Persistence and accumulation of micronucleated hepatocytes in liver of rats after repeated administration of diethylnitrosamine

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 755, Issue 2, 2013, Pages 100-107

  Narumi, Kazunori ^a   Ashizawa, Koji ^b   Fujiishi, Yohei ^a   Tochinai, Ryota ^a   Okada, Emiko ^a   Tsuzuki, Yasuhiro ^b   Tatemoto, Hideki ^c   Hamada, Shuichi ^d   Kaneko, Kimiyuki ^a   Ohyama, Wakako ^a  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d LSI MEDIENCE CORPORATION   (Japan)

Author keywords

Accumulation; Diethylnitrosamine; DNA labeling; Liver micronucleus assay; Persistence; Repeated administration

Indexed keywords

DIETHYLNITROSAMINE; DNA NUCLEOTIDYLEXOTRANSFERASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENOTOXICITY; HISTOLOGY; LIVER CARCINOGENESIS; LIVER CELL; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; THEORETICAL MODEL;

ACCUMULATION; DIETHYLNITROSAMINE; DNA LABELING; LIVER MICRONUCLEUS ASSAY; PERSISTENCE; REPEATED ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; CELL SEPARATION; DEOXYURIDINE; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; IN SITU NICK-END LABELING; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; MICRONUCLEUS TESTS; MODELS, GENETIC; MUTAGENS; RATS; TIME FACTORS;

RATTUS; RODENTIA;

EID: 84881025057     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2013.03.012     Document Type: Article

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