Antibacterial activity of a series of N2, N4- disubstituted quinazoline-2,4-diamines

Journal of Medicinal Chemistry

Volumn 57, Issue 7, 2014, Pages 3075-3093

  Van Horn, Kurt S ^a   Burda, Whittney N ^a   Fleeman, Renee ^a   Shaw, Lindsey N ^a   Manetsch, Roman ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N (FURAN 2 YLMETHYL)QUINAZOLIN 4 AMINE; 2 CHLORO N ISOPROPYLQUINAZOLIN 4 AMINE; 2 [4 (FURAN 2 YLMETHYLAMINO)QUINAZOLIN 2 YLAMINO]ETHANOL; 2 [4 (METHYLAMINO)QUINAZOLIN 2 YLAMINO]ETHANOL; 2,4 DICHLOROQUINAZOLINE; ANTIINFECTIVE AGENT; N 2 (FURAN 2 YLMETHYL) N 4 ISOPROPYLQUINAZOLINE 2,4 DIAMINE; N 2 (FURAN 2 YLMETHYL) N 4 METHYLQUINAZOLINE 2,4 DIAMINE; N 2 (TERT BUTYL) N 4 (FURAN 2 YLMETHYL)QUINAZOLINE 2,4 DIAMINE; N 2 ,N 4 DIISOPROPYLQUINAZOLINE 2,4 DIAMINE; N 2 CYCLOBUTYL N 4 (FURAN 2 YLMETHYL)QUINAZOLINE 2,4 DIAMINE; N 2 CYCLOHEXYL N 4 (FURAN 2 YLMETHYL)QUINAZOLINE 2,4 DIAMINE; N 2 CYCLOPENTYL N 4 (FURAN 2 YLMETHYL)QUINAZOLINE 2,4 DIAMINE; N 2 CYCLOPENTYL N 4 METHYLQUINAZOLINE 2,4 DIAMINE; N 2 CYCLOPROPYL N 4 (FURAN 2 YLMETHYL)QUINAZOLINE 2,4 DIAMINE; N 2 CYCLOPROPYL N 4 METHYLQUINAZOLINE 2,4 DIAMINE; N 2 ETHYL N 4 (FURAN 2 YLMETHYL)QUINAZOLINE 2,4 DIAMINE; N 2 ETHYL N 4 ISOPROPYLQUINAZOLINE 2,4 DIAMINE; N 2 ISOPROPYL N (2,2,2 TRIFLUOROETHYL)QUINAZOLINE 2,4 DIAMINE; N 2 ISOPROPYL N 4 METHYLQUINAZOLINE 2,4 DIAMINE; N 2,2,2 TRIFUOROETHYL 2 CHLOROQUINAZOLIN 4 AMINE; N 2,N 4 DIMETHYLQUINAZOLINE 2,4 DIAMINE; N 4 (FURAN 2 YLMETHYL) N 2 METHYLQUINAZOLINE 2,4 DIAMINE; N 4 ETHYL N 2 ISOPROPYLQUINAZOLINE 2,4 DIAMINE; N 4 ISOPROPYL N 2 METHYLQUINAZOLINE 2,4 DIAMINE; N E THYL 2 CHLOROQUINAZOLIN 4 AMINE; N METHYL 2 CHLOROQUINAZOLIN 4 AMINE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG SOLUBILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; DIAMINES; DISEASE MODELS, ANIMAL; HEMOLYSIS; HUMANS; LARVA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PERITONITIS; QUINAZOLINES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898470099     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500039e     Document Type: Article

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