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Volumn 194, Issue 9, 2015, Pages 4362-4370

Regulatory T cells require TCR signaling for their suppressive function

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CT10 PROTEIN; DIACYLGLYCEROL; DIACYLGLYCEROL KINASE; INTEGRIN; PHOSPHOLIPASE C GAMMA; PROTEIN SH2; REGULATOR PROTEIN; SLP 76 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SLP-76 SIGNAL TRANSDUCING ADAPTOR PROTEINS;

EID: 84928498802     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402384     Document Type: Article
Times cited : (48)

References (57)
  • 2
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim, J. M., J. P. Rasmussen, and A. Y. Rudensky. 2007. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8: 191-197.
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 4
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 5
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid, Y., and B. T. Rouse. 2005. Natural regulatory T cells in infectious disease. Nat. Immunol. 6: 353-360.
    • (2005) Nat. Immunol. , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 7
    • 84859316999 scopus 로고    scopus 로고
    • Foxp3(+) regulatory T cells, immune stimulation and host defence against infection
    • Rowe, J. H., J. M. Ertelt, and S. S. Way. 2012. Foxp3(+) regulatory T cells, immune stimulation and host defence against infection. Immunology 136: 1-10.
    • (2012) Immunology , vol.136 , pp. 1-10
    • Rowe, J.H.1    Ertelt, J.M.2    Way, S.S.3
  • 9
    • 0034093737 scopus 로고    scopus 로고
    • Signal transduction by the TCR for antigen
    • Kane, L. P., J. Lin, and A. Weiss. 2000. Signal transduction by the TCR for antigen. Curr. Opin. Immunol. 12: 242-249.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 242-249
    • Kane, L.P.1    Lin, J.2    Weiss, A.3
  • 12
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
    • (2002) Nat. Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 14
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • Knoechel, B., J. Lohr, E. Kahn, J. A. Bluestone, and A. K. Abbas. 2005. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202: 1375-1386.
    • (2005) J. Exp. Med. , vol.202 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 15
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran, A. E., K. L. Holzapfel, Y. Xing, N. R. Cunningham, J. S. Maltzman, J. Punt, and K. A. Hogquist. 2011. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208: 1279-1289.
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 16
    • 0043244867 scopus 로고    scopus 로고
    • Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo
    • Walker, L. S., A. Chodos, M. Eggena, H. Dooms, and A. K. Abbas. 2003. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J. Exp. Med. 198: 249-258.
    • (2003) J. Exp. Med. , vol.198 , pp. 249-258
    • Walker, L.S.1    Chodos, A.2    Eggena, M.3    Dooms, H.4    Abbas, A.K.5
  • 17
    • 68949105350 scopus 로고    scopus 로고
    • Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking
    • Available at
    • Kim, J. K., M. Klinger, J. Benjamin, Y. Xiao, D. J. Erle, D. R. Littman, and N. Killeen. 2009. Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS ONE 4: e6580. Available at: http://www.plosone.org/article/comments/info%3Adoi%2F10.1371%2Fjournal.pone.0006580.
    • (2009) PLoS ONE , vol.4 , pp. e6580
    • Kim, J.K.1    Klinger, M.2    Benjamin, J.3    Xiao, Y.4    Erle, D.J.5    Littman, D.R.6    Killeen, N.7
  • 18
    • 70349566221 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells do not require stimulation through their TCR to suppress
    • Szymczak-Workman, A. L., C. J. Workman, and D. A. Vignali. 2009. Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress. J. Immunol. 182: 5188-5192.
    • (2009) J. Immunol. , vol.182 , pp. 5188-5192
    • Szymczak-Workman, A.L.1    Workman, C.J.2    Vignali, D.A.3
  • 19
    • 33646578505 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression
    • Oderup, C., L. Cederbom, A. Makowska, C. M. Cilio, and F. Ivars. 2006. Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression. Immunology 118: 240-249.
    • (2006) Immunology , vol.118 , pp. 240-249
    • Oderup, C.1    Cederbom, L.2    Makowska, A.3    Cilio, C.M.4    Ivars, F.5
  • 22
  • 23
    • 4644369302 scopus 로고    scopus 로고
    • Interleukin-2 is essential for CD4+CD25+ regulatory T cell function
    • de la Rosa, M., S. Rutz, H. Dorninger, and A. Scheffold. 2004. Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur. J. Immunol. 34: 2480-2488.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2480-2488
    • De La Rosa, M.1    Rutz, S.2    Dorninger, H.3    Scheffold, A.4
  • 24
    • 36248976097 scopus 로고    scopus 로고
    • CD4+ CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan, P., L. Zheng, S. Ishihara, J. Reed, and M. J. Lenardo. 2007. CD4+ CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat. Immunol. 8: 1353-1362.
    • (2007) Nat. Immunol. , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 25
    • 78449287872 scopus 로고    scopus 로고
    • A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity
    • Au-Yeung, B. B., S. E. Levin, C. Zhang, L. Y. Hsu, D. A. Cheng, N. Killeen, K. M. Shokat, and A. Weiss. 2010. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat. Immunol. 11: 1085-1092.
    • (2010) Nat. Immunol. , vol.11 , pp. 1085-1092
    • Au-Yeung, B.B.1    Levin, S.E.2    Zhang, C.3    Hsu, L.Y.4    Cheng, D.A.5    Killeen, N.6    Shokat, K.M.7    Weiss, A.8
  • 26
    • 48249103057 scopus 로고    scopus 로고
    • Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
    • Onishi, Y., Z. Fehervari, T. Yamaguchi, and S. Sakaguchi. 2008. Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. USA 105: 10113-10118.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 10113-10118
    • Onishi, Y.1    Fehervari, Z.2    Yamaguchi, T.3    Sakaguchi, S.4
  • 27
    • 64849088870 scopus 로고    scopus 로고
    • Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function
    • Tran, D. Q., D. D. Glass, G. Uzel, D. A. Darnell, C. Spalding, S. M. Holland, and E. M. Shevach. 2009. Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function. J. Immunol. 182: 2929-2938.
    • (2009) J. Immunol. , vol.182 , pp. 2929-2938
    • Tran, D.Q.1    Glass, D.D.2    Uzel, G.3    Darnell, D.A.4    Spalding, C.5    Holland, S.M.6    Shevach, E.M.7
  • 29
    • 40449106468 scopus 로고    scopus 로고
    • Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76
    • Jordan, M. S., J. E. Smith, J. C. Burns, J. E. Austin, K. E. Nichols, A. C. Aschenbrenner, and G. A. Koretzky. 2008. Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity 28: 359-369.
    • (2008) Immunity , vol.28 , pp. 359-369
    • Jordan, M.S.1    Smith, J.E.2    Burns, J.C.3    Austin, J.E.4    Nichols, K.E.5    Aschenbrenner, A.C.6    Koretzky, G.A.7
  • 34
    • 0032541062 scopus 로고    scopus 로고
    • Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell
    • Yablonski, D., M. R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science 281: 413-416.
    • (1998) Science , vol.281 , pp. 413-416
    • Yablonski, D.1    Kuhne, M.R.2    Kadlecek, T.3    Weiss, A.4
  • 35
    • 76249134097 scopus 로고    scopus 로고
    • Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis
    • Bushar, N. D., E. Corbo, M. Schmidt, J. S. Maltzman, and D. L. Farber. 2010. Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis. Proc. Natl. Acad. Sci. USA 107: 827-831.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 827-831
    • Bushar, N.D.1    Corbo, E.2    Schmidt, M.3    Maltzman, J.S.4    Farber, D.L.5
  • 36
    • 78650509025 scopus 로고    scopus 로고
    • Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells
    • Wiehagen, K. R., E. Corbo, M. Schmidt, H. Shin, E. J. Wherry, and J. S. Maltzman. 2010. Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells. Blood 116: 5560-5570.
    • (2010) Blood , vol.116 , pp. 5560-5570
    • Wiehagen, K.R.1    Corbo, E.2    Schmidt, M.3    Shin, H.4    Wherry, E.J.5    Maltzman, J.S.6
  • 37
    • 84908123494 scopus 로고    scopus 로고
    • Continuous requirement for the TCR in regulatory T cell function
    • Levine, A. G., A. Arvey, W. Jin, and A. Y. Rudensky. 2014. Continuous requirement for the TCR in regulatory T cell function. Nat. Immunol. 15: 1070-1078.
    • (2014) Nat. Immunol. , vol.15 , pp. 1070-1078
    • Levine, A.G.1    Arvey, A.2    Jin, W.3    Rudensky, A.Y.4
  • 40
    • 0037163130 scopus 로고    scopus 로고
    • Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta
    • Zhong, X. P., E. A. Hainey, B. A. Olenchock, H. Zhao, M. K. Topham, and G. A. Koretzky. 2002. Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. J. Biol. Chem. 277: 31089-31098.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31089-31098
    • Zhong, X.P.1    Hainey, E.A.2    Olenchock, B.A.3    Zhao, H.4    Topham, M.K.5    Koretzky, G.A.6
  • 42
    • 34447327781 scopus 로고    scopus 로고
    • Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules
    • Ménasché, G., S. Kliche, N. Bezman, and B. Schraven. 2007. Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules. Immunol. Rev. 218: 82-91.
    • (2007) Immunol. Rev. , vol.218 , pp. 82-91
    • Ménasché, G.1    Kliche, S.2    Bezman, N.3    Schraven, B.4
  • 44
    • 84891833990 scopus 로고    scopus 로고
    • The adaptor protein Crk in immune response
    • Liu, D. 2014. The adaptor protein Crk in immune response. Immunol. Cell Biol. 92: 80-89.
    • (2014) Immunol. Cell Biol. , vol.92 , pp. 80-89
    • Liu, D.1
  • 45
    • 52249086931 scopus 로고    scopus 로고
    • The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1
    • Nolz, J. C., L. P. Nacusi, C. M. Segovis, R. B. Medeiros, J. S. Mitchell, Y. Shimizu, and D. D. Billadeau. 2008. The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. J. Cell Biol. 182: 1231-1244.
    • (2008) J. Cell Biol. , vol.182 , pp. 1231-1244
    • Nolz, J.C.1    Nacusi, L.P.2    Segovis, C.M.3    Medeiros, R.B.4    Mitchell, J.S.5    Shimizu, Y.6    Billadeau, D.D.7
  • 46
    • 0037592093 scopus 로고    scopus 로고
    • Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b
    • Zhang, W., Y. Shao, D. Fang, J. Huang, M. S. Jeon, and Y. C. Liu. 2003. Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b. J. Biol. Chem. 278: 23978-23983.
    • (2003) J. Biol. Chem. , vol.278 , pp. 23978-23983
    • Zhang, W.1    Shao, Y.2    Fang, D.3    Huang, J.4    Jeon, M.S.5    Liu, Y.C.6
  • 49
    • 36349034646 scopus 로고    scopus 로고
    • Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion
    • Ghandour, H., X. Cullere, A. Alvarez, F. W. Luscinskas, and T. N. Mayadas. 2007. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood 110: 3682-3690.
    • (2007) Blood , vol.110 , pp. 3682-3690
    • Ghandour, H.1    Cullere, X.2    Alvarez, A.3    Luscinskas, F.W.4    Mayadas, T.N.5
  • 50
    • 1642482866 scopus 로고    scopus 로고
    • Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1
    • Katagiri, K., M. Shimonaka, and T. Kinashi. 2004. Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1. J. Biol. Chem. 279: 11875-11881.
    • (2004) J. Biol. Chem. , vol.279 , pp. 11875-11881
    • Katagiri, K.1    Shimonaka, M.2    Kinashi, T.3
  • 51
    • 18044405159 scopus 로고    scopus 로고
    • Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4
    • Dillon, T. J., K. D. Carey, S. A. Wetzel, D. C. Parker, and P. J. Stork. 2005. Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4. Mol. Cell. Biol. 25: 4117-4128.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 4117-4128
    • Dillon, T.J.1    Carey, K.D.2    Wetzel, S.A.3    Parker, D.C.4    Stork, P.J.5
  • 52
    • 24644506094 scopus 로고    scopus 로고
    • CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function
    • Schneider, H., E. Valk, S. da Rocha Dias, B.Wei, and C. E. Rudd. 2005. CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. Proc. Natl. Acad. Sci. USA 102: 12861-12866.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 12861-12866
    • Schneider, H.1    Valk, E.2    Da Rocha Dias, S.3    Wei, B.4    Rudd, C.E.5
  • 54
    • 80051944092 scopus 로고    scopus 로고
    • Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
    • Wing, K., T. Yamaguchi, and S. Sakaguchi. 2011. Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation. Trends Immunol. 32: 428-433.
    • (2011) Trends Immunol. , vol.32 , pp. 428-433
    • Wing, K.1    Yamaguchi, T.2    Sakaguchi, S.3
  • 55
    • 84894287170 scopus 로고    scopus 로고
    • Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1
    • Kloog, Y., and A. Mor. 2014. Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1. Mol. Cell. Biol. 34: 978-988.
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 978-988
    • Kloog, Y.1    Mor, A.2
  • 56
    • 70449721003 scopus 로고    scopus 로고
    • A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity
    • Hsu, L. Y., Y. X. Tan, Z. Xiao, M. Malissen, and A. Weiss. 2009. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J. Exp. Med. 206: 2527-2541.
    • (2009) J. Exp. Med. , vol.206 , pp. 2527-2541
    • Hsu, L.Y.1    Tan, Y.X.2    Xiao, Z.3    Malissen, M.4    Weiss, A.5
  • 57
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi, T., Y. Kuniyasu, M. Toda, N. Sakaguchi, M. Itoh, M. Iwata, J. Shimizu, and S. Sakaguchi. 1998. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10: 1969-1980.
    • (1998) Int. Immunol. , vol.10 , pp. 1969-1980
    • Takahashi, T.1    Kuniyasu, Y.2    Toda, M.3    Sakaguchi, N.4    Itoh, M.5    Iwata, M.6    Shimizu, J.7    Sakaguchi, S.8


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