-
1
-
-
0034127726
-
In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring
-
Hayashi M., MacGregor J.T., Gatehouse D.G., Adler I.D., Blakey D.H., Dertinger S.D., Krishna G., Morita T., Russo A., Sutou S. In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring. Environ. Mol. Mutagen. 2000, 35:234-252.
-
(2000)
Environ. Mol. Mutagen.
, vol.35
, pp. 234-252
-
-
Hayashi, M.1
MacGregor, J.T.2
Gatehouse, D.G.3
Adler, I.D.4
Blakey, D.H.5
Dertinger, S.D.6
Krishna, G.7
Morita, T.8
Russo, A.9
Sutou, S.10
-
2
-
-
33846132354
-
In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test
-
Hayashi M., MacGregor J.T., Gatehouse D.G., Blakey D.H., Dertinger S.D., Abramsson-Zetterberg L., Krishna G., Morita T., Russo A., Asano N., Suzuki H., Ohyama W., Gibson D. In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test. Mutat. Res. 2007, 627:10-30.
-
(2007)
Mutat. Res.
, vol.627
, pp. 10-30
-
-
Hayashi, M.1
MacGregor, J.T.2
Gatehouse, D.G.3
Blakey, D.H.4
Dertinger, S.D.5
Abramsson-Zetterberg, L.6
Krishna, G.7
Morita, T.8
Russo, A.9
Asano, N.10
Suzuki, H.11
Ohyama, W.12
Gibson, D.13
-
3
-
-
34447097135
-
Optimum conditions for detecting hepatic micronuclei caused by numerical chromosome aberration inducers in mice
-
Igarashi M., Setoguchi M., Takada S., Itoh S., Furuhama K. Optimum conditions for detecting hepatic micronuclei caused by numerical chromosome aberration inducers in mice. Mutat. Res. 2007, 632:89-98.
-
(2007)
Mutat. Res.
, vol.632
, pp. 89-98
-
-
Igarashi, M.1
Setoguchi, M.2
Takada, S.3
Itoh, S.4
Furuhama, K.5
-
4
-
-
58149126271
-
Evaluation of a liver micronucleus assay with 12 chemicals using young rats (II): a study by the Collaborative Study Group for the Micronucleus Test/Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group
-
Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group, Suzuki H., Takasawa H., Kobayashi K., Terashima Y., Shimada Y., Ogawa I., Tanaka J., Imamura T., Miyazaki A., Hayashi M. Evaluation of a liver micronucleus assay with 12 chemicals using young rats (II): a study by the Collaborative Study Group for the Micronucleus Test/Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group. Mutagenesis 2009, 9-16.
-
(2009)
Mutagenesis
, pp. 9-16
-
-
Suzuki, H.1
Takasawa, H.2
Kobayashi, K.3
Terashima, Y.4
Shimada, Y.5
Ogawa, I.6
Tanaka, J.7
Imamura, T.8
Miyazaki, A.9
Hayashi, M.10
-
5
-
-
77954902380
-
Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS)
-
Takasawa H., Suzuki H., Ogawa I., Shimada Y., Kobayashi K., Terashima Y., Matsumoto H., Aruga C., Oshida K., Ohta R., Imamura T., Miyazaki A., Kawabata M., Minowa S., Hayashi M. Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2010, 698:30-37.
-
(2010)
Mutat. Res.
, vol.698
, pp. 30-37
-
-
Takasawa, H.1
Suzuki, H.2
Ogawa, I.3
Shimada, Y.4
Kobayashi, K.5
Terashima, Y.6
Matsumoto, H.7
Aruga, C.8
Oshida, K.9
Ohta, R.10
Imamura, T.11
Miyazaki, A.12
Kawabata, M.13
Minowa, S.14
Hayashi, M.15
-
6
-
-
77954893923
-
Evaluation of a liver micronucleus assay in young rats (IV): a study using a double-dosing/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS)
-
Takasawa H., Suzuki H., Ogawa I., Shimada Y., Kobayashi K., Terashima Y., Matsumoto H., Oshida K., Ohta R., Imamura T., Miyazaki A., Kawabata M., Minowa S., Maeda A., Hayashi M. Evaluation of a liver micronucleus assay in young rats (IV): a study using a double-dosing/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2010, 698:24-29.
-
(2010)
Mutat. Res.
, vol.698
, pp. 24-29
-
-
Takasawa, H.1
Suzuki, H.2
Ogawa, I.3
Shimada, Y.4
Kobayashi, K.5
Terashima, Y.6
Matsumoto, H.7
Oshida, K.8
Ohta, R.9
Imamura, T.10
Miyazaki, A.11
Kawabata, M.12
Minowa, S.13
Maeda, A.14
Hayashi, M.15
-
7
-
-
78649866118
-
Relationship between DNA damage and micronucleus in mouse liver
-
Igarashi M., Nagata M., Itoh S., Yamoto T., Tsuda S. Relationship between DNA damage and micronucleus in mouse liver. J. Toxicol. Sci. 2010, 35:881-889.
-
(2010)
J. Toxicol. Sci.
, vol.35
, pp. 881-889
-
-
Igarashi, M.1
Nagata, M.2
Itoh, S.3
Yamoto, T.4
Tsuda, S.5
-
8
-
-
84862314362
-
Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy
-
Itoh S., Hattori C., Nagata M., Sanbuissho A. Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy. Mutat. Res. 2012, 747:98-103.
-
(2012)
Mutat. Res.
, vol.747
, pp. 98-103
-
-
Itoh, S.1
Hattori, C.2
Nagata, M.3
Sanbuissho, A.4
-
9
-
-
84863783469
-
Development of a repeated-dose liver micronucleus assay using adult rats: an investigation of diethylnitrosamine and 2,4-diaminotoluene
-
Narumi K., Ashizawa K., Takashima R., Takasawa H., Katayama S., Tsuzuki Y., Tatemoto H., Morita T., Hayashi M., Hamada S. Development of a repeated-dose liver micronucleus assay using adult rats: an investigation of diethylnitrosamine and 2,4-diaminotoluene. Mutat. Res. 2012, 747:234-239.
-
(2012)
Mutat. Res.
, vol.747
, pp. 234-239
-
-
Narumi, K.1
Ashizawa, K.2
Takashima, R.3
Takasawa, H.4
Katayama, S.5
Tsuzuki, Y.6
Tatemoto, H.7
Morita, T.8
Hayashi, M.9
Hamada, S.10
-
10
-
-
84867122378
-
Gender differences in the liver micronucleus test in rats with partial hepatectomy
-
Itoh S., Hattori C., Nagata M., Takasaki W. Gender differences in the liver micronucleus test in rats with partial hepatectomy. Toxicol. Lett. 2012, 214:296-300.
-
(2012)
Toxicol. Lett.
, vol.214
, pp. 296-300
-
-
Itoh, S.1
Hattori, C.2
Nagata, M.3
Takasaki, W.4
-
11
-
-
84873428968
-
Development of a repeated-dose liver micronucleus assay using adult rats (II): further investigation of 1,2-dimethylhydrazine and 2,6-diaminotoluene
-
Takasawa H., Takashima R., Hattori A., Narumi K., Kawasako K., Morita T., Hayashi M., Hamada S. Development of a repeated-dose liver micronucleus assay using adult rats (II): further investigation of 1,2-dimethylhydrazine and 2,6-diaminotoluene. Mutat. Res. 2013, 751:12-18.
-
(2013)
Mutat. Res.
, vol.751
, pp. 12-18
-
-
Takasawa, H.1
Takashima, R.2
Hattori, A.3
Narumi, K.4
Kawasako, K.5
Morita, T.6
Hayashi, M.7
Hamada, S.8
-
12
-
-
84881025057
-
Persistence and accumulation of micronucleated hepatocytes in liver of rats after repeated administration of diethylnitrosamine
-
Narumi K., Ashizawa K., Fujiishi Y., Tochinai R., Okada E., Tsuzuki Y., Tatemoto H., Hamada S., Kaneko K., Ohyama W. Persistence and accumulation of micronucleated hepatocytes in liver of rats after repeated administration of diethylnitrosamine. Mutat. Res. 2013, 755:100-107.
-
(2013)
Mutat. Res.
, vol.755
, pp. 100-107
-
-
Narumi, K.1
Ashizawa, K.2
Fujiishi, Y.3
Tochinai, R.4
Okada, E.5
Tsuzuki, Y.6
Tatemoto, H.7
Hamada, S.8
Kaneko, K.9
Ohyama, W.10
-
13
-
-
84928793055
-
-
Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use, S2(R1), ICH harmonized tripartite guideline, Current Step 4 version, 9 November 2011.
-
ICH (The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use), Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use, S2(R1), ICH harmonized tripartite guideline, Current Step 4 version, 9 November 2011.
-
(The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use)
-
-
-
14
-
-
84928777016
-
Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) - Mammalian Mutagenicity Study Group (MMS)
-
(in preparation)
-
Hamada S., Ohyama W., Takashima R., Shimada K., Matsumoto K., Kawakami S., Uno F., Sui H., Shimada Y., Imamura T., Matsumura S., Sanada H., Inoue K., Muto S., Ogawa I., Hayashi A., Takayanagi T., Ogiwara Y., Maeda A., Okada E., Terashima Y., Takasawa H., Narumi K., Wako Y., Kawasako K., Sano M., Ohashi N., Morita T., Kojima H., Honma M., Hayashi M. Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) - Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2014, (in preparation).
-
(2014)
Mutat. Res.
-
-
Hamada, S.1
Ohyama, W.2
Takashima, R.3
Shimada, K.4
Matsumoto, K.5
Kawakami, S.6
Uno, F.7
Sui, H.8
Shimada, Y.9
Imamura, T.10
Matsumura, S.11
Sanada, H.12
Inoue, K.13
Muto, S.14
Ogawa, I.15
Hayashi, A.16
Takayanagi, T.17
Ogiwara, Y.18
Maeda, A.19
Okada, E.20
Terashima, Y.21
Takasawa, H.22
Narumi, K.23
Wako, Y.24
Kawasako, K.25
Sano, M.26
Ohashi, N.27
Morita, T.28
Kojima, H.29
Honma, M.30
Hayashi, M.31
more..
-
15
-
-
0018831167
-
A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo
-
Tates A.D., Neuteboom I., Hofker M. A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutat. Res. 1980, 74:11-20.
-
(1980)
Mutat. Res.
, vol.74
, pp. 11-20
-
-
Tates, A.D.1
Neuteboom, I.2
Hofker, M.3
-
16
-
-
0023860450
-
A non-invasive micronucleus assay in the rat liver
-
Braithwaite I., Ashby J. A non-invasive micronucleus assay in the rat liver. Mutat. Res. 1988, 203:23-32.
-
(1988)
Mutat. Res.
, vol.203
, pp. 23-32
-
-
Braithwaite, I.1
Ashby, J.2
-
17
-
-
0028855364
-
An improved method of mouse liver micronucleus analysis: an application to age-related genetic alteration and polyploidy study
-
Uryvaeva I.V., Delone G.V. An improved method of mouse liver micronucleus analysis: an application to age-related genetic alteration and polyploidy study. Mutat. Res. 1995, 334:71-80.
-
(1995)
Mutat. Res.
, vol.334
, pp. 71-80
-
-
Uryvaeva, I.V.1
Delone, G.V.2
-
18
-
-
78650672179
-
Micronucleus assays in rodent tissues other than bone marrow
-
Morita T., MacGregor J.T., Hayashi M. Micronucleus assays in rodent tissues other than bone marrow. Mutagenesis 2011, 26:223-230.
-
(2011)
Mutagenesis
, vol.26
, pp. 223-230
-
-
Morita, T.1
MacGregor, J.T.2
Hayashi, M.3
-
19
-
-
0030740884
-
An evaluation of micronucleus induction in bone marrow and in hepatocytes isolated from collagenase perfused liver or from formalin-fixed liver using four-week-old rats treated with known clastogens
-
Parton J.W., Garriott M.L. An evaluation of micronucleus induction in bone marrow and in hepatocytes isolated from collagenase perfused liver or from formalin-fixed liver using four-week-old rats treated with known clastogens. Environ. Mol. Mutagen. 1997, 29:379-385.
-
(1997)
Environ. Mol. Mutagen.
, vol.29
, pp. 379-385
-
-
Parton, J.W.1
Garriott, M.L.2
-
20
-
-
2642554637
-
A liver micronucleus assay using young rats exposed to diethylnitrosamine: methodological establishment and evaluation
-
Suzuki H., Shirotori T., Hayashi M. A liver micronucleus assay using young rats exposed to diethylnitrosamine: methodological establishment and evaluation. Cytogenet. Genome Res. 2004, 104:299-303.
-
(2004)
Cytogenet. Genome Res.
, vol.104
, pp. 299-303
-
-
Suzuki, H.1
Shirotori, T.2
Hayashi, M.3
-
21
-
-
20144374698
-
Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS)
-
Suzuki H., Ikeda N., Kobayashi K., Terashima Y., Shimada Y., Suzuki T., Hagiwara T., Hatakeyama S., Nagaoka K., Yoshida J., Saito Y., Tanaka J., Hayashi M. Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2005, 583:133-145.
-
(2005)
Mutat. Res.
, vol.583
, pp. 133-145
-
-
Suzuki, H.1
Ikeda, N.2
Kobayashi, K.3
Terashima, Y.4
Shimada, Y.5
Suzuki, T.6
Hagiwara, T.7
Hatakeyama, S.8
Nagaoka, K.9
Yoshida, J.10
Saito, Y.11
Tanaka, J.12
Hayashi, M.13
-
22
-
-
0025930779
-
Evaluation of the in vivo genotoxicity of the structural analogues 2,6-diaminotoluene and 2,4-diaminotoluene using the rat micronucleus test and rat liver UDS assay
-
George E., Westmoreland C. Evaluation of the in vivo genotoxicity of the structural analogues 2,6-diaminotoluene and 2,4-diaminotoluene using the rat micronucleus test and rat liver UDS assay. Carcinogenesis 1991, 12:2233-2237.
-
(1991)
Carcinogenesis
, vol.12
, pp. 2233-2237
-
-
George, E.1
Westmoreland, C.2
-
23
-
-
0030871409
-
Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A, and 2B). The summary report of the 6th collaboration study by CSGMT/JEMS MMS
-
[Erratum, Mutat. Res. 391 (1997) 259-267]
-
Morita T., Asano N., Awogi T., Sasaki Y.F., Sato S., Shimada H., Sutou S., Suzuki T., Wakata A., Sofuni T., Hayashi M. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A, and 2B). The summary report of the 6th collaboration study by CSGMT/JEMS MMS. Mutat. Res. 1997, 389:3-122. [Erratum, Mutat. Res. 391 (1997) 259-267].
-
(1997)
Mutat. Res.
, vol.389
, pp. 3-122
-
-
Morita, T.1
Asano, N.2
Awogi, T.3
Sasaki, Y.F.4
Sato, S.5
Shimada, H.6
Sutou, S.7
Suzuki, T.8
Wakata, A.9
Sofuni, T.10
Hayashi, M.11
-
25
-
-
77956448685
-
Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies
-
Rothfuss A., O'Donovan M., De Boeck M., Brault D., Czich A., Custer L., Hamada S., Plappert-Helbig U., Hayashi M., Howe J., Kraynak A.R., van der Leede B.-J., Nakajima M., Priestley C., Thybaud V., Saigo K., Sawant S., Shi J., Storer R., Struwe M., Vock E., Galloway S. Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies. Mutat. Res. 2010, 702:40-69.
-
(2010)
Mutat. Res.
, vol.702
, pp. 40-69
-
-
Rothfuss, A.1
O'Donovan, M.2
De Boeck, M.3
Brault, D.4
Czich, A.5
Custer, L.6
Hamada, S.7
Plappert-Helbig, U.8
Hayashi, M.9
Howe, J.10
Kraynak, A.R.11
van der Leede, B.-J.12
Nakajima, M.13
Priestley, C.14
Thybaud, V.15
Saigo, K.16
Sawant, S.17
Shi, J.18
Storer, R.19
Struwe, M.20
Vock, E.21
Galloway, S.22
more..
-
26
-
-
79959743462
-
Improvement of in vivo genotoxicity assessment: combination of acute tests and integration into standard toxicity testing
-
Rothfuss A., Honma M., Czich A., Aardema M.J., Burlinson B., Galloway S., Hamada S., Kirkland D., Heflich R.H., Howe J., Nakajima M., O'Donovan M., Plappert-Helbig U., Priestley C., Recio L., Schuler M., Uno Y., Martus H.J. Improvement of in vivo genotoxicity assessment: combination of acute tests and integration into standard toxicity testing. Mutat. Res. 2011, 723:108-120.
-
(2011)
Mutat. Res.
, vol.723
, pp. 108-120
-
-
Rothfuss, A.1
Honma, M.2
Czich, A.3
Aardema, M.J.4
Burlinson, B.5
Galloway, S.6
Hamada, S.7
Kirkland, D.8
Heflich, R.H.9
Howe, J.10
Nakajima, M.11
O'Donovan, M.12
Plappert-Helbig, U.13
Priestley, C.14
Recio, L.15
Schuler, M.16
Uno, Y.17
Martus, H.J.18
-
28
-
-
84928794037
-
Single-dose liver micronucleus assay in adult rats with rest period, Abstract number GTEST026
-
Shimada K., Yamamoto M., Takashima M., Aoki Y., Miyamae Y., Wakata A. Single-dose liver micronucleus assay in adult rats with rest period, Abstract number GTEST026. the 11th ICEM 2013, 292.
-
(2013)
the 11th ICEM
, pp. 292
-
-
Shimada, K.1
Yamamoto, M.2
Takashima, M.3
Aoki, Y.4
Miyamae, Y.5
Wakata, A.6
-
29
-
-
23644444334
-
Chromosome breakage is primarily responsible for the micronuclei induced by 1,4-dioxane in the bone marrow and liver of young CD-1 mice
-
Roy S.K., Thilagar A.K., Eastmond D.A. Chromosome breakage is primarily responsible for the micronuclei induced by 1,4-dioxane in the bone marrow and liver of young CD-1 mice. Mutat. Res. 2005, 586:28-37.
-
(2005)
Mutat. Res.
, vol.586
, pp. 28-37
-
-
Roy, S.K.1
Thilagar, A.K.2
Eastmond, D.A.3
-
30
-
-
84928785370
-
Investigation of repeated dose liver micronucleus assay in cynomolgus monkeys
-
(abstract)
-
Ishii H., Takashima R., Sasaki Y., Hashimoto S., Doi T., Hamada S. Investigation of repeated dose liver micronucleus assay in cynomolgus monkeys. J. Toxicol. Sci. 2012, 37(Suppl.):244. (abstract).
-
(2012)
J. Toxicol. Sci.
, vol.37
, pp. 244
-
-
Ishii, H.1
Takashima, R.2
Sasaki, Y.3
Hashimoto, S.4
Doi, T.5
Hamada, S.6
-
32
-
-
33745126288
-
Detection of clastogenic and aneugenic damage in newborn rats
-
Udroiu I., Ieradi L.A., Cristaldi M., Tanzarella C. Detection of clastogenic and aneugenic damage in newborn rats. Environ. Mol. Mutagen. 2006, 47:320-324.
-
(2006)
Environ. Mol. Mutagen.
, vol.47
, pp. 320-324
-
-
Udroiu, I.1
Ieradi, L.A.2
Cristaldi, M.3
Tanzarella, C.4
-
33
-
-
0017101039
-
Preparation of isolated rat liver cells
-
Seglen P.O. Preparation of isolated rat liver cells. Methods Cell Biol. 1976, 13:29-83.
-
(1976)
Methods Cell Biol.
, vol.13
, pp. 29-83
-
-
Seglen, P.O.1
-
34
-
-
0030900082
-
An improved method for the mouse liver micronucleus test
-
Igarashi M., Shimada H. An improved method for the mouse liver micronucleus test. Mutat. Res. 1997, 391:49-55.
-
(1997)
Mutat. Res.
, vol.391
, pp. 49-55
-
-
Igarashi, M.1
Shimada, H.2
-
35
-
-
84928776427
-
Evaluation of repeated dose micronucleus assays of the liver using N-nitrosopyrrolidine: a report of the collaborative study by CSGMT/JEMS.MMS
-
Ogawa I., Hagio S., Furukawa S., Abe M., Kuroda Y., Hayashi S., Wako Y., Kawasako K. Evaluation of repeated dose micronucleus assays of the liver using N-nitrosopyrrolidine: a report of the collaborative study by CSGMT/JEMS.MMS. Mutat. Res. 2015, 780-781:25-30.
-
(2015)
Mutat. Res.
, pp. 25-30
-
-
Ogawa, I.1
Hagio, S.2
Furukawa, S.3
Abe, M.4
Kuroda, Y.5
Hayashi, S.6
Wako, Y.7
Kawasako, K.8
|