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Volumn , Issue , 2005, Pages 63-94

Pathogenetic mechanisms underlying myelodysplastic syndromes

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EID: 84928639100     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511545269.004     Document Type: Chapter
Times cited : (8)

References (159)
  • 1
    • 0000091325 scopus 로고    scopus 로고
    • The myelodysplastic syndromes
    • 3rd edn, ed. R. Hoffman, E. Benz, S. Shattil, and H. Cohen. New York: Churchill Livingstone
    • Greenberg, P. L. (2000). The myelodysplastic syndromes. In Hematology: Basic Principles and Practice, 3rd edn, ed. R. Hoffman, E. Benz, S. Shattil, and H. Cohen. New York: Churchill Livingstone, pp. 1106–29.
    • (2000) Hematology: Basic Principles and Practice , pp. 1106-1129
    • Greenberg, P.L.1
  • 2
    • 0022633801 scopus 로고
    • The molecular biology and functions of the granulocytemacrophage colony stimulating factors
    • Metcalf, D. (1986). The molecular biology and functions of the granulocytemacrophage colony stimulating factors. Blood, 67, 257–67.
    • (1986) Blood , vol.67 , pp. 257-267
    • Metcalf, D.1
  • 3
    • 0029024169 scopus 로고
    • The effect of stem-cell factor, interleukin-3 and erythropoietin on in vitro erythropoiesis in myelodysplastic syndromes
    • Verbeek, W., Vehmeyer, K., Wormann, B. et al. (1995). The effect of stem-cell factor, interleukin-3 and erythropoietin on in vitro erythropoiesis in myelodysplastic syndromes. J. Cancer Res. Clin. Oncol., 121, 338–42.
    • (1995) J. Cancer Res. Clin. Oncol , vol.121 , pp. 338-342
    • Verbeek, W.1    Vehmeyer, K.2    Wormann, B.3
  • 4
    • 0025091773 scopus 로고
    • Haemopoietic colony stimulating factorspromote cell survivalby suppressing apoptosis
    • Williams, G. T., Smith, C., Spooncer, E., Dexter, T. M., and Taylor, D. R. (1990). Haemopoietic colony stimulating factorspromote cell survivalby suppressing apoptosis. Nature, 343, 76.
    • (1990) Nature , vol.343 , pp. 76
    • Williams, G.T.1    Smith, C.2    Spooncer, E.3    Dexter, T.M.4    Taylor, D.R.5
  • 5
    • 0024448197 scopus 로고
    • Circulating erythropoietin in patients with myelodysplastic syndrome
    • Jacobs, A., Janowska, A., Caro, J. et al. (1989). Circulating erythropoietin in patients with myelodysplastic syndrome. Br. J. Haematol., 73, 36.
    • (1989) Br. J. Haematol , vol.73 , pp. 36
    • Jacobs, A.1    Janowska, A.2    Caro, J.3
  • 6
    • 0345702914 scopus 로고
    • Production of granulocyte colony stimulating factor by normal andmyelodysplastic syndrome peripheral blood cells
    • Greenberg, P. L., MacKichan, M., Negrin, R., Renick, M., and Ginzton, N. (1990). Production of granulocyte colony stimulating factor by normal andmyelodysplastic syndrome peripheral blood cells. Blood, 76(suppl. 1), 146.
    • (1990) Blood , vol.76 , Issue.1 , pp. 146
    • Greenberg, P.L.1    Mac Kichan, M.2    Negrin, R.3    Renick, M.4    Ginzton, N.5
  • 7
    • 0027086859 scopus 로고
    • Measurement of serum cytokine levels in patients with myelodysplastic syndromes
    • Verhoef, G. E., DeSchouwer, P., Ceuppens, J. L. et al. (1992).Measurement of serum cytokine levels in patients with myelodysplastic syndromes. Leukemia, 6, 1268.
    • (1992) Leukemia , vol.6 , pp. 1268
    • Verhoef, G.E.1    De Schouwer, P.2    Ceuppens, J.L.3
  • 8
    • 0025117715 scopus 로고
    • Some hemopoietic negative regulators
    • Axelrad, A. (1990). Some hemopoietic negative regulators. Exp. Hematol., 18, 143–50.
    • (1990) Exp. Hematol , vol.18 , pp. 143-150
    • Axelrad, A.1
  • 9
    • 0034022396 scopus 로고    scopus 로고
    • Negative regulators of hemopoiesis and stroma function in patientswithmyelodysplastic syndrome
    • Deeg, H. J., Beckham, C., Loken, M. R. et al. (2000). Negative regulators of hemopoiesis and stroma function in patientswithmyelodysplastic syndrome. Leuk. Lymphoma, 37, 405–14.
    • (2000) Leuk. Lymphoma , vol.37 , pp. 405-414
    • Deeg, H.J.1    Beckham, C.2    Loken, M.R.3
  • 10
    • 0029763467 scopus 로고    scopus 로고
    • Fas (Cd95) receptor and
    • Gersuk, G. M., Lee, J., Beckham, C. A., Anderson, J., and Deeg, J. H. (1996). Fas (CD95) receptor and Fas-ligand expression in bone marrowcells frompatientswith myelodysplastic syndrome. Blood, 88, 1122.
    • (1996) Blood , vol.88 , pp. 1122
    • Gersuk, G.M.1    Lee, J.2    Beckham, C.A.3    Erson, J.4    Deeg, J.H.5
  • 11
    • 0032753447 scopus 로고    scopus 로고
    • Angiogenesis in myelodysplastic syndromes
    • Pruneri, G., Bertolini, F., Soligo, D. et al. (1999). Angiogenesis in myelodysplastic syndromes. Br. J. Cancer, 81, 1398–401.
    • (1999) Br. J. Cancer , vol.81 , pp. 1398-1401
    • Pruneri, G.1    Bertolini, F.2    Soligo, D.3
  • 12
    • 0026500331 scopus 로고
    • Treatment ofmdswith hemopoietic growth factors
    • Greenberg, P. L. (1992).Treatment ofMDSwith hemopoietic growth factors. Semin. Oncol., 19, 106.
    • (1992) Semin. Oncol , vol.19 , pp. 106
    • Greenberg, P.L.1
  • 13
    • 0025332227 scopus 로고
    • In vitro differentiative and proliferative effects of human recombinant colony-stimulating factors on marrow hemopoiesis in myelodysplastic syndromes
    • Nagler, A., Ginzton, N., Bangs, C. et al. (1990). In vitro differentiative and proliferative effects of human recombinant colony-stimulating factors on marrow hemopoiesis in myelodysplastic syndromes. Leukemia, 4, 193–202.
    • (1990) Leukemia , vol.4 , pp. 193-202
    • Nagler, A.1    Ginzton, N.2    Bangs, C.3
  • 14
    • 0020523189 scopus 로고
    • Comparative analysis of the influence of human gamma, alpha, and beta interferons on human multipotential, erythroid and granulocyte-macrophage progenitor cells
    • Broxmeyer, H. E., Lu, L., Platzer, E. et al. (1983). Comparative analysis of the influence of human gamma, alpha, and beta interferons on human multipotential, erythroid and granulocyte-macrophage progenitor cells. J. Immunol., 131, 1300–5.
    • (1983) J. Immunol , vol.131 , pp. 1300-1305
    • Broxmeyer, H.E.1    Lu, L.2    Platzer, E.3
  • 15
    • 0022831823 scopus 로고
    • Effects of recombinant tumor necrosis factor on proliferation and differentiation of leukemic and normal hemopoietic cells in vitro: Relationship to cell surface receptor
    • Peetre, C., Gullberg, U., Nilsson, E. et al. (1986). Effects of recombinant tumor necrosis factor on proliferation and differentiation of leukemic and normal hemopoietic cells in vitro: relationship to cell surface receptor. J. Clin. Invest., 78, 1694–700.
    • (1986) J. Clin. Invest , vol.78 , pp. 1694-1700
    • Peetre, C.1    Gullberg, U.2    Nilsson, E.3
  • 16
    • 0023141312 scopus 로고
    • Effect of recombinant human tumor necrosis factoronthe colony growth ofhumanleukemia progenitor cellsandnormal hematopoietic progenitor cells
    • Murase, T., Hofta, T., Saito, H. et al. (1987). Effect of recombinant human tumor necrosis factoronthe colony growth ofhumanleukemia progenitor cellsandnormal hematopoietic progenitor cells. Blood, 69, 467–72.
    • (1987) Blood , vol.69 , pp. 467-472
    • Murase, T.1    Hofta, T.2    Saito, H.3
  • 17
    • 0030294026 scopus 로고    scopus 로고
    • Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes
    • Shetty, V., Mundle, S., Alvi, S., et al
    • Shetty, V., Mundle, S., Alvi, S. et al. (1996).Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes. Leuk. Res., 20, 891–900.
    • (1996) Leuk. Res , vol.20 , pp. 891-900
    • Shetty, V.1    Mundle, S.2    Alvi, S.3
  • 18
    • 0028932815 scopus 로고
    • Hematopoietic growth factor receptors: Structure variations and alternatives of receptor complex formation in normal hematopoiesis and in hematopoietic disorders
    • Budel, L. M., Dong, F., Lowenberg, B. et al. (1995). Hematopoietic growth factor receptors: structure variations and alternatives of receptor complex formation in normal hematopoiesis and in hematopoietic disorders. Leukemia, 9, 553–61.
    • (1995) Leukemia , vol.9 , pp. 553-561
    • Budel, L.M.1    Dong, F.2    Lowenberg, B.3
  • 19
    • 0030926080 scopus 로고    scopus 로고
    • Bouscary, D., De Vos, J., Guesnu, M. et al. (1997). Fas/Apo-1 (CD95) expression and apoptosis in patients with yelodysplastic syndromes. Leukemia, 11, 839–45.
    • (1997) Fas/Apo-1 , vol.11 , pp. 839-845
    • Bouscary, D.1    De Vos, J.2    Guesnu, M.3
  • 20
    • 0035892123 scopus 로고    scopus 로고
    • Expression of tumor necrosis factor-related apoptosis-inducing ligand
    • Zang, D. Y., Goodwin, R., Loken, M. R., Bryant, E., and Deeg, H. J. (2001). Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: effects on in vitro hemopoiesis. Blood, 98, 3058–65.
    • (2001) Blood , vol.98 , pp. 3058-3065
    • Zang, D.Y.1    Goodwin, R.2    Loken, M.R.3    Bryant, E.4    Deeg, H.J.5
  • 21
    • 0029090167 scopus 로고
    • Direct evidence for tumor necrosis factor-induced itochondrial reactive oxygen intermediates and their involvement in cytotoxicity
    • Goossens, V., Grooten, J., De Vos, K., and Fiers, W. (1995). Direct evidence for tumor necrosis factor-induced itochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl Acad. Sci. U.S.A., 92, 8115.
    • (1995) Proc. Natl Acad. Sci. U.S.A , vol.92 , pp. 8115
    • Goossens, V.1    Grooten, J.2    De Vos, K.3    Fiers, W.4
  • 22
    • 0030664927 scopus 로고    scopus 로고
    • Oxidative dna damage in cd34+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-αconcentration
    • Peddie, C., Wolf, R., McLellan, L., Collins, A. R., and Bowen, T. (1997). Oxidative DNA damage in CD34+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-α concentration. Br. J. Haematol., 99, 625.
    • (1997) Br. J. Haematol , vol.99 , pp. 625
    • Peddie, C.1    Wolf, R.2    Mc Lellan, L.3    Collins, A.R.4    Bowen, T.5
  • 23
    • 0141680971 scopus 로고    scopus 로고
    • Oxidative stress and the myelodysplastic syndromes
    • Farquhar, M. J. and Bowen, D. (2003). Oxidative stress and the myelodysplastic syndromes. Int. J. Hematol., 77, 342–50.
    • (2003) Int. J. Hematol , vol.77 , pp. 342-350
    • Farquhar, M.J.1    Bowen, D.2
  • 24
    • 0029016931 scopus 로고
    • Selleri, c., anderson, s., and young, n
    • Fas antigen expression in CD34+ human marrow cells is induced by interferon-α and tumor necrosis factor-α and potentiates cytokine-mediated hematopoietic suppression in vitro
    • Maciejewski, J. P., Selleri, C., Anderson, S., and Young, N. (1995). Fas antigen expression in CD34+ human marrow cells is induced by interferon-α and tumor necrosis factor-α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood, 85, 3183.
    • (1995) Hematopoietic suppression , vol.85 , pp. 3183
    • Maciejewski, J.P.1
  • 25
    • 0031656518 scopus 로고    scopus 로고
    • A role for tnf-α
    • Gersuk, G., Beckham, C., Loken, M. et al. (1998). A role for TNF-α, Fas and Fas ligand inmarrowfailure ssociatedwithmyelodysplastic syndrome.Br. J.Haematol., 103, 176–88.
    • (1998) Br. J.Haematol , vol.103 , pp. 176-188
    • Gersuk, G.1    Beckham, C.2    Loken, M.3
  • 26
    • 0023662289 scopus 로고
    • The tgf-beta family of growth and differentiation factors
    • Massague, J. (1987). The TGF-beta family of growth and differentiation factors. Cell, 49, 437–8.
    • (1987) Cell , vol.49 , pp. 437-438
    • Massague, J.1
  • 27
    • 0023776105 scopus 로고
    • Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro
    • Sing, G. K., Keller, J., Ellingsworth, J. R. et al. (1988). Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro. Blood, 72, 1504–11.
    • (1988) Blood , vol.72 , pp. 1504-1511
    • Sing, G.K.1    Keller, J.2    Ellingsworth, J.R.3
  • 28
    • 0027300330 scopus 로고
    • Comparative analysis of the human macrophage inflammatory protein family of cytokines (Chemokines) on proliferation of human myeloid progenitor cells
    • Broxmeyer, H. E., Sherry, B., Cooper, S., Lu, L. et al. (1993). Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. J. Immunol., 150, 3448–58.
    • (1993) J. Immunol , vol.150 , pp. 3448-3458
    • Broxmeyer, H.E.1    Sherry, B.2    Cooper, S.3    Lu, L.4
  • 29
    • 0035013475 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor inhibits fas-triggered apoptosis in bone marrowcells isolated from patients with refractory anemia with ringed sideroblasts
    • Schmidt-Mende, J., Tehranchi, R., Forsblom, A. M., Joseph, B. et al. (2001).Granulocyte colony-stimulating factor inhibits Fas-triggered apoptosis in bone marrowcells isolated from patients with refractory anemia with ringed sideroblasts. Leukemia, 15, 742–51.
    • (2001) Leukemia , vol.15 , pp. 742-751
    • Sc hmidt-Mende, J.1    Tehranchi, R.2    Forsblom, A.M.3    Joseph, B.4
  • 30
    • 0037307728 scopus 로고    scopus 로고
    • Granulocyte colonystimulating factor inhibits spontaneous cytochrome c release and mitochondriadependent apoptosis of myelodysplastic syndrome hematopoietic progenitors
    • Tehranchi, R., Fadeel, B., Forsblom, A. M. et al. (2003). Granulocyte colonystimulating factor inhibits spontaneous cytochrome c release and mitochondriadependent apoptosis of myelodysplastic syndrome hematopoietic progenitors. Blood, 101, 1080–6.
    • (2003) Blood , vol.101 , pp. 1080-1086
    • Tehranchi, R.1
  • 31
    • 0032941565 scopus 로고    scopus 로고
    • Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal cd34-positive cell proliferation and differentiation in vitro
    • Aizawa, S., Nakano, M., Iwase, O. et al. (1999). Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leuk. Res., 23, 239–46.
    • (1999) Leuk. Res , vol.23 , pp. 239-246
    • Aizawa, S.1    Nakano, M.2    Iwase, O.3
  • 32
    • 0034490531 scopus 로고    scopus 로고
    • Abnormalities of adherent layers grown from bone marrow of patients with myelodysplasia
    • Tennant, G. B., Walsh, V., Truran, L. N. et al. (2000). Abnormalities of adherent layers grown from bone marrow of patients with myelodysplasia. Br. J. Haematol., 111, 853–62.
    • (2000) Br. J. Haematol , vol.111 , pp. 853-862
    • Tennant, G.B.1    Walsh, V.2    Truran, L.N.3
  • 33
    • 0025237669 scopus 로고
    • Functional studies of bonemarrowhaemopoietic and stromal cells inthemyelodysplastic syndrome (Mds)
    • Coutinho, L. H., Geary, C., Chang, J., Harrison, C., and Testa, N. G. (1990). Functional studies of bonemarrowhaemopoietic and stromal cells inthemyelodysplastic syndrome (MDS). Br. J. Haematol., 75, 16–25.
    • (1990) Br. J. Haematol , vol.75 , pp. 16-25
    • Coutinho, L.H.1    Geary, C.2    Chang, J.3    Harrison, C.4    Testa, N.G.5
  • 34
    • 0036113574 scopus 로고    scopus 로고
    • Functional disturbance of marrowstromal microenvironment in themyelodysplastic syndromes
    • Tauro, S., Hepburn, M., Peddie, C. M., Bowen, D. T., and Pippard, M. J. (2002). Functional disturbance of marrowstromal microenvironment in themyelodysplastic syndromes. Leukemia, 16, 785–90.
    • (2002) Leukemia , vol.16 , pp. 785-790
    • Tauro, S.1    Hepburn, M.2    Peddie, C.M.3    Bowen, D.T.4    Pippard, M.J.5
  • 35
    • 2942624154 scopus 로고    scopus 로고
    • Bone marrow stroma in childhood myelodysplastic syndrome: Composition, ability to sustain hematopoiesis in vitro, and altered gene expression
    • Borojevic, R., Roela, R., Rodarte, R. S. et al. (2004). Bone marrow stroma in childhood myelodysplastic syndrome: composition, ability to sustain hematopoiesis in vitro, and altered gene expression. Leuk. Res., 28, 831–44.
    • (2004) Leuk. Res , vol.28 , pp. 831-844
    • Borojevic, R.1    Roela, R.2    Rodarte, R.S.3
  • 36
    • 0034791259 scopus 로고    scopus 로고
    • Effects of vascular endothelial and platelet-derived growth factor receptor inhibitors on long-term cultures from normal human bone marrow
    • Duhrsen, U., Martinez, T., Vohwinkel, G., et al
    • Duhrsen, U., Martinez, T., Vohwinkel, G. et al. (2001). Effects of vascular endothelial and platelet-derived growth factor receptor inhibitors on long-term cultures from normal human bone marrow. Growth Factors, 19, 1–17.
    • (2001) Growth Factors , vol.19 , pp. 1-17
    • Duhrsen, U.1    Martinez, T.2    Vohwinkel, G.3
  • 37
    • 0034452770 scopus 로고    scopus 로고
    • The capacity of connective tissue stromas to sustain myelopoiesis depends both upon the growth factors and the local intercellular environment
    • Carvalho, M. A., Arcanjo, K., Silva, L. C., and Borojevic, R. (2000). The capacity of connective tissue stromas to sustain myelopoiesis depends both upon the growth factors and the local intercellular environment. Biol. Cell, 92, 605–14.
    • (2000) Biol. Cell , vol.92 , pp. 605-614
    • Carvalho, M.A.1    Arcanjo, K.2    Silva, L.C.3    Borojevic, R.4
  • 38
    • 0032710319 scopus 로고    scopus 로고
    • Clinical applications of angiogeneic growth factors and their inhibitors
    • Ferrara, N. and Alitalo, K. (1999). Clinical applications of angiogeneic growth factors and their inhibitors. Nat. Med., 5, 1359–64.
    • (1999) Nat. Med , vol.5 , pp. 1359-1364
    • Ferrara, N.1    Alitalo, K.2
  • 39
    • 0035283119 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immaturemyeloid precursors and leukemia progenitor formation in myelodysplastic syndromes
    • Bellamy, W. T., Richer, L., Sirjani, D., et al
    • Bellamy, W. T., Richer, L., Sirjani, D. et al. (2001). Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immaturemyeloid precursors and leukemia progenitor formation in myelodysplastic syndromes. Blood, 97, 1427–34.
    • (2001) Blood , vol.97 , pp. 1427-1434
    • Bellamy, W.T.1    Richer, L.2    Sirjani, D.3
  • 40
    • 0035167615 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signaling pathway as an emerging target in hematologic malignancies
    • List, A. F. (2001).Vascular endothelial growth factor signaling pathway as an emerging target in hematologic malignancies. Oncologist, 6(suppl. 5), 24–31.
    • (2001) Oncologist , vol.6 , Issue.5 , pp. 24-31
    • List, A.F.1
  • 41
    • 0036172782 scopus 로고    scopus 로고
    • The nature of chromosomal aberrations detected in humans exposed to benzene
    • Zhang, L., Eastmond, D., and Smith, M. T. (2002). The nature of chromosomal aberrations detected in humans exposed to benzene. Crit. Rev. Toxicol., 32, 1–42.
    • (2002) Crit. Rev. Toxicol , vol.32 , pp. 1-42
    • Zhang, L.1    Eastmond, D.2    Smith, M.T.3
  • 42
    • 0034665786 scopus 로고    scopus 로고
    • Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
    • Aguayo, A., Kantarjian, H., Manshouri, T. et al. (2000). Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood, 96, 2240–5.
    • (2000) Blood , vol.96 , pp. 2240-2245
    • Aguayo, A.1    Kantarjian, H.2    Manshouri, T.3
  • 43
    • 0038792224 scopus 로고    scopus 로고
    • Map kinase signaling pathways and hematologic malignancies
    • Platanias, L. C. (2003).Map kinase signaling pathways and hematologic malignancies. Blood, 101, 4667–79.
    • (2003) Blood , vol.101 , pp. 4667-4679
    • Platanias, L.C.1
  • 44
    • 0037040869 scopus 로고    scopus 로고
    • Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type i interferons and transforming growth factor-beta on normal hematopoiesis
    • Verma, A., Deb, D., Sassano, A. et al. (2002).Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. J. Biol. Chem., 277, 7726–35.
    • (2002) J. Biol. Chem , vol.277 , pp. 7726-7735
    • Verma, A.1
  • 45
    • 0037097528 scopus 로고    scopus 로고
    • Cutting edge: Activation of the
    • Verma, A., Deb, D., Sassano, A. et al. (2002). Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. J. Immunol., 168, 5984–8.
    • (2002) J. Immunol , vol.168 , pp. 5984-5988
    • Verma, A.1    Deb, D.2    Sassano, A.3
  • 46
    • 0034585292 scopus 로고    scopus 로고
    • Non-transferrin-bound iron in myelodysplastic syndromes: A marker of ineffective erythropoiesis?
    • Cortelezzi, A., Cattaneo, C., Cristiani, S. et al. (2000). Non-transferrin-bound iron in myelodysplastic syndromes: a marker of ineffective erythropoiesis? Hematol. J., 1, 153–8.
    • (2000) Hematol. J , vol.1 , pp. 153-158
    • Cortelezzi, A.1    Cattaneo, C.2    Cristiani, S.3
  • 47
    • 0037111773 scopus 로고    scopus 로고
    • Characterization of gene expression of cd34+ cells from normal and myelodysplastic bone marrow
    • Hofmann, W. K., De Vos, S., Komor, M. et al. (2002). Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow. Blood, 100, 3553–60.
    • (2002) Blood , vol.100 , pp. 3553-3560
    • Hofmann, W.K.1    De Vos, S.2    Komor, M.3
  • 48
    • 0141590411 scopus 로고    scopus 로고
    • Antioxidant enzyme expression in myelodysplastic and acute myeloid leukemia bone marrow: Further evidence of a pathogenetic role for oxidative stress?
    • Bowen, D., Wang, L., Frew, M., Kerr, R., andGroves, M
    • Bowen, D., Wang, L., Frew, M., Groves, R., and Groves, M.(2003).Antioxidant enzyme expression in myelodysplastic and acute myeloid leukemia bone marrow: further evidence of a pathogenetic role for oxidative stress? Haematologica, 88, 1070–2.
    • (2003) Haematologica , vol.88 , pp. 1070-1072
    • Bowen, D.1    Wang, L.2    Cabantchik, I.3    Frew, M.4    Groves, R.5    Groves, M.6
  • 50
    • 0031001278 scopus 로고    scopus 로고
    • Iron-chelating therapy and the treatment of thalassemia
    • Olivieri, N. and Brittenham, G. (1997). Iron-chelating therapy and the treatment of thalassemia. Blood, 89, 739.
    • (1997) Blood , vol.89 , pp. 739
    • Olivieri, N.1    Brittenham, G.2
  • 51
    • 0029933087 scopus 로고    scopus 로고
    • The effect of iron chelation on haemopoiesis inmdspatientswith transfusional iron overload
    • Jensen, P.D., Heickendorff, L., Pedersen, B., et al
    • Jensen, P.D., Heickendorff, L., Pedersen, B. et al. (1996). The effect of iron chelation on haemopoiesis inMDSpatientswith transfusional iron overload. Br. J.Haematol., 94, 288–99.
    • (1996) Br. J.Haematol , vol.94 , pp. 288-299
    • Jensen, P.D.1    Heickendorff, L.2    Pedersen, D.3
  • 52
    • 0038486942 scopus 로고    scopus 로고
    • Clinical trial of deferiprone iron chelation therapy in beta-thalassaemia/haemoglobin
    • E patients in Thailand
    • Pootrakul, P., Sinrankapracha, P., Sankote, J., Kachintorn, U. et al. (2003). Clinical trial of deferiprone iron chelation therapy in beta-thalassaemia/haemoglobin E patients in Thailand. Br. J. Haematol., 122, 305–10.
    • (2003) Chelation therapy , vol.122 , pp. 305-310
    • Pootrakul, P.1    Sinrankapracha, P.2    Sankote, J.3    Kachintorn, U.4
  • 53
    • 0026686248 scopus 로고
    • Immunologic abnormalities in myelodysplastic syndromes
    • Hamblin, T. (1992). Immunologic abnormalities in myelodysplastic syndromes. Hematol. Oncol. Clin. North Am., 6, 571.
    • (1992) Hematol. Oncol. Clin. North Am , vol.6 , pp. 571
    • Hamblin, T.1
  • 54
    • 0020565912 scopus 로고
    • Decreasedthelper cells in themyelodysplastic syndromes
    • Bynoe, A. G., Scott, C., Ford, P. et al. (1983). DecreasedThelper cells in themyelodysplastic syndromes. Br. J. Haematol.54, 97.
    • (1983) Br. J. Haematol , vol.54 , pp. 97
    • Bynoe, A.G.1
  • 55
    • 0020676227 scopus 로고
    • Studies of t lymphocytes in preleukemic disorders and acute nonlymphocytic leukemia: In vitro radiosensitivity, mitogenic responsiveness, colony formation, and enumeration of lymphocytic subpopulations
    • Knox, S. J., Greenberg, P., Anderson, R.W. et al. (1983). Studies of T lymphocytes in preleukemic disorders and acute nonlymphocytic leukemia: in vitro radiosensitivity, mitogenic responsiveness, colony formation, and enumeration of lymphocytic subpopulations. Blood, 61, 449.
    • (1983) Blood , vol.61 , pp. 449
    • Knox, S.1
  • 56
    • 0026665812 scopus 로고
    • In vitro hematopoiesis inmyelodysplasia: Liquid and soft-gel culture studies
    • Richert-Boe, K. E. and Bagby, G. J. (1992). In vitro hematopoiesis inmyelodysplasia: liquid and soft-gel culture studies. Hematol. Oncol. Clin. North Am., 6, 543–56.
    • (1992) Hematol. Oncol. Clin. North Am , vol.6 , pp. 543-556
    • Richert-Boe, K.E.1    Bagby, G.J.2
  • 57
    • 0024509491 scopus 로고
    • Clonal analysis ofmyelodysplastic syndromes: Evidence of multipotent stem cell origin
    • Janssen, J.W. G., Buschle, M., Layton, M. et al. (1989). Clonal analysis ofmyelodysplastic syndromes: evidence of multipotent stem cell origin. Blood, 73, 248.
    • (1989) Blood , vol.73 , pp. 248
    • Janssen, J.1    Buschle, M.2    Layton, M.3
  • 58
    • 0026348155 scopus 로고
    • Clonality of cell populations in refractory anaemia using combined approach of gene loss and x linked restriction fragment length polymorphism methylation analysis
    • Abrahamson, G., Boultwood, J., Madden, J. et al. (1991). Clonality of cell populations in refractory anaemia using combined approach of gene loss and X linked restriction fragment length polymorphism methylation analysis. Br. J. Haematol., 79, 550.
    • (1991) Br. J. Haematol , vol.79 , pp. 550
    • Abrahamson, G.1    Boultwood, J.2    Madden, J.3
  • 59
    • 0027476532 scopus 로고
    • Cytogenetic clonality inmyelodysplastic syndromes studied with fluorescence in situ hybridization: Lineage, response to growth factor therapy and clonal expansion
    • Anastasi, J., Feng, J., Le Beau, M. M. et al. (1993).Cytogenetic clonality inmyelodysplastic syndromes studied with fluorescence in situ hybridization: lineage, response to growth factor therapy and clonal expansion. Blood, 81, 1580.
    • (1993) Blood , vol.81 , pp. 1580
    • Anastasi, J.1    Feng, J.2    Le Beau, M.M.3
  • 60
    • 0027410946 scopus 로고
    • Clonality in mds: Demonstration of pluripotent stem cell origin using x linked restriction fragment length polymorphisms
    • Tsukamot, N., Morita, K., Maehara, T. et al. (1993). Clonality in MDS: demonstration of pluripotent stem cell origin using X linked restriction fragment length polymorphisms. Br. J. Haematol., 83, 589.
    • (1993) Br. J. Haematol , vol.83 , pp. 589
    • Tsukamot, N.1    Morita, K.2    Maehara, T.3
  • 61
    • 0026781966 scopus 로고
    • Clonal involvement of granulocytes and monocytes, but not of t and b lymphocytes and natural killer cells in patients with myelodysplasia: Analysis by x linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene
    • van Kamp, H., Fibbe, W., Jansen, R. P. M. et al. (1992). Clonal involvement of granulocytes and monocytes, but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: analysis by X linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene. Blood, 80, 1774.
    • (1992) Blood , vol.80 , pp. 1774
    • Van Kamp, H.1    Fibbe, W.2    Jansen, R.3
  • 62
    • 0026780475 scopus 로고
    • Clonal lymphocytes are detectable in only some cases of mds
    • Culligan, D. J., Cachai, P., Whittaker, J. et al. (1992). Clonal lymphocytes are detectable in only some cases of MDS. Br. J. Haematol., 81, 346.
    • (1992) Br. J. Haematol , vol.81 , pp. 346
    • Culligan, D.J.1    Cachai, P.2    Whittaker, J.3
  • 63
    • 0027533768 scopus 로고
    • Myeloid but not lymphoid cells carry the 5q deletion: Polymerase chain reaction analysis of loss of heterozygosity using mini repeat sequences on highly purified cell fractions
    • Kroef, M. J. P. L., Fibbe, W., Mout, R. et al. (1993).Myeloid but not lymphoid cells carry the 5q deletion: polymerase chain reaction analysis of loss of heterozygosity using mini repeat sequences on highly purified cell fractions. Blood, 81, 1849.
    • (1993) Blood , vol.81 , pp. 1849
    • Kroef, M.1
  • 64
    • 0029932590 scopus 로고    scopus 로고
    • Biologic and clinical implications of marrowculture studies in the myelodysplastic syndromes
    • Greenberg, P. L. (1996). Biologic and clinical implications of marrowculture studies in the myelodysplastic syndromes. Semin. Hematol., 33, 163–75.
    • (1996) Semin. Hematol , vol.33 , pp. 163-175
    • Greenberg, P.L.1
  • 65
    • 0024996914 scopus 로고
    • In vitro studies of erythropoietin-dependent regulation of erythropoiesis in myelodysplastic syndromes
    • Merchav, S., Nielson, O., Rosenbaum, H. et al.(1990). In vitro studies of erythropoietin-dependent regulation of erythropoiesis in myelodysplastic syndromes. Leukemia, 4, 771–4.
    • (1990) Leukemia , vol.4 , pp. 771-774
    • Merchav, S.1    Nielson, O.2    Rosenbaum, H.3
  • 66
    • 0025645740 scopus 로고
    • Apoptosis is a commonhistopathological finding inmyelodysplasia: The correlate of ineffective haematopoiesis
    • Clark, D. M. and Lambert, I. (1990).Apoptosis is a commonhistopathological finding inmyelodysplasia: the correlate of ineffective haematopoiesis. Leuk. Lymphoma, 2, 415.
    • (1990) Leuk. Lymphoma , vol.2 , pp. 415
    • Lambert, I.1
  • 67
    • 0029020851 scopus 로고
    • Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes
    • Raza, A., Gezer, S., Mundle, S. et al. (1995). Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood, 86, 268.
    • (1995) Blood , vol.86 , pp. 268
    • Raza, A.1    Gezer, S.2    Mundle, S.3
  • 68
    • 0028930939 scopus 로고
    • Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis
    • Raza, A., Mundle, S., Iftikhar, A. et al. (1995). Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis. Am. J. Hematol., 48, 143.
    • (1995) Am. J. Hematol , vol.48 , pp. 143
    • Raza, A.1    Mundle, S.2    Iftikhar, A.3
  • 69
    • 0029957664 scopus 로고    scopus 로고
    • Altered oncogene expression and apoptosis in myelodysplastic syndrome marrow cells
    • Rajapaksa, R., Ginzton, N., Rott, L., and Greenberg, P. L. (1996). Altered oncogene expression and apoptosis in myelodysplastic syndrome marrow cells. Blood, 88, 4275–87.
    • (1996) Blood , vol.88 , pp. 4275-4287
    • Rajapaksa, R.1    Ginzton, N.2    Rott, L.3    Greenberg, P.L.4
  • 70
    • 0032408713 scopus 로고    scopus 로고
    • Apoptosis and its role in mds: Implications for disease natural history and treatment
    • Greenberg, P. L. (1998). Apoptosis and its role in MDS: implications for disease natural history and treatment. Leukemia Res., 22, 1123–36.
    • (1998) Leukemia Res , vol.22 , pp. 1123-1136
    • Greenberg, P.L.1
  • 71
    • 0033781130 scopus 로고    scopus 로고
    • Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes
    • Shimazaki, K., Ohshima, K., Suzumiya, J., Kawasaki, C., and Kikuchi, M. (2000). Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes. Br. J. Haematol., 110, 584–90.
    • (2000) Br. J. Haematol , vol.110 , pp. 584-590
    • Shimazaki, K.1    Ohshima, K.2    Suzumiya, J.3    Kawasaki, C.4    Kikuchi, M.5
  • 72
    • 0036848438 scopus 로고    scopus 로고
    • More cell death in refractory anemia with excess blasts in transformation than in acutemyeloid leukemia
    • Huh, Y. O., Jilani, I., Estey, E. et al. (2002). More cell death in refractory anemia with excess blasts in transformation than in acutemyeloid leukemia. Leukemia, 16, 2249–52.
    • (2002) Leukemia , vol.16 , pp. 2249-2252
    • Huh, Y.O.1    Jilani, I.2    Estey, E.3
  • 73
    • 0032744065 scopus 로고    scopus 로고
    • Sequential activation of caspase- 1 and caspase-3-like proteases during apoptosis in myelodysplastic syndromes
    • Ali, A., Mundle, S., Ragasa, D. et al. (1999). Sequential activation of caspase- 1 and caspase-3-like proteases during apoptosis in myelodysplastic syndromes. J. Hematother. Stem Cell Res., 8, 343–56.
    • (1999) J. Hematother. Stem Cell Res , vol.8 , pp. 343-356
    • Ali, A.1    Mundle, S.2    Ragasa, D.3
  • 74
    • 0035100089 scopus 로고    scopus 로고
    • Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases
    • Hellstrom-Lindberg, E., Schmidt-Mende, J., Forsblom, A. M. et al. (2001). Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases. Br. J. Haematol., 112, 714–26.
    • (2001) Br. J. Haematol , vol.112 , pp. 714-726
    • Hellstrom-Lindberg, E.1
  • 75
    • 0034551738 scopus 로고    scopus 로고
    • The role of apoptosis, proliferation and the bcl2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to mds
    • Parker, J., Mufti, G., Rasool, F. et al. (2000). The role of apoptosis, proliferation and the Bcl2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood, 96, 3932–8.
    • (2000) Blood , vol.96 , pp. 3932-3938
    • Parker, J.1    Mufti, G.2    Rasool, F.3
  • 76
    • 0028956550 scopus 로고
    • Regulators of cell death
    • Korsmeyer, S. (1995). Regulators of cell death. Trends Genet., 11, 101.
    • (1995) Trends Genet , vol.11 , pp. 101
    • Korsmeyer, S.1
  • 77
    • 0031464448 scopus 로고    scopus 로고
    • Bcl-2 family proteins: Regulators of apoptosis and chemoresistance in hematologic malignancies
    • Reed, J. C. (1997). Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies. Semin. Hematol., 34, 9.
    • (1997) Semin. Hematol , vol.34 , pp. 9
    • Reed, J.C.1
  • 78
    • 0032171391 scopus 로고    scopus 로고
    • expression by myeloid precursors in myelodysplastic syndromes: impact on disease progression
    • Davis, R. E. and Greenberg, P. (1998). Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: impact on disease progression. Leuk. Res., 22, 767–77.
    • (1998) Bcl-2 , vol.22 , pp. 767-777
    • Davis, R.E.1    Greenberg, P.2
  • 79
    • 0036113177 scopus 로고    scopus 로고
    • Expression and prognostic significance of bcl-2 family proteins inmyelodysplastic syndromes
    • Boudard, D., Vasselon, C., Bertheas, M. F. et al. (2002). Expression and prognostic significance of Bcl-2 family proteins inmyelodysplastic syndromes.Am. J.Hematol., 70, 115–25.
    • (2002) Am. J.Hematol , vol.70 , pp. 115-125
    • Boudard, D.1    Vasselon, C.2    Bertheas, M.F.3
  • 80
    • 0022538534 scopus 로고
    • Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes
    • Jacobs, R. A., Cornbleet, M., Vardiman, J. et al. (1986). Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes. Blood, 67, 1765.
    • (1986) Blood , vol.67 , pp. 1765
    • Jacobs, R.A.1    Cornbleet, M.2    Vardiman, J.3
  • 81
    • 0025046596 scopus 로고
    • Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute nonlymphocytic leukemia
    • Pedersen-Bjergaard, J., Philip, P., Larsen, S. O. et al. (1990). Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute nonlymphocytic leukemia. Blood, 76, 1083.
    • (1990) Blood , vol.76 , pp. 1083
    • Pedersen-Bjergaard, J.1    Philip, P.2    Larsen, S.O.3
  • 82
    • 0023684505 scopus 로고
    • Chromosome abnormalities and karyotypic evolution in 83 patients with myelodysplastic syndrome and predictive value for prognosis
    • Horiike, S., Taniwaki, M., Misawa, S. et al. (1988). Chromosome abnormalities and karyotypic evolution in 83 patients with myelodysplastic syndrome and predictive value for prognosis. Cancer, 62, 1129.
    • (1988) Cancer , vol.62 , pp. 1129
    • Horiike, S.1
  • 83
    • 0034119050 scopus 로고    scopus 로고
    • Cytogenetic analogy between myelodysplastic syndrome and acute myeloid leukemia of elderly patients
    • Rossi, G., Pelizzari, A., Bellotti, D., Tonelli, M., and Barlati, S. (2000). Cytogenetic analogy between myelodysplastic syndrome and acute myeloid leukemia of elderly patients. Leukemia, 14, 636–41.
    • (2000) Leukemia , vol.14 , pp. 636-641
    • Rossi, G.1    Pelizzari, A.2    Bellotti, D.3    Tonelli, M.4    Barlati, S.5
  • 84
    • 0029966854 scopus 로고    scopus 로고
    • The tel/platelet-derived growth factor beta receptor (Pdgf beta r) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates pdgf beta r kinase-dependent signaling pathways
    • Carroll, M., Tomasson, M., Barker, G. F., Golub, T. R., and Gilliland, D. G. (1996). The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. Proc. Natl Acad. Sci. U.S.A., 93, 14845–50.
    • (1996) Proc. Natl Acad. Sci. U.S.A , vol.93 , pp. 14845-14850
    • Carroll, M.1    Tomasson, M.2    Barker, G.F.3    Golub, T.R.4    Gilliland, D.G.5
  • 85
    • 0036682958 scopus 로고    scopus 로고
    • K., meade, k., nakamura, r., barrett, j., and dunbar, c. E
    • Magnusson, M. K., Meade, K., Nakamura, R., Barrett, J., and Dunbar, C. E. (2002). Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene. Blood, 100, 1088–91.
    • (2002) Receptor fusion oncogene , vol.100 , pp. 1088-1091
    • Magnusson, M.1
  • 86
    • 0024380306 scopus 로고
    • Mechanisms of
    • Yunis, J. J., Boot, A. J. M., Mayer, M. G., and Bos, J. L. (1989). Mechanisms of ras mutation in myelodysplastic syndrome. Oncogene, 4, 609.
    • (1989) Oncogene , vol.4 , pp. 609
    • Yunis, J.J.1    Boot, A.2    Mayer, M.G.3    Bos, J.L.4
  • 88
    • 1542503817 scopus 로고    scopus 로고
    • Acquisition of
    • Shih, L. Y., Huang, C., Wang, P. N. et al. (2004). Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia. Leukemia, 18, 466–75.
    • (2004) Leukemia , vol.18 , pp. 466-475
    • Shih, L.Y.1    Huang, C.2    Wang, P.N.3
  • 89
    • 0027181645 scopus 로고
    • mutations are associated with poor prognosis and increased risk of leukaemia inmyelodysplastic syndrome
    • Paquette, R. L., Landow, E., Pierre, R.V. et al. (1993). N-ras mutations are associated with poor prognosis and increased risk of leukaemia inmyelodysplastic syndrome. Blood, 82, 590–9.
    • (1993) N-Ras , vol.82 , pp. 590-599
    • Paquette, R.L.1    Landow, E.2    Pierre, R.V.3
  • 90
    • 0030036452 scopus 로고    scopus 로고
    • G
    • andmyelodysplasia: lessons fromthe last decade
    • Parker, J. andMufti, G. (1996). Ras andmyelodysplasia: lessons fromthe last decade. Semin. Hematol., 33, 206.
    • (1996) Ras , vol.33 , pp. 206
    • Parker, J.A.1
  • 91
    • 0028210052 scopus 로고
    • Mutations in the
    • Neubauer, A., Greenberg, P., Negrin, R. et al. (1994). Mutations in the ras protooncogenes in patients with myelodysplastic syndromes. Leukemia, 8, 638.
    • (1994) Leukemia , vol.8 , pp. 638
    • Neubauer, A.1    Greenberg, P.2    Negrin, R.3
  • 92
    • 4444272661 scopus 로고    scopus 로고
    • Constitutive activation of the mek/erk pathway mediates all effects of oncogenic
    • Zhang, J. and Lodish, H. (2004). Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors. Blood, 104, 1679–87.
    • (2004) Blood , vol.104 , pp. 1679-1687
    • Zhang, J.1    Lodish, H.2
  • 93
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg, P., Cox, C., Le Beau, M. M. et al. (1997). International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood, 89, 2079–88.
    • (1997) Blood , vol.89 , pp. 2079-2088
    • Greenberg, P.1    Cox, C.2    Le Beau, M.M.3
  • 94
    • 0025190309 scopus 로고
    • mutations in myelodysplastic, leukemic, and normal subjects
    • Ridge, S. A., Worwood, M., Oscier, D. et al. (1990). FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc. Natl Acad. Sci. U.S.A., 87, 1377.
    • (1990) FMS , vol.87 , pp. 1377
    • Ridge, S.A.1    Worwood, M.2    Oscier, D.3
  • 95
    • 0025276780 scopus 로고
    • Mutation of the human
    • Tobal, K., Pagliuca, A., Bhatt, B. et al. (1990).Mutation of the human FMS gene (MCSFreceptor) nmyelodysplastic syndromesandacutemyeloid leukemia. Leukemia, 4, 486.
    • (1990) Leukemia , vol.4 , pp. 486
    • Tobal, K.1    Pagliuca, A.2    Bhatt, B.3
  • 96
    • 3242799751 scopus 로고    scopus 로고
    • and, TP53, mutations in patientswithmyelodysplastic syndromeand a del(5q)
    • Fidler, C., Watkins, F., Bowen, D. T. et al. (2004). NRAS, FLT3 and TP53 mutations in patientswithmyelodysplastic syndromeand a del(5q).Haematologica, 89, 865–6.
    • (2004) NRAS , vol.89 , pp. 865-866
    • Fidler, C.1    Watkins, F.2    Bowen, D.T.3
  • 97
    • 0025894713 scopus 로고    scopus 로고
    • Sidransky, d., vogelstein, b., andharris, C. C. (1991)
    • Hollstein, M., Sidransky, D., Vogelstein, B., andHarris, C. C. (1991). p53 mutations in human cancers. Science, 253, 49.
    • Science , vol.253 , pp. 49
    • Hollstein, M.1
  • 98
    • 0026336513 scopus 로고
    • Mutations in the
    • Jonveaux, P., Fenaux, P., Quiquandon, I. et al.(1991).Mutations in the p53 gene in myelodysplastic syndromes. Oncogene, 6, 2243.
    • (1991) Oncogene , vol.6 , pp. 2243
    • Jonveaux, P.1    Fenaux, P.2    Quiquandon, I.3
  • 99
    • 0028172868 scopus 로고
    • mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • Wattel, E., Preudhomme, C., Hecquet, B. et al.(1994). P53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood, 84, 3148.
    • (1994) P53 , vol.84 , pp. 3148
    • Wattel, E.1
  • 100
    • 0029619252 scopus 로고
    • Mutations of the
    • Mori, N., Hidai, H., Yokota, J. et al.(1995).Mutations of the p53 gene inmyelodysplastic syndrome and overt leukemia. Leuk. Res., 19, 869.
    • (1995) Leuk. Res , vol.19 , pp. 869
    • Mori, N.1    Hidai, H.2    Yokota, J.3
  • 101
    • 0027247412 scopus 로고
    • Mutations of the
    • Sugimoto, K., Hirano, N., Toyoshima, H. et al.(1993). Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia. Blood, 81, 3022.
    • (1993) Blood , vol.81 , pp. 3022
    • Sugimoto, K.1    Hirano, N.2    Toyoshima, H.3
  • 102
    • 0028955808 scopus 로고
    • mutations emerge at early phase ofmyelodysplastic syndrome and are associated with complex chromosomal abnormalities
    • Kaneko, H., Misawa, S., Horiike, S. et al. (1995). TP53 mutations emerge at early phase ofmyelodysplastic syndrome and are associated with complex chromosomal abnormalities. Blood, 85, 2189.
    • (1995) TP53 , vol.85 , pp. 2189
    • Kaneko, H.1    Misawa, S.2    Horiike, S.3
  • 103
    • 0035725856 scopus 로고    scopus 로고
    • International prognostic scoring system and
    • Kita-Sasai, Y., Horiike, S., Misawa, S. et al. (2001). International prognostic scoring system and TP53mutations are independent prognostic indicators for patientswith myelodysplastic syndrome. Br. J. Haematol., 115, 301–12.
    • (2001) Br. J. Haematol , vol.115 , pp. 301-312
    • Kita-Sasai, Y.1    Horiike, S.2    Misawa, S.3
  • 104
    • 0037409886 scopus 로고    scopus 로고
    • Configuration of the
    • Horiike, S., Kita-Sasai, Y., Nakao, M., and Taniwaki, M. (2003).Configuration of the TP53 gene as an independent prognostic parameter of myelodysplastic syndrome. Leuk. Lymphoma, 44, 915–22.
    • (2003) Leuk. Lymphoma , vol.44 , pp. 915-922
    • Horiike, S.1    Kita-Sasai, Y.2    Nakao, M.3
  • 105
    • 10544255085 scopus 로고    scopus 로고
    • Microsatellite instability and
    • Ben-Yehuda, D., Krichevsky, S., Caspi, O. et al. (1996).Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood, 88, 4296.
    • (1996) Blood , vol.88 , pp. 4296
    • Krichevsky, S.1
  • 106
    • 0032868343 scopus 로고    scopus 로고
    • Distinct genetic involvement of the
    • Horiike, S., Misawa, S., Kaneko, H. et al.(1999). Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of nos 5 and/or 7 and its possible relationship to replication error phenotype. Leukemia, 13, 1235.
    • (1999) Leukemia , vol.13 , pp. 1235
    • Horiike, S.1    Misawa, S.2    Kaneko, H.3
  • 107
    • 1142310671 scopus 로고    scopus 로고
    • and, TP53, mutations in therapy-relatedmyeloid malignancies with abnormalities of chromosomes 5 and 7
    • Side, L. E., Curtiss, N., Teel, K., Kratz, C. et al. (2004). RAS, FLT3, and TP53 mutations in therapy-relatedmyeloid malignancies with abnormalities of chromosomes 5 and 7. Genes Chromosomes Cancer, 39, 217–22.
    • (2004) RAS , vol.39 , pp. 217-222
    • Side, L.E.1    Curtiss, N.2    Teel, K.3    Kratz, C.4
  • 108
    • 0038011942 scopus 로고    scopus 로고
    • Significant correlation between the degree of
    • Cilloni, D., Gottardi, E., Messa, F., Fava, M. et al. (2003). Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes. J. Clin. Oncol., 21, 1988–95.
    • (2003) J. Clin. Oncol , vol.21 , pp. 1988-1995
    • Cilloni, D.1    Gottardi, E.2    Messa, F.3    Fava, M.4
  • 109
    • 84928635061 scopus 로고    scopus 로고
    • Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1
    • acute
    • Nakao, M., Horiike, S., Fukushima-Nakase, Y., Nishimura, M. et al. (2004). Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute
    • (2004) Detected
    • Nakao, M.1    Horiike, S.2    Fukushima-Nakase, Y.3    Nishimura, M.4
  • 110
    • 3242799751 scopus 로고    scopus 로고
    • and, TP53, mutations in patientswithmyelodysplastic syndromeand a del(5q)
    • Fidler, C., Watkins, F., Bowen, D. T. et al. (2004). NRAS, FLT3 and TP53 mutations in patientswithmyelodysplastic syndromeand a del(5q).Haematologica, 89, 865–6.
    • (2004) NRAS , vol.89 , pp. 865-866
    • Fidler, C.1    Watkins, F.2    Bowen, D.T.3
  • 111
    • 0025894713 scopus 로고    scopus 로고
    • Sidransky, d., vogelstein, b., andharris, C. C. (1991)
    • Hollstein, M., Sidransky, D., Vogelstein, B., andHarris, C. C. (1991). p53 mutations in human cancers. Science, 253, 49.
    • Science , vol.253 , pp. 49
    • Hollstein, M.1
  • 112
    • 0026336513 scopus 로고
    • Mutations in the
    • Jonveaux, P., Fenaux, P., Quiquandon, I. et al.(1991).Mutations in the p53 gene in myelodysplastic syndromes. Oncogene, 6, 2243.
    • (1991) Oncogene , vol.6 , pp. 2243
    • Jonveaux, P.1    Fenaux, P.2    Quiquandon, I.3
  • 113
    • 0028172868 scopus 로고
    • mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • attel, E., Preudhomme, C., Hecquet, B. et al.(1994). P53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood, 84, 3148.
    • (1994) P53 , vol.84 , pp. 3148
    • Attel, E.1
  • 114
    • 0029619252 scopus 로고
    • Mutations of the
    • Mori, N., Hidai, H., Yokota, J. et al.(1995).Mutations of the p53 gene inmyelodysplastic syndrome and overt leukemia. Leuk. Res., 19, 869.
    • (1995) Leuk. Res , vol.19 , pp. 869
    • Mori, N.1    Hidai, H.2    Yokota, J.3
  • 115
    • 0027247412 scopus 로고
    • Mutations of the
    • Sugimoto, K., Hirano, N., Toyoshima, H. et al.(1993). Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia. Blood, 81, 3022.
    • (1993) Blood , vol.81 , pp. 3022
    • Sugimoto, K.1    Hirano, N.2    Toyoshima, H.3
  • 116
    • 0028955808 scopus 로고
    • mutations emerge at early phase ofmyelodysplastic syndrome and are associated with complex chromosomal abnormalities
    • Kaneko, H., Misawa, S., Horiike, S. et al. (1995). TP53 mutations emerge at early phase ofmyelodysplastic syndrome and are associated with complex chromosomal abnormalities. Blood, 85, 2189.
    • (1995) TP53 , vol.85 , pp. 2189
    • Kaneko, H.1    Misawa, S.2    Horiike, S.3
  • 117
    • 0035725856 scopus 로고    scopus 로고
    • International prognostic scoring system and
    • Kita-Sasai, Y., Horiike, S., Misawa, S. et al. (2001). International prognostic scoring system and TP53mutations are independent prognostic indicators for patientswith myelodysplastic syndrome. Br. J. Haematol., 115, 301–12.
    • (2001) Br. J. Haematol , vol.115 , pp. 301-312
    • Kita-Sasai, Y.1
  • 118
    • 0037409886 scopus 로고    scopus 로고
    • Configuration of the
    • Horiike, S., Kita-Sasai, Y., Nakao, M., and Taniwaki, M. (2003).Configuration of the TP53 gene as an independent prognostic parameter of myelodysplastic syndrome. Leuk. Lymphoma, 44, 915–22.
    • (2003) Leuk. Lymphoma , vol.44 , pp. 915-922
    • Horiike, S.1    Kita-Sasai, Y.2    Nakao, M.3    Taniwaki, M.4
  • 119
    • 10544255085 scopus 로고    scopus 로고
    • Microsatellite instability and
    • Ben-Yehuda, D., Krichevsky, S., Caspi, O. et al. (1996).Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood, 88, 4296.
    • (1996) Blood , vol.88 , pp. 4296
    • Krichevsky, S.1
  • 120
    • 0032868343 scopus 로고    scopus 로고
    • Distinct genetic involvement of the
    • Horiike, S., Misawa, S., Kaneko, H. et al.(1999). Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of nos 5 and/or 7 and its possible relationship to replication error phenotype. Leukemia, 13, 1235.
    • (1999) Leukemia , vol.13 , pp. 1235
    • Horiike, S.1    Misawa, S.2    Kaneko, H.3
  • 121
    • 1142310671 scopus 로고    scopus 로고
    • and, TP53, mutations in therapy-relatedmyeloid malignancies with abnormalities of chromosomes 5 and 7
    • Side, L. E., Curtiss, N., Teel, K., Kratz, C. et al. (2004). RAS, FLT3, and TP53 mutations in therapy-relatedmyeloid malignancies with abnormalities of chromosomes 5 and 7. Genes Chromosomes Cancer, 39, 217–22.
    • (2004) RAS , vol.39 , pp. 217-222
    • Side, L.E.1    Curtiss, N.2    Teel, K.3    Kratz, C.4
  • 122
    • 0038011942 scopus 로고    scopus 로고
    • Significant correlation between the degree of
    • Cilloni, D., Gottardi, E., Messa, F., Fava, M. et al. (2003). Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes. J. Clin. Oncol., 21, 1988–95.
    • (2003) J. Clin. Oncol , vol.21 , pp. 1988-1995
    • Cilloni, D.1    Gottardi, E.2    Messa, F.3    Fava, M.4
  • 123
    • 3042541853 scopus 로고    scopus 로고
    • Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute myeloblastic leukaemia and myelodysplastic syndrome
    • Nakao, M., Horiike, S., Fukushima-Nakase, Y., Nishimura, M. et al. (2004). Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute myeloblastic leukaemia and myelodysplastic syndrome. Br. J. Haematol., 125, 709–19.
    • (2004) Br. J. Haematol , vol.125 , pp. 709-719
    • Nakao, M.1    Horiike, S.2    Fukushima-Nakase, Y.3    Nishimura, M.4
  • 124
    • 1542373639 scopus 로고    scopus 로고
    • High incidence of somaticmutations in the
    • Harada, H., Haroda, Y., Niimi, H. et al. (2004).High incidence of somaticmutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood, 103, 2316–24.
    • (2004) Blood , vol.103 , pp. 2316-2324
    • Harada, H.1    Haroda, Y.2    Niimi, H.3
  • 126
    • 0242352337 scopus 로고    scopus 로고
    • Low expression of
    • Erpelinck, C., Lowenberg, B., and Delwel, R. (2003). Low expression of MDS1-EVI1-like-1 (MEL1) and EVI1- like-1 (EL1) genes in favorable-risk acute myeloid leukemia. Exp. Hematol., 31, 1066–72.
    • (2003) Exp. Hematol , vol.31 , pp. 1066-1072
    • Erpelinck, C.1    Lowenberg, B.2    Delwel, R.3
  • 127
    • 0033302205 scopus 로고    scopus 로고
    • Xu, K., Wang, L., Hao, Y. et al. (1999). Evi-1 and MDS1-Evi-1 genes in pathogenesis of myelodysplastic syndromes and post-MDS acute myeloid leukemia. Chin. Med. J. (Engl.), 112, 1112–18.
    • (1999) Evi-1 , vol.112 , pp. 1112-1118
    • Xu, K.1    Wang, L.2    Hao, Y.3
  • 128
    • 4143053704 scopus 로고    scopus 로고
    • Internal tandem duplication of fms-like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome
    • Shih, L. Y., Lin, T., Wang, P. N. et al. (2004). Internal tandem duplication of fms-like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome. Cancer, 101, 989–98.
    • (2004) Cancer , vol.101 , pp. 989-998
    • Shih, L.Y.1
  • 129
    • 16944366584 scopus 로고    scopus 로고
    • Tandem duplications of the
    • Horiike, S., Yokota, S., Nakao, M., Iwai, T. et al.(1997). Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation ofmyelodysplasia. Leukemia, 11, 1442–6.
    • (1997) Leukemia , vol.11 , pp. 1442-1446
    • Horiike, S.1    Yokota, S.2    Nakao, M.3    Iwai, T.4
  • 130
    • 0036660412 scopus 로고    scopus 로고
    • Novel transcription factors in human cd34 antigen-positive hematopoietic cells
    • Gomes, I., Sharma, T., Edassery, S. et al. (2002). Novel transcription factors in human CD34 antigen-positive hematopoietic cells. Blood, 100, 107–19.
    • (2002) Blood , vol.100 , pp. 107-119
    • Gomes, I.1    Sharma, T.2    Edassery, S.3
  • 131
    • 0034982567 scopus 로고    scopus 로고
    • Transcription factors that regulate growth and differentiation of myeloid cells
    • Nagamura-Inoue, T., Tamura, T. T., and Ozato, K. (2001). Transcription factors that regulate growth and differentiation of myeloid cells. Int. Rev. Immunol., 20, 83–105.
    • (2001) Int. Rev. Immunol , vol.20 , pp. 83-105
    • Nagamura-Inoue, T.1    Tamura, T.T.2    Ozato, K.3
  • 132
    • 0034684620 scopus 로고    scopus 로고
    • Signal transduction and the
    • Yordy, J. S. and Muise-Helmericks, R. (2000). Signal transduction and the Ets family of transcription factors. Oncogene, 19, 6503–13.
    • (2000) Oncogene , vol.19 , pp. 6503-6513
    • Yordy, J.S.1
  • 133
    • 4544353968 scopus 로고    scopus 로고
    • Ets proteins in biological control and cancer
    • Hsu, T., Trojanowska, M., and Watson, D. K. (2004). Ets proteins in biological control and cancer. J. Cell Biochem., 91, 896–903.
    • (2004) J. Cell Biochem , vol.91 , pp. 896-903
    • Hsu, T.1    Trojanowska, M.2    Watson, D.K.3
  • 134
    • 2442489942 scopus 로고    scopus 로고
    • Unique and selective effects of five ets family members
    • Kopp, J. L., Wilder, P., Desler, M. et al. (2004). Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the promoter of the type II transforming growth factor-beta receptor gene. J. Biol. Chem., 279, 19407–20.
    • (2004) J. Biol. Chem , vol.279 , pp. 19407-19420
    • Kopp, J.L.1    Wilder, P.2    Desler, M.3
  • 135
    • 10244247751 scopus 로고    scopus 로고
    • The ets-family transcription factor, pu.1, is necessary for the maintenance of fetal liver hematopoietic stem cells. [epub ahead of print]
    • Kim, H. G., De Guzman, C., Swindle, C. S. et al. (2004). The ETS-family transcription factor, PU.1, is necessary for the maintenance of fetal liver hematopoietic stem cells. [Epub ahead of print]. Blood, 104, 3894–900.
    • (2004) Blood , vol.104 , pp. 3894-3900
    • Kim, H.G.1    De Guzman, C.2    Swindle, C.S.3
  • 136
    • 11944253332 scopus 로고
    • Polymorphism of the proto-oncogene
    • Kerckaert, J. P., Duterque-Coquillaud, M., Collyn-d’Hooghe, M. et al. (1990). Polymorphism of the proto-oncogene ETS-1 in hematological malignancies. Leukemia, 4, 16–19.
    • (1990) Leukemia , vol.4 , pp. 16-19
    • Kerckaert, J.1    Duterque-Coquillaud, M.2    Collyn-Hooghe, M.3
  • 137
    • 0029033747 scopus 로고
    • TEL, gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13)
    • Wlodarska, I., Mecucci, C., Marynen, P. et al.(1995). TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13). Blood, 85, 2848–52.
    • (1995) Blood , vol.85 , pp. 2848-2852
    • Wlodarska, I.1    Mecucci, C.2    Marynen, P.3
  • 138
    • 0036814971 scopus 로고    scopus 로고
    • Molecular genetics of human leukemias: New insights into therapy
    • Gilliland, D. G. (2002). Molecular genetics of human leukemias: new insights into therapy. Semin. Hematol., 39(suppl. 3), 6–11.
    • (2002) Semin. Hematol , vol.39 , Issue.3 , pp. 6-11
    • Gilliland, D.G.1
  • 139
    • 1342311013 scopus 로고    scopus 로고
    • The role of signal transducer and activator of transcription factors in leukemogenesis
    • Sternberg, D.W. and Gilliland, D. (2004). The role of signal transducer and activator of transcription factors in leukemogenesis. J. Clin. Oncol., 22, 361–71.
    • (2004) J. Clin. Oncol , vol.22 , pp. 361-371
    • Sternberg, D.W.1    Gilliland, D.2
  • 140
    • 0031035425 scopus 로고    scopus 로고
    • Erythropoietininduced activation of
    • Hoefsloot, L. H., van Amelsvoort, M., Broeders, L. C. et al. (1997). Erythropoietininduced activation of STAT5 is impaired in the myelodysplastic syndrome. Blood, 89, 1690–700.
    • (1997) Blood , vol.89 , pp. 1690-1700
    • Hoefsloot, L.H.1    Van Amelsvoort, M.2    Broeders, L.C.3
  • 141
    • 0032902504 scopus 로고    scopus 로고
    • Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes
    • Ohyashiki, J. H., Iwama, H., Yahata, N. et al. (1999). Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes. Clin. Cancer Res., 5, 1155–60.
    • (1999) Clin. Cancer Res , vol.5 , pp. 1155-1160
    • Ohyashiki, J.H.1    Iwama, H.2    Yahata, N.3
  • 142
    • 0037388243 scopus 로고    scopus 로고
    • Telomere dynamics in myelodysplastic syndrome determined by telomere measurement of marrow metaphases
    • Sashida, G., Ohyashiki, J., Nakajima, A. et al. (2003). Telomere dynamics in myelodysplastic syndrome determined by telomere measurement of marrow metaphases. Clin. Cancer Res., 9, 1489–96.
    • (2003) Clin. Cancer Res , vol.9 , pp. 1489-1496
    • Sashida, G.1    Ohyashiki, J.2    Nakajima, A.3
  • 143
    • 0037789547 scopus 로고    scopus 로고
    • Imbalance between apoptosis and telomerase activity in myelodysplastic syndromes: Possible role in ineffective hemopoiesis
    • Ohshima, K., Karube, K., Shimazaki, K. et al. (2003). Imbalance between apoptosis and telomerase activity in myelodysplastic syndromes: possible role in ineffective hemopoiesis. Leuk. Lymphoma, 44, 1339–46.
    • (2003) Leuk. Lymphoma , vol.44 , pp. 1339-1346
    • Ohshima, K.1    Karube, K.2    Shimazaki, K.3
  • 144
    • 0041966056 scopus 로고    scopus 로고
    • Reversal of human cellular senescence: Roles of the
    • Beausejour, C. M., Krtolica, A., Galimi, F. et al. (2003). Reversal of human cellular senescence: roles of the p53 and p16 pathways. Embo. J., 22, 4212–22.
    • (2003) Embo. J , vol.22 , pp. 4212-4222
    • Beausejour, C.M.1    Krtolica, A.2    Galimi, F.3
  • 145
    • 0142153982 scopus 로고    scopus 로고
    • Profiling aberrantdnamethylation in hematologic neoplasms: A view from the tip of the iceberg
    • Esteller, M. (2003). Profiling aberrantDNAmethylation in hematologic neoplasms: a view from the tip of the iceberg. Clin. Immunol., 109, 80–8.
    • (2003) Clin. Immunol , vol.109 , pp. 80-88
    • Esteller, M.1
  • 146
    • 0032523011 scopus 로고    scopus 로고
    • Methylationof the
    • Quesnel, B., Guillerm, G., Vereecque, R. et al. (1998).Methylationof the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood, 91, 2985–90.
    • (1998) Blood , vol.91 , pp. 2985-2990
    • Vereecque, R.1
  • 147
    • 0142261186 scopus 로고    scopus 로고
    • Gene silencing of the
    • Lubbert, M. (2003). Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes? Leukemia, 17, 1762–4.
    • (2003) Leukemia , vol.17 , pp. 1762-1764
    • Lubbert, M.1
  • 148
    • 0141502199 scopus 로고    scopus 로고
    • Methylation of
    • Christiansen, D. H., Andersen, M., and Pedersen-Bjergaard, J. (2003).Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia. Leukemia, 17, 1813–19.
    • (2003) Leukemia , vol.17 , pp. 1813-1819
    • Christiansen, D.H.1    Ersen, M.2    Pedersen-Bjergaard, J.3
  • 149
    • 0242624636 scopus 로고    scopus 로고
    • Epigenetic targets in hematopoietic malignancies
    • Claus, R. and Lubbert, M. (2003). Epigenetic targets in hematopoietic malignancies. Oncogene, 22, 6489–96.
    • (2003) Oncogene , vol.22 , pp. 6489-6496
    • Claus, R.1    Lubbert, M.2
  • 150
    • 0037108309 scopus 로고    scopus 로고
    • Demethylation of a hypermethylated
    • Daskalakis, M., Nguyen, T., Nguyen, C. et al. (2002). Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2’- deoxycytidine (decitabine) treatment. Blood, 100, 2957–64.
    • (2002) Blood , vol.100 , pp. 2957-2964
    • Daskalakis, M.1    Nguyen, T.2    Nguyen, C.3
  • 151
    • 1842862749 scopus 로고    scopus 로고
    • The relationship of patient age to the pathobiology of the clonal myeloid diseases
    • Lichtman, M. A. and Rowe, J. (2004). The relationship of patient age to the pathobiology of the clonal myeloid diseases. Semin. Oncol., 31, 185–97.
    • (2004) Semin. Oncol , vol.31 , pp. 185-197
    • Lichtman, M.A.1    Rowe, J.2
  • 152
    • 0041968702 scopus 로고    scopus 로고
    • Integrating epithelial cancer, aging stroma and cellular senescence
    • Krtolica, A. and Campisi, J. (2003). Integrating epithelial cancer, aging stroma and cellular senescence. Adv. Gerontol., 11, 109–16.
    • (2003) Adv. Gerontol , vol.11 , pp. 109-116
    • Krtolica, A.1    Campisi, J.2
  • 153
  • 154
    • 0037238101 scopus 로고    scopus 로고
    • Cellular senescence and apoptosis: How cellular responses might influence aging phenotypes
    • Campisi, J. (2003). Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. l. Exp. Gerontol., 38, 5–11.
    • (2003) Exp. Gerontol , vol.38 , pp. 5-11
    • Campisi, J.1
  • 155
    • 0036829090 scopus 로고    scopus 로고
    • Cancer and aging: A model for the cancer promoting effects of the aging stroma
    • Krtolica, A. and Campisi, J. (2002). Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int. J. Biochem. Cell Biol., 34, 1401–14.
    • (2002) Int. J. Biochem. Cell Biol , vol.34 , pp. 1401-1414
    • Krtolica, A.1    Campisi, J.2
  • 156
    • 2942570699 scopus 로고    scopus 로고
    • A., rubio, m., dolle, m.E., campisi, j., andvijg, j
    • Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture
    • Busuttil, R. A., Rubio, M., Dolle, M.E., Campisi, J., andVijg, J. (2003). Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell, 2, 287–94.
    • (2003) Murine cells in culture , vol.2 , pp. 287-294
    • Busuttil, R.1
  • 157
    • 0842333177 scopus 로고    scopus 로고
    • Increased risk for aplastic anemia andmyelodysplastic syndrome in individuals lacking glutathione s-transferase genes
    • Sutton, J. F., Stacey, M., Kearns, W. G. et al. (2004). Increased risk for aplastic anemia andmyelodysplastic syndrome in individuals lacking glutathione S-transferase genes. Pediatr. Blood Cancer, 42, 122–6.
    • (2004) Pediatr. Blood Cancer , vol.42 , pp. 122-126
    • Sutton, J.F.1    Stacey, M.2
  • 158
    • 0035949708 scopus 로고    scopus 로고
    • Polymorphism in glutathione stransferase p1 is associated with susceptibility to chemotherapy-induced leukemia
    • Allan, J. M., Wild, C., Rollinson, S. et al. (2001). Polymorphism in glutathione Stransferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc. Natl Acad. Sci. U.S.A., 98, 11592–7.
    • (2001) Proc. Natl Acad. Sci. U.S.A , vol.98 , pp. 11592-11597
    • Allan, J.M.1    Wild, C.2    Rollinson, S.3
  • 159
    • 0036321541 scopus 로고    scopus 로고
    • Metabolic enzyme polymorphisms and susceptibility to acute leukemia in adults
    • Morgan, G. J. and Smith, M. (2002). Metabolic enzyme polymorphisms and susceptibility to acute leukemia in adults. Am. J. Pharmacogenomics, 2, 79–92.
    • (2002) Am. J. Pharmacogenomics , vol.2 , pp. 79-92
    • Morgan, G.J.1    Smith, M.2


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