Elucidating the molecular basis of action of a classic drug: Guanidine compounds as inhibitors of voltage-gated potassium channels

Molecular Pharmacology

Volumn 80, Issue 6, 2011, Pages 1085-1095

  Kalia, Jeet ^a   Swartz, Kenton J ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANIDINE DERIVATIVE; PROTEIN SUBUNIT; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; HYDROPHOBICITY; MEMBRANE DEPOLARIZATION; MOLECULAR DYNAMICS; NEUROMUSCULAR DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; STEADY STATE; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP; WILD TYPE; XENOPUS LAEVIS;

ANIMALS; FEMALE; GUANIDINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN BINDING; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; XENOPUS LAEVIS;

EID: 81555204234     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.074989     Document Type: Article

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