-
1
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
HARMAN, D. 1956. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11: 298-300.
-
(1956)
J. Gerontol.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
2
-
-
0020346520
-
Active oxygen metabolites and their action in the hepatocyte: Studies on chemiluminescence responses and alkane production
-
CADENAS, E. et al. 1982. Active oxygen metabolites and their action in the hepatocyte: studies on chemiluminescence responses and alkane production. Agents Actions Suppl. 11: 203-216.
-
(1982)
Agents Actions Suppl.
, vol.11
, pp. 203-216
-
-
Cadenas, E.1
-
3
-
-
0000572335
-
The aging process and cancerogenesis
-
FAILLA, G. 1958. The aging process and cancerogenesis. Ann. N.Y. Acad. Sci. 71: 1124-1140.
-
(1958)
Ann. N.Y. Acad. Sci.
, vol.71
, pp. 1124-1140
-
-
Failla, G.1
-
4
-
-
0002235236
-
On the nature of the aging process
-
SZILARD, L. 1959. On the nature of the aging process. Proc. Natl. Acad. Sci. USA 45: 30-45.
-
(1959)
Proc. Natl. Acad. Sci. USA
, vol.45
, pp. 30-45
-
-
Szilard, L.1
-
5
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
HAYFLICK, L. & P.S. MOORHEAD. 1961. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25: 585-621.
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
6
-
-
0038049143
-
Cancer and ageing: Rival demons?
-
CAMPISI, J. 2003. Cancer and ageing: rival demons? Nat. Rev. Cancer 3: 339-349.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 339-349
-
-
Campisi, J.1
-
7
-
-
0142075332
-
Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells
-
KASHINO, G. et al. 2003. Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells. Free Radical Biol. Med. 35: 438-443.
-
(2003)
Free Radical Biol. Med.
, vol.35
, pp. 438-443
-
-
Kashino, G.1
-
8
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative life span of murine fibroblasts
-
PARRINELLO, S. et al. 2003. Oxygen sensitivity severely limits the replicative life span of murine fibroblasts. Nat. Cell. Biol. 5: 741-747.
-
(2003)
Nat. Cell. Biol.
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
-
9
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
-
VON ZGLINICKI, T. et al. 1995. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp. Cell Res. 220: 186-193.
-
(1995)
Exp. Cell Res.
, vol.220
, pp. 186-193
-
-
Von Zglinicki, T.1
-
10
-
-
0029051426
-
Oxidative DNA damage and senescence of human diploid fibroblast cells
-
CHEN, Q. et al. 1995. Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc. Natl. Acad. Sci. USA 92: 4337-4341.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4337-4341
-
-
Chen, Q.1
-
11
-
-
0021223916
-
Oxygen modulates growth of human cells at physiologic partial pressures
-
BALIN, A.K., A.J. FISHER & D.M. CARTER. 1984. Oxygen modulates growth of human cells at physiologic partial pressures. J. Exp. Med. 160: 152-166.
-
(1984)
J. Exp. Med.
, vol.160
, pp. 152-166
-
-
Balin, A.K.1
Fisher, A.J.2
Carter, D.M.3
-
12
-
-
0028915601
-
The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives
-
SAITO, H., A.T. HAMMOND & R.E. MOSES. 1995. The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives. Exp. Cell Res. 217: 272-279.
-
(1995)
Exp. Cell Res.
, vol.217
, pp. 272-279
-
-
Saito, H.1
Hammond, A.T.2
Moses, R.E.3
-
13
-
-
0017405185
-
Low oxygen concentration extends the life span of cultured human diploid cells
-
PACKER, L. & K. FUEHR. 1977. Low oxygen concentration extends the life span of cultured human diploid cells. Nature 267: 423-425.
-
(1977)
Nature
, vol.267
, pp. 423-425
-
-
Packer, L.1
Fuehr, K.2
-
14
-
-
0025973702
-
Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage
-
SHIGENAGA, M.K. & B.N. AMES. 1991. Assays for 8-hydroxy-2′- deoxyguanosine: a biomarker of in vivo oxidative DNA damage. Free Radical Biol. Med. 10: 211-216.
-
(1991)
Free Radical Biol. Med.
, vol.10
, pp. 211-216
-
-
Shigenaga, M.K.1
Ames, B.N.2
-
15
-
-
0000870509
-
Chromosome aberrations in liver cells in relation to the somatic theory of aging
-
CURTIS, H. & C. CROWLEY. 1963. Chromosome aberrations in liver cells in relation to the somatic theory of aging. Radiat. Res. 19: 337-344.
-
(1963)
Radiat. Res.
, vol.19
, pp. 337-344
-
-
Curtis, H.1
Crowley, C.2
-
16
-
-
0030028185
-
Somatic mutations are frequent and increase with age in human kidney epithelial cells
-
MARTIN, G.M. et al. 1996. Somatic mutations are frequent and increase with age in human kidney epithelial cells. Hum. Mol. Genet. 5: 215-221.
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 215-221
-
-
Martin, G.M.1
-
17
-
-
0036154895
-
Aging alters the apoptotic response to genotoxic stress
-
SUH, Y. et al. 2002. Aging alters the apoptotic response to genotoxic stress. Nat. Med. 8: 3-4.
-
(2002)
Nat. Med.
, vol.8
, pp. 3-4
-
-
Suh, Y.1
-
18
-
-
0029166930
-
The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting
-
RAMSEY, M.J. et al. 1995. The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat. Res. 338: 95-106.
-
(1995)
Mutat. Res.
, vol.338
, pp. 95-106
-
-
Ramsey, M.J.1
-
19
-
-
0032999752
-
Frequency of spontaneous chromosome aberrations in mice: Effects of age
-
TUCKER, J.D. et al. 1999. Frequency of spontaneous chromosome aberrations in mice: effects of age. Mutat. Res. 425: 135-141.
-
(1999)
Mutat. Res.
, vol.425
, pp. 135-141
-
-
Tucker, J.D.1
-
20
-
-
0029144265
-
Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans
-
JONES, I.M. et al. 1995. Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans. Mutat. Res. 338: 129-139.
-
(1995)
Mutat. Res.
, vol.338
, pp. 129-139
-
-
Jones, I.M.1
-
21
-
-
0027400411
-
Effect of dietary restriction on in vivo somatic mutation in mice
-
DEMPSEY, J.L., M. PFEIFFER & A.A. MORLEY. 1993. Effect of dietary restriction on in vivo somatic mutation in mice. Mutat. Res. 291: 141-145.
-
(1993)
Mutat. Res.
, vol.291
, pp. 141-145
-
-
Dempsey, J.L.1
Pfeiffer, M.2
Morley, A.A.3
-
22
-
-
0011555560
-
Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species
-
HART, R.W. & R.B. SETLOW. 1974. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc. Natl. Acad. Sci. USA 71: 2169-2173.
-
(1974)
Proc. Natl. Acad. Sci. USA
, vol.71
, pp. 2169-2173
-
-
Hart, R.W.1
Setlow, R.B.2
-
23
-
-
0032085368
-
Accelerated accumulation of somatic mutations in the senescence- accelerated mouse
-
ODAGIRI, Y. et al. 1998. Accelerated accumulation of somatic mutations in the senescence-accelerated mouse. Nat. Genet. 19: 116-117.
-
(1998)
Nat. Genet.
, vol.19
, pp. 116-117
-
-
Odagiri, Y.1
-
24
-
-
0028856635
-
Plasmid-based transgenic mouse model for studying in vivo mutations
-
BOERRIGTER, M.E. et al. 1995. Plasmid-based transgenic mouse model for studying in vivo mutations. Nature 377: 657-659.
-
(1995)
Nature
, vol.377
, pp. 657-659
-
-
Boerrigter, M.E.1
-
25
-
-
0024374202
-
Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo
-
GOSSEN, J.A. et al. 1989. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA 86: 7971-7975.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 7971-7975
-
-
Gossen, J.A.1
-
26
-
-
0031592241
-
Transgenic mouse models for studying mutations in vivo: Applications in aging research
-
VIJG, J. et al. 1997. Transgenic mouse models for studying mutations in vivo: applications in aging research. Mech. Ageing Dev. 99: 257-271.
-
(1997)
Mech. Ageing Dev.
, vol.99
, pp. 257-271
-
-
Vijg, J.1
-
27
-
-
0030699271
-
Rapid accumulation of genome rearrangements in liver, but not in brain of old mice
-
DOLLÉ, M.E. et al. 1997. Rapid accumulation of genome rearrangements in liver, but not in brain of old mice. Nat. Genet. 17: 431-434.
-
(1997)
Nat. Genet.
, vol.17
, pp. 431-434
-
-
Dollé, M.E.1
-
28
-
-
0034682523
-
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine
-
DOLLÉ, M.E. et al. 2000. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc. Natl. Acad. Sci. USA 97: 8403-8408.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8403-8408
-
-
Dollé, M.E.1
-
29
-
-
0034646079
-
Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse
-
ONO, T. et al. 2000. Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse. Mutat. Res. 447: 165-177.
-
(2000)
Mutat. Res.
, vol.447
, pp. 165-177
-
-
Ono, T.1
-
30
-
-
0030033714
-
Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations
-
DOLLÉ, M.E. et al. 1996. Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations. Mutagenesis 11: 111-118.
-
(1996)
Mutagenesis
, vol.11
, pp. 111-118
-
-
Dollé, M.E.1
-
31
-
-
0037198009
-
Large genome rearrangements as a primary cause of aging
-
VIJG, J. & M.E. DOLLÉ. 2002. Large genome rearrangements as a primary cause of aging. Mech. Ageing Dev. 123: 907-915.
-
(2002)
Mech. Ageing Dev.
, vol.123
, pp. 907-915
-
-
Vijg, J.1
Dollé, M.E.2
-
32
-
-
0036851242
-
Genome dynamics in aging mice
-
DOLLÉ, M.E. & J. VIJG. 2002. Genome dynamics in aging mice. Genome Res. 12: 1732-1738.
-
(2002)
Genome Res.
, vol.12
, pp. 1732-1738
-
-
Dollé, M.E.1
Vijg, J.2
-
33
-
-
2942570699
-
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture
-
BUSUTTIL, R.A. et al. 2003. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell 2: 287-294.
-
(2003)
Aging Cell
, vol.2
, pp. 287-294
-
-
Busuttil, R.A.1
-
34
-
-
0028577685
-
Mutagenicity of metabolic oxygen radicals in mammalian cell cultures
-
GILLE, J.J., C.G. VAN BERKEL & H. JOENJE. 1994. Mutagenicity of metabolic oxygen radicals in mammalian cell cultures. Carcinogenesis 15: 2695-2699.
-
(1994)
Carcinogenesis
, vol.15
, pp. 2695-2699
-
-
Gille, J.J.1
Van Berkel, C.G.2
Joenje, H.3
-
35
-
-
0024408986
-
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
-
VAUPEL, P., F. KALLINOWSKI & P. OKUNIEFF. 1989. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 49: 6449-6465.
-
(1989)
Cancer Res.
, vol.49
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
36
-
-
0037115963
-
Oxidative nucleotide damage: Consequences and prevention
-
SEKIGUCHI, M. & T. TSUZUKI. 2002. Oxidative nucleotide damage: consequences and prevention. Oncogene 21: 8895-8904.
-
(2002)
Oncogene
, vol.21
, pp. 8895-8904
-
-
Sekiguchi, M.1
Tsuzuki, T.2
-
37
-
-
0031239958
-
DNA repair: Caretakers of the genome?
-
CUNNINGHAM, R.P. 1997. DNA repair: caretakers of the genome? Curr. Biol. 7: R576-R579.
-
(1997)
Curr. Biol.
, vol.7
-
-
Cunningham, R.P.1
|