Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 2, 2010, Pages 827-831

  Bushar, Nicholas D ^a   Corbo, Evann ^b   Schmidt, Michelle ^b   Maltzman, Jonathan S ^b   Farber, Donna L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Immune memory; Linker adapter; Signal transduction

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; JANUS KINASE 3; PHOSPHOPROTEIN; PROTEIN SLP 76; PROTEIN TYROSINE PHOSPHATASE SHP; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; EFFECTOR CELL; GENE DELETION; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; MEMORY T LYMPHOCYTE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEADY STATE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DOWN-REGULATION; GENE TRANSFER TECHNIQUES; GENES, REPORTER; HOMEOSTASIS; IMMUNOLOGIC MEMORY; INTERLEUKIN-7; LUMINESCENT PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 76249134097     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908126107     Document Type: Article

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