Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 747, Issue 1, 2012, Pages 98-103

  Itoh, Satoru ^a   Hattori, Chiharu ^a   Nagata, Mayumi ^a   Sanbuissho, Atsushi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Liver; Micronucleus test; Numerical chromosome aberration; Partial hepatectomy; Structural chromosome aberration

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CARBENDAZIM; COLCHICINE; DIETHYLNITROSAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CLASSIFICATION; CONTROLLED STUDY; GENOTOXICITY; LIVER CELL; LIVER MICRONUCLEUS TEST; LIVER WEIGHT; MALE; METAPHASE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; NUMERICAL CHROMOSOME ABERRATION; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; STRUCTURAL CHROMOSOME ABERRATION; TOXICITY TESTING;

ANEUGENS; ANIMALS; BENZIMIDAZOLES; CARBAMATES; CHROMOSOME ABERRATIONS; COLCHICINE; DIETHYLNITROSAMINE; DIMETHYLHYDRAZINES; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATECTOMY; LIVER; MALE; MICRONUCLEUS TESTS; MUTAGENS; RATS; RATS, INBRED F344;

ANIMALIA; MUS; RATTUS;

EID: 84862314362     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.04.007     Document Type: Article

References (21)

1. ICH Harmonised Tripartite Guideline, Guidance on Specific Aspects of Regulatory Genotoxicity Tests for Pharmaceuticals. Available at: . http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm065007.htm.
2. ICH Harmonised Tripartite Guideline, Genotoxicity: A Standard Battery for Genotoxicity Testing of Pharmaceuticals. Available at: . http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm065007.htm.
3. ICH Harmonised Tripartite Guideline, Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use S2(R1), Current Step 4 Version Dated 9 November 2011. Available at: . http://www.ich.org/products/guidelines/safety/article/safety-guidelines.html.
4. Tates A.D., Neuteboom I., Hofker M., den Engelse L. A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutat. Res. 1980, 74:11-20.
5. Tates A.D., Neuteboom I. Micronucleus test with rat hepatocytes to detect induction of clastogenic damage. Evaluation of Short-Term Tests for Carcinogens 1987, 1400-1404. Cambridge University Press, Cambridge. J. Ashby (Ed.).
6. Igarashi M., Setoguchi M., Takada S., Itoh S., Furuhama K. Optimum conditions for detecting hepatic micronuclei caused by numerical chromosome aberration inducers in mice. Mutat. Res. 2007, 632:89-98.
7. Natarajan A.T., Tates A.D., van Buul P.P.W., Meijers M., de Vogel N. Cytogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro, I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of rat-liver microsomes. Mutat. Res. 1976, 37:83-90.
8. Data Book of Chromosomal Aberration Test in vitro 1987, 141. L.I.C., Tokyo. revised ed. M. Ishidate (Ed.).
9. Xu W., Adler I.-D. Clastogenic effects of known and suspect spindle poisons studied by chromosome analysis in bone marrow cells. Mutagenesis 1990, 5:371-374.
10. Vigreux C., Poul J.M., Deslandes E., Lebailly P., Godard T., Sichel F., Henry-Amar M., Gauduchon P. DNA damaging effects of pesticides measured by the single cell gel electrophoresis assay (comet assay) and the chromosomal aberration test, in CHOK1 cells. Mutat. Res. 1998, 419:79-90.
11. Suzuki H., Shirotori T., Hayashi M. A liver micronucleus assay using young rats exposed to diethylnitrosamine: methodological establishment and evaluation. Cytogenet. Genome Res. 2004, 104:299-303.
12. Igarashi M., Shimada H. An improved method for the mouse liver micronucleus test. Mutat. Res. 1997, 391:49-55.
13. Hamada C., Yoshino K., Matsumoto K., Nomura M., Yoshimura I. Tree-type algorithm for statistical analysis in chronic toxicity studies. J. Toxicol. Sci. 1998, 23:173-181.
14. Matsuoka A., Matsuura K., Sakamoto H., Hayashi M., Sofuni T. A proposal for a simple way to distinguish aneugens from clastogens in the in vitro micronucleus test. Mutagenesis 1999, 4:385-389.
15. Igarashi M., Nagata M., Itoh S., Yamoto T., Tsuda S. Relationship between DNA damage and micronucleus in mouse liver. J. Toxicol. Sci. 2010, 35:881-889.
16. Kirsch-Volders M., Vanhauwaert A., De Boeck M., Decordier I. Importance of detecting numerical versus structural chromosome aberrations. Mutat. Res. 2002, 504:137-148.
17. Takasawa H., Suzuki H., Ogawa I., Shimada Y., Kobayashi K., Terashima Y., Matsumoto H., Oshida K., Ohta R., Imamura T., Miyazaki A., Kawabata M., Minowa S., Maeda A., Hayashi M. Evaluation of a liver micronucleus assay in young rats (IV): a study using a double-dosing/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2010, 698:24-29.
18. Suzuki H., Ikeda N., Kobayashi K., Terashima Y., Shimada Y., Suzuki T., Hagiwara T., Hatakeyama S., Nagaoka K., Yoshida J., Saito Y., Tanaka J., Hayashi M. Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats: a study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2005, 583:133-145.
19. Suzuki H., Takasawa H., Kobayashi K., Terashima Y., Shimada Y., Ogawa I., Tanaka J., Imamura T., Miyazaki A., Hayashi M. Evaluation of a liver micronucleus assay with 12 chemicals using young rats (II): a study by the Collaborative Study Group for the Micronucleus Test/Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group. Mutagenesis 2009, 24:9-16.
20. Parton J.W., Garriott M.L. An evaluation of micronucleus induction in bone marrow and in hepatocytes isolated from collagenase perfused liver or from formalin-fixed liver using four week-old rats treated with known clastogens. Environ. Mol. Mutagen. 1997, 29:379-385.
21. Takasawa H., Suzuki H., Ogawa I., Shimada Y., Kobayashi K., Terashima Y., Matsumoto H., Aruga C., Oshida K., Ohta R., Imamura T., Miyazaki A., Kawabata M., Minowa S., Hayashi M. Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2010, 698:30-37.