Gender differences in the liver micronucleus test in rats with partial hepatectomy

Toxicology Letters

Volumn 214, Issue 3, 2012, Pages 296-300

  Itoh, Satoru ^a   Hattori, Chiharu ^a   Nagata, Mayumi ^a   Takasaki, Wataru ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Gender difference; Liver; Micronucleus test; Numerical chromosome aberration; Partial hepatectomy; Structural chromosome aberration

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CARBENDAZIM; COLCHICINE; DIETHYLNITROSAMINE;

ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CHROMOSOME ABERRATION; FEMALE; LIVER CELL; LIVER FUNCTION TEST; MALE; MICRONUCLEUS TEST; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

1,2-DIMETHYLHYDRAZINE; ANIMALS; BENZIMIDAZOLES; CARBAMATES; COLCHICINE; DIETHYLNITROSAMINE; FEMALE; GENDER IDENTITY; HEPATECTOMY; HEPATOCYTES; LIVER; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENS; RATS; RATS, INBRED F344; SEX FACTORS;

RATTUS;

EID: 84867122378     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.09.003     Document Type: Article

References (18)

1. Braithwaite I., Ashby J. A non-invasive micronucleus assay in the rat liver. Mutation Research 1998, 203:23-32.
2. Hamada C., Yoshino K., Matsumoto K., Nomura M., Yoshimura I. Tree-type algorithm for statistical analysis in chronic toxicity studies. Journal of Toxicological Sciences 1998, 23:173-181.
3. ICH Harmonised Tripartite Guideline, 2011. Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use S2(R1). Current Step 4 version dated 9 November 2011. Available at: http://www.ich.org/products/guidelines/safety/article/safety-guidelines.html.
4. Igarashi M., Shimada H. An improved method for the mouse liver micronucleus test. Mutation Research 1997, 391:49-55.
5. Igarashi M., Setoguchi M., Takada S., Itoh S., Furuhama K. Optimum conditions for detecting hepatic micronuclei caused by numerical chromosome aberration inducers in mice. Mutation Research 2007, 632:89-98.
6. Data Book of Chromosomal Aberration Test in vitro 1987, 141. L.I.C., Tokyo. revised edition. M. Ishidate (Ed.).
7. Itoh S., Hattori C., Nagata M., Sanbuissho A. Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy. Mutation Research 2012, 747:98-103.
8. Kirsch-Volders M., Vanhauwaert A., De Boeck M., Decordier I. Importance of detecting numerical versus structural chromosome aberrations. Mutation Research 2002, 504:137-148.
9. Kirsch-Volders M., Sofuni T., Aardema M., Albertini S., Eastmond D., Fenech M., Ishidate M., Kirchner S., Lorge E., Morita T., Norppa H., Surrallés J., Vanhauwaer A., Wakata A. Report from the in vitro micronucleus assay working group. Mutation Research 2003, 540:153-163.
10. Matsuoka A., Matsuura K., Sakamoto H., Hayashi M., Sofuni T. A proposal for a simple way to distinguish aneugens from clastogens in the in vitro micronucleus test. Mutagenesis 1999, 4:385-389.
11. Morita T., Asano N., Awogi T., Sasaki Y.F., Sato S., Shimada H., Sutou S., Suzuki T., Wakata A., Sofuni T., Hayashi M. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A and 2B). The summary report of the 6th collaborative study by CSGMT/JEMS MMS. Mutation Research 1997, 389:3-122.
12. Natarajan A.T., Tates A.D., van Buul P.P.W., Meijers M., de Vogel N. Cytogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro. I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of rat-liver microsomes. Mutation Research 1976, 37:83-90.
13. Pfuhler S., Kirkland D., Kasper P., Hayashi M., Vanparys P., Carmichael P., Dertinger S., Eastmond D., Elhajouji A., Krul C., Rothfuss A., Schoening G., Smith A., Speit G., Thomas C., Benthem J.V., Corvi R. Reduction of use of animals in regulatory genotoxicity testing: identification and implementation opportunities-report from an ECVAM workshop. Mutation Research 2009, 680:31-42.
14. Suzuki H., Shirotori T., Hayashi M. A liver micronucleus assay using young rats exposed to diethylnitrosamine: methodological establishment and evaluation. Cytogenetic and Genome Research 2004, 104:299-303.
15. Tates A.D., Neuteboom I., Hofker M., den Engelse L. A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutational Research 1980, 74:11-20.
16. The Collaborative Study Group for the Micronucleus Test, 1986. Sex difference in the micronucleus test. Mutational Research 172, 151-163.
17. Vigreux C., Poul J.M., Deslandes E., Lebailly P., Godard T., Sichel F., Henry-Amar M., Gauduchon P. DNA damaging effects of pesticides measured by the single cell gel electrophoresis assay (comet assay) and the chromosomal aberration test, in CHOK1 cells. Mutation Research 1998, 419:79-90.
18. Xu W., Adler I-D. Clastogenic effects of known and suspect spindle poisons studied by chromosome analysis in mouse bone marrow cells. Mutagenesis 1990, 5:371-374.