Sequential activation of caspase-1 and caspase-3-like proteases during apoptosis in myelodysplastic syndromes

Journal of Hematotherapy and Stem Cell Research

Volumn 8, Issue 4, 1999, Pages 343-356

  Ali, Ambereen ^a   Mundle, Suneel D ^a   Ragasa, Deborah ^a   Reza, Samina ^a   Shetty, Vilasini ^a   Mativi, B Yifwayimare ^a   Cartlidge, Jonathan D ^a   Azharuddin, Mohammed ^a   Qawi, Huma ^a   Dar, Saleem ^a   Raza, Azra ^a  

^a RUSH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEINASE;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SEPARATION; CYTOPENIA; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASE 1; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; HUMANS; MYELODYSPLASTIC SYNDROMES;

EID: 0032744065     PISSN: 15258165     EISSN: None     Source Type: Journal    
DOI: 10.1089/152581699320108     Document Type: Article

References (65)

1. Nicholson DW. (1996). ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nature Biotech 14:297.
2. Thompson CB. (1995). Apoptosis in the pathogenesis and treatment of disease. Science 267:1456.
3. Raza A, S Gregory and HD Preisler. (1996). The myelodysplastic syndromes in 1996: complex stem cell disorders confounded by dual actions of cytokines. Leuk Res 20:881.
4. Raza A, S Gezer, S Mundle, et al. (1995). Apoptosis in the bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood 86:268.
5. Clark DM and IA Lambert. (1990). Apoptosis is a common histopathological finding in myelodysplasia: the correlate of ineffective haematopoiesis. Leuk Lymphoma 2:415.
6. Yoshida Y. (1993). Hypothesis. Apoptosis may be the mechanism responsible for the premature intramedullary cell death in the myelodysplastic syndrome. Leukemia 7:144.
7. Raza A, S Mundle, A Iftikar, et al. (1995). Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies on myelodysplastics reveals extensive apoptosis as the probable basis for the ineffective hematopoiesis. Am J Hematol 48:143.
8. Bogdanovic AD, GM Jankovic and MD Colovic. (1996). Apoptosis in bone marrow of myelodysplastic syndrome patients. Blood 87:3064.
9. Lepelley P, L Campergue, N Grardel, et al. (1996). Is apoptosis a massive process in myelodysplastic syndromes? Br J Haematol 95:368.
10. Hellstrom-Lindberg E, L Kanter-Lewensohn and A Ost. (1997). Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocytes-csf and erythropoietin. Leuk Res 21:415.
11. Cortelezzi A, M Di Stefano, B Sarina, et al. (1996). Apoptosis in myelodysplastic syndromes (MDS): putative role of the Bcl-2 protooncogene. Blood 88 (Suppl 1) (Part 1 of 2):95a (abstract).
12. Kliche KO and M Andreeff. (1996). Hyperapoptosis as pathophysiologic basis of myelodysplastic syndromes (MDS). Blood 88 (Suppl 1) (Part 1 of 2):639a (abstract).
13. Raza A, S Gezer, S Gregory, et al. (1996). Anti-cytokine therapy produces responses in patients with myelodysplastic syndromes (MDS). Blood 88 (Suppl 1) (Part 1 of 2):580a (abstract).
14. Raza A, S Mundle, V Shetty, et al. (1996). A paradigm shift in myelodysplastic syndromes. Leukemia 10:1648.
15. Shetty V, S Mundle, S Alvi, et al. (1996). Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes. Leuk Res 20:891.
16. Raza A, S Mundle, V Shetty, et al. (1996). Novel sights into the biology of myelodysplastic syndromes: excessive apoptosis and the role of cytokines. Int J Hematol 63:265.
17. Gersek M, B Cassandra, MR Loken, et al. (1998). A role for tumour necrosis factor-α, Fas and Fas-ligand in marrow failure associated with myelodysplastic syndrome. Br J Haematol 103:176.
18. Mundle SD, A Ali, JD Cartlidge, et al. (1998). Evidence for the involvement of tumor necrosis factor-α in apoptotic death of bone marrow cells in myelodysplastic syndromes. Am J Hematol 60:36.
19. Kaufmann SH. (1996). Proteolytic cleavage during chemotherapy induced apoptosis. Mol Med Today 2:298.
20. Earnshaw WC. (1995). Nuclear changes in apoptosis. Curr Opin Cell Biol 7:337.
21. Martin SJ and DR Green. (1995). Protease activation during apoptosis: death by a thousand cuts? Cell 82:349.
22. Nicholson DW, A Ali, NA Thornberry, et al. (1995). Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37.
23. Sleath PR, RC Hendrickson, SR Kronheim, et al. (1990). Substrate specificity of the protease that processes human interleukin 1 beta. J Biol Chem 265:14526.
24. Howard AD, MJ Kostura, N Thornberry, et al. (1991). IL-1 converting-enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha. J Immunol 147:2964.
25. Takahashi A, ES Alnemri, YA Lazebnik, et al. (1996). Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci USA 93:8395.
26. Fernandes-Alnemri T, G Litwack and ES Alnemri. (1995). Mch2, a new member of the apoptotic Ced-3/ICE cysteine protease gene family. Cancer Res 55:2737.
27. Fraser A and GA Evan. (1996). Licence to kill. Cell 85:781.
28. Thornberry NA, HG Bull, JR Calaycay, et al. (1992). A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:768.
29. Nagata S. (1997). Apoptosis by death factor. Cell 88:355.
30. Alnemri ES, DJ Livingston, DW Nicholson, et al. (1996). Human ICE/CED-3 protease nomenclature. Cell 87:171.
31. Enari M, RV Talanian, WW Wong, et al. (1996). Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380:723.
32. Greidinger EL, DK Miller, T Yamin, et al. (1996). Sequential activation of three distinct ICE-like activities in Fas-ligand Jurkat cells. FEBS Lett 390:299.
33. Rodriguez I, K Matsura, C Ody, et al. (1996). Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against fas-mediated fulminant liver destruction and death. J Exp Med 184:2067.
34. Susin SA, N Zamzami, M Castedo, et al. (1997). The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO/CD95- and ceremide-induced apoptosis. J Exp Med 186:25.
35. Casciola-Rosen L, DW Nicholson, T Chang et al. (1996). Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med 183:1957.
36. Rosen A and L Casciola-Rosen. (1997). Macromolecular substrates for the ICE-like proteases during apoptosis. J Cell Biochem 64:50.
37. Liu X, H Zou, C Slaughter, et al. (1997). DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175.
38. Mundle SD, P Venugopal, JD Cartlidge, et al. (1996). Indication of an involvement of interleukin-1β converting enzyme-like protease in intermedullary apoptotic cell death in the bone marrow of patients with myelodysplastic syndromes. Blood 88:2640.
39. Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72:248.
40. Wang X, NG Zelenski, J Yang, et al. (1996). Cleavage of sterol regulatory element binding, proteins (SREBPs) by CPP32 during apoptosis. EMBO J 15:1012.
41. Cain K, SH Inayat-Hussain, C Couet, et al. (1996). A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes. Biochem J 314:27.
42. Fearnhead HO, D Dinsdale and GM Cohen. (1995). An interleukin-1β-converting enzyme-like protease is a common mediator of apoptosis in thymocytes. FEBS Lett 375:283.
43. Slee EA, H Zhu, SC Chow, et al. (1996). Benzyloxycarbonyl-Val-Ala-Asp (Ome) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J 315:21.
44. Irvine AE, K Magill, LE Somerville, et al. (1998). Spontaneous intermedullary apoptosis is present in disorders other than myelodysplasia. Exp Hematol 26:435.
45. Parcharidou A, A Raza, T Economopoulos, et al. (1999). Extensive apoptosis of bone marrow cells as evaluated by the in situ end-labelling (ISEL) technique may be the basis for ineffective haematopoiesis in patients with myelodysplastic syndromes. Eur J Haematol 62:19.
46. Zou H, WJ Henzel, X Liu, et al. (1995). Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90:405.
47. Li P, D Nijhawan, I Budihardjo, et al. (1997). Cytochrome c and dATP-dependent formation of apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479.
48. Krajewski S, RD Gascoyne, JM Zapata, et al. (1997). Immunolocalization of the ICE/Ced-3-family protease, CPP32 (caspase-3), in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes. Blood 89:3817.
49. Krajewska M, H-G Wang, S Krajewski, et al. (1997). Immunohistochemical analysis of in vivo patterns of expression of CPP32 (caspase-3), a cell death protease. Cancer Res 57:1605.
50. Singer II, S Scott, J Chin, et al. (1995). The interleukin-1β-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immunoelectron microscopy. J Exp Med 182:1447.
51. Chandler JM, GM Cohen and M MacFarlane. (1998). Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. J Biol Chem 273:10815.
52. Mao P-L, Y Jiang, BY Wee, et al. (1998). Activation of caspase-1 in the nucleus requires nuclear translocation of pro-caspase-1 mediated by its prodomain. J Biol Chem 273:23621.
53. Mativi BY, S Mundle, A Ali, et al. (1997). Fas/Fas-L system could be one of the mediators of excessive apoptosis in myelodysplastic syndromes (MDS). Blood 90 (Suppl 1) (Part 1 of 2):202a (abstract).
54. Hellstrom-Lindberg E, AM Farsblom, Z Syuckova, et al. (1997). Effects of G-CSF, EPO, SCF, ATRA and the CD 95 blocking antibody f(ab′)2 on in vitro apoptosis and proliferation in myelodysplastic (MDS) bone marrow. Blood 90 (Suppl 1) (Part 1 of 2):521a (abstract).
55. Macfarlane M, K Cain, X-M Sun, et al. (1997). Processing/activation of at least four interleukin-1β converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells. J Cell Biol 137:469.
56. Boldin MP, TM Goncharov, YV Goltsev, et al. (1996). Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/Apo-1- and TNF receptor-induced cell death. Cell 85:803.
57. Fernandez-Alnemri T, RC Armstrong, J Krebs, et al. (1996). In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA 93:7464.
58. Muzio M, AM Chinnaiyan, FC Kischkel, et al. (1996). FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817.
59. Drexler HCA. (1997). Activation of the cell death program by inhibition of proteosome function. Proc Natl Acad USA 94:855.
60. Deas O, C Dumont, M MacFarlane, et al. (1998). Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes. J Immunol 161:3375.
61. Wallach D. (1997). Placing death under control. Nature 388:123.
62. Tewari M and VM Dixit. (1995). Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 270:3255.
63. Ellis HM and HR Horvitz. (1986). Genetic control of programmed cell death in the nematode C. elegans. Cell 44:817.
64. Li P, H Allen, S Banerjee, et al. (1995). Mice deficient in IL-1β-converting enzyme are defective in the production of mature IL-1β and resistant to endotoxic shock. Cell 80:401.
65. Kuida K, TS Zheng, SQ Na, et al. (1996). Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368.