1    Dale, V.Q.2    Denes, A.3
  • 34
    • 39349105381 scopus 로고    scopus 로고
    • Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans
    • Haeusler KG, Schmidt WU, Fohring F, et al. Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovasc Dis 2008;25: 50-8
    • (2008) Cerebrovasc Dis , vol.25 , pp. 50-58
    • Haeusler, K.G.1    Schmidt, W.U.2    Fohring, F.3
  • 35
    • 38149044364 scopus 로고    scopus 로고
    • Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke
    • Vogelgesang A, Grunwald U, Langner S, et al. Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke. Stroke 2008;39: 237-41
    • (2008) Stroke , vol.39 , pp. 237-241
    • Vogelgesang, A.1    Grunwald, U.2    Langner, S.3
  • 36
    • 59349112750 scopus 로고    scopus 로고
    • Harms and benefits of lymphocyte subpopulations in patients with acute stroke
    • Urra X, Cervera A, Villamor N, et al. Harms and benefits of lymphocyte subpopulations in patients with acute stroke. Neuroscience 2009;158:1174-83
    • (2009) Neuroscience , vol.158 , pp. 1174-1183
    • Urra, X.1    Cervera, A.2    Villamor, N.3
  • 37
    • 84925361289 scopus 로고    scopus 로고
    • Splenic responses in ischemic stroke: New insights into stroke pathology
    • Liu ZJ, Chen C, Li FW, et al. Splenic responses in ischemic stroke: new insights into stroke pathology. CNS Neurosci Ther 2015;21(4):320-6
    • (2015) CNS Neurosci Ther , vol.21 , Issue.4 , pp. 320-326
    • Liu, Z.J.1    Chen, C.2    Li, F.W.3
  • 38
    • 79953284058 scopus 로고    scopus 로고
    • Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses
    • Denes A, McColl BW, Leow-Dyke SF, et al. Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses. J Cereb Blood Flow Metab 2011;31:1036-50
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 1036-1050
    • Denes, A.1    McColl, B.W.2    Leow-Dyke, S.F.3
  • 39
    • 78649908826 scopus 로고    scopus 로고
    • Common infections and the risk of stroke
    • Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol 2010;6:681-94
    • (2010) Nat Rev Neurol , vol.6 , pp. 681-694
    • Grau, A.J.1    Urbanek, C.2    Palm, F.3
  • 40
    • 40749120506 scopus 로고    scopus 로고
    • Acute ischaemic stroke and infection: Recent and emerging concepts
    • Emsley HC, Hopkins SJ. Acute ischaemic stroke and infection: recent and emerging concepts. Lancet Neurol 2008;7:341-53
    • (2008) Lancet Neurol , vol.7 , pp. 341-353
    • Emsley, H.C.1    Hopkins, S.J.2
  • 41
    • 0035157347 scopus 로고    scopus 로고
    • Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke
    • Di Napoli M, Papa F, Bocola V. Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke. Stroke 2001;32:133-8
    • (2001) Stroke , vol.32 , pp. 133-138
    • Di Napoli, M.1    Papa, F.2    Bocola, V.3
  • 42
    • 0032921864 scopus 로고    scopus 로고
    • C-reactive protein and outcome after ischemic stroke
    • Muir KW, Weir CJ, Alwan W, et al. C-reactive protein and outcome after ischemic stroke. Stroke 1999;30:981-5
    • (1999) Stroke , vol.30 , pp. 981-985
    • Muir, K.W.1    Weir, C.J.2    Alwan, W.3
  • 43
    • 22644432934 scopus 로고    scopus 로고
    • Prognostic role of C-reactive protein in very old patients with acute ischaemic stroke
    • Masotti L, Ceccarelli E, Forconi S, Cappelli R. Prognostic role of C-reactive protein in very old patients with acute ischaemic stroke. J Intern Med 2005;258: 145-52
    • (2005) J Intern Med , vol.258 , pp. 145-152
    • Masotti, L.1    Ceccarelli, E.2    Forconi, S.3    Cappelli, R.4
  • 44
    • 33748967907 scopus 로고    scopus 로고
    • Inflammatory markers and in-hospital mortality in acute ischaemic stroke
    • Rallidis LS, Vikelis M, Panagiotakos DB, et al. Inflammatory markers and in-hospital mortality in acute ischaemic stroke. Atherosclerosis 2006;189:193-7
    • (2006) Atherosclerosis , vol.189 , pp. 193-197
    • Rallidis, L.S.1    Vikelis, M.2    Panagiotakos, D.B.3
  • 45
    • 70349636710 scopus 로고    scopus 로고
    • Inflammatory markers and poor outcome after stroke: A prospective cohort study and systematic review of interleukin-6
    • Whiteley W, Jackson C, Lewis S, et al. Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin-6. PLoS Med 2009;6:e1000145
    • (2009) PLoS Med , vol.6 , pp. e1000145
    • Whiteley, W.1    Jackson, C.2    Lewis, S.3
  • 46
    • 33646682844 scopus 로고    scopus 로고
    • Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis
    • Montaner J, Fernandez-Cadenas I, Molina CA, et al. Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis. Stroke 2006;37:1205-10
    • (2006) Stroke , vol.37 , pp. 1205-1210
    • Montaner, J.1    Fernandez-Cadenas, I.2    Molina, C.A.3
  • 47
    • 71849109771 scopus 로고    scopus 로고
    • C-reactive protein in the very early phase of acute ischemic stroke: Association with poor outcome and death
    • den Hertog HM, van Rossum JA, van der Worp HB, et al. C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death. J Neurol 2009;256:2003-8
    • (2009) J Neurol , vol.256 , pp. 2003-2008
    • Den Hertog, H.M.1    Van Rossum, J.A.2    Van Der Worp, H.B.3
  • 48
    • 65649149373 scopus 로고    scopus 로고
    • Admission C-reactive protein after acute ischemic stroke is associated with stroke severity and mortality: The 'Bergen stroke study'
    • Idicula TT, Brogger J, Naess H, et al. Admission C-reactive protein after acute ischemic stroke is associated with stroke severity and mortality: the 'Bergen stroke study'. BMC Neurol 2009;9:18
    • (2009) BMC Neurol , vol.9 , pp. 18
    • Idicula, T.T.1    Brogger, J.2    Naess, H.3
  • 49
    • 0036214866 scopus 로고    scopus 로고
    • Inflammation-mediated damage in progressing lacunar infarctions: A potential therapeutic target
    • Castellanos M, Castillo J, Garćia MM, et al. Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target. Stroke 2002;33:982-7
    • (2002) Stroke , vol.33 , pp. 982-987
    • Castellanos, M.1    Castillo, J.2    Garćia, M.M.3
  • 50
    • 33748539771 scopus 로고    scopus 로고
    • Hyperthermia is a surrogate marker of inflammation-mediated cause of brain damage in acute ischaemic stroke
    • Leira R, Rodŕiguez-Yáñez M, Castellanos M, et al. Hyperthermia is a surrogate marker of inflammation-mediated cause of brain damage in acute ischaemic stroke. J Intern Med 2006;260:343-9
    • (2006) J Intern Med , vol.260 , pp. 343-349
    • Leira, R.1    Rodŕiguez-Yáñez, M.2    Castellanos, M.3
  • 51
    • 0033982642 scopus 로고    scopus 로고
    • Cortisol axis abnormalities early after stroke-relationships to cytokines and leptin
    • Johansson A, Ahren B, Nasman B, et al. Cortisol axis abnormalities early after stroke-relationships to cytokines and leptin. J Intern Med 2000;247:179-87
    • (2000) J Intern Med , vol.247 , pp. 179-187
    • Johansson, A.1    Ahren, B.2    Nasman, B.3
  • 52
    • 1642566530 scopus 로고    scopus 로고
    • Urine albumin excretion in acute ischaemic stroke is related to serum interleukin-6
    • Dziedzic T, Slowik A, Szczudlik A. Urine albumin excretion in acute ischaemic stroke is related to serum interleukin-6. Clin Chem Lab Med 2004;42:182-5
    • (2004) Clin Chem Lab Med , vol.42 , pp. 182-185
    • Dziedzic, T.1    Slowik, A.2    Szczudlik, A.3
  • 53
    • 65549158746 scopus 로고    scopus 로고
    • Monocyte subtypes predict clinical course and prognosis in human stroke
    • Urra X, Villamor N, Amaro S, et al. Monocyte subtypes predict clinical course and prognosis in human stroke. J Cereb Blood Flow Metab 2009;29:994-1002
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 994-1002
    • Urra, X.1    Villamor, N.2    Amaro, S.3
  • 54
    • 84862818964 scopus 로고    scopus 로고
    • Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction
    • Kim J, Song TJ, Park JH, et al. Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis 2012;222:464-7
    • (2012) Atherosclerosis , vol.222 , pp. 464-467
    • Kim, J.1    Song, T.J.2    Park, J.H.3
  • 55
    • 34347268434 scopus 로고    scopus 로고
    • Brain-immune communication pathways
    • Quan N, Banks WA. Brain-immune communication pathways. Brain Behav Immun 2007;21:727-35
    • (2007) Brain Behav Immun , vol.21 , pp. 727-735
    • Quan, N.1    Banks, W.A.2
  • 56
    • 84904100340 scopus 로고    scopus 로고
    • In-depth conversation: Spectrum and kinetics of neuroimmune afferent pathways
    • Quan N. In-depth conversation: spectrum and kinetics of neuroimmune afferent pathways. Brain Behav Immun 2014;40:1-8
    • (2014) Brain Behav Immun , vol.40 , pp. 1-8
    • Quan, N.1
  • 57
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • Dantzer R, O'Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008;9:46-56
    • (2008) Nat Rev Neurosci , vol.9 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3
  • 58
    • 0032891837 scopus 로고    scopus 로고
    • Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat
    • Quan N, Stern EL, Whiteside MB, Herkenham M. Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J Neuroimmunol 1999;93:72-80
    • (1999) J Neuroimmunol , vol.93 , pp. 72-80
    • Quan, N.1    Stern, E.L.2    Whiteside, M.B.3    Herkenham, M.4
  • 59
    • 33847759064 scopus 로고    scopus 로고
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    • Qin L, Wu X, Block ML, et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 2007;55:453-62
    • (2007) Glia , vol.55 , pp. 453-462
    • Qin, L.1    Wu, X.2    Block, M.L.3
  • 60
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • Chen J, Buchanan JB, Sparkman NL, et al. Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav Immun 2008;22: 301-11
    • (2008) Brain Behav Immun , vol.22 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3
  • 61
    • 84904777916 scopus 로고    scopus 로고
    • Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: Importance of CCR2/CCL2 signaling
    • Cazareth J, Guyon A, Heurteaux C, et al. Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling. J Neuroinflammation 2014;11:132
    • (2014) J Neuroinflammation , vol.11 , pp. 132
    • Cazareth, J.1    Guyon, A.2    Heurteaux, C.3
  • 62
    • 79953662385 scopus 로고    scopus 로고
    • Immune system to brain signaling: Neuropsychopharmacological implications
    • Capuron L, Miller AH. Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 2011;130: 226-38
    • (2011) Pharmacol Ther , vol.130 , pp. 226-238
    • Capuron, L.1    Miller, A.H.2
  • 63
    • 65549100690 scopus 로고    scopus 로고
    • Systemic inflammatory response reactivates immune-mediated lesions in rat brain
    • Serres S, Anthony DC, Jiang Y, et al. Systemic inflammatory response reactivates immune-mediated lesions in rat brain. J Neurosci 2009;29:4820-8
    • (2009) J Neurosci , vol.29 , pp. 4820-4828
    • Serres, S.1    Anthony, D.C.2    Jiang, Y.3
  • 64
    • 84255194791 scopus 로고    scopus 로고
    • Systemic inflammation induces axon injury during brain inflammation
    • Moreno B, Jukes JP, Vergara-Irigaray N, et al. Systemic inflammation induces axon injury during brain inflammation. Ann Neurol 2011;70:932-42
    • (2011) Ann Neurol , vol.70 , pp. 932-942
    • Moreno, B.1    Jukes, J.P.2    Vergara-Irigaray, N.3
  • 65
    • 77956230017 scopus 로고    scopus 로고
    • Contribution of systemic inflammation to chronic neurodegeneration
    • Perry VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol 2010;120:277-86
    • (2010) Acta Neuropathol , vol.120 , pp. 277-286
    • Perry, V.H.1
  • 66
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout JP, Chen J, Abraham J, et al. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 2005;19:1329-31
    • (2005) FASEB J , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3
  • 67
    • 49549087762 scopus 로고    scopus 로고
    • Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system
    • Godbout JP, Moreau M, Lestage J, et al. Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology 2008;33: 2341-51
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2341-2351
    • Godbout, J.P.1    Moreau, M.2    Lestage, J.3
  • 68
    • 84888859097 scopus 로고    scopus 로고
    • Endotoxin-induced experimental systemic inflammation in humans: A model to disentangle immune-to-brain communication
    • Schedlowski M, Engler H, Grigoleit JS. Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication. Brain Behav Immun 2014;35:1-8
    • (2014) Brain Behav Immun , vol.35 , pp. 1-8
    • Schedlowski, M.1    Engler, H.2    Grigoleit, J.S.3
  • 69
    • 34247338117 scopus 로고    scopus 로고
    • Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1-and neutrophil-dependent mechanisms
    • McColl BW, Rothwell NJ, Allan SM. Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1-and neutrophil-dependent mechanisms. J Neurosci 2007;27:4403-12
    • (2007) J Neurosci , vol.27 , pp. 4403-4412
    • McColl, B.W.1    Rothwell, N.J.2    Allan, S.M.3
  • 70
    • 58149357031 scopus 로고    scopus 로고
    • Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice
    • McColl BW, Rothwell NJ, Allan SM. Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci 2008;28:9451-62
    • (2008) J Neurosci , vol.28 , pp. 9451-9462
    • McColl, B.W.1    Rothwell, N.J.2    Allan, S.M.3
  • 71
    • 34247619336 scopus 로고    scopus 로고
    • Peripheral inflammation exacerbates damage after global ischemia independently of temperature and acute brain inflammation
    • Spencer SJ, Mouihate A, Pittman QJ. Peripheral inflammation exacerbates damage after global ischemia independently of temperature and acute brain inflammation. Stroke 2007;38:1570-7
    • (2007) Stroke , vol.38 , pp. 1570-1577
    • Spencer, S.J.1    Mouihate, A.2    Pittman, Q.J.3
  • 72
    • 79952073266 scopus 로고    scopus 로고
    • Influenza virus infection aggravates stroke outcome
    • Muhammad S, Haasbach E, Kotchourko M, et al. Influenza virus infection aggravates stroke outcome. Stroke 2011;42:783-91
    • (2011) Stroke , vol.42 , pp. 783-791
    • Muhammad, S.1    Haasbach, E.2    Kotchourko, M.3
  • 73
    • 84925945426 scopus 로고    scopus 로고
    • Systemic inflammation impairs tissue reperfusion through endothelin-dependent mechanisms in cerebral ischemia
    • Murray KN, Girard S, Holmes WM, et al. Systemic inflammation impairs tissue reperfusion through endothelin-dependent mechanisms in cerebral ischemia. Stroke 2014;45:3412-19
    • (2014) Stroke , vol.45 , pp. 3412-3419
    • Murray, K.N.1    Girard, S.2    Holmes, W.M.3
  • 74
    • 84902256480 scopus 로고    scopus 로고
    • Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Iba
    • Denes A, Pradillo JM, Drake C, et al. Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Iba. Ann Neurol 2014;75: 670-83
    • (2014) Ann Neurol , vol.75 , pp. 670-683
    • Denes, A.1    Pradillo, J.M.2    Drake, C.3
  • 75
    • 8344247671 scopus 로고    scopus 로고
    • Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats
    • Gill R, Kemp JA, Sabin C, Pepys MB. Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. J Cereb Blood Flow Metab 2004;24:1214-18
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 1214-1218
    • Gill, R.1    Kemp, J.A.2    Sabin, C.3    Pepys, M.B.4
  • 76
    • 41249098692 scopus 로고    scopus 로고
    • Inflammatory and injury responses to ischemic stroke in obese mice
    • Terao S, Yilmaz G, Stokes KY, et al. Inflammatory and injury responses to ischemic stroke in obese mice. Stroke 2008;39:943-50
    • (2008) Stroke , vol.39 , pp. 943-950
    • Terao, S.1    Yilmaz, G.2    Stokes, K.Y.3
  • 77
    • 0034745247 scopus 로고    scopus 로고
    • Acute-phase proteins before cerebral ischemia in stroke-prone rats: Identification by proteomics
    • Sironi L, Tremoli E, Miller I, et al. Acute-phase proteins before cerebral ischemia in stroke-prone rats: identification by proteomics. Stroke 2001;32:753-60
    • (2001) Stroke , vol.32 , pp. 753-760
    • Sironi, L.1    Tremoli, E.2    Miller, I.3
  • 78
    • 84872812639 scopus 로고    scopus 로고
    • Interleukin-1 b accelerates the onset of stroke in stroke-prone spontaneously hypertensive rats
    • Chiba T, Itoh T, Tabuchi M, et al. Interleukin-1 b accelerates the onset of stroke in stroke-prone spontaneously hypertensive rats. Mediators Inflamm 2012;2012:701976
    • (2012) Mediators Inflamm , vol.2012 , pp. 701976
    • Chiba, T.1    Itoh, T.2    Tabuchi, M.3
  • 79
    • 77955570393 scopus 로고    scopus 로고
    • Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats
    • Chiba T, Ezaki O. Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats. Biochem Biophys Res Commun 2010;399:98-103
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 98-103
    • Chiba, T.1    Ezaki, O.2
  • 80
    • 0020086264 scopus 로고
    • Isolation and characterization of C-reactive protein and serum amyloid P component in the rat
    • de Beer FC, Baltz ML, Munn EA, et al. Isolation and characterization of C-reactive protein and serum amyloid P component in the rat. Immunology 1982;45:55-70
    • (1982) Immunology , vol.45 , pp. 55-70
    • De Beer, F.C.1    Baltz, M.L.2    Munn, E.A.3
  • 82
    • 33846856622 scopus 로고    scopus 로고
    • C-reactive protein (CRP)-lowering agents
    • Prasad K. C-reactive protein (CRP)-lowering agents. Cardiovasc Drug Rev 2006;24:33-50
    • (2006) Cardiovasc Drug Rev , vol.24 , pp. 33-50
    • Prasad, K.1
  • 83
    • 84896488117 scopus 로고    scopus 로고
    • Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities
    • Scheller J, Garbers C, Rose-John S. Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities. Semin Immunol 2014;26:2-12
    • (2014) Semin Immunol , vol.26 , pp. 2-12
    • Scheller, J.1    Garbers, C.2    Rose-John, S.3
  • 84
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • Jones SA, Scheller J, Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest 2011;121:3375-83
    • (2011) J Clin Invest , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 85
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicenter randomised placebo-controlled trial
    • Emery P, Keystone E, Tony HP, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicenter randomised placebo-controlled trial. Ann Rheum Dis 2008;67:1516-23
    • (2008) Ann Rheum Dis , vol.67 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3
  • 86
    • 84865377662 scopus 로고    scopus 로고
    • Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis
    • Sodenkamp J, Waetzig GH, Scheller J, et al. Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. Immunobiology 2012;217:996-1004
    • (2012) Immunobiology , vol.217 , pp. 996-1004
    • Sodenkamp, J.1    Waetzig, G.H.2    Scheller, J.3
  • 87
    • 84872182482 scopus 로고    scopus 로고
    • IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
    • Hoge J, Yan I, Jänner N, et al. IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. J Immunol 2013;190:703-11
    • (2013) J Immunol , vol.190 , pp. 703-711
    • Hoge, J.1    Yan, I.2    Jänner, N.3
  • 88
    • 25444517949 scopus 로고    scopus 로고
    • A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients
    • Emsley HC, Smith CJ, Georgiou RF, et al. A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. J Neurol Neurosurg Psychiatry 2005;76:1366-72
    • (2005) J Neurol Neurosurg Psychiatry , vol.76 , pp. 1366-1372
    • Emsley, H.C.1    Smith, C.J.2    Georgiou, R.F.3
  • 89
    • 84923005762 scopus 로고    scopus 로고
    • Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity
    • Giles JA, Greenhalgh AD, Davies CL, et al. Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity. Eur J Immunol 2015;45:525-30
    • (2015) Eur J Immunol , vol.45 , pp. 525-530
    • Giles, J.A.1    Greenhalgh, A.D.2    Davies, C.L.3
  • 90
    • 0033638849 scopus 로고    scopus 로고
    • The sympathetic nerve-an integrative interface between two supersystems: The brain and the immune system
    • Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-638
    • (2000) Pharmacol Rev , vol.52 , pp. 595-638
    • Elenkov, I.J.1    Wilder, R.L.2    Chrousos, G.P.3    Vizi, E.S.4
  • 91
    • 0034713266 scopus 로고    scopus 로고
    • Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    • Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000;405:458-62
    • (2000) Nature , vol.405 , pp. 458-462
    • Borovikova, L.V.1    Ivanova, S.2    Zhang, M.3
  • 92
    • 66149103723 scopus 로고    scopus 로고
    • Cholinergic control of inflammation
    • Rosas-Ballina M, Tracey KJ. Cholinergic control of inflammation. J Intern Med 2009;265:663-79
    • (2009) J Intern Med , vol.265 , pp. 663-679
    • Rosas-Ballina, M.1    Tracey, K.J.2
  • 93
    • 78650783571 scopus 로고    scopus 로고
    • Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model
    • Wang YY, Lin SY, Chuang YH, et al. Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model. Am J Physiol Endocrinol Metab 2011;300: E155-63
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , pp. E155-E163
    • Wang, Y.Y.1    Lin, S.Y.2    Chuang, Y.H.3
  • 94
    • 84862676439 scopus 로고    scopus 로고
    • Antibiotic therapy for preventing infections in patients with acute stroke
    • Westendorp WF, Vermeij JD, Vermeij F, et al. Antibiotic therapy for preventing infections in patients with acute stroke. Cochrane Database Syst Rev 2012;1: CD008530
    • (2012) Cochrane Database Syst Rev , vol.1 , pp. CD008530
    • Westendorp, W.F.1    Vermeij, J.D.2    Vermeij, F.3
  • 95
    • 84920943309 scopus 로고    scopus 로고
    • DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury
    • Liesz A, Dalpke A, Mracsko E, et al. DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury. J Neurosci 2015;35:583-98
    • (2015) J Neurosci , vol.35 , pp. 583-598
    • Liesz, A.1    Dalpke, A.2    Mracsko, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.