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Volumn 35, Issue , 2014, Pages 1-8

Endotoxin-induced experimental systemic inflammation in humans: A model to disentangle immune-to-brain communication

Author keywords

Cytokines; Experimental inflammation; FMRI; Human endotoxemia; Immune to brain communication; Lipopolysaccharide (LPS); Sickness behavior

Indexed keywords

ENDOTOXIN; INTERLEUKIN 10; TOLL LIKE RECEPTOR 4; TYPHOID VACCINE; CYTOKINE; LIPOPOLYSACCHARIDE;

EID: 84888859097     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2013.09.015     Document Type: Review
Times cited : (158)

References (81)
  • 1
    • 78651181077 scopus 로고
    • Febrile responses to the intracisternal injection of endogenous (leucocytic) pyrogen in the rabbit
    • Adler R.D., Joy R.J. Febrile responses to the intracisternal injection of endogenous (leucocytic) pyrogen in the rabbit. Proc. Soc. Exp. Biol. Med. 1965, 119:660-663.
    • (1965) Proc. Soc. Exp. Biol. Med. , vol.119 , pp. 660-663
    • Adler, R.D.1    Joy, R.J.2
  • 2
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4:499-511.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 4
    • 35848936089 scopus 로고    scopus 로고
    • From therapy to experimental model: a hundred years of endotoxin administration to human subjects
    • Bahador M., Cross A.S. From therapy to experimental model: a hundred years of endotoxin administration to human subjects. J. Endotoxin Res. 2007, 13:251-279.
    • (2007) J. Endotoxin Res. , vol.13 , pp. 251-279
    • Bahador, M.1    Cross, A.S.2
  • 5
    • 0017058576 scopus 로고
    • Intracerebroventricular administration of leukocytic endogenous mediators (LEM) in the rat
    • Bailey P.T., Abeles F.B., Hauer E.C., Mapes C.A. Intracerebroventricular administration of leukocytic endogenous mediators (LEM) in the rat. Proc. Soc. Exp. Biol. Med. 1976, 153:419-423.
    • (1976) Proc. Soc. Exp. Biol. Med. , vol.153 , pp. 419-423
    • Bailey, P.T.1    Abeles, F.B.2    Hauer, E.C.3    Mapes, C.A.4
  • 6
    • 33746311486 scopus 로고    scopus 로고
    • The blood-brain barrier in psychoneuroimmunology
    • Banks W.A. The blood-brain barrier in psychoneuroimmunology. Neurol. Clin. 2006, 24:413-419.
    • (2006) Neurol. Clin. , vol.24 , pp. 413-419
    • Banks, W.A.1
  • 8
    • 0030043899 scopus 로고    scopus 로고
    • Immune-neuro-endocrine interactions: facts and hypotheses
    • Besedovsky H.O., del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 1996, 17:64-102.
    • (1996) Endocr. Rev. , vol.17 , pp. 64-102
    • Besedovsky, H.O.1    del Rey, A.2
  • 10
    • 0023889666 scopus 로고
    • Interleukin-1 immunoreactive innervation of the human hypothalamus
    • Breder C.D., Dinarello C.A., Saper C.B. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 1988, 240:321-324.
    • (1988) Science , vol.240 , pp. 321-324
    • Breder, C.D.1    Dinarello, C.A.2    Saper, C.B.3
  • 11
    • 43049177729 scopus 로고    scopus 로고
    • Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans
    • Brydon L., Harrison N.A., Walker C., Steptoe A., Critchley H.D. Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biol. Psychiatry 2008, 63:1022-1029.
    • (2008) Biol. Psychiatry , vol.63 , pp. 1022-1029
    • Brydon, L.1    Harrison, N.A.2    Walker, C.3    Steptoe, A.4    Critchley, H.D.5
  • 13
    • 67649853033 scopus 로고    scopus 로고
    • Dispositional optimism and stress-induced changes in immunity and negative mood
    • Brydon L., Walker C., Wawrzyniak A.J., Chart H., Steptoe A. Dispositional optimism and stress-induced changes in immunity and negative mood. Brain. Behav. Immun. 2009, 23:810-816.
    • (2009) Brain. Behav. Immun. , vol.23 , pp. 810-816
    • Brydon, L.1    Walker, C.2    Wawrzyniak, A.J.3    Chart, H.4    Steptoe, A.5
  • 14
    • 9644276925 scopus 로고    scopus 로고
    • Cytokines and psychopathology: lessons from interferon-alpha
    • Capuron L., Miller A.H. Cytokines and psychopathology: lessons from interferon-alpha. Biol. Psychiatry 2004, 56:819-824.
    • (2004) Biol. Psychiatry , vol.56 , pp. 819-824
    • Capuron, L.1    Miller, A.H.2
  • 15
    • 0034079672 scopus 로고    scopus 로고
    • Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy
    • Capuron L., Ravaud A., Dantzer R. Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy. J. Clin. Oncol. 2000, 18:2143-2151.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2143-2151
    • Capuron, L.1    Ravaud, A.2    Dantzer, R.3
  • 16
    • 79959740393 scopus 로고    scopus 로고
    • Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms
    • Capuron L., Schroecksnadel S., Feart C., Aubert A., Higueret D., Barberger-Gateau P., Laye S., Fuchs D. Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol. Psychiatry 2011, 70:175-182.
    • (2011) Biol. Psychiatry , vol.70 , pp. 175-182
    • Capuron, L.1    Schroecksnadel, S.2    Feart, C.3    Aubert, A.4    Higueret, D.5    Barberger-Gateau, P.6    Laye, S.7    Fuchs, D.8
  • 18
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • Cohen J. The immunopathogenesis of sepsis. Nature 2002, 420:885-891.
    • (2002) Nature , vol.420 , pp. 885-891
    • Cohen, J.1
  • 19
    • 3242722725 scopus 로고    scopus 로고
    • Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase
    • Cohen O., Reichenberg A., Perry C., Ginzberg D., Pollmacher T., Soreq H., Yirmiya R. Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase. J. Mol. Neurosci. 2003, 21:199-212.
    • (2003) J. Mol. Neurosci. , vol.21 , pp. 199-212
    • Cohen, O.1    Reichenberg, A.2    Perry, C.3    Ginzberg, D.4    Pollmacher, T.5    Soreq, H.6    Yirmiya, R.7
  • 20
    • 52949117520 scopus 로고    scopus 로고
    • Malaise in the water maze: Untangling the effects of LPS and IL-1beta on learning and memory
    • Cunningham C., Sanderson D.J. Malaise in the water maze: Untangling the effects of LPS and IL-1beta on learning and memory. Brain Behav. Immun. 2008, 22:1117-1127.
    • (2008) Brain Behav. Immun. , vol.22 , pp. 1117-1127
    • Cunningham, C.1    Sanderson, D.J.2
  • 21
    • 0035165407 scopus 로고    scopus 로고
    • Cytokine-induced sickness behavior: where do we stand?
    • Dantzer R. Cytokine-induced sickness behavior: where do we stand?. Brain Behav. Immun. 2001, 15:7-24.
    • (2001) Brain Behav. Immun. , vol.15 , pp. 7-24
    • Dantzer, R.1
  • 22
    • 0034695168 scopus 로고    scopus 로고
    • Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?
    • Dantzer R., Konsman J.P., Bluthe R.M., Kelley K.W. Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?. Auton. Neurosci. 2000, 85:60-65.
    • (2000) Auton. Neurosci. , vol.85 , pp. 60-65
    • Dantzer, R.1    Konsman, J.P.2    Bluthe, R.M.3    Kelley, K.W.4
  • 23
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: when the immune system subjugates the brain
    • Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 24
    • 70350218960 scopus 로고    scopus 로고
    • A critical review of human endotoxin administration as an experimental paradigm of depression
    • DellaGioia N., Hannestad J. A critical review of human endotoxin administration as an experimental paradigm of depression. Neurosci. Biobehav. Rev. 2010, 34:130-143.
    • (2010) Neurosci. Biobehav. Rev. , vol.34 , pp. 130-143
    • DellaGioia, N.1    Hannestad, J.2
  • 25
    • 0036398446 scopus 로고    scopus 로고
    • The IL-1 family and inflammatory diseases
    • Dinarello C.A. The IL-1 family and inflammatory diseases. Clin. Exp. Rheumatol. 2002, 20:S1-13.
    • (2002) Clin. Exp. Rheumatol. , vol.20
    • Dinarello, C.A.1
  • 26
    • 79955768949 scopus 로고    scopus 로고
    • Electrical activity in rat cortico-limbic structures after single or repeated administration of lipopolysaccharide or staphylococcal enterotoxin B
    • Doenlen R., Krugel U., Wirth T., Riether C., Engler A., Prager G., Engler H., Schedlowski M., Pacheco-Lopez G. Electrical activity in rat cortico-limbic structures after single or repeated administration of lipopolysaccharide or staphylococcal enterotoxin B. Proc. Biol. Sci. 2011, 278:1864-1872.
    • (2011) Proc. Biol. Sci. , vol.278 , pp. 1864-1872
    • Doenlen, R.1    Krugel, U.2    Wirth, T.3    Riether, C.4    Engler, A.5    Prager, G.6    Engler, H.7    Schedlowski, M.8    Pacheco-Lopez, G.9
  • 28
    • 67651067679 scopus 로고    scopus 로고
    • An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences
    • Eisenberger N.I., Inagaki T.K., Rameson L.T., Mashal N.M., Irwin M.R. An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage 2009, 47:881-890.
    • (2009) Neuroimage , vol.47 , pp. 881-890
    • Eisenberger, N.I.1    Inagaki, T.K.2    Rameson, L.T.3    Mashal, N.M.4    Irwin, M.R.5
  • 30
    • 77951878127 scopus 로고    scopus 로고
    • Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood
    • Eisenberger N.I., Inagaki T.K., Mashal N.M., Irwin M.R. Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain. Behav. Immun. 2010, 24:558-563.
    • (2010) Brain. Behav. Immun. , vol.24 , pp. 558-563
    • Eisenberger, N.I.1    Inagaki, T.K.2    Mashal, N.M.3    Irwin, M.R.4
  • 31
    • 36849037934 scopus 로고    scopus 로고
    • Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being
    • Elenkov I.J. Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being. Neurochem. Int. 2008, 52:40-51.
    • (2008) Neurochem. Int. , vol.52 , pp. 40-51
    • Elenkov, I.J.1
  • 32
    • 33645087923 scopus 로고    scopus 로고
    • Molecular mechanisms involved in T cell migration across the blood-brain barrier
    • Engelhardt B. Molecular mechanisms involved in T cell migration across the blood-brain barrier. J. Neural Transm. 2006, 113:477-485.
    • (2006) J. Neural Transm. , vol.113 , pp. 477-485
    • Engelhardt, B.1
  • 33
    • 0021175639 scopus 로고
    • Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?
    • Fontana A., Weber E., Dayer J.M. Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?. J. Immunol. 1984, 133:1696-1698.
    • (1984) J. Immunol. , vol.133 , pp. 1696-1698
    • Fontana, A.1    Weber, E.2    Dayer, J.M.3
  • 34
    • 0029816476 scopus 로고    scopus 로고
    • IL1 beta impairs relational but not procedural rodent learning in a water maze task
    • Gibertini M. IL1 beta impairs relational but not procedural rodent learning in a water maze task. Adv. Exp. Med. Biol. 1996, 402:207-217.
    • (1996) Adv. Exp. Med. Biol. , vol.402 , pp. 207-217
    • Gibertini, M.1
  • 35
    • 0029027101 scopus 로고
    • Spatial learning impairment in mice infected with Legionella pneumophila or administered exogenous interleukin-1-beta
    • Gibertini M., Newton C., Friedman H., Klein T.W. Spatial learning impairment in mice infected with Legionella pneumophila or administered exogenous interleukin-1-beta. Brain. Behav. Immun. 1995, 9:113-128.
    • (1995) Brain. Behav. Immun. , vol.9 , pp. 113-128
    • Gibertini, M.1    Newton, C.2    Friedman, H.3    Klein, T.W.4
  • 42
    • 68049131222 scopus 로고    scopus 로고
    • Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity
    • Harrison N.A., Brydon L., Walker C., Gray M.A., Steptoe A., Critchley H.D. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol. Psychiatry 2009, 66:407-414.
    • (2009) Biol. Psychiatry , vol.66 , pp. 407-414
    • Harrison, N.A.1    Brydon, L.2    Walker, C.3    Gray, M.A.4    Steptoe, A.5    Critchley, H.D.6
  • 44
    • 0024159821 scopus 로고
    • Biological basis of the behavior of sick animals
    • Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 1988, 12:123-137.
    • (1988) Neurosci. Biobehav. Rev. , vol.12 , pp. 123-137
    • Hart, B.L.1
  • 46
    • 20144362430 scopus 로고    scopus 로고
    • A meta-analytic review of the effects of acute cortisol administration on human memory
    • Het S., Ramlow G., Wolf O.T. A meta-analytic review of the effects of acute cortisol administration on human memory. Psychoneuroendocrinology 2005, 30:771-784.
    • (2005) Psychoneuroendocrinology , vol.30 , pp. 771-784
    • Het, S.1    Ramlow, G.2    Wolf, O.T.3
  • 47
    • 34347261376 scopus 로고    scopus 로고
    • Central nervous system recognition of peripheral inflammation: a neural, hormonal collaboration
    • Hopkins S.J. Central nervous system recognition of peripheral inflammation: a neural, hormonal collaboration. Acta Biomed. 2007, 78(Suppl. 1):231-247.
    • (2007) Acta Biomed. , vol.78 , Issue.SUPPL. 1 , pp. 231-247
    • Hopkins, S.J.1
  • 48
    • 84876821683 scopus 로고    scopus 로고
    • Low-dose endotoxin potentiates capsaicin-induced pain in man: Evidence for a pain neuroimmune connection
    • Hutchinson M.R., Buijs M., Kwok Y.H., Gentgall M., Williams D., Rolan P. Low-dose endotoxin potentiates capsaicin-induced pain in man: Evidence for a pain neuroimmune connection. Brain Behav. Immun. 2013, 30:3-11.
    • (2013) Brain Behav. Immun. , vol.30 , pp. 3-11
    • Hutchinson, M.R.1    Buijs, M.2    Kwok, Y.H.3    Gentgall, M.4    Williams, D.5    Rolan, P.6
  • 49
    • 84855174215 scopus 로고    scopus 로고
    • Inflammation selectively enhances amygdala activity to socially threatening images
    • Inagaki T.K., Muscatell K.A., Irwin M.R., Cole S.W., Eisenberger N.I. Inflammation selectively enhances amygdala activity to socially threatening images. Neuroimage 2012, 59:3222-3226.
    • (2012) Neuroimage , vol.59 , pp. 3222-3226
    • Inagaki, T.K.1    Muscatell, K.A.2    Irwin, M.R.3    Cole, S.W.4    Eisenberger, N.I.5
  • 57
    • 0022399614 scopus 로고
    • Suppression of food intake during infection: is interleukin-1 involved?
    • McCarthy D.O., Kluger M.J., Vander A.J. Suppression of food intake during infection: is interleukin-1 involved?. Am. J. Clin. Nutr. 1985, 42:1179-1182.
    • (1985) Am. J. Clin. Nutr. , vol.42 , pp. 1179-1182
    • McCarthy, D.O.1    Kluger, M.J.2    Vander, A.J.3
  • 58
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    • Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 2009, 65:732-741.
    • (2009) Biol. Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 61
    • 0036429451 scopus 로고    scopus 로고
    • Low levels of circulating inflammatory cytokines - do they affect human brain functions?
    • Pollmacher T., Haack M., Schuld A., Reichenberg A., Yirmiya R. Low levels of circulating inflammatory cytokines - do they affect human brain functions?. Brain. Behav. Immun. 2002, 16:525-532.
    • (2002) Brain. Behav. Immun. , vol.16 , pp. 525-532
    • Pollmacher, T.1    Haack, M.2    Schuld, A.3    Reichenberg, A.4    Yirmiya, R.5
  • 63
    • 0031773020 scopus 로고    scopus 로고
    • Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning
    • Pugh C.R., Kumagawa K., Fleshner M., Watkins L.R., Maier S.F., Rudy J.W. Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain Behav. Immun. 1998, 12:212-229.
    • (1998) Brain Behav. Immun. , vol.12 , pp. 212-229
    • Pugh, C.R.1    Kumagawa, K.2    Fleshner, M.3    Watkins, L.R.4    Maier, S.F.5    Rudy, J.W.6
  • 64
    • 84878155936 scopus 로고    scopus 로고
    • Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias
    • Raison C.L., Miller A.H. Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias. Brain. Behav. Immun. 2013, 31:1-8.
    • (2013) Brain. Behav. Immun. , vol.31 , pp. 1-8
    • Raison, C.L.1    Miller, A.H.2
  • 65
    • 30544445602 scopus 로고    scopus 로고
    • Cytokines sing the blues: inflammation and the pathogenesis of depression
    • Raison C.L., Capuron L., Miller A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006, 27:24-31.
    • (2006) Trends Immunol. , vol.27 , pp. 24-31
    • Raison, C.L.1    Capuron, L.2    Miller, A.H.3
  • 67
    • 2542466803 scopus 로고    scopus 로고
    • Signaling the brain in systemic inflammation: role of sensory circumventricular organs
    • Roth J., Harre E.M., Rummel C., Gerstberger R., Hubschle T. Signaling the brain in systemic inflammation: role of sensory circumventricular organs. Front. Biosci. 2004, 9:290-300.
    • (2004) Front. Biosci. , vol.9 , pp. 290-300
    • Roth, J.1    Harre, E.M.2    Rummel, C.3    Gerstberger, R.4    Hubschle, T.5
  • 69
    • 70349106365 scopus 로고    scopus 로고
    • How T-cell-dependent and -independent challenges access the brain: vascular and neural responses to bacterial lipopolysaccharide and staphylococcal enterotoxin B
    • Serrats J., Sawchenko P.E. How T-cell-dependent and -independent challenges access the brain: vascular and neural responses to bacterial lipopolysaccharide and staphylococcal enterotoxin B. Brain Behav. Immun. 2009, 23:1038-1052.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 1038-1052
    • Serrats, J.1    Sawchenko, P.E.2
  • 71
    • 0034990845 scopus 로고    scopus 로고
    • Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus
    • Shaw K.N., Commins S., O'Mara S.M. Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus. Behav. Brain Res. 2001, 124:47-54.
    • (2001) Behav. Brain Res. , vol.124 , pp. 47-54
    • Shaw, K.N.1    Commins, S.2    O'Mara, S.M.3
  • 72
    • 0023682391 scopus 로고
    • Effects of interferon alpha on performance in man: a preliminary report
    • Smith A., Tyrrell D., Coyle K., Higgins P. Effects of interferon alpha on performance in man: a preliminary report. Psychopharmacology (Berl.) 1988, 96:414-416.
    • (1988) Psychopharmacology (Berl.) , vol.96 , pp. 414-416
    • Smith, A.1    Tyrrell, D.2    Coyle, K.3    Higgins, P.4
  • 74
    • 4644360427 scopus 로고    scopus 로고
    • Mild acute inflammatory stimulation induces transient negative mood
    • Strike P.C., Wardle J., Steptoe A. Mild acute inflammatory stimulation induces transient negative mood. J. Psychosom. Res. 2004, 57:189-194.
    • (2004) J. Psychosom. Res. , vol.57 , pp. 189-194
    • Strike, P.C.1    Wardle, J.2    Steptoe, A.3
  • 76
    • 0028857633 scopus 로고
    • Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication
    • Watkins L.R., Goehler L.E., Relton J.K., Tartaglia N., Silbert L., Martin D., Maier S.F. Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 1995, 183:27-31.
    • (1995) Neurosci. Lett. , vol.183 , pp. 27-31
    • Watkins, L.R.1    Goehler, L.E.2    Relton, J.K.3    Tartaglia, N.4    Silbert, L.5    Martin, D.6    Maier, S.F.7
  • 77
    • 0037072285 scopus 로고    scopus 로고
    • Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging
    • Weaver J.D., Huang M.H., Albert M., Harris T., Rowe J.W., Seeman T.E. Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology 2002, 59:371-378.
    • (2002) Neurology , vol.59 , pp. 371-378
    • Weaver, J.D.1    Huang, M.H.2    Albert, M.3    Harris, T.4    Rowe, J.W.5    Seeman, T.E.6
  • 78
    • 34347252651 scopus 로고    scopus 로고
    • Environmental context differentially affects behavioral, leukocyte, cortisol, and interleukin-6 responses to low doses of endotoxin in the rhesus monkey
    • Willette A.A., Lubach G.R., Coe C.L. Environmental context differentially affects behavioral, leukocyte, cortisol, and interleukin-6 responses to low doses of endotoxin in the rhesus monkey. Brain. Behav. Immun. 2007, 21:807-815.
    • (2007) Brain. Behav. Immun. , vol.21 , pp. 807-815
    • Willette, A.A.1    Lubach, G.R.2    Coe, C.L.3
  • 79
    • 20444422230 scopus 로고    scopus 로고
    • Acute inflammation and negative mood: mediation by cytokine activation
    • Wright C.E., Strike P.C., Brydon L., Steptoe A. Acute inflammation and negative mood: mediation by cytokine activation. Brain Behav. Immun. 2005, 19:345-350.
    • (2005) Brain Behav. Immun. , vol.19 , pp. 345-350
    • Wright, C.E.1    Strike, P.C.2    Brydon, L.3    Steptoe, A.4
  • 80
    • 78651412528 scopus 로고    scopus 로고
    • Immune modulation of learning, memory, neural plasticity and neurogenesis
    • Yirmiya R., Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain. Behav. Immun. 2011, 25:181-213.
    • (2011) Brain. Behav. Immun. , vol.25 , pp. 181-213
    • Yirmiya, R.1    Goshen, I.2
  • 81
    • 17844376268 scopus 로고    scopus 로고
    • Cortisol in mood disorders
    • Young A.H. Cortisol in mood disorders. Stress 2004, 7:205-208.
    • (2004) Stress , vol.7 , pp. 205-208
    • Young, A.H.1


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