Stevia rebaudiana Bert. leaf extracts as a multifunctional source of natural antioxidants

Molecules

Volumn 20, Issue 4, 2015, Pages 5468-5486

  Gaweł Bȩben, Katarzyna ^a   Bujak, Tomasz ^a   Nizioł Łukaszewska, Zofia ^a   Antosiewicz, Beata ^a   Jakubczyk, Anna ^b   Karaś, Monika ^b   Rybczyńska, Kamila ^a  

^a UNIVERSITY OF INFORMATION TECHNOLOGY AND MANAGEMENT   (Poland)

^b UNIVERSITY OF LIFE SCIENCES IN LUBLIN   (Poland)

Author keywords

Cytotoxicity; Fibroblasts; Free radical scavenging; Iron (II) ion chelating; Polyphenols; Stevia rebaudiana

Indexed keywords

ANTIOXIDANT; FLAVONOID; PHENOL DERIVATIVE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT;

CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; HUMAN; ISOLATION AND PURIFICATION; PLANT LEAF; SKIN; STEVIA;

ANTIOXIDANTS; CELL LINE; FIBROBLASTS; FLAVONOIDS; HUMANS; PHENOLS; PHYTOCHEMICALS; PLANT EXTRACTS; PLANT LEAVES; SKIN; STEVIA;

EID: 84928677228     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20045468     Document Type: Article

References (69)

1. Ahmad, N.; Fazal, H.; Abbasi, B.H.; Rahman, S.; Anwar, S.; Khan, M.A.; Abdul Basir, A.; Inayat, H.; Zameer, R.; Khalil, SA.; et al. DPPH scavenging antioxidant potential in regenerated tissues of Stevia rebaudiana, Citrus sinensis and Saccharum officinarum. J. Med. Plants Res. 2011, 5, 3293-3297.
2. Durak, A.; Baraniak, B.; Jakubczyk, A.; ͆wica, M. Biologically active peptides obtained by enzymatic hydrolysis of Adzuki bean seeds. Food Chem. 2013, 141, 2177-2183.
3. Ghosh, S.; Subudhi, E.; Nayak, S. Antimicrobial assay of Stevia rebaudiana Bertoni leaf extracts against 10 pathogens. Int. J. Integr. Biol. 2008, 2, 27-31.
4. Aburjai, T.; Natsheh, F.M. Plants used in cosmetics. Phytother. Res. 2003, 17, 987-1000.
5. Gechev, T.S.; Hille, J.; Woerdenbag, H.J.; Benina, M.; Mehterov, N.; Toneva, V.; Fernie, A.R.; Mueller-Roeber, B. Natural products from resurrection plants: Potential for medical applications. Biotechnol. Adv. 2014, 36, 1091-1101.
6. Jomova, K.; Valko, M. Advances in metal-induced oxidative stress and human disease. Toxicology 2011, 283, 65-87.
7. Maladěnka, P.; Zatloukalová, L.; Filipský, T.; Hardina, R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic. Biol. Med. 2010, 49, 963-975.
8. Valadez-Vega, C.; Delgado-Olivares, L.; Morales-González, J.A.; García, E.A.; Ibarra, J.R.V.; Moreno, E.R.; Gutiérrez, M.S.; Martínez, M.T.S.; Clara, Z.P.; Ramos, Z.C. The role of natural antioxidants in cancer disease. In Oxidative Stress and Chronic Degenerative Diseases - A Role for Antioxidants; Morales-Gonzalez, J.A., Ed.; In Techopen: Rijeka, Croatia, 2013; pp. 391-418, doi:10.5772/51503.
9. Nowak, D.; Kidoń, M.; Syta, M. Evaluation of changes in the antioxidant properties of dried beetroot and celery depending upon the unit operations. Żywn. Nauka Technol. Jakość 2008, 4, 227-235.
10. Leja, M.; Mareczek, A. Selected compounds in plants that affect their biological value. Antioxidant properties of plants. In Monograph; Kraków, A.R., Ed.; The University of Agriculture Poland: Kraków, Poland, 2005; pp. 15-20.
11. Weisburger, J.H. Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea. Food Chem. Toxicol. 1999, 37, 943-948.
12. Lorencini, M.; Brohem, C.A.; Dieamant, G.C.; Zanchin, N.I.; Maibach, H.I. Active ingredients against human epidermal aging. Ageing Res. Rev. 2014, 15, 100-115.
13. Makimura, M.; Hirasawa, M.; Kobayashi, K.; Indo, J.; Sakanaka, S.; Taguchi, T.; Otake, S. Inhibitory effect of tea catechins on collagenase activity. J. Periodontol. 1993, 64, 630-636.
14. Sin, B.Y.; Kim, H.P. Inhibition of collagenase by naturally - Occurring flavonoids. Arch. Pharm. Res. 2005, 10, 1152-1155.
15. Sharma, D. Pharmacological properties of flavonoids including flavonoligands - Integration of protectors with drug development from plants. J. Sci. Ind. Res. 2006, 65, 477-484.
16. Brewer, M.S. Natural antioxidants: Sources, compounds, mechanisms of action, and potential applications. Comp. Rev. Food Sci. Food Saf. 2011, 10, 221-247.
17. Elias, R.J.; Kellerby, S.S.; Decker, E.A. Antioxidant activity of proteins and peptides. Crit. Rev. Food Sci. Nutr. 2008, 48, 430-441.
18. Gupta, E.; Purwar, S.; Sandaram, S.; Gai, G.K. Nutritional and therapeutic values of Stevia rebaudiana: A review. J. Med. Plants Res. 2013, 7, 3343-3353.
19. Goyal, S.; Samsher, S.; Goyal, R. Stevia (Stevia rebaudiana) a bio-sweetener: A review. Int. J. Food Sci. Nutr. 2010, 61, 1-10.
20. Rajasekaran, T.; Ramakrishna, A.; Udaya Sankar, K.; Giridhar, P.; Ravishankar, G. Analysis of predominant steviosides in Stevia rebaudiana Bertoni by liquid chromatography/electrospray ionization-mass spectrometry. Food Biotechnol. 2008, 22, 179-188.
21. Debnath, M. Clonal propagation and antimicrobial activity of an endemic medicinal plant Stevia rebaudiana. J. Med. Plant. Res. 2008, 2, 45-51.
22. Bugaj, B.; Leszczyńska, T.; Pysz, M.; Kopeć, A.; Pacholkarz, J.; Pysz-Izdebska, K. Characteristics and health promoting properties of Stevia rebaudiana Bertoni. Żywn. Nauka Technol. Jakość 2013, 3, 27-38.
23. Kim, J.S.; Yang, M.; Lee, O.H.; Kang, S.N. The antioxidant activity and the bioactive compound content of Stevia rebaudiana water extracts. Food Sci. Technol. 2011, 44, 1328-1332.
24. Rao, G.N.; Rao, P.P.; Balaswamy, K.; Satyanarayane, A. Antioxidant activity of Stevia (Stevia rebaudiana L.) leaf powder and a commercial Stevioside powder. J. Food Pharm. Sci. 2014, 2, 32-38.
25. Tadhani, M.B.; Patel, V.H.; Subhash, R. In vitro antioxidant activities of Stevia rebaudiana leaves and callus. J. Food Compos. Anal. 2007, 20, 323-329.
26. Cai, Y.Z.; Sun, M.; Xing, J.; Luo, Q.; Corke, H. Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants. Life Sci. 2006, 78, 2872-2888.
27. Hatano, T.; Edamatsu, R.; Mori, A.; Fujita, Y.; Yasuhara, E. Effect of interaction of tannins with co-existing substances. Effects of tannins and related polyphenols on superoxide anion radical and on DPPH radical. Chem. Pharm. Bull. 1989, 37, 2016-2021.
28. Duh, P.D.; Tu, Y.Y.; Yen, G.C. Antioxidant activity of water extract of Harng Jyur (Chrysanthemum morifolium Ramat). Lebensm. Wiss. Technol. 1999, 32, 269-277.
29. Oksana, S.; Marian, B.; Mahendraand, R.; Bo, S.H. Plant phenolic compounds for food, pharmaceuticaland cosmetiñs production. J. Med. Plants Res. 2012, 6, 2526-2539.
30. Arct, J.; Pytkowska, K. Flavonoids as components of biologically active cosmeticals. Clin. Dermatol. 2008, 26, 347-357.
31. Muanda, F.N.; Soulimani, R.; Diop, B.; Dico, A. Study on chemical composition and biological activities of essential oil and extracts from Stevia rebaudiana Bertoni leaves. Food Sci. Technol. 2011, 44, 1865-1872.
32. Formica, J.V.; Regelson, W. Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol. 1995, 33, 1061-1080.
33. Maiti, K.; Mukherjee, K.; Gantait, A.; Ahamed, H.N.; Saha, P.B.; Mukherjee, P.K. Enhanced therapeutic benefit of quercetin phospholipid complex in carbon tetrachloride - Induced acute liver injury in rats: A comperative study. Iran. J. Pharmacol. Ther. 2005, 4, 84-90.
34. Kakkar, S.; Bais, S. A review on protocatechuic acid and its pharmacological potential. ISRN Pharmacol. 2014, 2014, 952943.
35. Srinivasan, M.; Sudheer, A.R.; Menon, V.P. Ferulic acid: Therapeutic potential through its antioxidant property. J. Clin. Biochem. Nutr. 2007, 40, 92-100.
36. Graf, E. Antioxidant potential of ferulic acid. Free Radic. Biol. Med. 1992, 13, 435-448.
37. Monti, D.; Tampucci, S.; Chetoni, P.; Burgalassi, S.; Saino, V.; Centini, M.; Staltari, L.; Anselmi, C. Permeation and distribution of ferulic acid and its α-cyclodextrin complex from different formulations in hairless rat skin. Pharm. Sci. Technol. 2011, 12, 514-520.
38. Bae, H.; Jayaprakasha, G.K.; Crosby, K.; Jifon, J.L.; Patil, B.S. Influence of extraction solvents on antioxidant activity and the content of bioactive compounds in non-pungent peppers. Plants Food Hum. Nutr. 2012, 67, 120-128.
39. Behbassat, N.; Yoncheva, K.; Hadjimitova, V.; Hrisova, N.; Kontantinov, S.; Lambov, N. Influence of the extraction solvent on antioxidant activity of Althaea officinalis L. root extracts. Cent. Eur. J. Biol. 2014, 9, 182-188.
40. Gopolakrishan, B.; Bawene, A.A.; Akki, K.S.; Hukkeri, V.S. Free radical scavenging activity of flavonoid containing leaf extracts of Stevia rebaudiana Bert. Anc. Sci. Life 2006, 25, 44-48.
41. Leccese, A.; Viti, R.; Bartolini, S. The effect of solvent extraction on antioxidant properties of apricot fruit. Cent. Eur. J. Biol. 2011, 6, 199-204.
42. Shukla, S.; Mehta, A.; Bajpai, A.K.; Shukla, S. In vitro antioxidant activity and total phenolic content of ethanolic leaft extract of Stevia rebaudiana Bert. Food Chem. Toxicol. 2009, 47, 2338-2343.
43. Lapornik, B.; Prošek, M.; Wondra, A.G. Comparison of extracts prepared from plant by-products using different solvents and extraction time. J. Food Eng. 2005, 71, 214-222.
44. Park, E.Y.; Murakami, H.; Mori, T.; Matsumura, Y. Effects of protein and peptide addition on lipid oxidation in power model system. J. Agric. Food Chem. 2005, 53, 137-144.
45. Zhu, K.; Zhou, H.; Qian, H. Antioxidant and free radical-scavenging activities of wheat germ protein hydrolysates prepared with alcalase. J. Process Biochem. 2006, 41, 1296-1302.
46. Shukla, S.; Mehta, A.; Mehta, P.; Bajpai, A.K. Antioxidant ability and total phenolic content of aqueous leaf extract of Stevia rebaudiana Bert. Exp. Toxicol. Pathol. 2012, 64, 807-811.
47. Biskup, I.; Golonka, I.; Gamian, A.; Sroka, Z. Antioxidant activity of selected phenols estimated by ABTS and FRAP methods. Postepy Hig. Med. Dosw. 2013, 67, 958-963.
48. Ishige, K.; Shubert, D.; Sagara, Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanism. Free Radic. Biol. Med. 2001, 30, 433-446.
49. Shivanna, N.; Naika, M.; Khanum, F.; Kaul, V.K. Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. J. Diabetes Complicat. 2013, 27, 103-113.
50. Kaushik, R.; Narayanan, P.; Vasudevan, V.; Muthukumaran, G.; Antony, U. Nutrient composition of cultivated Stevia leaves and the influence of polyphenols and plant pigments on sensory and antioxidant properties of leaf extracts. J. Food Sci. Technol. 2010, 47, 27-33.
51. Bast, A.; Haenen, G. The toxicity of antioxidants and their metabolites. Environ. Toxicol. Pharmacol. 2002, 11, 251-258.
52. Urban, J.D.; Carakostas, M.C.; Brusick, D.J. Steviol glycoside safety: Is the genotoxicity database sufficient? Food Chem. Toxicol. 2013, 51, 386-390.
53. Rajab, R.; Mohankumar, C.; Murugan, K.; Harish, M.; Mohanan, P.V. Purification and toxicity studies of stevioside from Stevia rebaudiana Bertoni. Toxicol. Int. 2009, 16, 49-54.
54. Nikiforov, A.I.; Rihner, M.O.; Eapen, A.K.; Thomas, J.A. Metabolism and toxicity studies supporting the safety of rebaudioside D. Int. J. Toxicol. 2013, 32, 261-273.
55. Atta-ur-Rahman. Studies on Natural Products Chemistry. Volume XXVII: Bioactive Natural Products (Part H); Elsevier: London, UK, 2002; pp. 307-308.
56. Repetto, G.; del Peso, A.; Zurita, J.L. Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat. Protoc. 2008, 3, 1125-1131.
57. Zanatta, C.F.; Ugartondo, V.; Mitjans, M.; Rocha-Filho, P.A.; Vinardell, M.P. Low cytotoxicity of creams and lotions formulated with Buriti oil (Mauritia flexuosa) assessed by the neutral red release test. Food Chem. Toxicol. 2008, 46, 2776-2781.
58. Jahan, J.A.; Mostafa, M.; Hossain, H.; Nimmi, J.; Sattar, A.; Alim, A.; Moeiz, S.M.J. Antioxidant activity of Stevia rebaudiana Bert. leaves from Bangladesh. Bang. Pharm. J. 2010, 13, 67-75.
59. Sutradhar, S.; Humera, U.P.A.; Muheem, A.M. Comperative study of antioxidant activity of methanolic and ethanolic extracts of Stevia rebaudiana leaves. Res. J. Pharm. Biol. Chem. Sci. 2013, 2, 674-679.
60. Zeng, J.; Cai, W.; Yang, W.; Wu, W. Antioxidant abilities, phenolics and flavonoids contents in the ethanolic extracts of the stems and leaves of different Stevia rebaudiana Bert. lines. Sugar Tech 2013, 15, 209-213.
61. Fukumoto, L.; Mazza, G. Assessing antioxidant and prooxidant activities of phenolic compounds. J. Agric. Food Chem. 2000, 44, 3597-3604.
62. Bozin, B.; Mimica-Dukic, N.; Samojlik, I.; Goran, A.; Igic, R. Phenolics as antioxidants in Garlic (Alium sativum L., Aliaceae). Food Chem. 2008, 111, 925-929.
63. Woisky, R.; Salatino, A. Analysis of propolis: Some parameters and procedure for chemical quality control. J. Apic. Res. 1998, 37, 99-105.
64. Matejic, J.S.; Dzamic, A.M.; Mihajilov-Krestev, T.; Radelovic, V.N.; Krivosej, Z.D.; Marin, P.D. Total phenolic content, flavonoid concentration, antioxidant and antimicrobial activity of methanol extracts from three Seselia L. taxa. Cent. Eur. J. Biol. 2012, 7, 1118-1122.
65. Bradford, M.M.A. Rapid and sensitive method for the quantitation of microg quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
66. Brand-Williamis, W.; Cuvelier, M.; Berset, C. Use of a free radical method to evaluate antioxidant activity. LWT Food Sci. Technol. 1995, 28, 25-30.
67. Re, R.; Pellegrini, N.; Protegente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying and improved ABTS radical cation decolorization assay. Free Radic. Biol. Med. 1999, 26, 1231-1237.
68. Decker, E.A.; Welch, B. Role of ferritin as a lipid oxidation catalyst in muscle food. J. Agric. Food Chem. 1990, 38, 674-677.
69. ͆wieca, M.; Baraniak, B. Nutritional and antioxidant potential of lentil sprouts affected by elicitation with temperature stress. J. Agric. Food Chem. 2014, 3306-3313.