Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes

Clinical Cancer Research

Volumn 5, Issue 5, 1999, Pages 1155-1160

  Ohyashiki, Junko H ^a,c   Iwama, Hiroshi ^a   Yahata, Naoyuki ^a   Ando, Keiko ^a   Hayashi, Shigefumi ^a   Shay, Jerry W ^b   Ohyashiki, Kazuma ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; CYTOGENETICS; ENZYME ACTIVITY; FEMALE; GENOME; HIGH RISK PATIENT; HUMAN; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; MYELODYSPLASTIC SYNDROME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; TELOMERE;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKEMIA, MYELOID; LIFE TABLES; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PRECANCEROUS CONDITIONS; PROGNOSIS; RISK FACTORS; SURVIVAL ANALYSIS; TELOMERASE; TELOMERE;

EID: 0032902504     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Bennett, J. M., Catovsky, D., Daniel, M. T., Flandrin. G., Galton, D. A. G., Gralnick, H. R., and Sultan, C. Proposals for the classification of the myelodysplastic syndromes. Br. J. Haematol., 51: 189-199, 1982.
2. Mufti, G. J., Stevens, J. R., Oscier, D. G., Hamblin, T. J., and Machin, D. Myelodysplastic syndromes: a scoring system with prognostic significance. Br. J. Haematol., 59: 425-433, 1985.
3. Toyama, K., Ohyashiki, K., Yoshida, Y., Abe, T., Asano, S., Hirai, H., Hirashima, K., Hotta, T., Kuramoto, A., Kuriya, S., Miyazaki, T., Kakishita, E., Mizoguchi, H., Okada, M., Shirakawa, S., Takaku, F., Tomonaga, M., Uchino, H., Yasunaga, K., and Nomura, T. Clinical implications of chromosomal abnormalities in 401 patients with myelodysplastic syndromes: a multicentric study in Japan. Leukemia (Baltimore), 7: 499-508, 1993.
4. Greenberg, P., Cox, C., Le Beau, M. M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., Ohyashiki, K., Toyama, K., Aul, C., Mufti, G., and Bennett, J. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood, 89: 2079-2088, 1997.
5. n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA, 85: 6622-6626, 1988.
6. Iwama, H., Ohyashiki, K., Ohyashiki, J. H., Hayashi, S., Yahata, N., Ando, K., Toyama, K., Hoshika, A., Takasaki, M., Mori, M., and Shay, J. W. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum. Genet., 102: 397-402, 1998.
7. Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., and Harley, C. B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA, 89: 10114-10118, 1992.
8. de Lange, T. Telomere dynamics and genome instability in human cancer. In: E. H. Blackburn and C. W. Greider (eds.), Telomeres, pp. 265-293. Plainview, NY: Cold Spring Harbor Laboratory Press, 1995.
9. Greider, C. W., and Blackburn, E. H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 43: 405-413, 1985.
10. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 266: 2011-2015, 1994.
11. Shay, J. W., and Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer, 33: 787-791, 1997.
12. Hiyama, K., Hirai, Y., Koizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., and Yamakido, M. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol., 155: 3711-3715, 1995.
13. Engelhardt, M., Kumar, R., Albanell, J., Pettengell, R., Han, W., and Moore, M. A. S. Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood, 90: 182-193, 1997.
14. Notaro, R., Cimmino, A., Tabarini, D., Rotoli, B., and Luzzatto, L. In vitro telomere dynamics of human hematopoietic stem cells. Proc. Natl. Acad. Sci. USA, 94: 13782-13785, 1997.
15. Curtis, R. E., Rowlings, P. A., Deeg, H. J., Shriner, D. A., Socie, G., Travis, L. B., Horowitz, M. M., Witherspoon, R. P., Hoover, R. N., Sobocinski, K. A., Fraueni, J. F., Jr., and Boice, J. D., Jr. Solid cancers after bone marrow transplantation. N. Engl. J. Med., 336: 897-904, 1997.
16. Wynn, R. F., Cross, M. A., Hatton, C., Will, A. M., Lashford, L. S., Dexter, T. M., and Testa, N. G. Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants. Lancet, 351: 178-181, 1998.
17. Shay, J. W. Accelerated telomere shortening in bone-marrow recipients. Lancet. 351: 153-154, 1998.
18. Akiyama, M., Hoshi, Y., Sakurai, S., Yamada, H., Yamada, O., and Mizoguchi, H. Changes of telomere length in children after hematopoietic stem cell transplantation. Bone Marrow Transplant., 21: 167-171, 1998.
19. Ohyashiki, J. H., Ohyashiki, K., Fujimura, T., Kawakubo, K., Shimamoto, T., Iwabuchi, A., and Toyama, K. Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes. Cancer Res., 54: 3557-3560, 1994.
20. Piatyszek, M. A., Kim, N. W., Weinrich, S. L., Hiyama, K., Hiyama, E., Wright, W. E., and Shay, J. W. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Methods Cell Sci., 17: 1-15, 1995.
21. Ohyashiki, J. H., Ohyashiki, K., Toyama, K., and Shay, J. W. A nonradioactive fluorescence-based telomeric repeat amplification protocol to detect and quantitate telomerase activity. Trends Genet., 12: 395-396, 1996.
22. Ohyashiki, J. H., Ohyashiki, K., Iwama, H., Hayashi, S., Toyama, K., and Shay, J. W. Clinical implications of telomerase activity levels in acute leukemia. Clin. Cancer Res., 3: 619-625, 1997.
23. Tahara, H., Kuniyasu, H., Yokazaki, H., Yasui, W., Shay, J. W., Ide, T., and Tahara, E. Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions. Clin. Cancer Res., 1: 1245-1251, 1995.
24. Ohyashiki, K., Ohyashiki, J. H., Nishimaki, J., Toyama, K., Ebihara, Y., Kato, H., Wright, W. E., and Shay, J. W. Cytological detection of telomerase activity using an in situ telomeric repeat amplification protocol assay. Cancer Res., 57: 2100-2103, 1997.
25. Bouscary, D., De Vos, J., Guesnu, M., Jondeau, K., Viguier, F., Melle, J., Picard, F., Dreyfus, F., and Fontenay-Roupie, M. Fas/Apo-1(CD95) expression and apoptosis in patients with myelodysplastic syndromes. Leukemia (Baltimore), 11: 839-845, 1997.
26. Raza, A., Gezer, S., Mundle, S., Gao, X. Z., Alvi, S., Borok, R., Rifkin, S., Iftikhar, A., Shetty, V., Parcharidou, A., Loew, J., Marcus, B., Kahn, Z., Chaney, C., Showel, J., Gregory, S., and Preisler, H. Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood, 86: 268-276, 1995.
27. Boultwood, J., Fidler, C., Kusec, R., Rack, K., Elliott, P. J. W., Atoyebi, O., Chapman, R., Oscier, D. G., and Wainscoat, J. S. Telomere length in myelodysplastic syndromes. Am. J. Hematol., 56: 266-271, 1997.
28. Ohyashiki, J. H., Ohyashiki, K., Aizawa, S., Kawakubo, K., Shimamoto, T., Iwama, H., Hayashi, S., and Toyama, K. Replication errors in hematological neoplasias: genomic instability in progression of disease is different among different types of leukemia. Clin. Cancer Res., 2: 1583-1589, 1996.
29. Ishikawa, F. Telomere crisis, the driving force in cancer cell evolution. Biochem. Biophys. Res. Commun., 230: 1-6, 1997.
30. Iwama, H., Ohyashiki, K., Ohyashiki, J. H., Hayashi, S., Kawakubo, K., Shay, J. W., and Toyama, K. The relationship between telomere length and therapy-associated cytogenetic responses in patients with chronic myeloid leukemia. Cancer (Phila.), 79: 1552-1560, 1997.