Evaluation of repeated dose micronucleus assays of the liver using N-nitrosopyrrolidine: A report of the collaborative study by CSGMT/JEMS.MMS

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 780-781, Issue , 2015, Pages 25-30

  Ogawa, Izumi ^a   Hagio, Soichiro ^a   Furukawa, Satoshi ^a   Abe, Masayoshi ^a   Kuroda, Yusuke ^a   Hayashi, Seigo ^a   Wako, Yumi ^b   Kawasako, Kazufumi ^b  

^a NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

^b LSI MEDIENCE CORPORATION   (Japan)

Author keywords

Integration; Liver micronucleus assay; N nitrosopyrrolidine; Repeated dose toxicity assay

Indexed keywords

CARCINOGEN; N NITROSOPYRROLIDINE;

ANIMAL; ANTIBODY SPECIFICITY; BONE MARROW; CHROMOSOME ABERRATION; COOPERATION; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECTS; HEALTH CARE ORGANIZATION; HUMAN; JAPAN; LIVER; LIVER CELL; MALE; MICRONUCLEUS TEST; ORAL DRUG ADMINISTRATION; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BONE MARROW; CARCINOGENS; CHROMOSOME ABERRATIONS; COOPERATIVE BEHAVIOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HEPATOCYTES; HUMANS; JAPAN; LIVER; MALE; MICRONUCLEUS TESTS; N-NITROSOPYRROLIDINE; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, PHARMACEUTICAL;

EID: 84928776427     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2014.05.007     Document Type: Article

References (28)

1. Wild D. Cytogenetic effects in the mouse of 17 chemical mutagens and carcinogens evaluated by the micronucleus test. Mutat. Res. 1978, 56:319-327.
2. Trzos R.J., Petzold G.L., Brunden M.N., Swenberg J.A. The evaluation of sixteen carcinogens in the rat using the micronucleus test. Mutat. Res. 1978, 58:79-86.
3. Cliet I., Melcion C., Cordier A. Lack of predictivity of bone marrow micronucleus test versus testis micronucleus test: comparison with four carcinogens. Mutat. Res. 1993, 292:105-111.
4. Tates A.D., Neuteboom I., Hofker M. A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutat. Res. 1980, 74:11-20.
5. Tates A.D. Validation studies with the micronucleus test for early spermatids of rats. A tool for detecting clastogenicity of chemicals in differentiating spermatogonia and spermatocytes. Mutagenesis 1992, 7:411-419.
6. Morita T., MacGregor J.T., Hayashi M. Micronucleus assays in rodent tissues other than bone marrow. Mutagenesis 2011, 26:223-230.
7. Coffing S., Engel M., Dickinson D., Thiffeault C., Spellman R., Shutsky T., Schuler M. The rat gut micronucleus assay: a good choice for alternative in vivo genetic toxicology testing strategies. Environ. Mol. Mutagen. 2011, 52:269-279.
8. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use S2(R1) Current Step 4 version, dated 9 November 2011.
9. Sasaki Y.F., Sekihashi K., Izumiyama F., Nishidate E., Saga A., Ishida K., Tsuda S. The Comet assay with multiple mouse organs: comparison of Comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database. Crit. Rev. Toxicol. 2000, 30:629-799.
10. Nesslany F., Zennouche N., Simar-Meintières S., Talahari I., Nkili-Mboui E.N., Marzin D. In vivo Comet assay on isolated kidney cells to distinguish genotoxic carcinogens from epigenetic carcinogens or cytotoxic compounds. Mutat. Res. 2007, 630:28-41.
11. Takasawa H., Suzuki H., Ogawa I., Shimada Y., Kobayashi K., Terashima Y., Matsumoto H., Aruga C., Oshida K., Ohta R., Imamura T., Miyazaki A., Kawabata M., Minowa S., Hayashi M. Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2010, 698:30-37.
12. Rothfuss A., O'Donovan M., De Boeck M., Brault D., Czich A., Custer L., Hamada S., Plappert-Helbig U., Hayashi M., Howe J., Kraynak A.R., van der Leede B.J., Nakajima M., Priestley C., Thybaud V., Saigo K., Sawant S., Shi J., Storer R., Struwe M., Vock E., Galloway S. Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies. Mutat. Res. 2010, 702:40-69.
13. Rothfuss A., Honma M., Czich A., Aardema M.J., Burlinson B., Galloway S., Hamada S., Kirkland D., Heflich R.H., Howe J., Nakajima M., O'Donovan M., Plappert-Helbig U., Priestley C., Recio L., Schuler M., Uno Y., Martus H.J. Improvement of in vivo genotoxicity assessment: combination of acute tests and integration into standard toxicity testing. Mutat. Res. 2011, 723:108-120.
14. Narumi K., Ashizawa K., Takashima R., Takasawa H., Katayama S., Tsuzuki Y., Tatemoto H., Morita T., Hayashi M., Hamada S. Development of a repeated-dose liver micronucleus assay using adult rats: an investigation of diethylnitrosamine and 2,4-diaminotoluene. Mutat. Res. 2012, 747:234-239.
15. Morita T., Asano N., Awogi T., Sasaki Y.F., Sato S., Shimada H., Sutou S., Suzuki T., Wakata A., Sofuni T., Hayashi M. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B). The summary report of the 6th collaborative study by CSGMT/JEMS.MMS. Mutat. Res. 1997, 389:3-122.
16. Hamada S., Ohyama W., Takashima R., Shimada K., Matsumoto K., Kawakami S., Uno F., Sui H., Shimada Y., Imamura T., Matsumura S., Sanada H., Inoue K., Muto S., Ogawa I., Hayashi A., Takayanagi T., Ogiwara Y., Maeda A., Okada E., Terashima Y., Takasawa H., Narumi K., Wako Y., Kawasako K., Sano M., Ohashi N., Morita T., Kojima H., Honma M., Hayashi M. Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) Mammalian Mutagenicity Study Group (MMS). Mutat. Res. 2015, 780-781:2-17.
17. Greenblatt M., Lijinsky W. Nitrosamine studies: neoplasms of liver and genital mesothelium N-nitrosopyrrolidine-treated MRC rats. J. Natl. Cancer Inst. 1972, 48:1687-1696.
18. Lijinsky W., Reuber M.D. Carcinogenic effect of nitrosopyrrolidine, nitrosopiperidine and nitrosohexamethyleneimine in Fischer rats. Cancer Lett. 1981, 12:99-103.
19. Gold L.S. The Carcinogenic Potency Database (CPDB) 2011, http://toxnet.nlm.nih.gov/cpdb/. Last updated: September 1, 2011 (accessed 17.04.13).
20. Bradley M.O., Bhuyan B., Francis M.C., Langenbach R., Peterson A., Huberman E. Mutagenesis by chemical agents in V79 Chinese hamster cells: a review and analysis of the literature. Mutat. Res. 1981, 87:81-142.
21. Mitchell A.D., Casciano D.A., Meltz M.L., Robinson D.E., Williams G.M., Halle E.S.V. Unscheduled DNA synthesis tests: a report of the U.S. environmental protection agency gene-tox program. Mutat. Res. 1983, 123:363-410.
22. Zielenska M., Guttenplan J.B. Effects of UV repair, error-prone repair and critical site of mutation on mutagenesis induced by N-nitrosamines. Mutat. Res. 1987, 180:11-20.
23. Kanki K., Nishikawa A., Masumura K., Umemura T., Imazawa T., Kitamura Y., Nohmi T., Hirose M. Analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate. Mol. Carcinog. 2005, 42:9-17.
24. Guttenplan J.B. N-nitrosamines: bacterial mutagenesis and in vitro metabolism. Mutat. Res. 1987, 186:81-134.
25. Loureiro A.P.M., Zhang W., Kassie F., Zhang S., Villalta P.W., Wang M., Hecht S.S. Mass spectrometric analysis of a cyclic 7,8-butanoguanine adduct of N-nitrosopyrrolidine: comparison to other N-nitrosopyrrolidine adducts in rat hepatic DNA. Chem. Res. Toxicol. 2009, 22:1728-1735.
26. Bingham E., Cohrssen B., Powell C. Patty's Toxicology 2001, vol. 4. John Wiley & Sons, New York, USA. 5th edition.
27. Hendzel M.J., Wei Y., Mancini M.A., Van Hooser A., Ranalli T., Brinkley B.R., Bazett-Jones D.P., Allis C.D. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 1997, 106:348-360.
28. Richard A., MacDonald M.D. "Lifespan" of liver cells: autoradiographic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats. Arch. Intern. Med. 1961, 107:335-343.