Epigenetic tailoring for the production of anti-infective cytosporones from the marine fungus Leucostoma persoonii

Marine Drugs

Volumn 10, Issue 4, 2012, Pages 762-774

  Beau, Jeremy ^a   Mahid, Nida ^a   Burda, Whittney N ^a   Harrington, Lacey ^a   Shaw, Lindsey N ^a   Mutka, Tina ^a   Kyle, Dennis E ^a   Barisic, Betty ^a   Van Olphen, Alberto ^a   Baker, Bill J ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Epigenetics; Fungus; Malaria; Mangrove; MRSA

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; AZITHROMYCIN; CENTHROMYCIN; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; CYTOSPORONE B; CYTOSPORONE C; CYTOSPORONE E; CYTOSPORONE R; DAPTOMYCIN; ERYTHROMYCIN; GENTAMICIN; LINEZOLID; METICILLIN; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; BACTERIAL COUNT; BIOFILM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EPIGENETICS; FUNGAL STRAIN; FUNGUS; FUNGUS ISOLATION; HUMAN; HUMAN CELL; IC 50; LEUCOSTOMA PERSOONII; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; PLASMODIUM FALCIPARUM;

FUNGI; LEUCOSTOMA PERSOONII; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PLASMODIUM FALCIPARUM;

EID: 84860602436     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md10040762     Document Type: Article

References (23)

1. Mumby, P.J.; Edwards, A.J.; Arias-González, J.E.; Lindeman, K.C.; Blackwell, P.G.; Gall, A.; Gorczynska, M.I.; Harborne, A.R.; Pescod, C.L.; Renken, H.; et al. Mangroves enhance the biomass of coral reef fish communities in the Caribbean. Nature 2004, 427, 533-536. (Pubitemid 38209109)
2. Liu, D.; Li, X.M.; Meng, L.; Li, C.S.; Gao, S.S.; Shang, Z.; Proksch, P.; Huang, C.G.; Wang, B.G. Asperolides A - C, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus Aspergillus wentii EN-48. J. Nat. Prod. 2011, 74, 1787-1791.
3. Cao, S.; Clardy, J. New naphthoquinones and a new delta-lactone produced by endophytic fungi from Costa Rica. Tetrahedron Lett. 2011, 52, 2206-2208.
4. Huang, H.; Feng, X.; Xiao, Z.; Liu, L.; Li, H.; Ma, L.; Lu, Y.; Ju, J.; She, Z.; Lin, Y. Azaphilones and p-terphenyls from the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2) isolated from the South China Sea. J. Nat. Prod. 2011, 74, 997-1002.
5. Crawford, J.M.; Clardy, J. Bacterial symbionts and natural products. Chem. Commun. 2011, 47, 7559-7566.
6. Cai, S.; Sun, S.; Zhou, H.; Kong, X.; Zhu, T.; Li, D.; Gu, Q. Prenylated polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07. J. Nat. Prod. 2011, 74, 1106-1110.
7. Cao, S.; Ross, L.; Tamayo, G.; Clardy, J. Asterogynins: Secondary metabolites from a costa rican endophytic fungus. Org. Lett. 2010, 12, 4661-4663.
8. Lu, Z.; Zhu, H.; Fu, P.; Wang, Y.; Zhang, Z.; Lin, H.; Liu, P.; Zhuang, Y.; Hong, K.; Zhu, W. Cytotoxic polyphenols from the marine-derived fungus Penicillium expansum. J. Nat. Prod. 2010, 73, 911-914.
9. Wen, L.; Cai, X.; Xu, F.; She, Z.; Chan, W.L.; Vrijmoed, L.L.P.; Jones, E.B.G.; Lin, Y. Three metabolites from the mangrove endophytic fungus Sporothrix sp. (#4335) from the South China Sea. J. Org. Chem. 2009, 74, 1093-1098.
10. Vervoort, H.C.; Draskovic, M.; Crews, P. Azonazine, a novel dipeptide from a hawaiian marine sediment-derived fungus, Aspergillus insulicola. Org. Lett. 2011, 13, 410-413.
11. Wang, X.; Filho, J.G.S.; Hoover, A.R.; King, J.B.; Ellis, T.K.; Powell, D.R.; Cichewicz, R.H. Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an Atlantic-Forest-derived Penicillium citreonigrum. J. Nat. Prod. 2010, 73, 942-948.
12. Scherlach, K.; Hertweck, C. Triggering cryptic natural product biosynthesis in microorganisms. Org. Biomol. Chem. 2009, 7, 1753-1760.
13. Schwab, E.K.; Bok, J.W.; Tribus, M.; Galehr, J.; Graessle, S.; Keller, N.P. Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot. Cell 2007, 6, 1656-1664. (Pubitemid 47483608)
14. Brady, S.F.; Wagenaar, M.M.; Singh, M.P.; Janso, J.E.; Clardy, J. The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Org. Lett. 2000, 2, 4043-4046.
15. Paranagama, P.A.; Wijeratne, E.M.; Gunatilaka, A.A. Uncovering biosynthetic potential of plant-associated fungi: Effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii. J. Nat. Prod. 2007, 70, 1939-1945.
16. Xu, J.; Kjer, J.; Sendker, J.; Wray, V.; Guan, H.; Edrada, R.; Müller, W.E.; Bayer, M.; Lin, W.; Wu, J.; Proksch, P. Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophoramucronata. Bioorg. Med. Chem. 2009, 17, 7362-7367.
17. Abrei, L.M.; Phipps, R.K.; Pfenning, L.H.; Gotfredsen, C.H.; Takahashi, J.A.; Larsen, T.O. ChemInform abstract: Cytosporones O (I), P (IIa) and Q (IIb) from an endophytic Cytospora sp. Tetrahedron Lett. 2010, 41, 1803-1805.
18. Trager, W.; Jenson, J.B. Cultivation of malarial parasites. Nature 1978, 273, 621-622. (Pubitemid 8352544)
19. Zhan, Y.; Du, X.; Chen, H.; Liu, J.; Zhao, B.; Huang, D.; Li, G.; Xu, Q.; Zhang, M.; Weimer, B.C.; et al. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat. Chem. Biol. 2008, 4, 548-556.
20. Borneman, J.; Hartin, R.J. PCR primers that amplify fungal rRNA genes from environmental samples. Appl. Environ. Microbiol. 2000, 66, 4356-4360.
21. Lebar, M.D.; Hahn, K.N.; Mutka, T.; Maignan, P.; van Olphen, A.; Kyle, D.E.; McClintock, J.B.; Amsler, C.D.; Baker, B.J. CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs. Bioorg. Med. Chem. 2011, 19, 5756-5762.
22. Burda, W.N.; Fields, K.B.; Gill, J.B.; Burt, R.; Shepherd, M.; Zhang, X.P.; Shaw, L.N. Neutral metallated and meso-substituted porphyrins as antimicrobial agents against gram-positive pathogens. Eur. J. Clin. Microbiol. Infect. Dis. 2012, 31, 327-335.
23. Beenken, K.E.; Blevins, J.S.; Smeltzer, M.S. Mutation of sarA in Staphylococcus aureus limits biofilm formation. Infect. Immun. 2003, 71, 4206-4211. (Pubitemid 36753758)