Multiple levels of regulation of the interleukin-6 system in stroke

Stroke

Volumn 34, Issue 8, 2003, Pages 1864-1869

  Acalovschi, Daniela ^a,c   Wiest, Tina ^a   Hartmann, Marius ^a   Farahmi, Maryam ^a   Mansmann, Ulrich ^a   Auffarth, Gerd U ^a   Grau, Armin J ^a   Green, Fiona R ^b   Grond Ginsbach, Caspar ^a   Schwaninger, Markus ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Acute phase reaction; Interleukins; Polymorphism

Indexed keywords

ADENOSINE; CYTOSINE; DNA; GUANINE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; OLIGONUCLEOTIDE; PROTEIN SUBUNIT; THREONINE;

ADULT; AGED; ALLELE; ARTICLE; ASTROCYTE; CELL LINE; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUSION GENE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HAPLOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REPORTER GENE; STATISTICAL SIGNIFICANCE;

ACUTE DISEASE; ANTIGENS, CD; ASTROCYTES; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CELL LINE; CEREBROVASCULAR ACCIDENT; CYTOKINE RECEPTOR GP130; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENES, REPORTER; HAPLOTYPES; HUMANS; INTERLEUKIN-6; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROSPECTIVE STUDIES; RECEPTORS, INTERLEUKIN-6; TRANSFECTION;

EID: 0041903685     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000079815.38626.44     Document Type: Article

References (27)

1. Di Napoli M, Papa F, Bocola V. Prognostic influence of increased c-reactive protein and fibrinogen levels in ischemic stroke. Stroke. 2001;32:133-138.
2. Di Napoli M, Papa F, Bocola V. C-reactive protein in ischemic stroke: an independent prognostic factor. Stroke. 2001;32:917-924.
3. Castillo J, Dávalos A, Marrugat J, Noya M. Timing for fever-related brain damage in acute ischemic stroke. Stroke. 1998;29:2455-2460.
4. Reith J, Jorgensen H, Pedersen P, Nakayama H, Raaschou H, Jeppesen L, Olsen T. Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet. 1996;347:422-425.
5. Maeda Y, Matsumoto M, Hori O, Kuwabara K, Ogawa S, Yan SD, Ohtsuki T, Kinoshita T, Kamada T, Stern DM. Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival. J Exp Med. 1994;180:2297-2308.
6. Suzuki S, Tanaka K, Nogawa S, Nagata E, Ito D, Dembo T, Fukuuchi Y. Temporal profile and cellular localization of interleukin-6 protein after focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1999;19:1256-1262.
7. Herrmann O, Tarabin V, Suzuki S, Attigah N, Coserea I, Schneider A, Vogel J, Prinz S, Schwab S, Monyer H, et al. Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia. J Cereb Blood Flow Metab. 2003;23:406-415.
8. Tarkowski E, Rosengren L, Blomstrand C, Wikkelsö C, Jensen C, Ekholm S, Tarkowski A. Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke. 1995;26:1393-1398.
9. Beamer NB, Coull BM, Clark WM, Hazel JS, Silberger JR. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol. 1995;37:800-805.
10. Vila N, Castillo J, Dávalos A, Chamorro A. Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke. 2000;31:2325-2329.
11. Terry CF, Loukaci V, Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem. 2000;275:18138-18144.
12. Pola R, Gaetani E, Flex A, Aloi F, Papaleo P, Gerardino L, De Martini D, Flore R, Pola P, Bernabei R. -174 g/c interleukin-6 gene polymorphism and increased risk of multi-infarct dementia: a case-control study. Exp Gerontol. 2002;37:949-955.
13. Revilla M, Obach V, Cervera A, Dávalos A, Castillo J, Chamorro A. A-174g/c polymorphism of the interleukin-6 gene in patients with lacunar infarction. Neurosci Lett. 2002;324:29-32.
14. Schöbitz B, Pezeshki G, Pohl T, Hemmann U, Heinrich PC, Holsboer F, Reul JM. Soluble interleukin-6 (IL-6) receptor augments central effects of II-6 in vivo. FASEB J. 1995;9:659-664.
15. Jostock T, Mullberg J, Ozbek S, Atreya R, Blinn G, Voltz N, Fischer M, Neurath MF. Rose-John S. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem. 2001;268:160-167.
16. Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J. 2001;15:43-58.
17. Grau AJ, Buggle F, Heindl S, Steichen-Wiehn C, Banerjee T, Maiwald M, Rohlfs M, Suhr H, Fiehn W, Becher H, et al. Recent infection as a risk factor for cerebrovascular ischemia. Stroke. 1995;26:373-379.
18. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial: Toast: Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41.
19. Dieler C, Frohlich E, Bourquain H, Holle R, von Kummer R. Simple volumetry of ischemic cerebral infarction using computerized tomography: interobserver and method comparison. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 1999;171:279-282.
20. Schwaninger M, Ringleb P, Annecke A, Winter R, Kohl B, Werle E, Fiehn W, Rieser PA, Walter-Sack I. Elevated plasma concentrations of lipoprotein(a) in medicated epileptic patients. J Neurol. 2000;247:687-690.
21. Schwaninger M, Petersen N, Prinz S, Sallmann S, Spranger M. Adenosine-induced expression of interleukin-6 in astrocytes through protein kinase a and nf-i16. Glia, 2000;31:51-58.
22. Fassbender K, Rossol S, Kammer T, Daffertshofer M, Wirth S, Dollman M, Hennerici M. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. J Neurol Sci. 1994;122:135-139.
23. Sallmann S, Juttler E, Prinz S, Petersen N, Knopf U, Weiser T, Schwaninger M. Induction of interleukin-6 by depolarization of neurons. J Neurosci. 2000;20:8637-8642.
24. Latini S, Pedata F. Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J Neurochem. 2001;79:463-484.
25. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P. The effect of novel polymorphisms in the interleukin-6 (II-6) gene on II-6 transcription and plasma II-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998;102:1369-1376.
26. Rauramaa R, Vaisanen SB, Luong LA, Schmidt-Trücksäss A, Penttilä IM, Bouchard C, Töyry J, Humphries SE. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arterioscler Thromb Vasc Biol. 2000;20:2657-2662.
27. Brull DJ, Montgomery HE, Sanders J, Dharmrait S, Luong L, Rumley A, Lowe GDO. Humphries SE. Interleukin-6 gene -174g→c and -572g→c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol. 2001;21:1458-1463.