Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library

AAPS Journal

Volumn 12, Issue 3, 2010, Pages 318-329

  Reilley, Kate J ^a   Giulianotti, Marc ^a   Dooley, Colette T ^a   Nefzi, Adel ^a   McLaughlin, Jay P ^a   Houghten, Richard A ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

analgesia; in vivo; mixture based libraries; opioid; testing

Indexed keywords

ANTINOCICEPTIVE AGENT; DELTA OPIATE RECEPTOR; HOT WATER; KAPPA OPIATE RECEPTOR; MORPHINE SULFATE; MU OPIATE RECEPTOR; NALOXONE; TPI 1818 101; TPI 1818 109; UNCLASSIFIED DRUG; ANALGESIC AGENT;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; BREATHING RATE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; EXPERIMENTAL TEST; IC 50; IN VIVO STUDY; LOCOMOTION; MALE; MOUSE; NONHUMAN; PLACE PREFERENCE; RESPIRATION DEPRESSION; TAIL WITHDRAWAL ASSAY; ANIMAL; BREATHING; C57BL MOUSE; CHEMISTRY; COMBINATORIAL CHEMISTRY; CONDITIONED REFLEX; DRUG EFFECTS;

ANALGESICS; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; CONDITIONING, CLASSICAL; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; RESPIRATION;

EID: 77955958888     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-010-9191-3     Document Type: Article

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