Development of a repeated-dose liver micronucleus assay using adult rats: An investigation of diethylnitrosamine and 2,4-diaminotoluene

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 747, Issue 2, 2012, Pages 234-239

  Narumi, Kazunori ^a,b   Ashizawa, Koji ^c   Takashima, Rie ^a   Takasawa, Hironao ^a   Katayama, Seiichi ^a   Tsuzuki, Yasuhiro ^c   Tatemoto, Hideki ^d   Morita, Takeshi ^e   Hayashi, Makoto ^f   Hamada, Shuichi ^a  

^a LSI MEDIENCE CORPORATION   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^c UNIVERSITY OF MIYAZAKI   (Japan)

^d UNIVERSITY OF THE RYUKYUS   (Japan)

^e NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^f Biosafety Research Center   (Japan)

Author keywords

2,4 Diaminotoluene; Adult rat; Diethylnitrosamine; Integration; Liver micronucleus assay; Repeated dose toxicity study

Indexed keywords

2,4 DIAMINOTOLUENE; COLLAGENASE; DIETHYLNITROSAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANIMAL WELFARE; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; GENOTOXICITY; IN VIVO STUDY; LIVER CELL; LIVER DEVELOPMENT; MALE; MICRONUCLEUS; MITOSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DIETHYLNITROSAMINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; LIVER; MALE; MICRONUCLEUS TESTS; MUTAGENS; PHENYLENEDIAMINES; RATS;

ANIMALIA; RATTUS; RODENTIA;

EID: 84863783469     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.05.012     Document Type: Article

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